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48 results about "Sclareolide" patented technology

Sclareolide is a sesquiterpene lactone natural product derived from various plant sources including Salvia sclarea, Salvia yosgadensis, and cigar tobacco. It is a close analog of sclareol, a plant antifungal compound.

Taste-improving composition and application of the same

The present invention provides a method for improving the taste of sweeteners, and a method for improving the taste of edible products containing sweeteners. The present invention can be worked by using sclareolide and 2-acetylpyrrole in combination with a sweetener. By using the method of the present invention, an astringent taste, bitter taste or aftertastes such as lingering taste originating especially in high-intensity sweeteners can be reduced, so that edible products with an improved taste can be provided.
Owner:SAN EI GEN F F I

A composition for lightening skin and hair

Suggested is a composition comprising (a) sclareolide and (b1) at least one tyrosinase inhibitor; and / or (b2) at least one sun protection factor; and / or (b3) at least one anti-oxidants; and / or (b4) at least one anti-inflammatory agent; and / or (b5) at least one desquamating agent. on condition that compound a is present in an amount of from 0.00001 to 0.001 % b.w. - calculated on the total composition.
Owner:SYMRISE GMBH & CO KG

Identification of compositions, compositions, and methods of treatment of obesity and overweight conditions

A method for the identification of a composition useful in the treatment of an overweight or obese person to reduce the person's body mass index is provided which comprises obtaining an extract of an ethnobotanical plant, and evaluating the activity of the extract in an assay selected from the group consisting of a lipolysis assay, an assay that measures the amount of glycerol introduced by a cell into a suspension medium of the cell, an adipocyte differentiation assay, an assay that measures the level of the enzyme glycerol-3-phosphate dehydrogenase, an assay that measures the inhibition of differentiation of preadipocytes to adipocytes, an assay that measures the accumulation of lipid in an adipocyte, an assay that measures the de-differentiation of adipocytes into preadipocytes, and combinations thereof. Sclareol and sclareol-like compounds and sclareolide and sclareolide-like compounds are identified as useful in the treatment of overweight and obese conditions and disorders and conditions associated with adipose tissue abnormalities. These compounds can be formulated for oral administration.
Owner:PHYTOMYCO RES CORP

Formula of tobacco flavoring essence containing purple perilla

The invention discloses a formula of tobacco flavoring essence containing purple perilla. According to the formula, the tobacco flavoring essence consists of the following components in percentage by mass: 10 to 15 percent of clary sage extractum, 0.3 to 0.8 percent of perillaldehyde, 5 to 10 percent of Yuanyan tobacco extractum, 2 to 8 percent of Guiyan tobacco extractum, 5 to 8 percent of liquorice extractum, 2 to 5 percent of red date extractum, 1.5 to 3 percent of clary sage lactone, 8 to 15 percent of licorice tincture. 6 to 10 percent of carob bean extractum, 1 to 5 percent of vanilla bean extract, 10 to 15 percent of propylene glycol, 10 to 15 percent of purified water and 10 to 15 percent of edible ethanol. According to the formula, purple perilla is added to increase tobacco fragrance and adjust the taste of the tobacco, so that the taste of the tobacco is improved, the natural sweet fragrance of the tobacco is enhanced, dry, astringent and bitter mouthfeel of customers is improved and requirements of the customers are met.
Owner:GUANGZHOU AOJIAN PERFUME

Clary sage lactone synthetic method

The clary sage lactone is synthesized with sclareol, epoxy sclareol, clary sage tetrol, abienol or their mixture as main material, hydrogen peroxide solution as oxidant, and VIB transition metal element as the catalyst for activating hydrogen peroxide. The clary sage lactone is produced inside the water-organic solvent mixture and obtained through conventional separation and purification. Compared with available technology, the present invention uses cheap and clean hydrogen peroxide aqua as oxidant and has the advantages of simplicity, less technological steps, short reaction time, high product yield, low cost, no environmental pollution, etc.
Owner:SHAANXI NORMAL UNIV

Elecampane fragrance type tobacco flavor based on perfume threshold value and mixing method thereof

