55 results about "Methyl Ketone" patented technology

The invention relates to a method for synthesizing trifloxystrobin through a one-pot method, and belongs to the technical field of organic synthesis.The method comprises the following steps that 1, E-2-(2-halomethylphenyl)-2-methoxyiminoacetic acid methyl ester, m-trifluoromethyl acetophenone, hydroxylamine hydrochloride or hydroxylamine sulfate and a solvent are added into a reaction flask, then alkali is added, and after addition is completed, a heat preservation reaction is conducted; and Step 2, after the reaction is finished, filtering to remove salt, and concentrating filtrate under reduced pressure to obtain trifloxystrobin. Compared with a traditional synthesis method of the trifloxystrobin, the synthesis method of the trifloxystrobin has the advantages that the 3-trifluoromethyl acetophenone and the E-2-(2-halomethylphenyl)-2-methoxyiminoacetic acid methyl ester are used as raw materials, the trifloxystrobin is directly synthesized by a one-pot method, the reaction route is short, the raw material cost is low, and the synthesis method of the trifloxystrobin by the one-pot method has the advantages that the synthesis efficiency is high, and the synthesis cost is low. The preparation method has the advantages that the preparation of m-trifluoromethyl acetophenone oxime from m-trifluoromethyl acetophenone is not needed, the whole synthesis process is simpler and more efficient, the reaction conditions are mild, and the preparation method is suitable for industrial large-scale production.

The invention relates to psychoactive medicines including methylone, 2C-B, MBDB, their respective salts, metabolites, isomers, enantiomers, solvates, isotopologues and isotopomers, polymorphs, prodrugs and analogs (2C-series and cathinones); their preparation, formulations, intermediates, routes of administration, dosing and schedule for medical uses for psychiatric and neurological conditions and disorders.

The invention provides a preparation method of an alpha-difluoroselenomethyl ketone derivative, which is a method for preparing the alpha-difluoroselenomethyl ketone derivative by using 2, 2-difluoroolefin and dialkyl diselenide in the presence of iodosobenzene diacetate. The preparation method specifically comprises the following steps: dissolving 2, 2-difluoroolefin and a dialkyl diselenide compound in an organic solvent, uniformly mixing, adding iodobenzene diacetate, and stirring and reacting at a certain temperature in an air atmosphere to obtain the product alpha-difluoro (seleno) methyl ketone derivative. The alpha-difluoroselenomethyl ketone derivative can be mildly and efficiently obtained by only adopting iodobenzene diacetate without necessary catalysts, alkali, persulfide and persulfate compounds in the prior art. Wherein R1 and R2 are aliphatic hydrocarbon, substituted and unsubstituted benzene, substituted and unsubstituted naphthalene or other aromatic groups.

This invention belongs to the field of organic synthesis and discloses a method for preparing α-difluoroselenomethyl ketone derivatives using electrochemistry. The method involves preparing α-difluoroselenomethyl ketone derivatives under electrochemical conditions using 2,2-difluorovinyl alcohol trimethylsilyl ether compounds and dialkyl diselenoether. Specifically, the 2,2-difluorovinyl alcohol trimethylsilyl ether compound and the dialkyl diselenoether compound are dissolved in an organic solvent, mixed thoroughly, an electrolyte is added, an inert electrode is inserted, and the reaction is carried out under electrostatic stirring at room temperature to obtain the product α-difluoro(selenomethyl) ketone derivative. This invention eliminates the need for catalysts, bases, persulfates, persulfates, or iodobenzene acetates considered necessary in the prior art; it only requires electrolysis to obtain α-difluoroselenomethyl ketone derivatives in a mild and efficient manner.

