349 results about "Tetrahydropyran" patented technology

The invention provides a method for synthesizing an aryl-substituted chiral tetrahydropyrane ring through desymmetry, which comprises the following steps: carrying out catalytic alcoholysis on cyclic anhydride as shown in a formula I or symmetric dicarboxylate as shown in a formula II to obtain an intermediate with a high ee value and a target spatial configuration as shown in a formula III, reacting with a methyl metal reagent to obtain lactone as shown in a formula IV, the ether shown in the formula V is obtained through reduction, the aryl hydrazine shown in the formula V-A is catalyzed through copper to obtain corresponding aryl hydrazine shown in the formula VI, and the aryl hydrazine and pyruvic acid derivatives are subjected to indole ring closing under acid catalysis to obtain a target product. Or the compound shown in the formula V-B is converted into an intermediate shown in the formula VIII through a functional group, and the intermediate reacts with an acrylic acid derivative to generate the target compound. According to the method, the use of a transition metal catalyst and SFC resolution in reported methods are avoided, the reaction cost is reduced, and the method is beneficial to amplified production and is an economic and environment-friendly technical route which is simple in post-treatment and convenient for amplified production.

The invention discloses collagen polypeptide firming and anti-wrinkle freeze-dried powder, and relates to the technical field of cosmetics. The invention relates to a biological preservative which is prepared from water, butanediol, a bacillus / soybean fermentation product extract, soluble collagen, acetyl hexapeptide-8, panthenol, 1, 2, 4-trimethyl-1, 3-pentanediol and a proper amount of water. The cosmetic is prepared from 1, 2-hexanediol, tetrahydromethylpyrimidine carboxylic acid, hydroxypropyl tetrahydropyrantriol, tremella polysaccharide, saccharide isomeride, a bifidus yeast fermentation product lysate, sodium hyaluronate, DNA sodium, a radix gentianae extract, mannitol, palmitoyl tripeptide-1, palmitoyl tetrapeptide-7, oligopeptide-1, decapeptide-4, oligopeptide-3, hydrolyzed royal jelly protein, folic acid and disodium hydrogen phosphate. The additive is composed of sodium dihydrogen phosphate, citric acid and sodium citrate. The mask can provide rich nutrients for skin, deeply care the skin, moisturize and relieve the skin, tighten the skin, resist wrinkles and make the skin moisturized, glossy, elastic and tight, and is high in use safety and wide in application prospect.

The invention belongs to the technical field of cosmetics, and discloses skin-tightening and anti-wrinkle essence. The skin-tightening anti-wrinkle essence is prepared from the following raw materials in percentage by mass: 1.5 to 2.5 percent of acetyl hexapeptide-8, 2.0 to 3.0 percent of palmitoyl pentapeptide-4, 3.0 percent of hydroxypropyl tetrahydropyrantriol, 2.0 percent of lipidosome-coated vitamin C ethyl ether, 0.5 percent of resveratrol PLGA microspheres, 0.8 percent of ceramide NP, 1.2 percent of pachymaran, 5.0 percent of glyceryl polyether-26, 0.3 percent of sodium hyaluronate, 0.5 percent of p-hydroxyacetophenone and 1, 3-propanediol, 0.5 percent of sodium hyaluronate, 0.5 percent of sodium hyaluronate, 0.5 percent of sodium hyaluronate and the balance of water. The 1, 2-hexanediol accounts for 0.6%, and the balance is deionized water. Multi-target anti-wrinkle, deep moisturizing and long-acting repairing are achieved by scientifically compounding active ingredients such as acetyl hexapeptide-8 and palmitoyl pentapeptide-4 and combining a lipidosome wrapping technology and a nano-microsphere slow release technology, the preparation process comprises the steps of lipidosome homogenization, nano-microsphere multiple emulsion method and low-temperature emulsification, the ingredient stability and transdermal efficiency are ensured, and the skin care effect is good. Experiments prove that the essence can significantly improve skin elasticity and reduce wrinkles, and has a significant anti-aging effect.

