39 results about "Methyl Ketone" patented technology

The invention provides a preparation method of an alpha-difluoroselenomethyl ketone derivative, which is a method for preparing the alpha-difluoroselenomethyl ketone derivative by using 2, 2-difluoroolefin and dialkyl diselenide in the presence of iodosobenzene diacetate. The preparation method specifically comprises the following steps: dissolving 2, 2-difluoroolefin and a dialkyl diselenide compound in an organic solvent, uniformly mixing, adding iodobenzene diacetate, and stirring and reacting at a certain temperature in an air atmosphere to obtain the product alpha-difluoro (seleno) methyl ketone derivative. The alpha-difluoroselenomethyl ketone derivative can be mildly and efficiently obtained by only adopting iodobenzene diacetate without necessary catalysts, alkali, persulfide and persulfate compounds in the prior art. Wherein R1 and R2 are aliphatic hydrocarbon, substituted and unsubstituted benzene, substituted and unsubstituted naphthalene or other aromatic groups.

This invention belongs to the field of organic synthesis and discloses a method for preparing α-difluoroselenomethyl ketone derivatives using electrochemistry. The method involves preparing α-difluoroselenomethyl ketone derivatives under electrochemical conditions using 2,2-difluorovinyl alcohol trimethylsilyl ether compounds and dialkyl diselenoether. Specifically, the 2,2-difluorovinyl alcohol trimethylsilyl ether compound and the dialkyl diselenoether compound are dissolved in an organic solvent, mixed thoroughly, an electrolyte is added, an inert electrode is inserted, and the reaction is carried out under electrostatic stirring at room temperature to obtain the product α-difluoro(selenomethyl) ketone derivative. This invention eliminates the need for catalysts, bases, persulfates, persulfates, or iodobenzene acetates considered necessary in the prior art; it only requires electrolysis to obtain α-difluoroselenomethyl ketone derivatives in a mild and efficient manner.

To provide methods for producing trifluoromethyl ketone and pentafluoroethyl ketone in economical, safe and industrial manners.SOLUTION: An ester compound represented by the general formula (1) is supplied and mixed with a base and trifluoromethane or pentafluoroethane in the presence of organic solvent by using a micro mixer and a micro reactor, and the reaction of them results in a trifluoromethyl ketone or pentafluoroethyl ketone represented by the general formula (3). [R1 is a naphthyl-1-yl group or the like; R2 is a methyl group or an ethyl group; Rf is a trifluoromethyl group or pentafluoroethyl group].SELECTED DRAWING: None

The present invention relates to the pharmaceutical field, and specifically to a compound of the following general formula I or a pharmaceutically acceptable salt, stereoisomer, tautomer, a composition containing the compound, a method for producing the same, and use in the pharmaceutical field. JPEG2025507883000103.jpg3547

The application provides a method for preparing a multi-carbon methyl ketone from acetone. In the method, the acetone is reacted with itself or a corresponding aldehyde to obtain the multi-carbon methyl ketone. In order to improve the yield of the multi-carbon methyl ketone, the acetone used in the reaction has a methanol content of less than or equal to 250 ppm, and preferably a methanol content of less than or equal to 200 ppm. After the acetone is reused, the methanol concentration in the reactor is less than or equal to 1.5%, so that the selectivity of the acetone to the multi-carbon methyl ketone is greater than or equal to 90%. The process flow of the application is simple, the product has good selectivity, and the device has high economic efficiency.

The application provides a Bacillus velezensis TCS001 volatile gas composition, which comprises 2-ethylhexanol, methyl nonyl methyl ketone, 2-decanol and 2-dodecanone, and the mass ratio of 2-ethylhexanol:methyl nonyl methyl ketone:2-decanol:2-dodecanone is 2-7:5-13:2-6:2-23. The Bacillus velezensis TCS001 volatile gas composition can be used as a safe and efficient gas-phase bacteriostatic material for the research and development of a novel fumigation preparation, is suitable for the prevention and treatment of diseases in a closed environment such as a greenhouse, a warehouse and the like, promotes crop growth, and has wide application value.

