26 results about "Sclareolide" patented technology

The invention relates to the technical field of perfume production, in particular to a composite catalyst, a preparation method thereof and a synthesis method of ambergris. The composite catalyst disclosed by the invention is obtained by quaternizing porous silicon dioxide and then loading aluminum trichloride; when the composite catalyst is applied to synthesis of ambergris, the composite catalyst can be matched with potassium borohydride, so that sclareolide can be subjected to a one-step reduction reaction to generate ambergris, the reaction condition is mild, the method is stable, generation of sclareolide ring-opening byproducts is reduced, the product yield is increased, and the yield can reach 95% or above.

The invention discloses a spot-fading, whitening and skin-tightening composition and a preparation method thereof, and particularly belongs to the technical field of cosmetics. The composition is prepared from an extract of bark of the cissampelos maculata, hydroxyl pinacolone 9-cis-retinoate, sclareolide, tetrahydromagnolol and a quercetin dimer. The composition provided by the invention can significantly reduce the skin melanin content, improve the skin brightness and significantly improve the skin elasticity and compactness, all the components have a synergistic effect, the effects of spot fading, whitening and skin tightening are effectively achieved, the preparation process provided by the invention is stable and controllable, and the composition is suitable for large-scale production and has wide application prospects. A novel efficient skin care composition and an application scheme are provided for the field of cosmetics.

The invention relates to a method for preparing norambrox ether from sclareolide. The method comprises the following steps: 1) preparing a red aluminum toluene solution; 2) dissolving sclareolide with toluene to obtain a sclareolide toluene solution, adding the sclareolide toluene solution into the red aluminum toluene solution for complete reaction, and quenching with a NaCl solution to obtain a reactant containing sclarediol; 3) carrying out oil-water separation on the reactant to obtain a primary organic phase and a water phase, so as to obtain an organic phase containing sclarediol; 4) carrying out a dehydration reaction on the organic phase containing sclarediol by using a molecular sieve, and after the reaction is completed, separating out an organic phase containing norambrox ether; 5, the organic phase containing the norambergyl ether is subjected to distillation concentration and crystallization separation, and a norambergyl ether product is obtained.According to the method, sclareolide is reduced through the red aluminum, and compared with lithium aluminum hydride, hydroboron and red aluminum, the red aluminum has the advantages of being good in stability, beneficial to industrialization, low in reaction temperature and safe.

The invention provides a preparation method of sclareolide and a catalyst, and belongs to the technical field of organic catalysis. The method comprises the following steps: dissolving sclareol by using a first solvent, adding a catalyst, adjusting the pH value of the solution under microwave conditions, dropwise adding hydrogen peroxide, heating and stirring for reaction, separating the catalyst, reusing, extracting the product by using a second solvent, and heating and refluxing to obtain sclareolide; the catalyst is imidazolyl ionic liquid / polyethylene glycol / maleic acid modified graphene oxide loaded with vacancy heteropolyacid salt. According to the preparation method of sclareolide, microwave-assisted reaction is adopted, so that the product yield of sclareolide is greatly improved. According to the invention, two mutually compatible reaction systems of alcohol and water are adopted, so that the environmental protection property of the process is greatly improved, and meanwhile, under the action of the catalyst, the method has a phase catalytic transfer effect, the reaction efficiency is improved, the reaction condition is mild, the product yield is high, and the method has a wide application prospect.

This invention discloses a composition for fading dark spots, whitening, and firming the skin, and its preparation method, specifically belonging to the field of cosmetic technology. The composition contains extracts of *Bretschneidera sinensis* bark, hydroxypinazone 9-cis-retinate, sage lactone, tetrahydromagnoliol, and quercetin dimer. The composition provided by this invention can significantly reduce skin melanin content, improve skin brightness, and significantly improve skin elasticity and firmness. The synergistic effect of the components effectively achieves the effects of fading dark spots, whitening, and firming the skin. The preparation process provided by this invention is stable and controllable, suitable for large-scale production, and provides a novel and highly effective skincare composition and application solution for the cosmetic field.