The invention provides a freeze-dried mask. The freeze-dried mask is prepared from the following raw materials in parts by weight: 70 to 90 parts of deionized water, 15 to 25 parts of algae extract, 3 to 5 parts of mannitol, 0.5 to 1 part of glycerol, 0.3 to 0.5 part of hydrolyzed collagen, 1 to 3 parts of amino acid mixture, 4 to 6 parts of hydroxypropyl tetrahydropyrantriol, 3 to 5 parts of tetrahydromethylpyrimidine carboxylic acid and 2 to 4 parts of hyaluronic acid. According to the freeze-dried mask disclosed by the invention, natural anti-wrinkle and moisturizing components such as the hydrolyzed collagen, the algae extract, the amino acid mixture and the hyaluronic acid are locked on the mask cloth in a freeze-drying manner, so that on one hand, the freeze-dried mask can better supplement moisture and nutrition for human skin when being used; on the other hand, the freeze-dried facial mask prepared from the natural beautifying and skin-care components is free of any irritating component during use, and does not cause damage to the human skin.

The invention relates to a sodium ion battery and a nitrile-based electrolyte thereof. The electrolyte comprises: a solvent formed by fluoroethylene carbonate and at least one selected from the group consisting of dinitrile, 3-methoxypropionitrile, isobutyronitrile, valeronitrile, ethylene glycol bis (propionitrile) ether and 4-cyano tetrahydropyran, wherein the volume fraction of fluoroethylene carbonate is 5-20%; and at least one sodium salt selected from the group consisting of sodium hexafluorophosphate, sodium trifluoromethanesulfonate, bis (trifluoromethylsulfonyl) imide sodium and bis (fluorosulfonyl) imide sodium, with a concentration of 2.0-4.0 mol L <-1 >. The electrolyte provided by the invention can simultaneously stabilize an interface between a positive electrode and a negative electrode, and has reasonable ionic conductivity and high electrochemical stability.

The invention discloses a low-concentration ether electrolyte adaptive to a high-voltage high-nickel ternary lithium ion battery, a preparation method of the low-concentration ether electrolyte and the lithium ion battery, and relates to the technical field of batteries. The ether electrolyte comprises a solvent and a solute; the solvent comprises an ether solvent, and is specifically at least one of 4-cyano tetrahydropyran, 2-(tetrahydro-2H-pyran-4-yl) acetonitrile, 2-methoxyacetonitrile, 2-ethyoxyl acetonitrile, 3-methoxypropionitrile, 3-ethyoxyl propionitrile, 3-butoxyl propionitrile, ethylene glycol bis (propionitrile) ether and 3-{2-[2-(2-cyano ethyoxyl) ethyoxyl] ethyoxyl} propionitrile. The ether solvent contains cyano groups, the strong electronegativity of the cyano groups enables the cyano groups to be coordinated with transition metal ions in the ternary material, and the cyano groups are preferentially adsorbed at the interface of the positive electrode material, so that the arrangement of solvent molecules at the interface has directivity, the proportion of ether oxygen bonds and carbon hydrogen atoms in double electric layers is reduced, and the performance of the positive electrode material is improved. And the sites which are easy to generate dehydrogenation reaction in the molecules are far away from the high-voltage positive electrode interface which is easy to generate oxidation reaction.

The present invention relates to a method for preparing dihydroxyammonium 5,5′-bistetrazole-1,1′-diolate. The method for preparing dihydroxyammonium 5,5′-bistetrazole-1,1′-diolate, according to one embodiment of the present invention, comprises the steps of: synthesizing 5,5′-bistetrazole-1,1′-diol dihydrate (1,1′-BTO) from ditetrahydropyranyl diazidoglyoxime (THP-DAG) by using a hydrochloric acid (HCl) solution in a first solvent; and reacting 1,1′-BTO with an amine solution so as to neutralize same and, simultaneously, obtaining dihydroxylammonium 5,5′-bistetrazole-1,1′-diolate (Thomas Klapotke explosive-50, TKX-50).

The invention relates to the technical field of organic synthesis, in particular to a method for constructing Orforglipron tetrahydropyran ring chirality through enzyme catalysis, which comprises the following steps: step S1, taking SM1 as a raw material, and carrying out hydrolysis resolution in a solvent, a buffer salt system and enzyme catalysis to obtain a chiral pure intermediate INT-1; step S2; performing ring closing on the INT-1 through Grignard reaction to synthesize a lactone intermediate; s3, carrying out Diball-H reduction, quenching, dichloromethane extraction and anhydrous sodium sulfate drying on the INT-4, and then reducing the INT-4 by using triethyl silane to obtain an intermediate INT3; step S4, coupling the INT-3 in the presence of a catalyst and a ligand to obtain an intermediate INT-4; step S5, carrying out deprotection and salification on the INT-4 to obtain an intermediate INT5; s6, closing an indole ring from INT5 to obtain a compound of which the general formula is A; chirality is constructed through enzyme catalysis, isomer impurities do not need to be split and separated through SFC when the chirality is constructed, the loss is reduced, the yield is increased, and a target product is obtained with high chiral selectivity; meanwhile, the cost is relatively reduced, and the cost is saved.

