60results about How to "Process raw materials are easy to get" patented technology

The invention discloses a preparation method of titanium pigment used in ship paint. The method comprises the following steps that: a. metatitanic acid is calcined, such that a titanium pigment crude product is obtained, the titanium pigment crude product is prepared into TiO2 slurry, and sodium hexametaphosphate is added to the slurry; b. the slurry is heated, a silicon-containing compound is added to the slurry, and the slurry is homogenized; c. the pH value of the TiO2 slurry is regulated to 0.8 to 4; d. after the slurry is slaked, an organic dispersant is added to the slurry, an aluminum-containing compound is added to the slurry, and the mixture is homogenized; e. the pH value of the TiO2 slurry is regulated to 4 to 8; f. the TiO2 slurry is slaked; g. the TiO2 slurry is filtered, such that the resistivity of the filter cake is greater than or equal to 100 [omega]M; and the filter cake is dried and heat treated; h. an organic surface conditioning agent is added to the filter cake, and the filter cake is crushed, such that the finished product is obtained. According to the present invention, nano-sized silicon oxide sol and alumina sol are prepared sequentially. Through physical adsorption and chemical absorption, a compact coating layer is formed on the surface of the TiO2 particles. Then, the coating layer is firmly attached to the surface of the TiO2 particles through chemical deposition. With the coating layer, the product provided by the present invention possesses good dispersibility, weatherability and corrosion resistance. Meanwhile, according to the method provided by the present invention, the raw materials are easy to obtain, the processes are smooth and are easy to control.

The invention belongs to the field of nano materials, and particularly relates to a preparation method of doped stannic oxide conductive nano powder. The preparation method is characterized by preparing the nano powder through a hydrothermal method. The method provided by the invention comprises the following steps of weighing stannous oxalate, adding hydrogen peroxide in an ice-water bath; adding water when the above system reacts to form a transparent solution; adding a fluorine- or stibium-containing material in the solution as a dopant; mixing uniformly; carrying out hydro-thermal treatment; washing and drying to obtain the doped stannic oxide conductive nano powder. The preparation method can obtain the doped stannic oxide conductive nano powder with uniform particle size, good dispersibility and high purity without high-temperature calcination. The preparation method has easily-available raw materials, extremely simple flow, high efficiency and good repeatability, and is beneficial for large-scale production.

The invention discloses a high epoxide number environment-friendly plasticizer production process. The production process comprises the following steps of: adding cottonseed oil, methanol and sodium methoxide into an ester exchange reactor for reaction to obtain mixed fatty acid methyl ester; adding into a rectifying tower for separation, and performing epoxidation, neutralization, washing and dehydration on methyl oleate obtained from the tower bottom to obtain a high epoxide number environment-friendly plasticizer; and performing sulfonation reaction on palmitic acid methyl ester obtained from the tower top and sulfur trioxide, and ageing, esterifying, neutralizing and drying to obtain an environment-friendly surfactant MES. By the production process, the raw materials are readily available, the process is advanced, equipment is simple, the high epoxide number plasticizer can be prepared, and the byproduct, namely the palmitic acid methyl ester can be used for producing the environment-friendly surfactant.

The invention discloses a synthetic method of azacitidine. The synthetic method comprises the following steps: with 5-azacytosine and tetraacetylribose as raw materials, protecting the raw materials by using trimethyl silicon, then performing butt joint on the raw materials together with 1,2,3,5-tetra-O-acetyl-beta-D-ribose under the catalysis of Lewis acid trimethylsilyl triflate to obtain glycoside, performing alcoholysis to remove protective groups, and performing recrystallization to obtain the azacitidine. According to the synthetic method disclosed by the invention, the 5-azacytosine and the tetraacetylribose are used as the raw materials, and in the reaction of obtaining the glycoside through butt joint, the Lewis acid trimethylsilyl triflate (TMSOTf) replaces tin tetrachloride, so that the problems that a crude metallic tin is overproof and after treatment causes emulsification easily and is inconvenient are avoided, process raw materials of the synthetic method are easy to obtain, and the synthetic method is simple in operation, high in yield, less in step, environment-friendly, and suitable for industrial production.