The present invention discloses a method for producing perillaldehyde and / or perillyl lactone, comprising: contacting a first component with a second component to produce perillaldehyde and / or perillyl lactone; wherein the first component is selected from components containing lysine-2-diol, and the second component is selected from enzymes or microorganisms or their cell lysates or enzyme extracts capable of converting lysine-2-diol into perillaldehyde and / or perillyl lactone.

This invention provides a novel technology that can enhance the carbonation sensation in carbonated beverages. [Solution] A carbonated beverage containing monomenthyl succinate and sclareolide.

This invention discloses a stress-resistant and yield-increasing plant growth regulator, its preparation method, and its application, belonging to the field of plant growth regulators. The stress-resistant and yield-increasing plant growth regulator of this invention comprises the following raw materials: *Suaeda salsa* extract, a stress-resistant biostimulant, propionyl brassinolide, styracil, polyaspartic acid, γ-aminobutyric acid, emulsifier, penetrant, co-emulsifier, pH buffer, and deionized water; wherein the stress-resistant biostimulant is perilla lactone. This invention significantly improves the tolerance of wheat to salt-alkali stress by strengthening the antioxidant system and osmotic regulation capacity, ensuring its basic survival and normal physiological functions; and effectively reverses stress-induced growth inhibition through mechanisms such as promoting root development, enhancing photosynthesis, and driving product translocation to grains, thereby achieving a significant yield increase under adverse conditions.

An agent containing at least one aroma compound selected from the group consisting of E-beta-damascone, S-(2-methyl-3-furyl)ethanethioate, beta-caryophyllene oxide, beta-ionone, 2,5-dihydroxy-1,4-dithiane, methyl anthranilate, S-furfuryl thioformate, 1-isothiocyanate-3-(methylthio)propane, nootkatone, 1,4-dioxacycloheptadecane-5,17-dione, sclareol, and sclareolide is effective for masking an unpleasant smell and for making oral products in which an unpleasant smell is masked.

Variants of squalene hopene cyclase (SHC) are provided for enzymatically converting homofarnesoic acid to sclareolide, which can be non-enzymatically converted to ambrox.

To provide a masking agent for unpleasant odors derived from plants, in particular a grassy odor of soybean and an unpleasant odor derived from fats and oils of processed meat products (such as a hexanal odor), a method for masking unpleasant odors using the compound, and a method for producing an oral product in which unpleasant odors are masked.SOLUTION: The present invention provides an unpleasant-odor masking agent for oral products which contains at least one aroma compound selected from the group consisting of E-beta-damascone, S-(2-methyl-3-furyl) ethanethioate, beta-caryophyllene oxide, beta-ionone, 2,5-dihydroxy-1,4-dithiane, methyl anthranilate, S-furfuryl thioformate, 1-isothiocyanate-3-(methylthio)propane, nootkatone, 1,4-dioxacycloheptadecane-5,17-dione, sclareol, and sclareolide.SELECTED DRAWING: None

The present application relates to a kind of bryonia lactone-containing soothing repair composition and its application in washing and caring product, the soothing repair composition includes the weight ratio of (1-10) :(0.1-5):(0.1-3):(0.1-3) bryonia lactone, sclareolide, artemisia princeps leaf extract and hyssop extract, the composition is by inhibiting inflammatory factor, scavenging free radical and strengthening barrier function etc. Path, realize from surface soothing to the synergistic effect of deep repair. The soothing repair composition of the present application is applied to shampoo, can carry out comprehensive, systematic, scientific conditioning maintenance to scalp, can eliminate barrier damage, sensitive, pruritus etc. Scalp problem from root, keep the healthy state of scalp and hair.