To provide methods for producing trifluoromethyl ketone and pentafluoroethyl ketone in economical, safe and industrial manners.SOLUTION: An ester compound represented by the general formula (1) is supplied and mixed with a base and trifluoromethane or pentafluoroethane in the presence of organic solvent by using a micro mixer and a micro reactor, and the reaction of them results in a trifluoromethyl ketone or pentafluoroethyl ketone represented by the general formula (3). [R1 is a naphthyl-1-yl group or the like; R2 is a methyl group or an ethyl group; Rf is a trifluoromethyl group or pentafluoroethyl group].SELECTED DRAWING: None

The present invention relates to the pharmaceutical field, and specifically to a compound of the following general formula I or a pharmaceutically acceptable salt, stereoisomer, tautomer, a composition containing the compound, a method for producing the same, and use in the pharmaceutical field. JPEG2025507883000103.jpg3547

The invention belongs to the technical field of fine chemical synthesis, and discloses a method for synthesizing methyl ketone by using an alkynediol byproduct. The method comprises the following steps: mixing the alkynediol byproduct polyketone polymer with a catalyst; introducing the mixed solution from the middle part of a tubular reactor, introducing N2 from the bottom of a tower reactor, entering the tubular reactor, and carrying out cracking reaction on the mixed solution in a bubbling manner to prepare methyl ketone; the catalyst is a solid acid catalyst and / or a solid base catalyst. According to the method, methyl ketone is prepared from the byproduct polyketone polymer of the alkyne diol, so that waste is turned into wealth, the raw material of the alkyne diol is synthesized again, and material waste is avoided; and the preparation process is simple, the reaction temperature is easy to control, the required equipment is simple, the production process is safe and reliable, and industrial production is easy. When the method is used for synthesizing methyl ketone, the polymer conversion rate is as high as 97.4%, and the methyl ketone yield is as high as 91.9%.

The invention discloses a yoghurt aroma type identification method established based on GC-O-MS and by utilizing a machine learning algorithm, key aroma active compounds of each aroma type can be obtained, the invention further discloses a Streptococcus thermophilus ST51 strain for producing methyl ketone compounds, and the preservation number of the Streptococcus thermophilus ST51 strain is CGMCC No.29907. The invention further discloses a method for identifying the aroma type of yoghurt based on GC-O-MS and a method for identifying the aroma type of yoghurt based on GC-O-MS and a method for identifying the aroma type of yoghurt based on GC-O-MS and a method for identifying the aroma type of yoghurt based on GC-O-MS. The invention further discloses application of the streptococcus thermophilus ST51 strain for producing the methyl ketone compounds in preparation of dairy products, and the model is used for predicting the aroma type of ST51 yoghourt. When the streptococcus thermophilus ST51 is used as a leavening agent to prepare yoghourt, methyl ketone compounds are generated, and the prepared yoghourt has unique pleasant aroma such as butter aroma and cream aroma.

The application provides a method for preparing a multi-carbon methyl ketone from acetone. In the method, the acetone is reacted with itself or a corresponding aldehyde to obtain the multi-carbon methyl ketone. In order to improve the yield of the multi-carbon methyl ketone, the acetone used in the reaction has a methanol content of less than or equal to 250 ppm, and preferably a methanol content of less than or equal to 200 ppm. After the acetone is reused, the methanol concentration in the reactor is less than or equal to 1.5%, so that the selectivity of the acetone to the multi-carbon methyl ketone is greater than or equal to 90%. The process flow of the application is simple, the product has good selectivity, and the device has high economic efficiency.

The application provides a Bacillus velezensis TCS001 volatile gas composition, which comprises 2-ethylhexanol, methyl nonyl methyl ketone, 2-decanol and 2-dodecanone, and the mass ratio of 2-ethylhexanol:methyl nonyl methyl ketone:2-decanol:2-dodecanone is 2-7:5-13:2-6:2-23. The Bacillus velezensis TCS001 volatile gas composition can be used as a safe and efficient gas-phase bacteriostatic material for the research and development of a novel fumigation preparation, is suitable for the prevention and treatment of diseases in a closed environment such as a greenhouse, a warehouse and the like, promotes crop growth, and has wide application value.

