121 results about "Dithiane" patented technology

Dithioamine reducing agents useful for the reduction of disulfide bonds. The reducing agents of this invention are useful, for example, to reduce disulfide bonds, particularly in proteins, or to prevent the formation of disulfide bonds, particularly in proteins and other biological molecules. Reducing agents of this invention are useful and suitable for application in a variety of biological applications, particularly as research and synthetic reagents. The invention provides S-acylated dithioamines which can be selectively activated reducing agents by removal of the S-acyl groups enzymatically or chemically. The invention further provides dithiane precursors of thioamino reducing agents. The invention provides dithioamine reducing agents, S-acylated dithioamines and dithianes which are immobilized on surfaces, including among others, glass, quartz, microparticles, nanoparticles and resins.

The polymerizable composition for an optical material of the present invention comprises a phenylene diisocyanate, at least one polythiol compound selected from the group consisting of 4-mercaptomethyl-1,8-dimercapto-3,6-dithiaoctane, 4,8-, 4,7- or 5,7-dimercaptomethyl-1,11-dimercapto-3,6,9-trithiaundecane, 2,5-bis(mercaptomethyl)-1,4-dithiane, bis(mercaptoethyl)sulfide, 1,1,3,3-tetrakis(mercaptomethylthio)propane, 4,6-bis(mercaptomethylthio)-1,3-dithiane, 2-(2,2-bis(mercaptomethylthio)ethyl)-1,3-dithietane, 1,1,2,2-tetrakis(mercaptomethylthio)ethane 3-mercaptomethyl-1,5-dimercapto-2,4-dithiapentane and tris(mercaptomethylthio)methane.

Disclosed is a polymerizable composition for o an optical material containing tolylene diisocyanate, hexamethylene diisocyanate, and one or more polythiol compounds selected from the group consisting of 4-mercaptomethyl-1,8-dimercapto-3,6-dithiaoctane,4,8-, 4,7- or 5,7-dimercaptomethyl-1,11-dimercapto-3,6,9-trithiaundecane, pentaerythritol tetrakismercaptoacetate, pentaerythritol tetrakismercaptopropionate, 2,5-bis(mercaptomethyl)-1,4-dithiane, bis(mercaptoethyl)sulfide, 1,1,3,3-tetrakis(mercaptomethylthio)propane, 4,6-bis(mercaptomethylthio)-1,3-dithiane and 2-(2,2-bis(mercaptomethylthio)ethyl)-1,3-dithietane.

A holographic recording medium includes a recording layer. The recording layer includes a framework being expressed with the following general formula (1),

In the above formula (1), Ar represents a substituted or unsubstituted group selected from benzothiophene group, naphthothiophene group, dibenzothiophene group, thienothiophene group, dithienobenzene group, benzothiazole group, naphthothiazole group, benzoisothiazole group, naphthoisothiazole group, phenothiazine group, phenoxathiin group, dithianaphthalene group, thianthrene group, thioxanthene group, and bithiophene group. In addition, n is an integer from 1 to 4.

The invention belongs to the field of medicinal chemistry, and discloses a technology for preparing aclidinium bromide. By adopting the technology, (R)-3-quinuclidinol, (C1)methyl-2,2-dithienyl glycolate and 3-phenoxy propyl bromide are taken as raw materials, and the aclidinium bromide is prepared by adopting a one-pot process. The method is simple to operate, and convenient for post-treatment, and has good application value.

The invention discloses a method for preparing tiotropium bromide, which comprises the following steps of: preparing scopine-2,2-dithienyl glycolate from scopine and methyl 2,2-dithienyl glycolate, reacting the scopine-2,2-dithienyl glycolate with methyl bromide to prepare a tiotropium bromide crude product, and refining the tiotropium bromide crude product to obtain a tiotropium bromide finishedproduct. The method is characterized in that: the scopine and the methyl 2,2-dithienyl glycolate undergo ester exchange reaction under the action of dimethylbenzene, and the mixed catalysts of sodiumand sodium methoxide, and after the reaction, reaction solution is post-treated to obtain the scopine-2,2-dithienyl glycolate. In the method, in the process of preparing the scopine-2,2-dithienyl glycolate, the sodium and the sodium methoxide are simultaneously taken as the catalysts, and scopine isomer content after the reaction is less than 0.1 percent which completely meets specifications in the trial standards of European pharmacopoeia; and the method solves a big problem for the conventional preparation of the tiotropium bromide and is easy to realize industrial production.

