14 results about "Dianhydrohexitol" patented technology

The invention relates to a method for preparing a C13-C29 alkyl diester of 1,4:3,6-dianhydrohexitol, said method comprising:a) a first step of esterification of 1,4:3,6-dianhydrohexitol with a fatty acid having a C13-C29 alkyl chain, said fatty acid being in excess, so as to form a reaction crude comprising a C13-C29 alkyl diester of 1,4:3,6-dianhydrohexitol and unreacted fatty acid;b) a second step of esterification of the unreacted fatty acid with a primary or aromatic diol.

The present invention relates to a process for preparing a polyester carbonate on the basis of cycloaliphatic diacids and at least one 1,4:3,6-dianhydrohexitol and at least one further aliphatic dihydroxy compound, to a polyester carbonate and to a molding compound and a molded product containing the polyester carbonate. The polyester carbonates according to the invention are characterized by good mechanical properties and molecular weights.

The present invention relates to a method for preparing polyestercarbonates based on cycloaliphatic diacids, at least one 1,4:3,6-dianhydrohexitol, and at least one additional aliphatic dihydroxy compound, the polyestercarbonates prepared according to the method, and molding compounds and molded bodies containing the polyestercarbonates. The method according to the invention is a direct synthesis in which all structural elements forming the subsequent polyestercarbonate are already present as monomers in the first process step. It is characterized by a specific ratio of 1,4:3,6-dianhydrohexitol to at least one additional aliphatic dihydroxy compound being advantageous.

A heat-resistant, bio-based polycarbonate ester prepared by melt polycondensation of 1,4:3,6-dianhydrohexitol and a carbonate or 1,4-cyclohexanedicarboxylate is disclosed. The heat-resistant, bio-based polycarbonate ester includes a repeat unit 1 of Formula 1, a repeat unit 2 of Formula 2, and a repeat unit 3 of Formula 3. The polycarbonate ester has excellent heat resistance, transparency, and processability. A method of producing the polycarbonate includes a step of melt polycondensation of 1,4:3,6-dianhydrohexitol and a carbonate or 1,4-cyclohexanedicarboxylate.

The object of this patent application relates to the field of hexitol for use in the prevention and / or treatment of diseases and / or symptoms caused by anaerobic pathogenic microorganisms, and more specifically to monoanhydrohexitol, dianhydrohexitol, or combinations thereof for use in the prevention and / or treatment of such diseases and / or symptoms. In one embodiment, the object is isosorbide for use in the prevention and / or treatment of diseases and / or symptoms associated with obligate anaerobic pathogenic bacteria such as Fusonucleatum, Porphyromonas gingivalis, Veillonella parvula, and Parvimonas micra.

The invention relates to a composition containing A) 60 to 80 wt. % of a polyester on the basis of terephthalic acid and at least one dianhydrohexitol and optionally additional diols, B) 10 to 30 wt. % of a polyester on the basis of succinic acid and at least one aliphatic, araliphatic or cycloaliphatic diol, and C) 3 to 12 wt. % of at least one mineral reinforcing material on the basis of talcum. The invention also relates to a method for producing a molding compound from the composition, to the molding compound itself and to moldings obtainable from the composition or the molding compound.

A process for the manufacture of a polyarylethersulfone “PAES” (P2) using recycled polymeric material, comprising heating a reaction medium (RM) comprising a recycled polymeric material containing a polyarylethersulfone “PAES” (P1), at least one monomer (M), an alkali salt-forming agent (A) and a polar aprotic solvent (S) to reach a reaction temperature of at least 150° C. to form a PAES (P2); and separating the forned PAES (P2) from the reaction medium. The PAES (P1) recycle ratio may be from 100 wt. % to 1 wt. %. The recycled polymeric material added to the reaction medium may further include other polymer(s), solid fillers, and / or additives. The monomer (M) may be at least one aromatic diol monomer (AA) and / or at least one aromatic dihalo monomer (BB). The diol (AA) may comprise bisphenol A, bisphenol S, biphenol, a 1,4:3,6-dianhydrohexitol sugar diol and / or tetramethyl bisphenol F, and the dihalo (BB) may comprise non-sulfonated and / or disulfonated dihalodiphenylsulfone.

A polyol composition, a composition for polyurethane preparation comprising the polyol composition, and a battery module according to the present invention comprise a compound represented by chemical formula 1 (see the description of the invention). In addition, the polyol composition according to the present invention comprises a first unit derived from at least one type of 1,4:3,6-dianhydrohexitol and a second unit derived from an alkylene oxide, and has a degree of unsaturation of 0.02 meq / g or less according to the following measurement method (see the description of the invention).

