The invention discloses an application of a composition containing cryptolepine analogues and small molecule terpene compounds in prevention and treatment of plant diseases. The bactericidal composition comprises the following effective components: cryptolepine, neocryptolepine, sclareol, sclareolide, (+/-)-limonene, citronellol, ambergris, perilla alcohol, perillaldehyde, 2-hexenal, 4-terpene alcohol, terpilenol, alpha-terpilenol, camphor, citral, geraniol, menthol, nerolidol, eudesmol, curcumenol, cedrol and beta-ionone. The bactericidal composition disclosed by the invention can be used for preventing and treating plant diseases caused by rhizoctonia solani, Rape sclerotinia stem rot bacteria, botrytis cinerea, fusarium graminearum, magnaporthe oryzae and phytophthora capsici. The components are all natural products, have the characteristics of low toxicity, low residue, environmental compatibility, difficult generation of drug resistance and the like, can cope with occurrence of drug resistance of diseases and reduce the drug cost, and are beneficial to comprehensive management of the diseases.