This invention provides a method for simultaneously detecting 17 heat-processing hazards in 4 categories, comprising: adding n-hexane to the sample, mixing thoroughly, discarding the n-hexane phase, extracting acrylamide, 5-hydroxymethylfurfural, and free heterocyclic amines using dimethyl ketone and ultrasound-assisted extraction, collecting the supernatant, and purifying it; simultaneously transferring the precipitate to another tube, reducing it with sodium tetrahydroborate, hydrolyzing it with hydrochloric acid to release bound heterocyclic amines and late-stage glycosylation products, and performing UPLC-MS / MS analysis. This invention is the first to propose a two-step extraction method for simultaneously determining 17 heat-processing hazards in 4 categories within 7 minutes using UPLC-MS / MS. The accuracy, precision, detection limit, quantitation limit, and recovery rate of the method were verified, and all test indicators met the requirements. This method is applicable to the determination of heat-processing hazards in four types of food matrices: high starch, high protein, high fat, and high sugar.

Described herein are materials and methods to generate beta-ketoadipates cost-efficiently and with reduced environmental impact from muconolactone. Advantageously, the described beta-ketoadipates, including dimethyl beta-ketoadipates, are more stable than traditional βKA and can be produced with a reduction in the amount of salt byproducts, by as much as half.

The application discloses a preparation method of rutile titanium oxide long fibers, and belongs to the field of titanium oxide preparation. The preparation steps comprise the following steps: mixing titanium chloride, ethylene glycol and ethanolamine, stirring and refluxing, filtering to obtain a clear and transparent solution, rotary evaporation of the clear and transparent solution to obtain a concentrated rectification product, mixing the rectification product with ethyl methyl ketone, adding deionized water into the mixture, stirring and refluxing to obtain an organic titanium solution; adding polyvinyl alcohol into the organic titanium solution, uniformly stirring to obtain a stable spinning solution, electrospinning, heat treating the fibers after spinning to obtain rutile titanium oxide long fibers. The titanium oxide fibers prepared by the method are of rutile structure, the fibers are continuous, not adhered to each other and smooth in surface, the preparation method is simple, suitable for industrialization, and has a wide application prospect.

Recombinant cells and methods for producing methyl ketones, such as medium-chain methyl ketones. The recombinant cells include recombinant acyl-ACP thioesterase genes, recombinant β-ketoacyl-CoA thioesterase genes, and recombinant acyl-CoA synthetase genes, in addition to other modifications. The methods include culturing the recombinant cells to produce the methyl ketones and isolating the produced methyl ketones.

The present disclosure relates to compounds and compositions, for example, anti-methanogenic compositions, comprising a trihalomethyl ketone and methods of administering the anti-methanogenic composition to a ruminant to reduce methane emissions. Systems and associated methods of reducing methane are further provided.

A porosity-free phenolic epoxy to use as a fill for nanostructures, the phenolic epoxy including i) poly(tetrahydrofuran); ii) polyglycidyl ether of phenol-formaldehyde; iii) ethyl methyl ketone; and iv) a solvent such as isopropanol. The phenolic epoxy creates a uniform, void free fill that improves silicon wafer processing, metrology, and TEM analysis. A method to fill a nanostructure with a porosity-free phenolic epoxy, includes placing tetrahydrofuran in a strong acid such that a ring of the tetrahydrofuran is opened to create a tetrahydrofuran monomer, polymerizing the tetrahydrofuran monomer to create poly(tetrahydrofuran), mixing the poly(tetrahydrofuran) with polyglycidyl ether of phenol-formaldehyde, ethyl methyl ketone, and isopropanol, and depositing one or more layers of the porosity-free phenolic epoxy onto a surface of a nanostructure.

The invention discloses a plant-based fiber, a preparation method thereof and application of the plant-based fiber in protective gloves, and relates to the technical field of high polymer materials. When the plant-based fiber is prepared, carboxylated carbon nanotubes are sequentially reacted with thionyl chloride and (2, 4-dihydroxyphenyl) (4-vinyl phenyl) ketone to prepare modified carbon nanotubes; the preparation method comprises the following steps: reacting 4-chloro-N, N-diethyl-6-methyl-1, 3, 5-triazine-2-amine with 6-chloro-1-hexene to generate quaternary ammonium salt, and then reacting with alkali lignin to prepare quaternized lignin; the preparation method comprises the following steps: reacting allyl phosphine dichloride with p-aminobenzoic acid to obtain binary acid; dibasic acid, ethylene glycol and terephthalic acid are subjected to a condensation polymerization reaction to prepare polyester; polyester, the modified carbon nanotubes and quaternized lignin are subjected to melt spinning, and the plant-based fiber is prepared. The plant-based fiber prepared by the invention has good flame retardant property, antistatic property, mechanical property and ultraviolet-proof property.

