Bisabolol-containing soothing repair composition and its use in wash-off products

Abstract

The present application relates to a kind of bryonia lactone-containing soothing repair composition and its application in washing and caring product, the soothing repair composition includes the weight ratio of (1-10) :(0.1-5):(0.1-3):(0.1-3) bryonia lactone, sclareolide, artemisia princeps leaf extract and hyssop extract, the composition is by inhibiting inflammatory factor, scavenging free radical and strengthening barrier function etc. Path, realize from surface soothing to the synergistic effect of deep repair. The soothing repair composition of the present application is applied to shampoo, can carry out comprehensive, systematic, scientific conditioning maintenance to scalp, can eliminate barrier damage, sensitive, pruritus etc. Scalp problem from root, keep the healthy state of scalp and hair.

Description

Technical Field

[0001] This invention relates to the technical field of soothing products, specifically to a soothing and repairing composition containing bisabolol and its application in personal care products. Background Technology

[0002] In recent years, changes in skincare habits, such as the overuse of cleansing products, excessive cleansing, increased environmental pollution, and rising stress, have collectively contributed to the increasing prevalence of sensitive skin problems and a continuous rise in the number of sufferers. Against this backdrop, soothing skincare products have emerged. These products can effectively alleviate skin allergic reactions and discomfort caused by climate change, UV radiation, and environmental pollution, soothing the skin, helping to adjust its condition, maintain skin health, and reduce the likelihood of inflammation. The scalp, as the body's most important control center and a natural barrier, is second only to the eyelids in terms of fragility and sensitivity.

[0003] Currently, most skincare products on the market targeting sensitive skin focus on moisturizing with oils, while also adding some soothing ingredients. Objectively speaking, this combination can indeed alleviate dryness and inflammation to some extent. However, this approach only addresses the symptoms and cannot fundamentally solve the underlying problems of scalp tightness and sensitivity. Furthermore, most cosmetic products still focus primarily on beautifying effects, with relatively little research on scalp barrier repair. Products that can achieve scalp moisturizing and repair functions within a wash-off formula are extremely rare. Summary of the Invention

[0004] The purpose of this invention is to overcome the shortcomings of the prior art and provide a soothing and repairing composition containing bisabolol and its application in personal care products.

[0005] To achieve the above objectives, the technical solution adopted by the present invention is as follows: In a first aspect, the present invention provides a soothing and repairing composition containing bisabolol, comprising the following components: bisabolol, perilla lactone, Artemisia argyi leaf extract and sage extract; wherein the weight ratio of bisabolol, perilla lactone, Artemisia argyi leaf extract and sage extract is (1-10):(0.1-5):(0.1-3):(0.1-3).

[0006] Bisabolol has moisturizing and anti-inflammatory effects. It can form a protective film on the skin surface to lock in moisture, reduce inflammation, relieve redness and itching, and promote skin renewal.

[0007] Perilla lactone can promote keratinocyte differentiation and lipid synthesis, and has the effects of strengthening the barrier and anti-inflammation.

[0008] Artemisia argyi leaf extract contains flavonoids and other substances that can inhibit inflammatory mediators, scavenge free radicals through its antioxidant capacity, protect the skin barrier from oxidative damage, promote the proliferation of stratum corneum cells, enhance skin cell metabolism, and have skin-revitalizing and anti-aging effects.

[0009] The extract of *Gynura divaricata* has antibacterial activity, inhibiting various harmful bacteria and relieving skin discomfort caused by them. Its volatile oil components can act on the sensory nerve endings of the skin, reducing the transmission of itching signals.

[0010] When bisabolol is combined with perilla lactone, artemisia leaf extract, and sage extract, the total antioxidant capacity is significantly improved, which can effectively remove excess free radicals and reduce skin oxidative stress damage.

[0011] Preferably, the weight ratio of bisabolol, perilla lactone, artemisia leaf extract, and sage extract is (2-6):(0.8-1.5):(0.3-0.6):(0.3-0.6).

[0012] Secondly, the present invention provides the application of the soothing and repairing composition containing bisabolol in the first aspect in the preparation of shampoo and body care products.

[0013] Preferably, the shampoo and conditioner products are hair shampoo and conditioner products, facial shampoo and conditioner products, and the amount of the soothing and repairing composition added is 0.1%-10% of the total weight of the shampoo and conditioner products.