The invention discloses an aggregation-induced emission near-infrared emission diketopyrrolopyrrole compound and a preparation method thereof. The method comprises the steps that 3,6-dithiophene diketopyrrolopyrrole reacts with twice molar weight of alkyl bromide so as to obtain 2,5-dialkyl-3,6-dithienopyrrolopyrrole, then the 2,5-dialkyl-3,6-dithienopyrrolopyrrole sequentially undergoes Vilsmeierreaction with phosphorus oxychloride/N,N-dimethylformamide and undergoes substitution reaction with N-bromosuccinimide so as to obtain 2,5-dialkyl-3-(5-formyl)thienyl-6-(5-bromine)thienyl diketopyrrolopyrrole, and then the 2,5-dialkyl-3-(5-formyl)thienyl-6-(5-bromine)thienyl diketopyrrolopyrrole undergoes Suzuki reaction with tetraphenyl ethylene boric acid ester so as to obtain 2,5-dialkyl-3(4-((E)-2-phenyl-1,2-disubstituted styryl)phenyl)thienyl-6-(5-formyl)thienyl diketopyrrolopyrrole. The compound has the emission range greater than 650 nm and has the aggregation-induced emission property.

The invention relates to a synthetic method of 1,3-dithiane structure-containing polysubstituted olefin derivatives. The method comprises the following steps: carrying out an oxyradical coupling reaction on 1,3-dithiane and polysubstituted olefins in a solvent in the presence of a catalyst Lewis acid and an activator N-chlorosuccimide with air or oxygen as an oxidant, separating, and purifying to obtain the 1,3-dithiane structure-containing polysubstituted olefin derivatives. The method has the advantages of avoiding of use of a metal catalyst due to cheap and easily available substrates used in the invention, environmental protection, simple reaction process and mild conditions, the 1,3-dithiane structure-containing polysubstituted olefin derivatives have good function group tolerance and can be directly obtained through a one-kettle process, the method has beneficial technical effects, and can be well applied in scientific researches and industrial production.

An object of the present invention is to provide photoacid generator, which shows very high sensitivity in the near ultraviolet range of about 300 to 400 nm, and also can remarkably increase a reaction rate of a photoreactive composition using the same, and to provide a photoreactive composition which can initiate the reaction even by irradiation with near ultraviolet light within a short time and also can obtain a desired reaction product. More particularly, the present invention provides a dithienyl sulfide disulfonium salt represented by the formula (A1):

wherein R^1a to R^4a each independently represents an optionally substituted monocyclic carbon ring group, an optionally substituted condensed polycyclic carbon ring group or an optionally substituted monocyclic heterocyclic group, and X⁻ represents an inorganic acid ion or an organic acid ion; a photoacid generator containing the dithienyl sulfide disulfonium salt, and a photoreactive composition containing the photoacid generator and an acid reactive compound; a dithienyl sulfide sulfonium salt represented by the formula (B1):

wherein R^1b and R^2b each independently represents an optionally substituted monocyclic carbon ring group, an optionally substituted condensed polycyclic carbon ring group or an optionally substituted monocyclic heterocyclic group, R^3b to R^5b each independently represents a hydrogen atom, an alkyl group having 1 to 10 carbon atoms, an alkoxy group having 1 to 4 carbon atoms, an acyl group or a hydroxyl group, and X⁻ represents an inorganic acid ion or an organic acid ion, a photoacid generator containing the same, and a photoreactive composition containing the photoacid generator; and a phenylthiothiophene sulfonium salt represented by the formula (C1):

wherein R^1c and R^2c each independently represents an optionally substituted monocyclic carbon ring group, an optionally substituted condensed polycyclic carbon ring group or an optionally substituted monocyclic heterocyclic group, and R^3c to R^7c each independently represents a hydrogen atom, an alkyl group having 1 to 10 carbon atoms, alkoxy group having 1 to 4 carbon atoms, an acyl group or a hydroxyl group, and X⁻ represents an inorganic acid ion or an organic acid ion, a photoacid generator containing the same, and a photoreactive composition containing the photoacid generator and an acid reactive compound.