The invention relates to elecampane fragrance type tobacco flavor based on a perfume threshold value and a mixing method thereof. The elecampane fragrance type tobacco flavor is prepared from, by weight, 1-20% of a fragrance base and 80-99% of solvent, wherein the fragrance base is prepared from, by weight, 0.5-5.0 parts of thujone, 0.1-2.0 parts of cedrol, 0.5-5.0 parts of terpinyl acetate, 0.5-5.0 parts of guaiol, 0.1-2.5 parts of guaiacol, 0.1-1.0 part of patchoulic alcohol and 0.2-3.0 parts of salvia sclare lactone. Elecampane fragrance type tobacco flavor is added into cut tobacco, a cigarette product is prepared by adopting the routine technology in the field, it is shown through sensory evaluation test results that compared with a blank sample without elecampane fragrance type tobacco flavor, fragrance quality of the cigarette sample with added elecampane fragrance type tobacco flavor becomes higher, fragrance amount is obviously increased, remaining taste is improved, and impurity gas is hidden.
Owner:CHINA TOBACCO HENAN IND +1

Method for biologically synthesizing sclareolide

The invention relates to a method for biologically synthesizing sclareolide. The method comprises the steps of taking a yeast culture medium and separately adding sclareol and a light white cryptococcus protoplast fluid into the yeast culture medium to obtain a mixture, wherein the sclareol accounts for 3-8% of the total mass of the yeast culture medium, and the light white cryptococcus protoplastfluid accounts for 4-10% of the total mass of the yeast culture medium; placing the mixture in a glass vessel, and then shaking the vessel for fermentation for 10 days on a shaking table at the temperature of 23-28 DEG C and the speed of 140-180 r / min to obtain sclareolide. According to the method, a microorganism conversion method is utilized, and sclareol is used as a substrate and converted bylight white cryptococcus to prepare sclareolide, so that the problems that a synthesis technology process of sclareolide based on a chemical method is environmentally unfriendly, complicated in step,low in safety and the like are solved, and a new way is provided for synthesizing sclareolide.
Owner:SHAANXI UNIV OF SCI & TECH

Identification of compositions, compositions, and methods of treatment of obesity and overweight conditions

A method for the identification of a composition useful in the treatment of an overweight or obese person to reduce the person's body mass index is provided which comprises obtaining an extract of an ethnobotanical plant, and evaluating the activity of the extract in an assay selected from the group consisting of a lipolysis assay, an assay that measures the amount of glycerol introduced by a cell into a suspension medium of the cell, an adipocyte differentiation assay, an assay that measures the level of the enzyme glycerol-3-phosphate dehydrogenase, an assay that measures the inhibition of differentiation of preadipocytes to adipocytes, an assay that measures the accumulation of lipid in an adipocyte, an assay that measures the de-differentiation of adipocytes into preadipocytes, and combinations thereof. Sclareol and sclareol-like compounds and sclareolide and sclareolide-like compounds are identified as useful in the treatment of overweight and obese conditions and disorders and conditions associated with adipose tissue abnormalities. These compounds can be formulated for oral administration.
Owner:PHYTOMYCO RES CORP

Compound sweetener suitable for sour drinks and preparation method of sweetener

InactiveCN102960823ASweet before cover upMask aftertasteFood scienceIcing sugarSucrose
The invention relates to a compound sweetener suitable for sour drinks and a preparation method of the sweetener. The compound sweetener is prepared from the following components: 3.33-8.33% of sucralose, 87.82-95.1% of glucose, 1.5-3.5% of maltodextrin, 0.01-0.05% of sclareolide, 0.01-0.05% of 2-acetylpyrrole and 0.05-0.25% of emulsifier; and the preparation method comprises the following process of: putting glucose and sucralose accounting for 40-60% of the total quantity into a multidimensional mixer for premixing at first; forming stable emulsion by the residual sucralose with other auxiliary sweeteners through emulsification; feeding the premixed mixture into a fluidized bed from the bottom of the spray fluidized bed under positive pressure so that the mixture flows in an accelerated manner from bottom to top; applying negative pressure to the upper part of the spray fluidized bed for vibration from top to bottom so that the mixture is boiled up and down in the fluidized bed to form fine sugar particles; and continuously spraying and dispersing the emulsion onto fine sugar particles in the fluidized bed by means of multi-point spray guns arranged on the sidewalls of the fluidized bed, thereby obtaining the compound sweetener.
Owner:苏州工业园区尚融科技有限公司