[0014] Thirdly, the present invention provides a shampoo comprising the following ingredients by weight percentage: 0.5%-5% of the soothing and repairing composition containing bisabolol as described in the first aspect, 15-25% of surfactant, 0.1-1% of chelating agent, 3-10% of moisturizer, 0.5-1.5% of thickener, 0.05-0.1% of preservative and 0.01-0.3% of pH adjuster, with the balance being deionized water.

[0015] Preferably, the surfactant comprises at least one of sodium lauroyl sarcosinate, cocamidopropyl betaine, sodium cocoyl methyl taurate, fatty alcohol polyoxyethylene ether, sodium lauroyl amphoteric acid, TEA salt of cocoyl glutamate, TEA salt of dodecylbenzenesulfonate, and disodium cocoyl amphoteric acid.

[0016] Preferably, the chelating agent includes at least one of disodium EDTA and / or tetrasodium diethylamine glutamate.

[0017] Preferably, the moisturizer includes at least one of propylene glycol, glycerin, butylene glycol, panthenol, sorbitol, and sodium hyaluronate.

[0018] Preferably, the thickener comprises at least one of PEG-120 methyl glucose triisostearate and acrylic (ester) copolymers.

[0019] Preferably, the preservative includes at least one selected from phenoxyethanol, sodium benzoate, p-hydroxyacetophenone, 1,2-hexanediol, and ethylhexylglycerin.

[0020] Preferably, the pH adjuster includes at least one of arginine, tromethamine, citric acid, sodium citrate, and lactic acid.

[0021] Compared with the prior art, the beneficial effects of the present invention are as follows: (1) The bisabolol, sage lactone, artemisia leaf extract and sage extract in the soothing and repairing composition of the present invention achieve a synergistic effect from surface soothing to deep repair through pathways such as inhibiting inflammatory factors, scavenging free radicals and strengthening barrier function.

[0022] (2) Applying the soothing and repairing composition of the present invention to shampoo can provide comprehensive, systematic and scientific conditioning and care for the scalp, and can eliminate scalp problems such as barrier damage, sensitivity and itching from the root, and maintain the health of the scalp and hair. Detailed Implementation

[0023] To better illustrate the purpose, technical solution, and advantages of the present invention, the present invention will be further described below in conjunction with specific embodiments.

[0024] The raw materials used in the following examples and comparative examples are from the following sources: Bisabolol: Manufacturer is Yili Chuaning Biotechnology Co., Ltd., trade name is Shuruining. ® Bisabolol; Perilla lactone: The manufacturer is Xi'an Tianmei Biotechnology Co., Ltd., and the trade name is perilla lactone. Artemisia argyi leaf extract: Manufacturer: Ichimaru Natural Beauty (Japan), product name: YOMOGI Liquid; Lingxiang extract: The manufacturer is Ningxia Xiangcao Biotechnology Co., Ltd., and the product name is Lingxiang extract. The specification is 20:1.

[0025] Unless otherwise specified, all other materials, reagents, etc. used in the examples and comparative examples are commercially available.

[0026] Example 1 A soothing and repairing composition containing bisabolol comprises bisabolol, perilla lactone, artemisia leaf extract and angelica extract in a weight ratio of 4:1:0.5:0.4; wherein the total mass fraction of said bisabolol, perilla lactone, artemisia leaf extract and angelica extract is 100 parts.

[0027] Example 2 A soothing and repairing composition containing bisabolol, comprising bisabolol, perilla lactone, Artemisia argyi leaf extract and sage extract in a weight ratio of 2:0.8:0.3:0.6; wherein the total mass fraction of said bisabolol, perilla lactone, Artemisia argyi leaf extract and sage extract is 100 parts.

[0028] Example 3 A soothing and repairing composition containing bisabolol, comprising bisabolol, perilla lactone, artemisia leaf extract and sage extract in a weight ratio of 6:1.5:0.6:0.6; wherein the total mass fraction of said bisabolol, perilla lactone, artemisia leaf extract and sage extract is 100 parts.

[0029] Example 4 A soothing and repairing composition containing bisabolol, comprising bisabolol, perilla lactone, artemisia leaf extract and sage extract in a weight ratio of 1:0.1:0.1:0.1; wherein the total mass fraction of said bisabolol, perilla lactone, artemisia leaf extract and sage extract is 100 parts.

[0030] Example 5 A soothing and repairing composition containing bisabolol, comprising bisabolol, perilla lactone, artemisia leaf extract and sage extract in a weight ratio of 10:5:3:3; wherein the total mass fraction of said bisabolol, perilla lactone, artemisia leaf extract and sage extract is 100 parts.