This invention provides a method for simultaneously detecting 17 heat-processing hazards in 4 categories, comprising: adding n-hexane to the sample, mixing thoroughly, discarding the n-hexane phase, extracting acrylamide, 5-hydroxymethylfurfural, and free heterocyclic amines using dimethyl ketone and ultrasound-assisted extraction, collecting the supernatant, and purifying it; simultaneously transferring the precipitate to another tube, reducing it with sodium tetrahydroborate, hydrolyzing it with hydrochloric acid to release bound heterocyclic amines and late-stage glycosylation products, and performing UPLC-MS / MS analysis. This invention is the first to propose a two-step extraction method for simultaneously determining 17 heat-processing hazards in 4 categories within 7 minutes using UPLC-MS / MS. The accuracy, precision, detection limit, quantitation limit, and recovery rate of the method were verified, and all test indicators met the requirements. This method is applicable to the determination of heat-processing hazards in four types of food matrices: high starch, high protein, high fat, and high sugar.

Described herein are materials and methods to generate beta-ketoadipates cost-efficiently and with reduced environmental impact from muconolactone. Advantageously, the described beta-ketoadipates, including dimethyl beta-ketoadipates, are more stable than traditional βKA and can be produced with a reduction in the amount of salt byproducts, by as much as half.

The application discloses a preparation method of rutile titanium oxide long fibers, and belongs to the field of titanium oxide preparation. The preparation steps comprise the following steps: mixing titanium chloride, ethylene glycol and ethanolamine, stirring and refluxing, filtering to obtain a clear and transparent solution, rotary evaporation of the clear and transparent solution to obtain a concentrated rectification product, mixing the rectification product with ethyl methyl ketone, adding deionized water into the mixture, stirring and refluxing to obtain an organic titanium solution; adding polyvinyl alcohol into the organic titanium solution, uniformly stirring to obtain a stable spinning solution, electrospinning, heat treating the fibers after spinning to obtain rutile titanium oxide long fibers. The titanium oxide fibers prepared by the method are of rutile structure, the fibers are continuous, not adhered to each other and smooth in surface, the preparation method is simple, suitable for industrialization, and has a wide application prospect.

In one aspect, the invention provides a synthetic method of methyl ketone hydrochloride, and 3, 4-methylenedioxypropiophenone (MDP) is used as a starting material. In another aspect, the disclosure provides stereoisomers of methyl ketones. In another aspect, the present disclosure provides phenylethylamine or cathinone covalently bound to a chemical moiety in the form of a prodrug. The prodrug forms described herein allow for slow / sustained / controlled delivery of the parent phenylethylamine or cathinone into the blood system in a manner that increases the duration of therapeutic efficacy.

The present invention discloses a method for deoxidation-reduction-alkenylation of methyl ketone compounds, characterized by comprising the following steps: mixing a methyl ketone compound, a reducing agent, and a solvent under the action of a protective gas and a catalyst, and then heating the mixture to react to obtain an alkenylation product; the structural formula of the methyl ketone compound is: #imgabs0#; the structural formula of the alkenylation product is: #imgabs1#. The beneficial effects of the present invention are as follows: (1) the raw materials of the present invention are widely available and easy to obtain, with low cost, and the synthesis of some raw materials is simple and efficient; the preparation method is simple to operate and the reaction conditions are mild; (2) no toxic or harmful gases are generated after the reaction, which has little impact on the atmosphere and also protects the health of operators; (3) the present invention has wide applicability and high yield; (4) in the present invention, the methyl ketone is directly deoxidized and reduced to the corresponding olefin without the participation of metal reagents, which not only has low cost and good functional group compatibility, but also has high chemical selectivity and conversion rate, and good applicability.

Recombinant cells and methods for producing methyl ketones, such as medium-chain methyl ketones. The recombinant cells include recombinant acyl-ACP thioesterase genes, recombinant β-ketoacyl-CoA thioesterase genes, and recombinant acyl-CoA synthetase genes, in addition to other modifications. The methods include culturing the recombinant cells to produce the methyl ketones and isolating the produced methyl ketones.