This invention discloses a method using arylmethyl ketones and 2-aryl- N This invention relates to a method for synthesizing dihydropyrrole derivatives using toluenesulfonylaziridine as a starting material, belonging to the field of organic synthetic chemistry. The method uses tris(dibenzylacetone)dipalladium (Pd2(dba)3) as a catalyst, and 2-iodobenzoic acid (IBX) and potassium persulfate (K2S2O8) as co-oxidants. N,N Using dimethylformamide (DMF) as both solvent and carbon source, the reaction is carried out in an oil bath at 100℃–120℃ for 15–24 h, followed by post-treatment to obtain dihydropyrrole derivatives. This invention utilizes readily available raw materials, is simple to operate, employs mild reaction conditions, exhibits broad functional group compatibility, provides high product selectivity, and is environmentally friendly. Yields can reach 51%–90%, making it suitable for large-scale preparation of structurally diverse dihydropyrrole derivatives. It has significant application value in drug development, natural product synthesis, and materials chemistry.

The application discloses a Wacker type oxidation preparation method of methyl ketone. The method comprises the following steps: adding a hydrocarbon compound, a palladium catalyst, a ligand and an oxidant into an alcohol solvent, and performing heating treatment under a protective atmosphere to obtain a methyl ketone compound, wherein the oxidant is an Oxone oxidant, and the ligand is 2-phenyl-1H-benzo[d]imidazole. The preparation method provided by the application has high catalytic activity of the catalytic system, and the catalyst loading is as low as 0.1-1 mol%, thereby greatly reducing the cost of noble metals. The ligand used has a simple structure and is convenient to synthesize, and high catalytic activity and high regioselectivity are realized. The Oxone used as the green oxidant has good water solubility and friendly by-products, the reaction is performed at 50-60 DEG C under normal pressure, the solvent used is cheap and low-toxic, and the condition is mild, safe and easy to scale up. The method has a wide applicable range of substrates, excellent functional group compatibility, single product and simple separation and purification.

The invention belongs to the technical field of luminescent materials, and particularly relates to an ultralow-doped efficient room-temperature phosphorescent material as well as a preparation method and application thereof. According to the invention, a phenyl [2-phenyl-1H-benzo [d] imidazole-5-yl] ketone derivative (PBM-R) molecule is used as an energy acceptor, and is doped with main materials such as N-methyl-4-bromobenzamide (BMB) and the like (an energy transfer carrier). After the two compounds are simply mixed and mechanically ground, triplet-triplet energy transfer (TTET) can be started, so that organic room-temperature phosphorescence emission is realized. It is worthy of notice that the phosphorescent material can maintain significant phosphorescent emission even at a low object doping level (the mass ratio of the subject to the object is as high as 10000: 1), so that the material consumption is significantly reduced and the photophysical stability is improved. The doping system is further applied to various information storage and encryption methods, and the potential of multi-scene application of the doping system is highlighted.

The present application relates to a kind of 4-substituted-5H-1,2,3-dithiazole-5-thione and derivative and its synthesis method.The present application uses in non-metal iodine compound catalysis, methyl ketone compound, nitrogen-containing small molecule and elemental sulfur are converted into the technical scheme of 4-substituted-5H-1,2,3-dithiazole-5-thione and derivative.This technical scheme has the following advantages: the reagent required stable nature, need not pretreatment, cheap and easy to obtain;One-pot synthesis, the economy advantage of step is obvious, save time and effort;Without using transition metal catalysis, metal residue problem is eliminated from the root;Using cheap iodine compound catalysis, reduce environmental pollution, save reaction cost;Cheap and easy to obtain, safe and stable nitrogen-containing small molecule provides nitrogen source, elemental sulfur provides sulfur source, elemental sulfur provides two types of structures of per-sulfur bond and carbon-sulfur double bond in reaction;Whole reaction system is simple, reaction equipment is less, and operation is simple;The 4-substituted-5H-1,2,3-dithiazole-5-thione synthesized has good biological activity function, is potential drug molecule.

The invention relates to psychoactive medicines including 2C-B, methylone, MBDB, their respective metabolites, isomers, enantiomers, polymorphs, and analogues (2C-series and cathinones); their preparation, formulations, intermediates, routes of administration, dosing and schedule for medical uses for psychiatric and neurological conditions and disorders.

