396 results about "Methyl Ketone" patented technology

A method for the preparation of aryl methyl ketones converts a variety of ethyl arenas to the corresponding aryl methyl ketones using a dioxygen-containing gas as the oxidant. The catalyst used for the reaction is a metal complex bearing general formulas as disclosed.

The invention discloses a method for preparing an ethyl methyl ketone by dehydrating a 2,3-butanediol, belonging to the technical field of chemical product preparation. The method is to prepare the ethyl methyl ketone by dehydrating the 2,3-butanediol under the action of molecular sieve solid acid catalyst. The method comprises the following steps: taking the 2,3-butanediol of 10-90 wt% as a raw material, pre-heating and vaporizing the raw material at a reaction temperature of 200-300 DEG C, the raw material gas after being aerified reacting through a catalyst layer with the 2,3-butanediol mass airspeed of 1.5-3.4h, and separating reactor outlet materiels by liquid-vapor separation to obtain the ethyl methyl ketone. The conversion rate of the 2,3-butanediol is 94.2-100%, and the selectivity of the ethyl methyl ketone can reach 70.1-94.2%. The catalyst adopted in the invention has high activity and high airspeed, thereby having high conversion rate of 2,3-butanediol with different concentration; the ethyl methyl ketone has high selectivity and productivity and is environmentally friendly, the process is simple and the catalyst has good stability.

The invention relates to a method for spearing butane from butylene with the multicomponent compound of ionic liquid, saline, ethyl methyl ketone and N-formylmorpholine. The content of ionic liquid in the multicomponent compound is 1.0 to 95 percent; the content of the saline in the multicomponent compound is 0.5 to 20 percent; the electropositive ion of the ionic liquid is iminazole electropositive ion, alkyl imidazole electropositive ion or alkyl quaternary ammonium ion, or the compound thereof; the electronegative ion is tetrafluoroborate electronegative ion, hexafluorophosphoric acid electronegative ion, nitrate ion, tetrachloro aluminic acid iron, heptachlor bi aluminic acid iron, chloride ion, bromine electronegative ion or the mixture; and the ionic liquid can be dimethylformamide potassium thiocyanate compound salt, dimethylformamide sodium sulfocyanate compound salt, or the compound; the saline is potassium thiocyanate, sodium sulfocyanate, ammonium thiocyanate, sodium nitrate, potassium nitrate, sodium iodide, potassium iodide, zinc chloride, copper chloride, zinc chloride, potassium bromide, or the compound thereof.

The invention relates to a method for preparing cyclopropyl methyl ketone, and belongs to the field of organic synthesis. The preparing method includes the following steps that metal halide and an inert solvent are added into a fixed bed reactor, the fixed bed reactor is heated to 185-195 DEG C, and then alpha-acetyl-gamma-butyrolactone is continuously added into the fixed bed reactor, and is subjected to a cleavage reaction; after the reaction is saturated, the alpha-acetyl-gamma-butyrolactone stops to be added, reaction distillation continues to be carried out till no product is distilled out, and a cyclopropyl-methyl-ketone crude product is obtained; the fixed bed reactor is connected with a rectifying tower, the prepared cyclopropyl-methyl-ketone crude product is transferred into the rectifying tower to be subjected to high tower dividing and then subjected to normal pressure rectification, the reflux ratio is adjusted, impurities are separated, and the high-purity cyclopropyl methyl ketone is obtained through distilling. The method is low in production cost, high in production efficiency, product yield and purity, small in by-product number, wastewater amount, waste material number and environment pollution and more suitable for industrial production.

The invention discloses a method for preparing long-chain alkane from biomass derivatives 5-HMF (hydroxymethyl furfural) or furaldehyde. According to the method, the biomass derivatives 5-HMF or furaldehyde are used as raw materials; a condensation product is formed after base catalysis and methyl ketone compound condensation; then, ketonic or alcoholic intermediates of tetrahydrofuran rings are obtained through hydrogenation catalysis; finally, the long-chain alkane is prepared through hydrogenation and ring opening dual catalysis preparation. The method has the advantages that the raw materials can be prepared from biological saccharides through hydrolysis and dehydration; the yield of the alkane is high; the consumption of catalysts is low; the reaction condition is mild; the process is clean and simple; in the reaction process of preparing the alkane from the condensation products, other operations and control are not needed except the program temperature rise; a new path for preparing the long-chain alkane from the biomass derivatives 5-HMF or furaldehyde by a one-pot method is opened up.