The present disclosure relates to compounds and compositions, for example, anti-methanogenic compositions, comprising a trihalomethyl ketone and methods of administering the anti-methanogenic composition to a ruminant to reduce methane emissions. Systems and associated methods of reducing methane are further provided.

A porosity-free phenolic epoxy to use as a fill for nanostructures, the phenolic epoxy including i) poly(tetrahydrofuran); ii) polyglycidyl ether of phenol-formaldehyde; iii) ethyl methyl ketone; and iv) a solvent such as isopropanol. The phenolic epoxy creates a uniform, void free fill that improves silicon wafer processing, metrology, and TEM analysis. A method to fill a nanostructure with a porosity-free phenolic epoxy, includes placing tetrahydrofuran in a strong acid such that a ring of the tetrahydrofuran is opened to create a tetrahydrofuran monomer, polymerizing the tetrahydrofuran monomer to create poly(tetrahydrofuran), mixing the poly(tetrahydrofuran) with polyglycidyl ether of phenol-formaldehyde, ethyl methyl ketone, and isopropanol, and depositing one or more layers of the porosity-free phenolic epoxy onto a surface of a nanostructure.

The invention discloses a plant-based fiber, a preparation method thereof and application of the plant-based fiber in protective gloves, and relates to the technical field of high polymer materials. When the plant-based fiber is prepared, carboxylated carbon nanotubes are sequentially reacted with thionyl chloride and (2, 4-dihydroxyphenyl) (4-vinyl phenyl) ketone to prepare modified carbon nanotubes; the preparation method comprises the following steps: reacting 4-chloro-N, N-diethyl-6-methyl-1, 3, 5-triazine-2-amine with 6-chloro-1-hexene to generate quaternary ammonium salt, and then reacting with alkali lignin to prepare quaternized lignin; the preparation method comprises the following steps: reacting allyl phosphine dichloride with p-aminobenzoic acid to obtain binary acid; dibasic acid, ethylene glycol and terephthalic acid are subjected to a condensation polymerization reaction to prepare polyester; polyester, the modified carbon nanotubes and quaternized lignin are subjected to melt spinning, and the plant-based fiber is prepared. The plant-based fiber prepared by the invention has good flame retardant property, antistatic property, mechanical property and ultraviolet-proof property.

This invention discloses a method using arylmethyl ketones and 2-aryl- N This invention relates to a method for synthesizing dihydropyrrole derivatives using toluenesulfonylaziridine as a starting material, belonging to the field of organic synthetic chemistry. The method uses tris(dibenzylacetone)dipalladium (Pd2(dba)3) as a catalyst, and 2-iodobenzoic acid (IBX) and potassium persulfate (K2S2O8) as co-oxidants. N,N Using dimethylformamide (DMF) as both solvent and carbon source, the reaction is carried out in an oil bath at 100℃–120℃ for 15–24 h, followed by post-treatment to obtain dihydropyrrole derivatives. This invention utilizes readily available raw materials, is simple to operate, employs mild reaction conditions, exhibits broad functional group compatibility, provides high product selectivity, and is environmentally friendly. Yields can reach 51%–90%, making it suitable for large-scale preparation of structurally diverse dihydropyrrole derivatives. It has significant application value in drug development, natural product synthesis, and materials chemistry.

The application discloses a Wacker type oxidation preparation method of methyl ketone. The method comprises the following steps: adding a hydrocarbon compound, a palladium catalyst, a ligand and an oxidant into an alcohol solvent, and performing heating treatment under a protective atmosphere to obtain a methyl ketone compound, wherein the oxidant is an Oxone oxidant, and the ligand is 2-phenyl-1H-benzo[d]imidazole. The preparation method provided by the application has high catalytic activity of the catalytic system, and the catalyst loading is as low as 0.1-1 mol%, thereby greatly reducing the cost of noble metals. The ligand used has a simple structure and is convenient to synthesize, and high catalytic activity and high regioselectivity are realized. The Oxone used as the green oxidant has good water solubility and friendly by-products, the reaction is performed at 50-60 DEG C under normal pressure, the solvent used is cheap and low-toxic, and the condition is mild, safe and easy to scale up. The method has a wide applicable range of substrates, excellent functional group compatibility, single product and simple separation and purification.