To provide a masking agent for unpleasant odors derived from plants, in particular a grassy odor of soybean and an unpleasant odor derived from fats and oils of processed meat products (such as a hexanal odor), a method for masking unpleasant odors using the compound, and a method for producing an oral product in which unpleasant odors are masked.SOLUTION: The present invention provides an unpleasant-odor masking agent for oral products which contains at least one aroma compound selected from the group consisting of E-beta-damascone, S-(2-methyl-3-furyl) ethanethioate, beta-caryophyllene oxide, beta-ionone, 2,5-dihydroxy-1,4-dithiane, methyl anthranilate, S-furfuryl thioformate, 1-isothiocyanate-3-(methylthio)propane, nootkatone, 1,4-dioxacycloheptadecane-5,17-dione, sclareol, and sclareolide.SELECTED DRAWING: None

The patent relates to a method for preparing marine terpenoid natural products based on a decarboxylation coupling reaction of carboxylic acid salt of sclareolide or carboxylic acid of sclareolide and quinone compounds, and belongs to the field of chemical synthesis. The method takes sclareolide as raw material, and realizes, for the first time, a Minisci decarboxylation coupling reaction of carboxylic acid salt of bicyclic sesquiterpene or carboxylic acid of sclareolide and p-benzoquinone promoted by Selectfluor, so that the synthesis steps of yahazunone are shortened from the previous 6-18 steps to 2 steps, and asymmetric synthesis of multiple yahazunone natural products is realized. The method has the characteristics of good step economy, simple operation and suitability for industrial production.

The present disclosure relates to the field of personal care and more particularly to a method for improving scalp condition and hair growth, which comprises applying to the scalp a composition comprising an active agent selected among sclareol, sclareol-like, sclareolide or sclareolide-like and a physiologically acceptable carrier

This invention relates to the field of tobacco technology, specifically to a flavored tobacco extract, its preparation method, and its application. The flavored tobacco extract provided by this invention comprises: ceftazidimetrienol, megastigmatrienone, nicotine, β-ionone, 4-hydroxy-β-dihydrodamascone, isovaleric acid, 2-methylbutyric acid, and perillaldehyde; the mass ratio of ceftazidimetrienol, megastigmatrienone, nicotine, β-ionone, 4-hydroxy-β-dihydrodamascone, isovaleric acid, 2-methylbutyric acid, and perillaldehyde in the flavored tobacco extract is (1.5-3.3):(0.1-0.25):(3.5-15):(0.0015-0.01):(0.01-0.1):(0.05-0.5):(0.005-0.02):(0.05-0.4). The aromatic tobacco extract provided by this invention has high safety, while the extract has a distinct aroma, good overall harmony, and a good overall sensory experience.

The invention discloses a method for synthesizing sclareolide by using recombinant saccharomyces cerevisiae, which comprises a recombinant saccharomyces cerevisiae strain for producing sclareolide, and the strain comprises a nucleotide sequence of exogenously coded sclareol synthase (SLS), a nucleotide sequence of exogenously coded cytochrome P450 oxidase and a nucleotide sequence of exogenously coded cytochrome P450 reductase (CPR). According to the invention, by enhancing upstream terpenoid precursor supply, a key rate-limiting enzyme gene, such as tHMG1 (deregulated form for catalyzing HMG-CoA reductase) and ERG20 (FPP synthase), in a mehydroxy acid pathway (MVA pathway) is overexpressed by introducing a strong promoter, and a carbon flow is guided to the sclareol synthesis direction; a sclareol synthesis module is introduced and optimized: a plant-derived sclareol synthase (SLS) gene is introduced, and sclareol synthase can generate sclareol through one-step cyclization by taking FPP as a substrate. The gene is subjected to codon optimization so as to adapt to an expression system of yeast.

The application discloses a method for synthesizing ambrox, relates to the field of daily chemicals and fragrances, and provides a one-pot two-step method for preparing ambrox by using sclareolide as raw material. The same solvent is used in the whole reaction process, a catalytic stabilizer is first added into the solvent, then a reducing agent is added, and finally the sclareolide is added, the catalytic stabilizer is used as a reagent for the second step reaction after the first step reaction, and then an acid methyl ester reagent is added to carry out the second step reaction, so that the whole reaction process is continuous and carried out in the same reactor, the operation steps are simplified, the reaction efficiency is improved, and the production cost is reduced.