Compound sweetener suitable for plant protein beverage and coffee and preparation method of compound sweetener

The invention relates to a compound sweetener suitable for plant protein beverage and coffee and a preparation method of the compound sweetener. The compound sweetener comprises 13.33 to 25 percent of sucralose, 20 to 30 percent of isomaltitol, 20 to 30 percent of erythritol, 14.34 to 46.44 percent of glucose, 0.15 to 0.3 percent of carboxymethylcellulose, 0.03 to 0.06 percent of sclareolide and 0.05 to 0.3 percent of emulsifier. The preparation method comprises the following steps of: feeding the sucralose and sugar alcohol as well as 60 to 70 percent of the total glucose into a multi-dimensional mixing machine for preliminary mixing; mixing the residual glucose, the emulsifier and the like and water to form stable emulsion; enabling the mixture to enter a spraying fluidized bed from the bottom of the spraying fluidized bed under positive pressure and flow sy an accelerated speed from bottom to top, applying negative pressure to the upper part of the spraying fluidized bed, vibrating the mixture from top to bottom so that the mixture overturns up and down in the fluidized bed to form fine sugar alcohol particles; and continuously spraying and dispersing the emulsion to the small sugar alcohol particles in the fluidized bed to obtain the compound sweetener.
Owner:苏州工业园区尚融科技有限公司

Novel PAR-1 inhibitor, preparation method and application thereof in prevention and/or treatment of thrombotic diseases

Belonging to the technical field of blood coagulation resistance, the invention particularly relates to a novel PAR-1 inhibitor, a preparation method and application thereof in prevention and / or treatment of thrombotic diseases. The novel PAR-1 inhibitor has a structural formula shown as the specification. A commercially available natural product sclareolide is adopted as the raw material, and thenovel PAR-1 inhibitor is prepared through four-step reaction. According to the PAR-1 inhibitor, the parent nucleus is highly similar to vorapaxar, the action target is clear, the structure is novel,and the activity is high, the IC50 value can reach the nanomole level, the safety is high, the preparation cost is low, and industrial batch production is easy to realize, therefore the PAR-1 inhibitor has good application prospects in serving as a candidate drug for treating thrombotic diseases.
Owner:SHANDONG UNIV +1

Method for synthesizing racemic sclareolide

The invention belongs to the technical field of daily use chemicals, and discloses a method for synthesizing racemic sclareolide. The synthetic method comprises the step of: making 4-methly-6-(2,6,6-trimethyl-1-cyclohexenyl)-3-hexene-1-acid serving as a raw material react with a solid super acid serving as a catalyst in an organic solvent to obtain racemic sclareolide. The method for synthesizing the racemic sclareolide is environmentally-friendly, is easy to operate, and has high yield; and the catalyst used in the synthetic method can be used repeatedly, so that the production cost is lowered, and the method is more suitable for industrial production.
Owner:北京安胜瑞力科技有限公司

Enzymatic cyclization of homofarnesylic acid

ActiveUS20190144899A1TransferasesFermentationPolyunsaturated carboxylic acidAmbroxide
The present invention relates to processes for the preparation of sclareolide and related compounds by the biocatalytic cyclization of polyunsaturated carboxylic acid compounds, in particular of homofarnesylic acid and related compounds; and to a process for the preparation of ambroxide via the biocatalytic cyclization of homofarnesylic acid to sclareolide.
Owner:BASF AG

Anti-pruritus functional composition and preparation method and application thereof

The invention relates to an anti-pruritus functional composition and a preparation method and application thereof. The composition is characterized by consisting of the following components in parts by mass: 1-10 parts of a mussel extract, 2-7 parts of a loquat leaf extract, 2-7 parts of a crocus sativus extract, 2-7 parts of tocotrienol, 1-3 parts of sclareolide, 1-3 parts of calcium pantetheinesulfonate, and 20-30 parts of beta-cyclodextrin. The anti-pruritus functional composition prepared by the invention is good in stability, is safe and mild, can quickly and effectively improve the pruritus of the elderly through the synergistic interaction of the active ingredients, and also has the excellent beneficial effects of moisturizing, skin barrier strengthening, analgesia and stability, body odor removal, skin comfort improvement, and the like.
Owner:PROYA COSMETICS