The invention relates to the field of pharmacy, particularly to 3R-1,1-dimethyl-3-(2-hydroxyl-2,2-dithienyl-2-acetoxyl) pyrrolidine bromide, 3S-1,1-dimethyl-3-(2-hydroxyl-2,2-dithienyl-2-acetoxyl) pyrrolidine bromide and applications of the 3R-1,1-dimethyl-3-(2-hydroxyl-2,2-dithienyl-2-acetoxyl) pyrrolidine bromide and the 3S-1,1-dimethyl-3-(2-hydroxyl-2,2-dithienyl-2-acetoxyl) pyrrolidine bromide to preparation of medicines for preventing or treating respiratory system diseases, urinary system diseases or gastrointestinal tract diseases.

The present invention relates to a benzodithiophene based copolymer containing pyridino[2,1,3]thiadiazole units and a preparing method and applications thereof. The polymer has a structural formula (I), wherein R₁ and R₂ are respectively selected from H or alkyl groups of C₁ to C₁₆; R₃ and R₄ are respectively selected from H, alkyl groups of C₁ to C₁₆, alkoxy groups of C₁ to C₁₆, or thiophene groups substituted by alkyl groups of C₁ to C₁₆; X is N and Y is CH, or X is CH and Y is N; and n is a natural number of 7 to 80. Applications of the benzodithiophene based copolymer containing pyridino[2,1,3]thiadiazole units in polymer solar cells, polymer organic light-emitting, polymer organic field effect transistors, polymer organic optical storage, polymer organic nonlinear materials or polymer organic laser are also provided.

Substituted dithiol pyrazine compounds useful as reducing agents in biologically relevant media having formula:

where variables are defined herein and corresponding oxidized pyrazine dithianes. Reducing agents useful to reduce disulfide bonds, particularly in proteins, or to prevent the formation of disulfide bonds, particularly in proteins, and other biological molecules. Reducing agents useful to regulate protein function in proteins in which a sulfhydryl group is associated with biological activity. Reducing agents useful and suitable for application in a variety of biological applications, particularly as research and synthetic reagents. S-acylated dithiol pyrazine compounds, where R₃ is an acyl group, are selectively activated as reducing agents by removal of the S-acyl groups enzymatically or chemically. Dithiol pyrazine reducing agents and corresponding S-acylated dithiol pyrazines, immobilized on surfaces or conjugated to other chemical species, are provided.

The invention belongs to the field of new materials, and particularly relates to a visible-light-regulated dithienyl ethylene fluorescent molecular switch and a preparation method and application thereof. The dithienyl ethylene derivative takes aniline alkynyl as a photosensitization group and perylene monoimide (PMI) as a fluorescent group, and comprises a structural unit shown as a formula (I) or a formula (II), wherein R1 and R2 are respectively and independently alkyl of C1-C10, alkyl alcohol of C1-C10 or aryl of C6-C20. When the derivative is used as a fluorescent molecular switch, the introduction of an aniline alkynyl group enables the fluorescence response wavelength of the molecular switch to be redshifted to a visible light region, and the derivative has the advantages of good thermal stability, good fatigue resistance, high cyclization rate, high fluorescence switch ratio and the like.

The invention provides a preparation method of an anti-sulfur poisoning platinum complex. The preparation method comprises the following steps: preparing a 1,3-dithiane benzene containing derivative intermediate A, preparing an unsaturated symmetrical epithio-silane intermediate B, connecting the 1,3-dithiane benzene containing derivative intermediate A to Pt through a phase transfer substitutionbond, then firstly substituting and then chelating the unsaturated symmetrical epithio-silane intermediate B to Pt, and obtaining the anti-sulfur poisoning platinum complex. The preparation method issimple and convenient, the reaction condition is mild, the production efficiency is high, the cost is low, and the industrial production is realized. A prepared catalyst has a highly symmetric complexstructure, the anti-sulfur poisoning platinum complex is stable at the room temperature, can be stored for long and has an excellent anti-sulfur poisoning catalytic effect, the catalytic activity ismore than 92%, the curing degrees of a sulfur-containing system and a non-sulfur system are basically the same and both reach more than 90%, and the anti-sulfur poisoning platinum complex has an excellent anti-sulfur poisoning capability, and is widely applied to the hydrosilylation.

The invention relates to the field of pharmacy, particularly to a polymorphic substance of 3R-1,1-dimethyl-3-(2-hydroxyl-2,2-dithienyl-2-acetoxyl) pyrrolidine bromide, a preparation method of the polymorphic substance and applications of the polymorphic substance to preparation of medicines for preventing or treating respiratory system diseases, urinary system diseases or gastrointestinal tract diseases.