A method for synthesizing a compound 2-[(2R,5S)-5-[2-methylfuro[3,2-b]imidazo[4,5-d]pyridin-1-yl]tetrahydropyran-2-yl]acetonitr ile as a selective JAK1 / TYK2 kinase inhibitor. The compound is prepared by taking 7-chloro-6-nitrofuro[3,2-b]pyridine as the starting material, and by nucleophilic substitution, palladium on carbon reduction and cyclization reactions. The present synthesis method has mild reaction conditions, high product yield and high purity, and is suitable for industrial production. A crystal form of the compound, crystal forms of the salts thereof and preparation methods thereof. The crystal form of the compound and the crystal forms of the salts thereof have good physical and chemical properties and are suitable for drug development.

The invention discloses a fermented caffeine eye cream composition. Comprising the following components in parts by weight: 30 to 80 parts of a fermentation composition, 1 to 5 parts of caffeine, 0.1 to 0.3 part of hydroxypropyl tetrahydropyrantriol, 0.5 to 2 parts of nicotinamide, 0.1 to 1 part of squalane, 0.01 to 0.5 part of a ceramide composition, 0.005 to 0.05 part of dipeptide diaminobutyryl benzyl amide diacetate, 0.005 to 0.05 part of a polypeptide composition, 0.01 to 0.5 part of carnosine, 0.01 to 0.5 part of tetrahydromethylpyrimidine carboxylic acid and 3 to 12 parts of a plant extract. The invention also discloses an eye cream containing the eye cream composition. The fermented caffeine eye cream composition provided by the invention can effectively smooth the skin surface, and is beneficial to preventing and comforting aging, improving skin elasticity, improving dark circles, relieving edema and removing under-eye puffiness.

The invention discloses an anti-wrinkle firming composition and application thereof, and particularly belongs to the technical field of skin care products. The composition is prepared from the following components in parts by mass: 0.1 to 10 parts of rhodiola rosea extract, 5 to 20 parts of hydroxypropyl tetrahydropyrantriol, 0.02 to 2 parts of polyrock extract and 0.5 to 2 parts of adenosine, wherein the polyrock extract is obtained by carrying out compound fermentation on lactobacillus acidophilus and bacillus licheniformis; according to the anti-wrinkle and firming composition provided by the invention, when the rhodiola rosea extract, the hydroxypropyl tetrahydropyrantriol, the polyrock extract and the adenosine are compounded for use, excellent effects of resisting oxidation and promoting collagen synthesis are shown; the anti-wrinkle and firming emulsion provided by the invention can effectively reduce wrinkles and improve skin elasticity, shows excellent performance, overcomes the problems of efficacy limitation and single action mechanism of a single component, and realizes efficient anti-wrinkle and firming effects under a multi-channel synergistic effect.

Disclosed herein is a solid Form A of 1-(6-ethyl-8-fluoro-4-methyl-3-(3-methyl-1,2,4-oxadiazol-5-yl)quinolin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)piperidin-4-amine hydrochloride exhibiting at least X-ray lines (in degrees 2θ ± 0.2) at 4.30, 8.59, 12.88, 18.82 and 21.34 in a powder diffraction pattern when measured using Cu Kα radiation. The solid Form A is an antagonist of the kappa-opioid receptor (KOR) and is useful for treating conditions that benefit from the same. Compositions comprising the solid Form A, as well as related methods of use are also disclosed.