The present invention discloses ibrutinib and a synthesis method thereof, comprising the following steps: (1) using SM1 (4-phenoxybenzoyl chloride) as a raw material, and carrying out a coupling reaction with SM2 (4,6-dichloropyrimidine) under the condition of a catalyst to obtain an intermediate M1 ((4,6-dichloropyrimidin-5-yl)(4-phenoxyphenyl)methyl ketone); (2) carrying out a cyclization reaction between M1 and SM3 (1-(3R-hydrazino-1-piperidinyl)-2-propylene-1-one) to obtain to the intermediate M2 (1-((R)-3-(4-chloro-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one); (3) subjecting M2 to a chlorination amination reaction to obtain ibrutinib (1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one). The ibrutinib synthesis method provided by the present invention has a reasonable route design, mild reaction conditions in each step, strong operability, low cost, high yield, simple process operation, is suitable for large-scale industrial production, and is of great significance.

This invention belongs to the field of organic synthesis technology and discloses a method for preparing cyclopropyl methyl ketone, comprising at least the following steps: 1) A mixture of acetaldehyde and allyl halide or allyl ester, along with a catalyst, is formed in a reaction vessel, heated and stirred to induce a hydroacylation reaction. Unreacted raw materials are removed by vacuum distillation to obtain an intermediate product. 2) The intermediate product obtained in step 1) is mixed with an alkaline catalyst, heated and kept at a constant temperature to obtain crude cyclopropyl methyl ketone, which is then purified by distillation to obtain pure cyclopropyl methyl ketone. The preparation method of this invention uses inexpensive and readily available raw materials, exhibits high atom economy, and has significant economic benefits; the alkaline catalyst used in step 2) is regenerable and can be further scaled up industrially.

The present invention relates to a kind of synthetic method of tebuconazole, belong to the technical field of organic synthesis, and its method flow comprises as follows: Step1, adds 1,2,4-triazole and dichloromethane in autoclave, adds alkali, after heating, insulation reaction;Step2, after reaction terminates, cool to room temperature, filter, filtrate is concentrated to obtain chloromethyl triazole;Step3, in reaction flask, under nitrogen protection, add solvent, add magnesium chips or zinc powder, add a small amount of initiator iodine, drip the mixed solution of chloromethyl triazole and pentanone, after completion of dropwise addition, insulation reaction;Step4, reaction terminates, adds dilute acid neutralization, and obtains tebuconazole through standing phase separation and organic phase concentration. The present invention is with p-chlorobenzyl cyanide and cyclopropyl methyl ketone as main raw materials, first p-chlorobenzyl cyanide is halogenated at the benzyl position, then under the alkaline conditions of potassium hydroxide and cyclopropyl methyl ketone, Darzen reaction obtains epoxide, and " one pot method " cyanohydrolysis, deacidification obtain target product under the acidic conditions of sulfuric acid.

This invention relates to the field of high-purity isopropanol preparation technology, and discloses a method for preparing isopropanol by hydrogenation of dimethyl ketone. The method includes: (1) purifying dimethyl ketone raw material to obtain purified dimethyl ketone; (2) reacting the purified dimethyl ketone with hydrogen in the presence of a hydrogenation catalyst to obtain isopropanol product; (3) refining the crude isopropanol product to obtain the high-purity isopropanol; wherein, in step (1), the purification method includes refining the dimethyl ketone raw material after contacting it with an oxidant; the amount of the oxidant is 0.01-0.05 wt% of the dimethyl ketone raw material; and the concentration of organic acids in the purified dimethyl ketone is less than or equal to 20 ppm. By controlling the concentration of organic acids in the purified dimethyl ketone reacting with hydrogen to be less than or equal to 20 ppm, the selectivity and content of isopropanol in the isopropanol product during the hydrogenation reaction can be increased, and the content of impurities, especially ether impurities, in the isopropanol product can be reduced.

The invention provides a preparation method of a 1, 3-dicyclopropyl-2-butene-1-one compound, belongs to the technical field of organic synthesis catalytic materials, and aims to solve the technical problem of low yield of ketene compounds. The preparation method of the ketene compound comprises the following steps: mixing cyclopropyl methyl ketone and a diaspore catalyst, and carrying out condensation reaction to generate 1, 3-dicyclopropyl-2-butene-1-ketone. The preparation method of the diaspore catalyst is simple and suitable for large-scale preparation. The surface of the material is rich in hydroxyl, and the material has the advantages of strong alkalinity, high catalytic efficiency and stable cycle activity. The diaspore has higher conversion efficiency and selectivity for self-condensation of cyclopropyl methyl ketone molecules, and can realize higher conversion rate under mild conditions.