A pressure-sensitive adhesive composition containing a pressure-sensitive adhesive that contains from 40 to 95% by mass of a rubber-based resin not containing a styrene-derived constituent unit, and a photochromic dye of a dithienylethene-based compound, wherein the content of the photochromic dye is from 0.40 to 8.00 parts by mass relative to 100 parts by mass of the pressure-sensitive adhesive, and a pressure-sensitive adhesive sheet having a pressure-sensitive adhesive layer formed of the pressure-sensitive adhesive composition have excellent weather resistance that can withstand long-term use, a relatively rapid rate of color change from colored to colorless, and excellent peelability to release sheets.

The invention provides a D-A-D type organic photo-thermal small molecular material and a preparation method thereof. The D-A-D type organic photo-thermal small molecular material contains an electronwithdrawing group 2,1,3-benzothiadiazole and an electron donating group 3,6-di(thiophen-2-yl)-2,5-dihydropyrrolo[3,4-c] pyrrole-1,4-dione. The preparation method comprises the steps: substituting H ona thiophene ring of bromo-isooctane substituted 3,6-di(thiophen-2-yl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione with N-bromo-succinimide, and carrying out a reaction with 2,1,3-benzothiadiazole-4,7-bis(pinacol borate) through Suzuki reaction to obtain the target product. With the introduction of an alkyl chain on the side chain of the electron donating group, the solubility of the organic photo-thermal material in the organic solvent is improved, the problem of poor solubility of the organic polymer is overcome, and favorable light stability is achieved.

The invention relates to a method for synthesizing alpha-1,3-dithiane substituted aldehyde compound. The preparation method comprises the following steps: under existence of an activating agent of N-chloro succinimide and a catalyst of Cu(II), dissolving 1,3-dithiane and substituted vinyl ether into an organic solvent, reacting for 1 to 4 hours under room temperature to 50 DEG C and separating and purifying to obtain alpha-1,3-dithiane substituted aldehyde compound. The method disclosed by the invention has moderate operation condition and avoids rigorous dewatering operation and device, the utilized commercialized vinyl ether compound is cheap and easy to obtain, a reaction process is simple, good functional group tolerance is obtained, a beneficial technological effect is obtained, and the method can be well applied to scientific researches and industrial production.

The invention provides a preparation method for 2,5-dihydroxyl-1,4-dithiane. The preparation method comprises the steps of adjusting pH of chloroacetaldehyde, preparing a sodium hydrosulfide solution,dropwise adding part of sodium hydrosulfide solution, carrying out a dropwise adding reaction, and carrying out aging. The 2,5-dihydroxyl-1,4-dithiane prepared by the method has a yield not lower than 90.0%; the appearance of the 2,5-dihydroxyl-1,4-dithiane prepared by the method is white-like or yellowish powder, and the content of dithiane is not lower than 97.0%; the moisture content is not higher than 0.5%; the clarity is of colorless transparent liquid (N,N-dimethylformamide serves as a solvent); and a melting range is 135.0 DEG C to 150.0 DEG C.

The invention discloses a preparation method of a 4-hydroxyl-3-substuted-thiazolane-2-ketone compound and relates to the technical field of medicine. The preparation method of the 4-hydroxyl-3-substuted-thiazolane-2-ketone compound includes the following steps of adding an acyl nitrine compound and 2,5-dyhydroxyl-1,4-dithiane into an organic solvent for a ring-closure reaction to obtain a reactionliquid; filtering the reaction liquid, obtaining a filtrate, removing impurities in the filtrate and then distilling the filtrate to obtain a concentrated liquid; conducting silica gel column chromatography on the concentrated liquid to obtain 4-hydroxyl-3-substuted-thiazolane-2-ketone. The provided preparation method can achieve efficient synthesis of 4-hydroxyl-3-substuted-thiazolane-2-ketone and increase the yield.

The present invention is directed to a golf ball and, more particularly, a golf ball core having a curable core composition comprising a dithiane compound, a rubber based compound comprising cis-1,4-polybutadiene rubber, a crosslinking agent comprising a metallic salt of unsaturated carboxylic acid in an amount between 10 to 50 parts per hundred of rubber (pphr), a peroxide initiator, one or more filler materials, and optionally an organ sulfur compound, are used to provide soft and resilient cores.