To provide a masking agent for unpleasant odors derived from plants, in particular a grassy odor of soybean and an unpleasant odor derived from fats and oils of processed meat products (such as a hexanal odor), a method for masking unpleasant odors using the compound, and a method for producing an oral product in which unpleasant odors are masked.SOLUTION: The present invention provides an unpleasant-odor masking agent for oral products which contains at least one aroma compound selected from the group consisting of E-beta-damascone, S-(2-methyl-3-furyl) ethanethioate, beta-caryophyllene oxide, beta-ionone, 2,5-dihydroxy-1,4-dithiane, methyl anthranilate, S-furfuryl thioformate, 1-isothiocyanate-3-(methylthio)propane, nootkatone, 1,4-dioxacycloheptadecane-5,17-dione, sclareol, and sclareolide.SELECTED DRAWING: None

The invention belongs to the field of biotechnology and microbial fermentation engineering, and particularly relates to a cryptococcus albidus strain and application thereof in production of sclareolide. A mutant strain with the most excellent performance is screened out through systematic wild strain screening, natural breeding, ARTP mutation breeding and other technical means, the mutant strain is named as Cryptococcus albidus FM1120, the preservation number is CCTCC NO: M 20251915, the preservation date is September 1, 2025, the preservation number is CCTCC NO: M 20251915, the preservation number is CCTCC NO: M 20251915, the preservation number is CCTCC NO: M 20251915, the preservation number is CCTCC NO: M 20251915, the preservation number is CCTCC NO: M 20251915, the preservation number is CCTCC NO: M 20251915, and the preservation number is CCTCC NO: M 20251915, and the preservation number is CCTCC NO: M 20251915. The preservation unit is China Center for Type Culture Collection. The invention also provides an application of the strain FM1120 in the production of sclareolide, sclareol is taken as a substrate, the conversion rate of sclareol reaches more than 90% through fermentation, the fermentation liquor has the advantages of few impurities, easiness in separation and purification of sclareolide, high purity and the like, and a new path is provided for the green preparation of sclareolide.

The present invention relates to a cosmetic skin lightening composition comprising the combination of sclareolide, kojic acid and ascorbyl glucoside, wherein kojic acid is encapsulated within a targeted microcapsule or nanocapsule having a melanocortin 1 receptor (MC1R) agonist peptide bound to the surface. It was found that such combination of active substances provided synergistic kin-whitening effect. The present invention also relates to the cosmetic use of this composition for skin whitening, particularly, for the elimination or reduction of hyperpigmented marks of the skin, such as UV exposure related marks, post-scar marks, post-inflammation marks, melasma marks, lentigo marks or age-related marks.

The invention discloses a stress-resistant yield-increasing plant growth regulator as well as a preparation method and application thereof, and belongs to the field of plant growth regulators. The stress-resistant and yield-increasing plant growth regulator comprises the following raw materials: a suaeda glauca extract, a stress-resistant biological stimulant, propionyl brassinolide, coronatine, polyaspartic acid, gamma-aminobutyric acid, an emulsifier, a penetrant, a co-emulsifier, a pH buffer agent and deionized water. The stress resistance biological stimulant is sclareolide. By strengthening an anti-oxidation system and the osmotic regulation capability, the tolerance of wheat to saline-alkali stress is remarkably improved, and the basic survival and normal physiological functions of wheat are guaranteed; growth inhibition caused by stress is effectively reversed through the mechanisms of promoting root development, enhancing photosynthesis, driving products to be transferred to grains and the like, so that the yield is remarkably increased under the adverse situation.