Compound sweetener suitable for acid beverage and preparation method thereof

InactiveCN102940184ASweet before cover upMask aftertasteFood preparationBiotechnologySucrose
The invention relates to a compound sweetener suitable for an acid beverage and a preparation method thereof. The compound sweetener comprises the following components: 8.33-16.67 percent of sucralose, 78.37-88.98 percent of glucose, 2.5-4.5 percent of maltodextrin, 0.03-0.06 percent of sclareolide, 0.01-0.05 percent of 2-acetylpyrrole and 0.15-0.35 percent of emulsifier. The process comprises the following steps of: throwing the glucose and sucralose which accounts for 40-60 percent of the total amount into a multidimensional mixing machine, and performing primary mixing; emulsifying the residual sucralose and other auxiliary sweeteners to form stable emulsion; throwing the mixed materials subjected to primary mixing into a fluidized bed of spray fluidization equipment from the lower part of the fluidized bed, mixing to accelerate spiral flow from bottom to top through positive pressure, and applying pulse negative pressure to the upper part of the fluidized bed by adjusting air quantity and air direction of an induced air device, so that a plurality of cloth bags on a porous clapboard vibrate up and down, and the mixed materials are impacted; and continuously spraying and dispersing the emulsion to the particles in the fluidized bed, thus obtaining the compound sweetener.
Owner:苏州工业园区尚融科技有限公司

Application of composition containing cryptolepine analogue and small molecule terpene compound in prevention and treatment of plant diseases

The invention discloses an application of a composition containing cryptolepine analogues and small molecule terpene compounds in prevention and treatment of plant diseases. The bactericidal composition comprises the following effective components: cryptolepine, neocryptolepine, sclareol, sclareolide, (+ / -)-limonene, citronellol, ambergris, perilla alcohol, perillaldehyde, 2-hexenal, 4-terpene alcohol, terpilenol, alpha-terpilenol, camphor, citral, geraniol, menthol, nerolidol, eudesmol, curcumenol, cedrol and beta-ionone. The bactericidal composition disclosed by the invention can be used for preventing and treating plant diseases caused by rhizoctonia solani, Rape sclerotinia stem rot bacteria, botrytis cinerea, fusarium graminearum, magnaporthe oryzae and phytophthora capsici. The components are all natural products, have the characteristics of low toxicity, low residue, environmental compatibility, difficult generation of drug resistance and the like, can cope with occurrence of drug resistance of diseases and reduce the drug cost, and are beneficial to comprehensive management of the diseases.
Owner:LANZHOU UNIVERSITY

Weight loss formulation

A weight loss product comprises a mixture of Alchemilla vulgaris, Olea europaea, Cuminum cyminum, and Mentha longiflora (in the weight proportion 12:10:5:4), to which additional ingredients have been added to increase weight loss efficacy. The additional ingredients may include, but are not limited to, Gamma-oryzanol, Caffeine, Cirsimarin, Fucoxanthin, Guggulsterones, Evodiamine, Forskolin, Sclareolide, Chromium, Hydroxycitric acid, Pinolenic acid, Conjugated linoleic acid, Potato protein, Raspberry ketone, Capsaicin, Synephrine, Dehydroepiandrosterone, Phenylethylamine, Orlistat, Glucomannan, or Vitamin C, or sources thereof, as well as herbal ingredients such as Guarana, Yerba Mate, Damiana, Green tea, Green coffee bean, Cinnamon, White kidney bean, Garcinia Cambogia, Nopal Cactus, Hoodia, Yohimbine, Malpighia glabra, Eurycoma Longifolia, Caralluma Fimbriata, Citrus aurantium, Gymnema Sylvestre, Lyceum barbarurn, Aloe Vera, Cayenne, Pomegranate, Blueberry, Billberry, or extracts of such herbal ingredients, and plant sources of antioxidants. A preferred additional ingredient is caffeine provided by caffeine anhydrous, Coffea Arabica, Coffea canephora, Camellia sinensis, Ilex paraguariensis, Guarana, Theobroma cacao, and kola nut. Other additional ingredients may be used as well in accordance with specific disclosed formulations.
Owner:NORTHERN INNOVATIONS HLDG