The invention discloses a method for synthesizing 3,5-dichlorobenzoic acid, which comprises the following steps: chlorinating benzonitrile used as a raw material to generate 3,5-dichlorobenzonitrile; and then, performing hydrolysis and acidification reaction to obtain 3,5-dichlorobenzoic acid. According to the invention, the benzonitrile is used as the raw material; sodium hypochlorite or a mixture of oxydol and hydrochloric acid is used in the chlorination process; the traditional chlorine gas chlorination process is omitted; the obtained 3,5-dichlorobenzonitrile is high in purity; no diazotization procedure is required; and the process safety is enhanced. The process has the advantages of accessible and cheap raw material, low production cost of the product, high process safety coefficient and short process flow, is simple to operate, is more beneficial to industrial production, is a new process for synthesizing 3,5-dichlorobenzoic acid, and provides a new idea for synthesizing propyzamide.

The present invention discloses a preparation method of a fimasartan potassium salt hydrate. The method is as below: reacting a starting material 1(2-(2-butyl-4-hydroxy-6-methylpyrimidine-5-yl)-N,N-dimethylacetamide) with a starting material 2 (N-(triphenylmethyl)-5-(4'-bromomethyl-biphenyl-2-yl) tetrazole) in the presence of an alkali metal hydride in a mixed solvent of ethyl acetate and DMF, so as to obtain a compound IV; hydrolyzing the compound IV under acidic conditions to remove the protective group to obtain a compound III; subjecting the compound II to a thioamidation reaction with a Lawesson's reagent to obtain a compound II; and subjecting the compound II and potassium hydroxide to a salt-forming reaction in a mixture of isopropyl alcohol and water to obtain a desired product. The present invention has the advantages of easily available process feedstock, mild reaction conditions at room temperature, economical performance, environment-friendliness and easiness to operation, reduces the process cost to a large extent, and is easy to realize industrial production.

The invention discloses a modified production method of asphalt. The modified production method provided by the invention comprises the following steps of: by utilizing waste rubber powder as a modified raw material, dissolving aromatic hydrocarbon oil components into non-road asphalt or standard road asphalt at a temperature in a range of 60-80 DEG C; then dissolving the waste rubber powder into the mixture at a temperature in a range of 180-220 DEG C and mixing to form a mixed asphalt raw material; finally, heating the mixed asphalt raw material to more than 300 DEG C and separating out fuel oil and the aromatic hydrocarbon oil through use of a continuous decompression and distillation method to obtain an asphalt regenerating agent and an asphalt finished-product. The modified production method provided by the invention has the advantages of easily-obtained raw materials, simple process, economical cost, no additional auxiliary agents and no influence on the environment; and a multi-stage variable-temperature dynamic dissolution process is adopted in the method so that the waste rubber components can be completely dissolved in the asphalt raw material, have good stability and do not chromatograph again. Particularly, the production method does not need use of complicated and high-energy-consumption special devices, such as a high-speed cutting emulsifying machine, a grinder and the like; and the production scale is easy to enlarge.

The invention belongs to the field of nanometer materials, and particularly relates to tungsten-doped stannic oxide sol nanocrystalline and a preparing method thereof. The invention aims to provide the preparing method of the tungsten-doped stannic oxide sol nanocrystalline. The preparing method includes the following steps that stannous oxalate and oxalic acid are added into water, hydrogen peroxide is added, after a transparent solution is formed by a reaction system, a tungsten doping agent is added, and the tungsten-doped stannic oxide sol nanocrystalline is obtained through hydro-thermal treatment, washing and solvent replacement. The tungsten-doped stannic oxide sol nanocrystalline which is uniform in particle size, high in dispersity and purity and high in solid content can be obtained without high-temperature calcination; raw materials in the technology are easy to obtain, and the flow path is simple, efficient, high in repeatability and beneficial for industrialization.