The invention relates to the technical field of material analysis, in particular to a method for measuring the content of VOC in cellulose ether. According to the test method provided by the invention, an internal standard method is adopted, ethylene glycol monomethyl ether, diethylene glycol dimethyl ether, diethylene glycol monomethyl ether, diethylene glycol butyl ether, triethylene glycol dimethyl ether, 1, 2-propylene glycol and the like are taken as calibration compounds, cyclopropyl methyl ketone is taken as an internal standard compound, and solid powdery cellulose ether is subjected to specific pretreatment; by combining certain gas chromatography conditions, the efficient separation of 10 VOCs such as ethylene glycol monomethyl ether is realized, and the content of the VOCs in the cellulose ether can be accurately determined. According to the method, the defect of detection of the VOC content in the cellulose ether is overcome, the stable and efficient analysis method is established, and the method is easy and convenient to operate, high in sensitivity, good in reproducibility and high in long-term stability.

This invention provides a method for producing intermediate chlorosubstituted phenyltrifluoromethyl ketones. [Solution] The following general formula (4) JPEG2026062955000020.jpg35170 Compounds represented by the following formula (5) are reacted with trifluoromethane to obtain the compound shown in the following general formula (5). JPEG2026062955000021.jpg35170 A method for producing chlorosubstituted phenyltrifluoromethyl ketones represented by [formula] is used.

This invention belongs to the technical field of pure organic small molecule room-temperature phosphorescent materials, specifically relating to a phenyl(triphenyl-2-yl) methyl ketone derivative exhibiting room-temperature phosphorescence, its preparation method, and its applications. To develop a pure organic RTP material with strong intermolecular interactions and the ability to block oxygen and water quenching, this invention designs and synthesizes a series of phenyl(triphenyl-2-yl) methyl ketone derivatives with strong intermolecular interactions. Even when crystallization is disrupted, these derivatives can maintain strong intermolecular interactions to stabilize the TT. n It also blocks the quenching of oxygen and water to a certain extent, so that it can easily emit room temperature phosphorescence regardless of whether it is in the crystalline, amorphous, nanoparticle or polymer state, which is more conducive to its production and application.

The invention belongs to the technical field of organic synthesis, and particularly relates to a synthetic method of cyclopropyl methyl ketone. By designing a novel catalytic path, 2-methylfuran is directly rearranged into cyclopropyl methyl ketone after hydrogenation, a chlorine-containing intermediate is avoided, the safety risk in the production process is greatly reduced, the product / intermediate is directly separated through reduced pressure distillation in the two-step reaction, complex extraction or multiple rectification is not needed, the high yield can be obtained, and the method is suitable for industrial production. And a high-purity product is obtained. Strong acid, strong base or chlorine-containing reagents are not used in the whole process, so that the generation of high-salinity wastewater and chlorine-containing pollutants is eliminated from the source, the main component of the wastewater is an ethanol / water mixed solution and can be directly recycled, the catalyst I and the catalyst II can be recycled through filtration, the reuse performance is stable, and the cost is low. Solid waste discharge and raw material cost are effectively reduced, and the method is green and environment-friendly.

This invention relates to certain benzodihydropyranol, quinone, or hydroquinone compounds and their derivatives for the treatment of heart failure with reduced ejection fraction (HFrEF). Specifically, this invention relates to benzodihydropyranol compounds selected from S-(6-hydroxy-2,5,7,8-tetramethyl-2-yl)(piperazin-1-yl) methyl ketone and S-(6-hydroxy-2,5,7,8-tetramethyl-2-yl)(4-(2-hydroxyethyl)piperazin-1-yl) methyl ketone, and their pharmaceutically acceptable salts.

A porosity-free phenolic epoxy to use as a fill for nanostructures, the phenolic epoxy including i) poly(tetrahydrofuran); ii) polyglycidyl ether of phenol-formaldehyde; iii) ethyl methyl ketone; and iv) a solvent such as isopropanol. The phenolic epoxy creates a uniform, void free fill that improves silicon wafer processing, metrology, and TEM analysis. A method to fill a nanostructure with a porosity-free phenolic epoxy, includes placing tetrahydrofuran in a strong acid such that a ring of the tetrahydrofuran is opened to create a tetrahydrofuran monomer, polymerizing the tetrahydrofuran monomer to create poly(tetrahydrofuran), mixing the poly(tetrahydrofuran) with polyglycidyl ether of phenol-formaldehyde, ethyl methyl ketone, and isopropanol, and depositing one or more layers of the porosity-free phenolic epoxy onto a surface of a nanostructure.