The invention relates to a method for producing monascus pigment with low content of citrinin by using rice as raw material, and the process thereof consists of the following steps: (1) rice milk is prepared; (2) the rice milk is added with 0.1 percent to 0.2 percent of ammonium nitrate, 0.15 percent to 0.25 percent of potassium dihydrogenphosphate, 0.1 percent to 0.2 percent of manganese sulfate, 1 percent to 2 percent of maize pulp and 1.5 percent to 2.5 percent of soybean powder, and the obtained mixture is heated to 121 DEG C to be kept for 20 minutes, and then cooled to 35 DEG C to 40 DEG C to obtain a fermentation culture solution; (3) monascus strains are transferred to a seed culture medium to be cultivated for 50 hours under the temperature of 31 DEG C to 33 DEG C, after being cultivated on a solid slant plane, and then an enlarged monascus culture solution is obtained; (4) 8 percent to 10 percent of the enlarged monascus culture solution is fed into the fermentation culture solution, and the obtained mixture is kept under the temperature of 31 DEG C to 37 DEG C, stirred and cultivated for 20 hours, hereafter, octanoic acid with the weight equal to 0.1 percent to 0.2 percent of the weight of rice and methyl ketone with the weight equal to 0.1 percent to 0.2 percent of the weight of rice are added, then the temperature is kept, and the mixture is stirred and cultivated for 85 hours to 95 hours, while the pressure of a fermentor is kept to be 0.04MPa to 0.06MPa so as to obtain a fermentation liquor; (5) the fermentation liquor is filtered, and the obtained filtrate is treated with spray drying or freeze drying after membrane concentration. The monascus pigment obtained by the method consists of less than 0.05 mg/kg of the monascus when color value is higher than 200.

The invention discloses a method for preparing an amide compound, which comprises the steps of configuration of reaction system. Methyl ketone, amine, catalyst, an oxidizing agent and solvent are use, wherein the general formula of the methyl ketone is RCOCH3, and R is selected from one kind of C6-C14 aryl group, C2-C8 alkenyl group, and five-or six-membered heterocyclic group; the amine is primary amine; the catalyst is selected from one kind of potassium iodide, iodine, tetramethyl ammonium iodide, tetrabutyl ammonium iodide, tetrahexyl ammonium iodide, bismuth iodide, lithium iodide, phenyl trimethyl ammonium iodide, benzyl trimethyl ammonium iodide or sodium iodide; the oxidizing agent is tert-butyl hydroperoxide; the solvent is selected from one kind of water, dichloromethane, ethyl acetate, toluene, 1,2-dichloroethane, 1,1,1-trichloroethane, acetonitrile, and isopropanol. The methyl ketone, the catalyst and the amine are added into the reaction system under the temperature of 0 DEG C and stirred for 5 minutes, and then the oxidizing agent is added to react for 2-48 hours to obtain the amide compound. The method provided by the invention is green, moderate, high in selectivity and wide in application range.

The invention discloses a preparation method of 1-(4-chlorphenyl)-2-cyclopropyl-1-acetone. The preparation method comprises the steps that: (1) cyclopropyl methyl ketone, dimethyl sulfate, dimethyl sulfide and sodium hydroxide take epoxidation reaction to obtain 2-cyclopropyl-2-methyl propylene oxide; (2) the 2-cyclopropyl-2-methyl propylene oxide is catalyzed and re-ranged by anhydrous zinc chloride at the room temperature to obtain 2-cyclopropyl propionaldehyde; (3) the 2-cyclopropyl propionaldehyde is oxidized by 40 percent oxydol at the room temperature to obtain 2-cyclopropyl monoprop; (4) the 2-cyclopropyl monoprop and thionyl chloride take reaction to obtain 2-cyclopropyl propionyl chloride; (5) the 2-cyclopropyl propionyl chloride takes reaction with chlorobenzene and anhydrous aluminum trichloride to obtain the 1-(4-chlorphenyl)-2-cyclopropyl-1-acetone with the content being 98.0 percent to 98.7 percent, and the total yield is 80.0 percent to 83.1 percent. The preparation method has the advantages that the steps are simple, raw materials are cheap and are easy to obtain, easy-self-ignition compounds are not used, organic solvents are not used in the steps (2) and (3), three wastes are few, and the preparation method is suitable for industrialization.