The invention discloses a penicillin V potassium micro-capsule and a preparation method thereof. The penicillin V potassium micro-capsule consists of a core material penicillin V potassium and a capsule wall material ethyecellulose. The preparation method comprises the following steps: 1) smashing and dissolving ethyecellulose in dichloromethane to obtain a solution a; 2) dissolving the smashed penicillin V potassium under stirring at a rotating speed of 100-500rpm in the solution a to obtain a solution b, and continuously stirring for 20-30 minutes; 3) controlling temperature of water and dispersing a surfactant in water to obtain a solution c; and 4) under the condition of stirring at a speed of 100-500rpm, adding the solution b into the solution c to form the penicillin V potassium micro-capsule, continuously stirring till dichloromethane is fully volatilized, filtering under reduced pressure, and washing the micro-capsule three times by using distilled water, and drying to obtain the penicillin V potassium micro-capsule. According to the invention, the micro-capsule is prepared by a drying-in-liquid method to eliminate harmful smell of penicillin V potassium so as to improve the compliance of the patient. The preparation process of the micro-capsule uses easily available and low-price raw materials, is low in production cost, simple in process operation, easy to operate and implement and high in yield.

The invention provides a preparation method and applications of AgBr/g-C3N4 composite powder, and relates to the technical field of composite powder preparation. The preparation method comprises following steps: adding cyanuric chloride, melamine, and urea into a beaker, measuring acetonitrile, pouring acetonitrile into the beaker, stirring to disperse acetonitrile; after stirring, pouring the mixture into a reactor, covering the reactor, placing the reactor in a temperature-constant blowing baking oven to carry out reactions; after reactions, filling generated substances into a plastic tube,carrying out centrifugation, washing, and drying to obtain rod shaped or tube shaped g-C3N4; weighing g-C3N4, silver nitrate, and CTAB, adding g-C3N4, silver nitrate, and CTAB into a beaker, adding anhydrous ethanol; carrying out reactions under the assistance of ultrasonic waves in the beaker, after reactions, pouring the reaction product into a plastic tube, and carrying out centrifugation, washing, and drying to obtain AgBr/g-C3N4 composite powder. The composite powder has a large specific surface area, the pore volume is 0.110 cc/g, the pore diameter is 17.171 nm, and the composite powderhas an excellent performance of degrading common organic dyes in the presence of visible light.

The invention belongs to the field of chemical synthesis, and particularly relates to a method for synthesizing lenalidomide. The method adopts three-step polymerization, and specifically comprises: (1) carrying out a bromination reaction on 2-methyl-3-nitromethyl benzoate as a starting raw material and a bromination reagent to generate a compound 1 2-bromomethyl-3-nitromethyl benzoate; (2) performing cyclization on the compound 1 and 3-aminopiperidine-2,6-dione hydrochloride under a solvent-free condition to generate a compound 2 3-(4-nitro-1-oxo-1,3-dihydroisoindole-2-yl)piperidine-2,6-dione; and (3) reducing the compound 2 with a reducing agent to obtain lenalidomide. According to the invention, the method is a novel preparation process method of lenalidomide, and has advantages of easily available process raw materials, short steps, simple and convenient operation, environmental friendliness, implementation value of industrial production, and social and economic benefits.

The invention discloses a synthetic method for vitamin D2 derivatives. The synthesis of the key intermediate C-24 hydroxyl group for the commercially-available drugs tacalcitol and calcipotriol is basically prepared by using a NaBH4 reduction method. The NaBH4 reduction method has the disadvantages that target product yield is about 50% and the byproduct C-24 hydroxyl epimer alcohol has no value in use. According to the invention, a byproduct 1 or a byproduct 4 respectively produced in preparation of tacalcitol or calcipotriol is used as a starting material, a Dess-Martin reagent is used as an oxidation reagent, and a reaction is carried out in an organic solvent at 0 DEG C to 100 DEG C; after the reaction is completed, cooling to room temperature is carried out and then treatment is carried out so as to obtain an intermediate 2 or 5, respectively; and after treatment, the intermediate 2 or 5 is subjected to a reduction reaction so as to obtain a compound 3 or 6, respectively. Compared with the prior art, the synthetic method provided by the invention has the advantages that raw materials are easily available; reaction conditions are mild; post-treatment is simple; the utilization rate of atoms is increased; and pollution is reduced.

