3results about How to "Three wastes less pollution" patented technology

The invention discloses a synthetic method of a water soluble ultraviolet light absorber BP-9. The method mainly comprises the following process steps: (1) carrying out methylation on the main raw materials of 2, 2', 4, 4'-tetrahydroxyl benzophenone, a transition metal salt catalyst and a mixed solvent which is prepared from dichloroethane and anhydrous ethanol in equal parts by weight to obtain 2, 2'-dihydroxyl-4, 4'-dimethoxyl benzophenone; (2) carrying out sulfonation reaction on the main raw materials of methylate, sulfamic acid and C1-C3 halohydrocarbon to obtain 2, 2'-dihydroxyl-4, 4'-dimethoxyl benzophenone-5, 5'-disulfonic acid; and (3) carrying out neutral reaction on the main raw materials of sulfonated product, inorganic base and ethanol water to finally obtain the BP-9 product. The synthetic method disclosed by the invention is few in reaction step, low in cost, high in product purity and stable in quality, and raw materials are easily available.

The invention relates to the technical field of drug intermediates, in particular to a method for synthesizing chiral indene amine, which comprises the following steps: synthesizing cis-chiral indene amine with high yield and high stereoselectivity by using indanone as a raw material through a ruthenium chiral diphosphine catalyst, and then transposing to obtain trans-chiral indene amine. The method has the advantages that the content of the product chiral indene amine trans-form is larger than 99% and 98% ee, the total yield is larger than 90%, the catalyst is convenient and easy to obtain, operation is easy, raw materials are easy to obtain, three-waste pollution is small, energy consumption is low, and the method is suitable for industrial production.

The invention relates to a synthesis method of a rilpivirine key intermediate, and belongs to the technical field of pharmacy. The name of the intermediate is (E)-3-(4-amino-3, 5-dimethylphenyl) acrylonitrile hydrochloride; the method comprises the following steps: 1, taking 2, 6-dimethylaniline as a starting material, and carrying out halogenation reaction and amino protection one-pot reaction to obtain an intermediate 1; step 2, carrying out Heck reaction and post-treatment on the intermediate 1 and acrylamide to prepare an intermediate 2; and step 3, carrying out dehydration reaction on the amide group of the intermediate 2 and carrying out one-time deprotection reaction on the amino group to finally obtain the required (E)-3-(4-amino-3, 5-dimethylphenyl) acrylonitrile hydrochloride. According to the method, high temperature, high pressure, toxic and harmful gas and the like are avoided in each step of operation, the method is very suitable for industrial production, and the technical scheme is high in yield and has great commercial application value.