10 results about "Sapogenin" patented technology

This invention belongs to the field of biomedical technology, specifically relating to a rapid purification method for umbilical cord MSC exosomes and their application in the preparation of drugs for treating COPD. This invention discloses a method for rapidly purifying umbilical cord mesenchymal stromal cell (MSC) exosomes and a pharmaceutical composition comprising umbilical cord MSC exosomes and yamosaponin. In this pharmaceutical composition, the umbilical cord MSC exosomes and yamosaponin synergistically enhance the dynamic compliance of COPD rats, reduce airway resistance, decrease pulmonary inflammation, and repair pulmonary dysfunction. This invention provides a new technical solution for the preparation of drugs for treating or improving COPD.

This invention discloses a low-allergen compound oral liquid for middle-aged and elderly people that protects the liver, stabilizes blood pressure, blood sugar, and blood lipids, combats aging, aids sleep, and prevents Alzheimer's disease. It belongs to the field of food and medicine homology health food technology. The invention uses kudzu root extract, Japanese raisin tree fruit extract, mulberry leaf extract, jujube seed saponins, Acer truncatum seed oil (nervonic acid), blueberry anthocyanins, bitter melon small molecule peptides, wolfberry polysaccharides, γ-aminobutyric acid, and chrysanthemum flavonoids as core active ingredients, refined with a prebiotic system. This invention achieves comprehensive conditioning effects for middle-aged and elderly people through the synergistic action of five pathways: liver protection and metabolism, vascular regulation, anti-oxidation and anti-aging, nerve calming, and brain nerve repair. It simultaneously nourishes and protects the liver, stabilizes blood pressure, blood sugar, and blood lipids, delays aging, improves intractable insomnia, enhances memory, slows brain atrophy, and prevents Alzheimer's disease. This formula strictly avoids eight common allergens, is pure and mild, and contains no irritating additives, making it suitable for long-term use by middle-aged and elderly people with weak constitutions. This product is an oral liquid formulation, with small molecule extraction, strong permeability, rapid absorption, low gastrointestinal burden, stable production process, and high safety. It has extremely high clinical promotion value and industrialization prospects.

The application relates to the technical field of biological medicine, and discloses a preparation method of a hederosapogenin STING channel inhibitor, which comprises the following steps: taking appropriate hederosapogenin and aromatic compounds, adding N,N-dimethylformamide as a reaction solvent, and adding appropriate K2CO3; stirring under a heating reflux state for a certain time, monitoring the reaction process through thin layer chromatography until the reaction is completed; after the reaction is completed, the N,N-dimethylformamide is evaporated under reduced pressure, the obtained residue is dissolved in dichloromethane, and the residue is extracted and washed with deionized water and saturated brine in sequence; the organic layer is collected, dried with anhydrous sodium sulfate, filtered, evaporated under reduced pressure, and a crude product is obtained; the crude product is separated and purified through a silica gel column chromatography, and a target compound, namely a STING channel inhibitor derivative, is obtained. The hederosapogenin is chemically modified to synthesize a derivative with high STING channel activity, which is used for treating immune and inflammation related diseases.

The invention relates to the technical field of traditional Chinese medicine analysis, in particular to a construction method of a characteristic spectrum of a traditional Chinese medicine compound preparation for treating senile dementia. The method is creatively characterized in that detection of characteristic peaks is realized through extraction, preparation and purification of an extract and specific gradient selection under a specific mobile phase condition. According to the method, seven chemical components in the traditional Chinese medicine compound preparation can be analyzed, seven characteristic peaks including epimedin C, ginsenoside Rd, pachymic acid, dehydrotumuloic acid, alpha-asarone, polygala mountain ketone III and tenuigenin are identified, verification research on specificity, precision, repeatability and stability is carried out on the method, and it is proved that the method is accurate and reliable. The technical means is used as a method for overall evaluation of the traditional Chinese medicine compound preparation, and a quality control system of the traditional Chinese medicine compound preparation is comprehensively improved.

The application relates to application of a smilagenin compound in preparation of a medicine for treating diseases caused by abnormal mitochondrion function, characterized in that the structural formula of the compound is shown in general formula (I). Through activity test of the smilagenin compound in related in-vivo and in-vitro models, it is found that many derivative compounds have superior cell protection activity, especially for various brain neuron cells related to mitochondrion, and the compounds have unexpected protection activity and very excellent blood-brain permeability, so that the compounds have potential wide application and great value for treating various diseases caused by abnormal mitochondrion function, make up for the deficiency of the smilagenin compound in the prior art, and have important scientific and commercial application value.

This invention provides a composition for alleviating fatty liver and its application, belonging to the field of pharmaceutical technology. The composition of this invention comprises the following components: dihydroberberine, neoruscosaponin, physalicylate, and trans-trimethoxyresveratrol, wherein the final concentrations of dihydroberberine, neoruscosaponin, physalicylate, and trans-trimethoxyresveratrol are all 5-15 μM. The composition of this invention can effectively alleviate hepatic fat accumulation, impaired liver function, and oxidative stress damage to the liver, and as a new product for the prevention and treatment of fatty liver, it has good application prospects.

This invention discloses a BAHD acyltransferase from Camellia oleifera and its applications. It relates to the field of enzyme engineering technology. The amino acid and nucleotide sequences of the BAHD acyltransferase are provided, along with related applications. This invention provides an enzyme with acyl transfer function from Camellia oleifera, which can be directly used as a catalyst for the acylation reaction of C-22 saponins in Camellia oleifera. Furthermore, this enzyme exhibits strong stability and activity, and its preparation method is simple and efficient, making it suitable for use in the biosynthesis of secondary metabolites.

This invention discloses a sleep-aid composition based on biotransformation technology, its preparation method, and its applications. The composition comprises jujube seed extract, sea buckthorn compound extract, γ-aminobutyric acid (GABA), and raspberry anthocyanin extract. Through a dual biotransformation process of "directional fiber-pectin dual-enzyme degradation" and "Lactobacillus plantarum-Saccharomyces cerevisiae symbiotic fermentation," the sugar chains of large molecular weight glycosides in the raw materials are broken down, efficiently enriching free small molecular weight jujube seed saponin A and isorhamnetin aglycone with high brain permeability, and achieving matrix synergy with GABA. The composition of this invention is safe and non-addictive, and can be used to prepare drugs or functional foods for sedation and hypnosis, prolonging slow-wave deep sleep, and promoting neural synapse regeneration and repair.

This invention relates to a method for synthesizing (S)-3-methylheptanoic acid, which further expands the application scope of steroidal saponin degradation waste. The method of this invention conveniently synthesizes (S)-3-methylheptanoic acid from (R)-γ-methyl-δ-butyrate lactone obtained from the degradation of steroidal saponins. The method provided by this invention is simpler and more efficient than existing methods. It also helps to improve the utilization rate of steroidal saponin resources and reduce the generation of waste during their utilization.