The present invention relates to a synthesis method for alpha-ketoamide compounds, wherein a plurality of alpha-ketoamide compounds can be prepared through the synthesis method. According to the present invention, cheap and easily available methyl ketone and amine are adopted as raw materials, various metal salts are adopted as catalysts, no medium solvent is required (a reaction further can be performed in an organic medium solvent), and the alpha-ketoamide compound is subjected to one step synthesis under an oxygen source condition of an atmospheric pressure; other additives such as an alkali, a ligand and the like are not used; the prepared alpha-ketoamide compound has a structure general formula represented by a formula I, wherein R1 is hydrogen atom, aryl, heteroaryl, aralkyl, alkyl, cycloalkyl and other substituted groups, and R2 and R3 are independently hydrogen atom, alkyl, cycloalkyl, aryl, heteroaryl, aralkyl and other substituted groups; and the method is an alpha-ketoamide compound synthesis method with characteristics of simpleness, efficiency, environment protection, mild conditions, high yield and no organic solvent.

The invention discloses a preparation method of alpha-keto amide, which comprises the following steps: (a), preparing a reaction system comprising methyl ketone, amine compounds, a catalysts, an oxidant and a solvent, wherein the general formula of methyl ketone is RCOCH3, and R is selected from one of C6-C14 of aryl, C2-C8 alkenyl, C2-C8 alkynyl, C1-C8 alkoxy or alkyl sulphanyl, C2-C8 phenolic group as a protection group, unsubstituted five-member or six-member heterocyclic group and substituted five-member or six-member heterocyclic group, and the amine compounds are selected from primary amine or secondary amine; and (b), mixing the reaction system to react for 2-48 hours at a room temperature to obtain alpha-keto amide. The invention discloses a new preparation method of alpha-keto amide. The reaction condition is moderate, and the reaction can undergo under the air condition without a complicated operation procedure; in addition, the preparation method is environment-friendly and meets the requirement and the direction of the contemporary green chemistry development.

The invention discloses a trifloxystrobin preparing method, including the steps as follows: (a) using ortho-methyl hypnone as raw material and using potassium permanganate to oxidize so as to obtain 2-(2'-methyl-phenyl)-2-carbonyl acetic acid; (b) making the product in step (a) react with methanol to obtain 2-(2'-methyl-phenyl)-2-carbonyl methyl acetate; (c) bromizing the product in step (b) to obtain 2-(2'-bromomethyl-phenyl)-2-carbonyl methyl acetate; (d) making the product in step (c) react with methoxy amine to obtain (E)-2-(2'-bromomethyl-phenyl)-2-carbonyl methyl acetate-O-methyl ketone oxime; (e) making the product in step (d) react with meta-trifluoromethyl hypnone oxime to obtain the product trifloxystrobin. It reduces the discharge of large amount of waste water in course of oxidization reaction, avoids esterification by adopting methyl- chloroformate, most operating conditions are moderate.

The invention discloses a synthetic method of intermediate cyclopropyl acetylene of an anti-aids drug efavirenz, and relates to the technical field of synthesis of cyclopropyl acetylene. The synthetic method comprises the following steps: reacting in an organic solvent to produce alpha, alpha-ethyl dichloride cyclopropane by taking cyclopropyl methyl ketone as a raw material and taking phosphorus pentachloride as a chlorinating agent; and obtaining the cyclopropyl acetylene by adding the alpha, alpha-ethyl dichloride cyclopropane into strong base aqueous liquor through a phase transfer catalyst. The synthetic method has the beneficial effects that the organic solvent and inorganic strong base are not needed to be adopted, expensive reagents such as the organic solvent and potassium tert-butoxide are avoided; moreover, process raw materials are easily available, process is simple, operation is convenient, cost is lowered and the three wastes are reduced, and therefore, the synthetic method is suitable for industrial production.

This invention provides new catalyst with high activity to synthesize methyl isopropenyl ketone and ethanone from MEK and carbinol, its preparation method and application in ketone preparation reaction. The catalyst comprises Zr, Mn, Zn and mixed oxide of alkali metal carried a little Pd. By this product, the reaction can run at very low temperature, does not coke easily, needs less raw material and the cost is lower.

The invention relates to a method for preparing alpha-alkylated ketone by coupling alcohol with alpha-methyl/methylene ketone. The method comprises the following steps: sequentially adding alpha-methyl/methylene ketone compounds and alcohol compounds into a reaction solvent, then, adding 2mol% of catalyst bistriphenylphosphine rhodium carbonyl chloride (RhCl (CO) (PPh3) 2), finally adding an inorganic alkali, and reacting at 50-100 DEG C to obtain reaction liquid after the reaction is completed; and filtering, concentrating and column chromatography separating the reaction liquid according to a conventional method to obtain the alpha-alkylated ketone. The method provided by the invention is efficient, rapid and environmental-friendly.