Method for separation purification of sclareolide from synthetic sclareol composites

The invention provides a method for separation purification of sclareolide from synthetic sclareol composites by using molecular distillation device for operation under pressure of 0.01-100.0Mpa, evaporative temperature 50-200 deg. C, cool-down temperature -15-80 deg. C, temperature difference between the evaporator and condenser 30-215 deg. C, the agitating speed 10-1000 rp.
Owner:TIANJIN UNIV

Application of sclareol and sclareolide in resisting filovirus infection

ActiveCN111265502AClear securityToxic and side effects are clearHydroxy compound active ingredientsAntiviralsAntiviral drugPharmaceutical drug
The invention discloses application of sclareol and sclareolide in resisting filovirus infection, wherein the application comprises application of sclareol or / and sclareolide in prevention or treatment of filovirus infection or combined application of sclareol or / and sclareolide and other antiviral drugs.
Owner:INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI

Composition including superoxide dismutase and prickly-pear cactus for minimizing and preventing hangovers

A composition including superoxide dismutase (SOD) and prickly pear cactus (OFI) protects against, minimizes the effects of, and hastens recovery from the typical symptoms associated with an alcohol induced hangover. In addition, sesamin and alpha-lipoic acid work with the SOD and OFI for enhanced antioxidant and therapeutic effects. Thiamine, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, milk thistle seed extract, flower pollen extract, eleuthero root extract, guggulsterones EZ, white willow bark extract, sclareolide, ginkgo biloba extract, caffeine, and boswellia serrata extract can be added to the composition for additional treatment of symptoms.
Owner:CELLUTIONS

Production technology of sclareolide synthesized from sclareol

The invention discloses a production technology of sclareolide synthesized from sclareol. The technology successively comprises the following steps of: cracking station, hydrolysis station, acidifying station, ring closing station and purification so as to obtain 95% of sclareolide. An oxidizing agent used in the method is a hydrogen peroxide composite oxidizing agent and a catalyst is heteropolyacid salt. The invention has the following beneficial effects: by the use of the composite oxidizing agent and the catalyst heteropolyacid salt for reaction instead of using a hydrogen peroxide single oxidizing agent, conversion rate is raised by 22-25%, reaction time is greatly shortened, and the reaction time is reduced from more than 20 hours to less than 10 hours.
Owner:JIAOZUO XINZHIYUAN TECH

Modified method for preparing sclareolide from sclareol

The invention relates to a preparation method of sclareolide, comprising the following steps of: (a). oxidizing sclareol to obtain a crude sclareolide product; and (b) crystallizing the crude sclareolide product obtained in the step (a) to obtain a pure sclareolide product. The preparation method is characterized in that sclareolide is recovered and processed from crystallization mother liquor obtained in the step (b), and the obtained sclareolide is mergered into the step (b) and crystallized and purified together with the synthesized crude sclareolide product. The invention adopts the environment-friendly method with simple operation, realizes the purpose of recovering sclareolide from the sclareolide crystallization mother liquor, improves the total recovery of the sclareolide and establishes a solid foundation for improving the commercial value of the sclareolide.
Owner:EAST CHINA UNIV OF SCI & TECH

Tobacco taste modification essence

The invention discloses a tobacco taste modification essence which mainly consists of the following components: 2-5 parts of maltol, 5-15 parts of trans-cinnamic acid, 1-5 parts of capric acid ethyl ester, 2-6 parts of glacial acetic acid, 40-60 parts of a date extract, 2-6 parts of an angelica dahurica tincture, 5-15 parts of a fenugreek extract, 5-15 parts of a tamarindus extract and 3-10 partsof propylene glycol. The tobacco taste modification essence disclosed by the invention is prepared from extracts prepared from natural plant raw materials such as the fenugreek extract, the tamarindusextract, sclareolide and the date extract, and common flavor enhancers such as maltol and capric acid ethyl ester as main components. The tobacco taste modification essence disclosed by the inventioncan be applied to a tobacco liquid and is capable of effectively removing spicy taste of tobacco smell, then cigarette can be relatively good in smoke satisfaction, high in fragrance quality and relatively soft and mellow and has the pleasant specific fragrance of tobacco and fragrance of nuts.
Owner:广东长利香精香料有限公司