The invention relates to a three-factor liposome as well as a preparation method and application thereof in skin-nourishing air cushion cream. The three-factor liposome is prepared from the following components in percentage by mass: 0.5 to 4 percent of hydrogenated lecithin, 30 to 70 percent of glycerol, 5 to 15 percent of grease, 0.1 to 0.5 percent of cholesterol, 1 to 10 percent of bose, 1 to 10 percent of Ectoine, 0.05 to 0.5 percent of ergothioneine, 0.1 to 1 percent of bisabolol, 0.1 to 1 percent of auxiliaries and the balance of solvent. The glassine is selected from one or two of S-type hydroxypropyl tetrahydropyrantriol and R-type hydroxypropyl tetrahydropyrantriol. The invention further discloses a preparation method of the glassine. The product disclosed by the invention is narrow in particle size distribution and higher in percutaneous absorption rate, can exert higher effects of relieving and repairing skin barrier and moisturizing and moisturizing than a common three-factor product, can help to maintain makeup, resist darkness and oxidation while nourishing the skin, overcomes the defects in the prior art, has great technical perspectiveness and market tonality, and has a good application prospect.

The invention belongs to the technical field of skin repair, and particularly relates to a natural skin repair composition which is prepared from isosorbide dimethyl ether, hydroxypropyl tetrahydropyrantriol, ferulic acid, a dandelion extract, a chamomile extract, sodium hyaluronate, Ectoine, squalane, tartaric acid and water, and a specific preparation method is provided. According to the skin repairing composition, the defects of an existing skin repairing composition are overcome, the isosorbide dimethyl ether is used for permeation, the hydroxypropyl tetrahydropyrantriol is brought into a corium layer and an epidermal layer, the three-dimensional hyaluronic acid repairing and protecting effect of internally promoting external coating is formed in cooperation with the ectoine, the sodium hyaluronate and the squalane, and the excellent skin repairing effect is achieved.

The invention belongs to the field of cosmetics, and discloses an anti-wrinkle soothing composition, application of the anti-wrinkle soothing composition and a cosmetic. Comprising the following components in parts by weight: 15-20 parts of hydroxypropyl tetrahydropyrantriol, 10-15 parts of tetrahydromethylpyrimidine carboxylic acid, 5-10 parts of a leukocyte extract, 5-20 parts of a leontopodium alpinum callus extract solution and the balance of a bifidus yeast fermentation product filtrate, through reasonable compounding of the five components, synthesis of collagen and elastin can be effectively promoted, and good anti-wrinkle and soothing effects are achieved.

Provided is a method for synthesizing a compound 2-[(2R,5S)-5-[2-[(R)-1-hydroxyethyl]furo[3,2-b]imidazo[4,5-d]pyridin-1-yl]tetrahydropyran-2-yl]acetonitrile as a selective JAK1 / TYK2 kinase inhibitor. The compound is prepared by nucleophilic substitution, palladium on carbon reduction, and cyclization reaction using 7-chloro-6-nitrofuro[3,2-b]pyridine as a starting material. The synthesis method has mild reaction conditions, high product yield, and high purity, and is suitable for industrial production. Further provided are a crystal form of the compound, crystal forma of its salts, and their preparation methods. The crystal form of the compound and the crystal forms of its salts have good physical and chemical properties and are suitable for drug development.

The invention provides an anti-wrinkle firming face cream and a preparation method and application thereof, and the anti-wrinkle firming face cream comprises the following components in percentage by mass: 4-20% of emollient, 2-9% of humectant, 0.5-3% of anti-wrinkle agent and the balance of solvent, the emollient comprises a plant extract; the plant extract comprises a citrus fruit extract, a burdock root extract, a phellinus linteus extract, a centella asiatica extract, a fig fruit extract, an apple fruit extract, a Kava pepper leaf / root / stem extract, a cocoa seed extract and a mussel extract; the humectant is prepared from glycerol, butanediol, betaine, sodium hyaluronate and trehalose; the anti-wrinkle agent is prepared from hydroxypropyl tetrahydropyrantriol. The anti-wrinkle and firming face cream provided by the invention is scientific in formula, and tests prove that the face cream has the effects of moisturizing, relieving, repairing, firming, resisting wrinkles, and being mild and non-irritating.

The present disclosure relates to crystal forms of a triazine dione derivative and a preparation method therefor. Specifically, the present disclosure relates to different crystal forms of (S)-6-((1-(2-fluoro-5-methylphenyl)ethyl)amino)-3-(tetrahydro-2H-pyran-4-yl)-1,3,5-triazine-2,4(1H,3H)-dione and a preparation method therefor. The crystal forms of (S)-6-((1-(2-fluoro-5-methylphenyl)ethyl)amino)-3-(tetrahydro-2H-pyran-4-yl)-1,3,5-triazine-2,4(1H,3H)-dione provided by the present disclosure have good stability and can be better used for clinical treatment.