The present invention provides, in part, dianhydrohexitol-based cationic lipids of Formula (I), and sub-formulas thereof: (I), or a pharmaceutically acceptable salt thereof. The present invention also provides, in part, dianhydrohexitol-based cationic lipids of Formulae (IIA), and sub-formulas thereof: (IIA), or a pharmaceutically acceptable salt thereof. The present invention also provides, in part, dianhydrohexitol-based cationic lipids of Formulae (IIB), and sub-formulas thereof: (IIB), or a pharmaceutically acceptable salt thereof. The compounds provided herein can be useful for delivery and expression of mRNA and encoded protein, e.g., as a component of liposomal delivery vehicle, and accordingly can be useful for treating various diseases, disorders and conditions, such as those associated with deficiency of one or more proteins.

The present invention provides, in part, a cationic dianhydrohexitol-based lipid having formula (I) and its sub-formula: (I), or a pharmaceutically acceptable salt thereof. The present invention also provides, in part, a cationic dianhydrohexitol-based lipid having formula (II) and its sub-formula: (II), or a pharmaceutically acceptable salt thereof. The compounds provided herein can be used to deliver and express mRNA and encoded proteins, for example, as components of liposomal delivery vehicles, and thus can be used to treat various diseases, disorders, and conditions, such as those associated with the lack of one or more proteins.

A copolycarbonate ester produced from a polymerizable composition according to the present invention can have various physical properties including a melt flow index (MFI) of 43 g / 10 minutes to 85 g / 10 minutes under a load of 2.16 kg at 260°C. according to ASTM D1238 by being copolymerized through the melt-polycondensation of: 1,4:3,6-dianhydrohexitol and / or a diol compound other than 1,4:3,6-dianhydrohexitol including 1,14-tetradecanediol, 1,4-cyclohexanedimethanol, tricyclodecane dimethanol, 3,9-bis(1,1-dimethyl-2-hydroxyethyl)-2,4,8,10-tetraoxaspiro[5,5]udecane, bicycle[2.2.2]octane-2,3-dimethanol, 2,2-bis(4-hydroxycyclohexyl)propane, 2,2,4,4-tetramethyl-1,3-cyclobutanediol, 1,1-bis(4-hydroxyphenyl)-3,3,5-trimethylcyclohexane, 9,9-bis(4-hydroxyphenyl)fluorene, or tetrahydofuran-2,5-dimethanol; a carbonate compound; and a petroleum-based and / or bio-based diphenyl ester and / or an additional diphenyl ester compound other than the petroleum-based and / or bio-based diphenyl ester including diphenyl sebacate, diphenyl decahydronaphthalene-2,6-dicarboxylate, diphenyl tetrahydrofuran-2,5-dicarboxylate, or 2,5-diphenyl-furandicarboxylate, and can thus be usefully applied to the manufacture of segmented products.

The present disclosure relates to 1,4:3,6-dianhydrohexitol, specifically isosorbide, and compositions comprising 1,4:3,6-dianhydrohexitol for treating oral inflammatory conditions. These conditions, which include both oral mucosal inflammation and periodontal diseases, are characterized by elevated levels of pro-inflammatory mediators, particularly IL-1 alpha and IL-8. Using the EpiOral™ model, isosorbide has demonstrated significant ability to reduce IL-1 alpha secretion and IL-8 gene expression in inflamed oral epithelial cells. These results support its therapeutic relevance in treating oral inflammatory conditions through modulation of key inflammatory mediators.

The present invention relates to a process for preparing a polyester carbonate comprising at least one 1, 4: 3, 6-dianhydrohexitol by melt transesterification reaction wherein the process comprises reactions in a specific chronological order. The obtained polyestercarbonate has good color and high molecular weight. Furthermore, the present invention relates to a polyester carbonate obtained by said method and to a molded body comprising the polyester carbonate.

An object of the present application is a composition comprising a compound having at least one heterocyclic ring and at least one antioxidant selected from the group consisting of antioxidants having at least two aromatic rings. In particular, the compound is selected from the group consisting of dianhydrohexitols, most particularly isosorbide. The compositions exhibit improved oxidation resistance, as well as lower yellowing during storage and after heat treatment. These compositions are useful in the preparation of polymers comprising isosorbide as comonomer.