The application belongs to the technical field of biomedical materials, and discloses a
molecular probe for detecting old chronic
atrophic gastritis and application, wherein the
molecular probe is a magnetic-optical dual-mode composite
nanoparticle coupled with Mcemp1; a preparation method of the
molecular probe comprises the following steps: Fe3O4@OA solution is prepared by taking
acetylacetone iron,
oleylamine and
dibenzyl ether as raw materials; after being modified by SPE-PEG2000-NH2
polymer, the
magnetic core Fe3O4-PEG-NH2 NPs are obtained through purification; after the
magnetic core is coupled with Mcemp1 and purification, the Fe3O4-PEG-Mcemp1 NPs are obtained; then, near-
infrared fluorescent dye ICG is labeled, and the magnetic-optical dual-mode composite
nanoparticle coupled with Mcemp1 is obtained after
dialysis. The application realizes non-invasive
continuous monitoring by intravenous administration of the magnetic particle probe, combines the dual-mode technology, quantifies the density of the gland in real time, dynamically tracks the
gastric mucosa, solves the problems of insufficient
penetration depth of the fluorescent probe and low quantitative precision, and fills the technical gap of dynamic evaluation and
cancer warning.