The invention discloses a skin-tightening anti-wrinkle essence and a preparation process thereof, and relates to the technical field of cosmetic preparation, and the preparation process comprises the following steps: obtaining animal umbilical cord tissue, culturing, collecting cell culture supernatant after culture, carrying out low-speed centrifugation to remove cells and dead cells, and carrying out concentration, filtration and sterilization through a tangential flow membrane technology to obtain the skin-tightening anti-wrinkle essence. The animal umbilical cord extract is obtained; the preparation method comprises the following steps: mixing the animal umbilical cord extract with water, butanediol, glycerol, hydroxypropyl tetrahydropyrantriol, 1, 2-hexanediol, trehalose, p-hydroxyacetophenone, allantoin, hydrolyzed sodium hyaluronate, sodium hyaluronate, tetrahydromethylpyrimidine carboxylic acid, xanthan gum and essence, homogenizing under a stirring condition, and standing for defoaming. By constructing an active stable microenvironment and an efficient transdermal delivery system, the technical problem that the animal umbilical cord extract serving as a core component is easy to inactivate and difficult to absorb is solved, and a faster and more stable skin structure remodeling effect is realized by utilizing the synergistic effect of the animal umbilical cord extract and functional components.

The invention provides a composition containing glaine and sodium mannose phosphate and application of the composition in functional skin care products. The composition is prepared from the following components in percentage by mass: 12 to 25 percent of hydroxypropyl tetrahydropyrantriol, 0.05 to 1 percent of sodium mannose phosphate, 0.001 to 0.01 percent of acetyl octapeptide-3, 0.1 to 0.5 percent of saccharomycetes / rice fermentation product filtrate, 0.01 to 0.15 percent of bifidus yeast fermentation product filtrate, 0.2 to 0.5 percent of lactobacillus / soybean milk fermentation product filtrate and the balance of water or other solvents. According to the composition, through synergistic matching of all the components, the composition can resist wrinkles, whiten the skin and brighten the skin color. The composition is used in skin care products, can effectively resist wrinkles, whiten and brighten skin, and enables the skin to keep a good state.

The invention relates to the technical field of skin care essence, in particular to double-layer essence with an anti-aging effect and a preparation method thereof.The double-layer essence with the anti-aging effect is composed of a water phase layer and an oil phase layer; the water-phase layer is prepared from the following raw materials in percentage by mass: 3-8% of hydroxypropyl tetrahydropyrantriol, 0.1-0.5% of tetrahydromethylpyrimidine carboxylic acid, 0.01-0.1% of a pepper kava extract, 1-5% of lactobacillus / soybean milk fermentation product filtrate, 1-5% of vitamin C ethyl ether, 1-5% of acetylchitosamine, 3-8% of 1, 3-butanediol and the balance of water. The invention relates to an anti-aging mask which comprises the following components in percentage by weight: 1-10% of 1, 3-butanediol, 0.01-0.1% of sodium hyaluronate, 0.1-0.5% of a buffer system, 5-10% of glycerol and the balance of deionized The oil phase layer is prepared from the following raw materials: 0.5-2% of ascorbyl tetraisopalmitate, 11-44% of compound plant-derived grease and 0.05-0.3% of tocopheryl acetate, and the problems that existing essence oil is lack of a multi-dimensional synergistic anti-aging effect, and the stability and transdermal absorption efficiency of water-soluble active ingredients and oil-soluble ingredients are difficult to consider are solved.

The present invention provides a compound having an effect of inhibiting the production of β-amyloid protein, especially an effect of inhibiting BACE1, and the compound can be used as a therapeutic agent or preventive agent for diseases induced by the production, secretion and / or deposition of β-amyloid protein. A compound of formula (I), wherein R 3 Each independently is an alkyl group optionally substituted by halogen, cyano, alkoxy, haloalkoxy or non-aromatic carbocyclic group, etc.; t is an integer of 0-3; R 5 is a hydrogen atom or a halogen; R 6 is selected from a hydrogen atom, a halogen and a substituted or unsubstituted alkyl group; Ring B is a substituted or unsubstituted pyrazine, etc.; or a pharmaceutically acceptable salt thereof.