Quality improver for river crab culture as well as preparation method and application of quality improver

The invention belongs to the technical field of aquaculture, and particularly relates to a quality improver for river crab culture and a preparation method and application thereof. According to the scheme, on the basis that sclareolide reported in the prior art has the antibacterial property, the characteristic that sclareolide can inhibit and eliminate bacterial biofilms is found, and the removal effect of sclareolide on staphylococcus aureus and escherichia coli biofilms is verified. The sclareolide is used as the quality improver for river crab culture, the antibacterial property and the antiviral property of the sclareolide are utilized to well protect river crab culture, and meanwhile, the characteristic advantage that the sclareolide can eliminate bacterial biofilms is utilized, so that the drug resistance is effectively reduced, and the river crab culture quality is improved. The compound can be used for preventing and treating diseases caused by staphylococcus aureus and Escherichia coli, and accords with the development direction of healthy breeding.
Owner:XUZHOU UNIV OF TECH

Compound sweetener suitable for vegetable protein drinks and coffee and preparation method of sweetener

The invention relates to a compound sweetener suitable for vegetable protein drinks and coffee and a preparation method of the sweetener. The compound sweetener is prepared from the following components: 8.33-16.67% of sucralose, 15-25% of isomaltitol, 15-25% of erythritol, 32.73-61.44% of glucose, 0.15-0.25% of carboxymethylcellulose, 0.03-0.05% of sclareolide and 0.05-0.3% of emulsifier; and the preparation method comprises the following process of: putting the sugar alcohols and glucose accounting for 60-80% of the total quantity into a multifunctional mixer and premixing the materials at first; mixing sucralose, the residual auxiliary sweetener, the emulsifier and the like with water, thereby obtaining emulsion; feeding the mixture into a fluidized bed of spray fluidization equipment from the lower part of the fluidized bed, and applying pulsed negative pressure to the upper part of the fluidized bed by adjusting the air volume and the air direction of an air inducing device so that a plurality of cloth bags on a porous separator vibrate up and down and hit the mixture; and spraying and dispersing the emulsion to the particles in the fluidized bed, thereby obtaining the sweetener.
Owner:苏州工业园区尚融科技有限公司

Synthesis method of sclareleaf sclareleaf diol compound

The invention provides a synthesis method of a sclarediol compound, which comprises the following steps: by taking sclareolide as a raw material, carrying out hydrogenation reaction under the action of a catalyst system consisting of metal iridium and ferrocene P, N, N skeleton structure ligands, so as to obtain sclarediol at high yield. The catalytic reaction needs to be carried out at room temperature to 100 DEG C by taking isopropanol, methylbenzene and the like as solvents under the action of alkali additives such as potassium tert-butoxide. The method has the advantages of high reaction activity, mild reaction conditions, cheap and easily available initial raw materials, cleanness, environmental protection and very high industrial application value.
Owner:DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI

Compound sweetener applied sour beverages and preparation method of sweetener

InactiveCN102960824AGreat tasteSweet before cover upFood scienceIcing sugarSucrose
The invention relates to a compound sweetener applied sour beverages and a preparation method of the sweetener. The compound sweetener is prepared from the following components: 13.33-25% of sucralose, 68.52-83.42% of glucose, 3-6% of maltodextrin, 0.04-0.08% of sclareolide, 0.01-0.05% of 2-acetylpyrrole and 0.2-0.35% of emulsifier; and the preparation method comprises the following process of: firstly putting sucralose and glucose accounting for 80-90% of total quantity into a multidimensional mixer for premixing; next, mixing other auxiliary sweeteners and the residual glucose with de-ionized water to form stable emulsion through emulsification; feeding the mixture in a fluidized bed from the bottom of the spray fluidized bed under positive pressure so that the mixture flows in an accelerated manner from bottom to top, and applying negative pressure to the upper part of the spray fluidized bed for vibration from top to bottom so that the mixture is boiled up and down in the fluidized bed to form fine sugar particles; and continuously spraying and dispersing the emulsion to the sugar particles in the fluidized bed by means of multipoint spray guns arranged on the side parts of the fluidized bed, thereby obtaining the compound sweetener.
Owner:苏州工业园区尚融科技有限公司
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