The present application relates to a kind of biosynthesis methods of sclareolide, comprising the following steps: 1) in the fermentation process, every interval one sampling period t1, the content of sclareol in fermentation liquor is sampled and detected, and according to the content of sclareol in fermentation liquor detection value, the feeding speed of sclareol is adjusted;2) the volatilization amount of sclareol in fermentation tail gas is continuously detected, every interval one metering period t2, the volatilization total amount of sclareol is counted once, and the total amount of sclareol feeding in metering period is counted, the ratio of the volatilization total amount of sclareol and the total amount of sclareol feeding is calculated;3) when the ratio is less than threshold value, increase the feeding speed of sclareol.The present application judges the consumption variation of sclareol by continuously monitoring the ratio of the volatilization amount of sclareol in fermentation tail gas and the feeding amount of sclareol, can improve the timeliness of the concentration control of sclareol in fermentation liquor.The conversion rate and yield of biosynthesis sclareolide can be further improved by using the method.

The invention belongs to the field of bioengineering, and relates to pantoea for improving the content of sclareolide in cigars and application, in particular to application of pantoea ST-1 in cigar tobacco leaves, and the pantoea ST-1 is used for improving the content of sclareolide in cigars. The Pantoea piersonii ST-1 is preserved in the China General Microbiological Culture Collection Center, and the preservation number of the Pantoea piersonii ST-1 is CGMCC (China General Microbiological Culture Collection Center) NO: 30671. The method comprises the following steps: inoculating pantoea ST-1 into an LB liquid culture medium, culturing to obtain bacterial liquid, and applying the bacterial liquid to the surfaces of cigar tobacco leaves subjected to primary fermentation for secondary fermentation. When the pantoea provided by the invention is used for fermenting the cigar tobacco leaves, rapid conversion of labdan compounds in the cigar tobacco leaves can be realized, and the content of sclareolide in the cigar tobacco leaves is increased, so that the quality of the cigar tobacco leaves is improved.

The invention relates to the technical field of organic synthesis, in particular to a method for preparing sclareolide through high-selectivity ozonation of sclareol based on a green deep eutectic solvent. According to the method, quaternization modified silica gel immobilized with DES is taken as a functional carrier of a fixed bed reactor, sclareol substrate working liquid is subjected to gas-liquid-solid three-phase ozonation reaction on the surface of a fixed bed at low temperature, ozonation effluent is subjected to mild decomposition and peroxidation of an intermediate through a two-phase catalytic bed, then lactonization closed loop is performed in a layered catalytic bed, and the sclareol is obtained. And finally, carrying out post-treatment to obtain the high-purity sclareolide. The process is high in yield, high in purity, good in selectivity, few in by-products and high in enantiomer retention capacity, the ozone conversion rate and the mass transfer efficiency are remarkably improved, the green process, precise microenvironment control and continuous production are achieved, the bottlenecks of low selectivity, heavy environmental protection burden and the like of a traditional process are broken through, and application and popularization value is achieved.

The invention provides a preparation process of super ambrota ether, and relates to the technical field of perfume production, and the preparation process comprises the following preparation steps: mixing palladium carbon powder and absolute ethyl alcohol, introducing nitrogen and carrying out ultrasonic oscillation, adding polyethyleneimine, heating and filtering to obtain core-shell particles; mixing and heating the core-shell particles, potassium borohydride and a citric acid solution, filtering and drying to obtain a composite reducing agent; the method comprises the following steps: mixing sclareolide, a composite reducing agent and tetrahydrofuran, exhausting, heating, cooling, filtering, adding n-hexane, standing, taking an upper oil phase, and distilling to obtain sclarediol; the method comprises the following steps: mixing sclarediol, methylbenzene and an acid catalyst, heating and refluxing, filtering, cooling and washing, standing and layering, separating out an upper organic phase, drying and filtering to obtain a prefabricated crude product; mixing and heating the prefabricated crude product and absolute ethyl alcohol, cooling and recrystallizing, filtering and separating, washing and drying to obtain the super ambrota ether. According to the method, the yield of the super ambrota ether can be improved, and the recovery of reaction raw materials is also realized.