The invention relates to a tebuconazole synthesis method, and belongs to the technical field of organic synthesis, the method flow comprises the following steps: Step 1: adding 1, 2, 4-triazole, DMF or NMP as a solvent, sodium hydroxide alkali liquor or potassium hydroxide alkali liquor, sodium iodide or potassium iodide as a catalyst and pentanone into a reaction flask, and heating to 80-90 DEG C; 2, methylation reagents are added in batches, the methylation reagents are preferably dimethyl sulfide sulfuric acid dimethyl ester onium salt, after addition is completed, heat preservation stirring is conducted, and the heat preservation time is 1-2 hours. P-chlorobenzyl cyanide and cyclopropyl methyl ketone are used as main raw materials, p-chlorobenzyl cyanide is subjected to halogenation at a benzyl position and then subjected to a Darzen reaction with cyclopropyl methyl ketone under the alkaline condition of potassium hydroxide to obtain an epoxide, a target product is obtained through one-pot cyano hydrolysis and deacidification under the acidic condition of sulfuric acid, the synthesis route is short, the process is simple, the raw material cost is low, and the method is suitable for industrial production. The process is simple and smooth, green and environment-friendly, and suitable for industrial large-scale production.

The invention belongs to the technical field of luminescent materials, and particularly relates to an ultralow-doped efficient room-temperature phosphorescent material as well as a preparation method and application thereof. According to the invention, a phenyl [2-phenyl-1H-benzo [d] imidazole-5-yl] ketone derivative (PBM-R) molecule is used as an energy acceptor, and is doped with main materials such as N-methyl-4-bromobenzamide (BMB) and the like (an energy transfer carrier). After the two compounds are simply mixed and mechanically ground, triplet-triplet energy transfer (TTET) can be started, so that organic room-temperature phosphorescence emission is realized. It is worthy of notice that the phosphorescent material can maintain significant phosphorescent emission even at a low object doping level (the mass ratio of the subject to the object is as high as 10000: 1), so that the material consumption is significantly reduced and the photophysical stability is improved. The doping system is further applied to various information storage and encryption methods, and the potential of multi-scene application of the doping system is highlighted.

The invention relates to a tebuconazole synthesis method, and belongs to the technical field of organic synthesis, the method flow comprises the following steps: Step 1, adding 1, 2, 4-triazole and dichloromethane into a pressure kettle, adding alkali, heating, and carrying out heat preservation reaction; step 2, after the reaction is finished, cooling to room temperature, filtering, and concentrating filtrate to obtain chloromethyl triazole; step 3, adding a solvent, magnesium chips or zinc powder and a small amount of initiator iodine into the reaction bottle under the protection of nitrogen, dropwise adding a mixed solution of chloromethyl triazole and pentanone, and carrying out heat preservation reaction after dropwise adding; and Step 4, after the reaction is finished, adding dilute acid for neutralization, standing for phase separation, and concentrating an organic phase to obtain tebuconazole. The preparation method comprises the following steps: by taking p-chlorobenzyl cyanide and cyclopropyl methyl ketone as main raw materials, firstly adding halogen on a benzyl position of p-chlorobenzyl cyanide, then carrying out Darzen reaction on p-chlorobenzyl cyanide and cyclopropyl methyl ketone under the alkaline condition of potassium hydroxide to obtain an epoxide, and carrying out'one-pot 'cyano hydrolysis and deacidification under the acidic condition of sulfuric acid to obtain a target product.