The invention discloses a new method for synthesizing milrinone. The method is characterized in that a compound of formula 3 and 4-pyridineboronic acid undergo a Suzuki coupling reaction to synthesize milrinone. The method has the advantages of easily available raw materials, high yield and simple post-treatment.

The invention discloses a device and a method for preparing hydrogen through coal/biomass chemical-looping gasification. According to the method, coal/biomass particles enter from the upper portion ofa moving bed gasification furnace, and are mixed with a circulating bed material containing calcium oxide and ferric oxide, water vapor is introduced into the gasification furnace, and pyrolysis andgasification reaction are performed to generate synthesis gas; the water vapor as an ejection gas flow enters a steam reactor along with the gasified coke and the bed material particles, and hydrogenis generated through a joint reaction with the water vapor in the steam reactor; the bed material enters an air reactor and is oxidized or decomposed, and the oxidized material or decomposed materialenters the gasification furnace again; hydrogen, carbon dioxide and nitrogen can be obtained from gas separated out of two cyclone separators; and the bed material particles continuously participate in an oxidation reduction or carbonization decomposition reaction and are recycled. The device is simple in structure, convenient to operate, scientific in process raw material, easy in raw material obtaining, low in cost, high in carbon utilization efficiency, less in pollutant and environment-friendly.

The invention discloses a preparation method of a silodosin key intermediate, and belongs to the technical field of medicine synthesis. Carrying out Friedel-Crafts reaction on indoline and trichloroacetonitrile to obtain a compound 1; brominating to obtain a compound 2; then carrying out substitution with 2-(3-bromopropoxy) tetrahydro-2H-pyran to obtain a compound 3; then carrying out nucleophilic addition with (S)-epoxypropane or (R)-epoxypropane at an ultralow temperature to obtain a compound 4; then carrying out Mitsunobu reaction with phthalimide to obtain a compound 5 (configuration inversion) or esterifying with paratoluensulfonyl chloride, and reacting with potassium phthalimide under the condition of inorganic alkali to obtain the compound 5; reducing through hydrazine hydrate to obtain a compound 6; then removing tetrahydropyran protection from p-toluenesulfonic acid to obtain a compound 7; performing amino Boc protection under an alkaline condition to obtain a compound 8; esterifying with benzoyl chloride to obtain a compound 9; removing Boc protection with hydrochloric acid to obtain a compound 10; and salifying with L-tartaric acid to obtain a compound 11. Compared with the prior art, the preparation method has the advantages that cyano groups synthesized by Vilsmeier reaction, hydroxylamine oximation and acetic anhydride dehydration at the 7 site and introduction of amino groups at the 5 site through nitro groups or reductive amination are avoided, and heavy metals such as Pd/Pt/Zn and the like do not need to be used; the continuous operation of the whole steps is increased, the production cost of the silodosin intermediate is greatly reduced, and industrial large-scale production is facilitated.

The invention relates to a cinnoline derivative midbody, in particular to a novel method for preparing cinnoline derivative midbody dichloro dimethyl benzoquinone. 2, 3-xylenol is adopted as starting raw materials in the method, and target compounds are obtained through oxidization and chlorination.

The invention discloses a production method for environmental-friendly low-temperature-resistant antiflaming compound plasticizer. The production method comprises the following steps: (1) preparing a plasticizer matrix: 1) esterification, 2) purification, 3) filter pressing purification, and 4) distillation; (2) preparing a low-temperature-resistant antiflaming system: evenly mixing nanosilicon dioxide, gas phase method silica aerogel, methyl hydrogen silicone oil, hydroxyl polydimethylsiloxane, vinyl trimethoxy silane, ammonium polyphosphate, reactive diluent, compatilizer, coupling reagent, flatting agent and mixed rare earth chloride at a ratio; (3) preparing the environmental-friendly low-temperature-resistant antiflaming compound plasticizer: evenly mixing the plasticizer matrix and the low-temperature-resistant antiflaming system obtained in the steps, wherein the addition of the low-temperature-resistant antiflaming system is 1.7-1.9wt% of the plasticizer matrix. The plasticizer has the advantages of good environmental protection property, high plastification efficiency, low temperature resistance, extremely low volatility and good stability.