Use of a material based on a thermoplastic polymer having a high content of antioxidants for packaging dianhydrohexitols

A technology of dianhydrohexitols and thermoplastic polymers, which is applied in the fields of effective components of heterocyclic compounds, transportation and packaging, and thin material treatment, and can solve problems such as the chemical stability of dianhydrohexitols that have not been mentioned

Active Publication Date: 2010-07-07
ROQUETTE FRERES SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, the document does not mention the chemical sta...

Method used

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Examples

Experimental program
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Effect test

example 1

[0050] 50 g of isosorbide in solid form (flakes) are introduced into a sachet (25 cm x 25 cm) consisting of the packaging material to be tested. The pouch is immediately sealed by welding using an impact sealer (type SZ 380 sold by Joisten & Kettenbaum GmbH & Co, Bergisch Gladbach, Germany). The sachet thus sealed is then introduced into a second sachet (made of aluminum and containing a polyethylene coating and sealed by welding using the same heat sealer) to ensure tightness against the outside atmosphere. The samples thus packaged were placed in a ventilated oven maintained at a temperature of 50°C. A control sample was enclosed in a glass flask and stored under the same conditions.

[0051] After a given period of time, the entire isosorbide sample was removed from the package and dissolved in permeate water to 40% by weight solids. The pH of the solution was measured for each sample.

[0052] The pH measurement results are shown in Table 1 below.

[0053] Table 1

[...

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Abstract

The present invention relates to the use of a packaging material based on a thermoplastic polymer for packaging a dianhydrohexitol, the packaging material comprising at least one thermoplastic polymer layer containing at least 0.1% by weight of at least one antioxidant (layer (A)), said layer (A) either being directly in contact with the dianhydrohexitol or being separated from the latter by a thermoplastic polymer layer (layer (B)) having a thickness at most equal to 150 [mu]m, and the thermoplastic polymer of the layer (A) and/or of the layer (B) being chosen independently from polyethylene, polypropylene, ethylene/polypropylene copolymers and blends of the latter.

Description

technical field [0001] The present invention relates to the use of a special thermoplastic material comprising a layer with a high content of antioxidants for packaging dianhydrohexitols. Background technique [0002] Dianhydrohexitol, also known as isohexitol, is a C 6 Product of internal dehydration of hydrogenated sugars (hexitols) such as sorbitol, mannitol and iditol. [0003] Among these dianhydrohydrogenated sugars, isosorbide is the one for which most industrial applications are developed and envisaged today, especially in the field of pharmaceuticals, in the field of intermediates of chemical synthesis and in the field of plastics. [0004] For many of these applications it is generally necessary to have a composition that is as pure as possible, in particular with a dianhydrohexitol content at least equal to 98.5% by weight, preferably at least equal to 99.5% by weight. [0005] The observation that dianhydrohexitols, and in particular isosorbide, are not only hi...

Claims

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Application Information

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IPC IPC(8): B32B27/18B32B27/32A61K31/34A61K9/14B65D81/24
CPCB32B27/18B32B2250/242B32B2307/7244B32B2250/24B32B2307/7246B32B27/32B32B27/08B32B27/20B32B2439/46B32B2264/108B32B2250/02A61K31/34Y10T428/1352Y10T428/31855B32B27/06B65D81/24
Inventor 帕特里克·富埃尔特斯马克西姆·安格勒特A·兰宾埃尔韦·维亚尔
Owner ROQUETTE FRERES SA
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