The present application relates to a kind of 4-substituted-5H-1,2,3-dithiazole-5-thione and derivative and its synthesis method.The present application uses in non-metal iodine compound catalysis, methyl ketone compound, nitrogen-containing small molecule and elemental sulfur are converted into the technical scheme of 4-substituted-5H-1,2,3-dithiazole-5-thione and derivative.This technical scheme has the following advantages: the reagent required stable nature, need not pretreatment, cheap and easy to obtain;One-pot synthesis, the economy advantage of step is obvious, save time and effort;Without using transition metal catalysis, metal residue problem is eliminated from the root;Using cheap iodine compound catalysis, reduce environmental pollution, save reaction cost;Cheap and easy to obtain, safe and stable nitrogen-containing small molecule provides nitrogen source, elemental sulfur provides sulfur source, elemental sulfur provides two types of structures of per-sulfur bond and carbon-sulfur double bond in reaction;Whole reaction system is simple, reaction equipment is less, and operation is simple;The 4-substituted-5H-1,2,3-dithiazole-5-thione synthesized has good biological activity function, is potential drug molecule.

The invention relates to psychoactive medicines including 2C-B, methylone, MBDB, their respective metabolites, isomers, enantiomers, polymorphs, and analogues (2C-series and cathinones); their preparation, formulations, intermediates, routes of administration, dosing and schedule for medical uses for psychiatric and neurological conditions and disorders.

The present invention discloses ibrutinib and a synthesis method thereof, comprising the following steps: (1) using SM1 (4-phenoxybenzoyl chloride) as a raw material, and carrying out a coupling reaction with SM2 (4,6-dichloropyrimidine) under the condition of a catalyst to obtain an intermediate M1 ((4,6-dichloropyrimidin-5-yl)(4-phenoxyphenyl)methyl ketone); (2) carrying out a cyclization reaction between M1 and SM3 (1-(3R-hydrazino-1-piperidinyl)-2-propylene-1-one) to obtain to the intermediate M2 (1-((R)-3-(4-chloro-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one); (3) subjecting M2 to a chlorination amination reaction to obtain ibrutinib (1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one). The ibrutinib synthesis method provided by the present invention has a reasonable route design, mild reaction conditions in each step, strong operability, low cost, high yield, simple process operation, is suitable for large-scale industrial production, and is of great significance.

The invention discloses a method for deoxidation reduction alkenylation of a methyl ketone compound, which is characterized by comprising the following steps: mixing the methyl ketone compound, a reducing agent and a solvent under the action of a protective gas and a catalyst, and then heating for reaction to obtain an alkenylation product, the structural formula of the methyl ketone compound is # imgabs0 #; the structural formula of the alkenylation product is # imgabs 1 #. The preparation method has the beneficial effects that (1) the raw materials are wide in source, easy to obtain and low in cost, and part of the raw materials are simple and efficient to synthesize; the preparation method is simple to operate and mild in reaction condition; (2) no toxic or harmful gas is generated after the reaction, the influence on the atmosphere is small, and the health of operators is also guaranteed; (3) the method has wide universality and high yield; (4) methyl ketone is directly deoxidized and reduced into corresponding olefin, no metal reagent participates in, the cost is lower, the compatibility of functional groups is good, the chemical selectivity and conversion rate are higher, and the universality is good.

This invention belongs to the field of organic synthesis technology and discloses a method for preparing cyclopropyl methyl ketone, comprising at least the following steps: 1) A mixture of acetaldehyde and allyl halide or allyl ester, along with a catalyst, is formed in a reaction vessel, heated and stirred to induce a hydroacylation reaction. Unreacted raw materials are removed by vacuum distillation to obtain an intermediate product. 2) The intermediate product obtained in step 1) is mixed with an alkaline catalyst, heated and kept at a constant temperature to obtain crude cyclopropyl methyl ketone, which is then purified by distillation to obtain pure cyclopropyl methyl ketone. The preparation method of this invention uses inexpensive and readily available raw materials, exhibits high atom economy, and has significant economic benefits; the alkaline catalyst used in step 2) is regenerable and can be further scaled up industrially.