The invention discloses tightening and anti-aging massage cream and a preparation method thereof, and belongs to the technical field of cosmetics. The massage cream comprises butanediol, glycerin, allantoin, carbomer, sodium hyaluronate, hydrolyzed collagen, a moistening agent, an emulsifier, a pH regulator, a penetration enhancer, a skin conditioner and an antioxidant. Through scientific and reasonable proportioning, various active ingredients with different effects are compounded, so that the massage cream can directly permeate skin tissues, increase cell viability, promote blood circulation, deeply nourish the skin, comprehensively improve the skin state and remarkably improve the skin compactness; through synergistic cooperation of natural active ingredients such as tetrahydromethylpyrimidinecarboxylic acid, bakuchiol, polypeptide, a plant extract aqueous solution, hydroxypropyl tetrahydropyrantriol and a helichrysum extract, the activity of collagenase can be effectively inhibited, fibroblasts are stimulated to generate collagen, and therefore the skin elasticity is remarkably improved, and meanwhile the purposes of tightening and resisting aging are achieved.

The application discloses a composition with long-acting anti-wrinkle, skin elasticity improvement and skin tightening effects, a preparation method and application thereof, and belongs to the technical field of cosmetics. The composition comprises the following efficacy components: Schizosaccharomyces pombe ferment lysate, hydroxypropyl tetrahydropyrane triol, lactose, whey protein, lactic acid, Lactarius volemus extract and palm leaf tree extract. The eye cream prepared by using the composition has very significant long-acting anti-wrinkle, skin elasticity improvement and skin tightening effects. After 28 days of use, the R2 value of skin elasticity at the corner of the eye is increased by more than 20%, the R0 value of total skin stretching displacement is decreased by more than 40%, the proportion of wrinkle area is decreased by more than 15%, and the wrinkle depth is decreased by more than 27%. The effect after 28 days of use is also significantly better than that after 14 days of use.

The invention discloses a whitening, anti-wrinkle, firming and soothing multi-effect composition, which is prepared from the following raw material components: nicotinamide, hydroxypropyl tetrahydropyrantriol, p-hydroxyacetophenone, glycerol, 1, 2-pentanediol, 1, 2-hexanediol, a barley extract composition, panthenol, a radix gentianae extract composition, an oat kernel extract composition and the balance of water. The barley extract, the radix gentianae extract and the oat kernel extract are added into the whitening, anti-wrinkle, firming and soothing multi-effect composition, so that melanosome can be inhibited from being transferred to the skin surface, DNA damage caused by UV is repaired, photoimmunosuppression is intervened, elastase and hyaluronidase are inhibited, and the whitening, anti-wrinkle, firming and soothing multi-effect composition has the advantages that the whitening, anti-wrinkle, firming and soothing functions are realized; the face cream prepared from the multi-effect composition for whitening, resisting wrinkles, tightening and relieving has the effects of whitening, resisting wrinkles, tightening and relieving.

The objective is to provide a diol-containing composition that enables the stable production of polycarbonate diol compositions for obtaining polyurethanes suitable for use in paints, coatings, and adhesives. [Solution] A diol-containing composition comprising a diol compound (4) represented by the following general formula (IV) and a tetrahydropyran compound (3-1) represented by the following general formula (III-1). [Formula 1] JPEG2026054816000039.jpg567 (In the above general formula (IV), n is an integer between 3 and 6.) [chemical 2] JPEG2026054816000040.jpg1572 (In the above general formula (III-1), R1 is a C2-C12 alkyl group or hydrogen atom, which may have substituents or heteroatoms.) A polycarbonate diol composition comprising the aforementioned diol-containing composition and a carbonate-based compound as raw materials.

The invention discloses a microgel bead coated polypeptide anti-aging composition and a preparation method thereof. The microgel bead coated polypeptide anti-aging composition comprises a phase A, a phase B and a phase C, the phase A also comprises purified water, a film-forming agent, a thickening agent, glycerol, butanediol, a humectant and sodium hyaluronate; the phase B also comprises beta-glucan, glycosylglycerol, a bletilla striata extract, ergothioneine, a rosa multiflora flower extract, a mussel extract, an antiseptic synergist, hydroxypropyl tetrahydropyrantriol and an emulsifier; the phase C further comprises jojoba oil, sodium alginate, gellan gum, chondrus crispus powder, acetyl hexapeptide-8 and acetyl octapeptide-3; according to the microgel bead coated polypeptide anti-aging composition and the preparation method thereof, acetyl hexapeptide-8 and acetyl octapeptide-3 are coated with microgel beads, so that the effects of acetyl hexapeptide-8 and acetyl octapeptide-3 can be better exerted, a series of unstable problems of active peptides are solved, and the anti-aging effect of the composition is improved. And the two active peptides are complementary to anti-aging and anti-wrinkle products in mechanism, so that the effect that 1 + 1 is greater than 2 is achieved.

This invention discloses a firming and wrinkle-reducing eye cream, comprising a moisturizer, a whitening agent, a skin repair additive composition, a thickener, a preservative, a film-forming agent, a skin moisturizer, and a surfactant. The weight ratio of the moisturizer, whitening agent, anti-aging additive composition, thickener, preservative, film-forming agent, skin moisturizer, and surfactant is 20:1:2:3:0.3:0.5:1:0.2. The moisturizer includes butylene glycol, glycerin, polydimethylsiloxane, and hydrogenated polyisobutylene. The skin-repairing additive composition includes hydroxypropyl tetrahydropyranotriol, adenosine, cell growth factors, ceramides, and salicylic acid, comprising olefins, betaine, trehalose, 1,2-hexanediol, hydrogenated lecithin, allantoin, and Euglena galactosides. The film-forming agents include polyacrylamide, cyclohexylsiloxane, and polydimethylsiloxane alcohol. The emollients include C13-14 isoparaffins, polydimethylsiloxane / vinyl dimethylsiloxane crosspolymers, and cyclopentamethoxysiloxane. This invention can repair cells and provide long-lasting anti-wrinkle and whitening protection for the corners of the eyes.

The invention provides a crystal form VI of an acrylamide compound, and the acrylamide compound is (S)-N-(5-((6-(2-(7, 7-dimethyl-1-oxo-1, 3, 4, 6, 7, 8-hexahydro-2H-cyclopentane [4, 5] pyrrolo [1, 2-a] pyrazine-2-yl)-3-(hydroxymethyl) pyridine-4-yl)-4-methyl-3-oxo-3, 3, 4-triazolo [1, 2-a] pyrazine-2-yl)-3-(hydroxymethyl) pyridine-4-yl)-4-methyl-3-oxo-3, 3, 4-triazolo [1, 2-a] pyrazine-2-yl)-3-(2, 3, 4-triazolo [1, 2-a] pyrazine-2-yl)-4- The crystal form VI is a 2-(2, 4-dihydropyrazine-2-yl) amino)-2-(2-methyl-4-(tetrahydro-2H-pyran-4-yl) piperazine-1-yl) 5phenyl) acrylamide compound, and an X-ray powder diffraction pattern of the crystal form VI comprises diffraction peaks with the following 2 theta angle values: 8-3 + / -0.2 degrees, 13.2 + / -0.2 degrees and 18.9 + / -0.2 degrees. The crystal form VI has the advantages of good stability and low hygroscopicity, and is suitable for industrial production of bulk drugs and development of preparation prescriptions.

The invention discloses an electrolyte, a lithium ion battery and an electronic product. The electrolyte comprises electrolyte salt and a solvent; wherein the concentration of the electrolyte salt is 0.1 mol / L-5 mol / L, and the ether solvent comprises one or more of dimethoxymethane, diethoxymethane, 1, 2-diethoxyethane, 1, 3-dioxolane, 1, 3-dioxane, 1, 4-dioxane, tetrahydrofuran, 2-methyltetrahydrofuran, tetrahydropyran, diethyl ether, cyclopentyl methyl ether, triethylene glycol dimethyl ether and tetraethylene glycol dimethyl ether. According to the electrolyte provided by the invention, the ether solvents are reasonably screened, and the ether solvents with relatively weak lithium salt dissolving capacity are selected, so that the electrolyte forms contact ion pairs and aggregation ion pairs at low concentration, and then anion derivative interface chemistry is introduced, and the obtained electrolyte reduces co-intercalation behaviors and is relatively good in stability at low temperature; the method is suitable for low-temperature environments.