[0031] Comparative Example 1 The only difference between Comparative Example 1 and Example 1 is that Comparative Example 1 does not add perilla lactone, but uses Artemisia argyi leaf extract and Agrimonia pilosa extract in a weight ratio of 0.5:0.4 to make up for the missing amount.

[0032] Comparative Example 2 The only difference between Comparative Example 2 and Example 1 is that Comparative Example 2 does not add Artemisia argyi leaf extract, but uses sage lactone and sage extract in a weight ratio of 1:0.4 to make up for the missing amount.

[0033] Comparative Example 3 The only difference between Comparative Example 3 and Example 1 is that Comparative Example 3 does not add sage extract, but uses sage lactone and artemisia leaf extract in a weight ratio of 1:0.5 to make up for the missing amount.

[0034] Performance testing Test Example 1: DPPH Free Radical Scavenging Test of the Composition The experimental method was as follows: the compositions of Examples 1-5 and Comparative Examples 1-3 were dissolved in anhydrous ethanol to prepare sample solutions. The mass concentration of the sample in the sample solution was 0.3%, and the test solutions of each group were obtained.

[0035] Preparation of DPPH solution: Weigh 20 mg DPPH, dissolve in anhydrous ethanol, and dilute to a final volume of 250 mL in a volumetric flask. The DPPH concentration is prepared to be 2 × 10⁻⁶. -4 mol / L; The specific testing method is as follows: 1) Take 1 mL of the test solution and 1 mL of 2×10 -4 Mix the mol / L DPPH solution thoroughly and label it tube A; 2) Take 1 mL of anhydrous ethanol and 1 mL of 2×10 -4 Mix the mol / L DPPH solution thoroughly and label tube B; 3) Mix 1 mL of anhydrous ethanol with 1 mL of the test solution and label it tube C; 4) After reacting the above numbered tubes in the dark for 30 minutes, measure the absorbance values ​​of tubes A, B, and C at 517 nm.

[0036] 5) Calculate the DPPH inhibition rate using the formula: DPPH inhibition rate (%) = (B + CA) / B. The results are shown in Table 1. The higher the DPPH inhibition rate, the better the composition's effect on scavenging free radicals.

[0037] Test Example 2: Test of the composition's inhibition of the inflammatory factor TNF-α The compositions of Examples 1-5 and Comparative Examples 1-3 were dissolved in anhydrous ethanol to prepare sample solutions. The mass concentration of the sample in the sample solution was 10 mg / L, and the test solutions of each group were obtained.

[0038] RAW264.7 cells grown to the logarithmic growth phase were fed with a 1.5 × 10⁻⁶ ppm. 5 Cells were seeded at a density of 800 μL / mL in 24-well plates and incubated at 37°C for 24 h in a 5% CO2 incubator. The cells were then divided into three groups: the experimental group received 50 μL of the test solution in the cell suspension (three replicates per group); the positive control group received 50 μL of 10 μg / mL dexamethasone in the cell suspension; and the blank group contained only cell suspension. After culturing the experimental, positive control, and blank groups for 1 h, they were stimulated with 1 μg / mL lipopolysaccharide (LPS). After incubation for 24 h, the cell culture medium was transferred to centrifuge tubes and centrifuged at 5000 rpm for 10 min. The cell supernatant was collected and analyzed according to the instructions of the mouse TNF-α enzyme-linked immunosorbent assay (ELISA) kit. The TNF-α inhibition rate was calculated using the following formula: Specific data are shown in Table 1. The higher the TNF-α inhibition rate, the better the anti-inflammatory effect of the composition.

[0039] Table 1. DPPH inhibition rate and TNF-α inhibition rate data of each composition Example 1 83.1 85.3 Example 2 82.8 84.6 Example 3 81.5 82.2 Example 4 77.2 75.5 Example 5 80.7 80.7 Comparative Example 1 63.5 58.4 Comparative Example 2 60.1 54.9 Comparative Example 3 68.3 62.6 As can be seen from the data of Examples 1-5 in Table 1, when the weight ratio of bisabolol, perilla lactone, Artemisia argyi leaf extract and Agrimonia pilosa extract is in the range of (2-6):(0.8-1.5):(0.3-0.6):(0.3-0.6), the composition has good effects in inhibiting inflammatory factors and scavenging free radicals.

[0040] Based on the data from Example 1 and Comparative Examples 1-3, it can be seen that when any one of the following is missing: perilla lactone, artemisia leaf extract, and sage extract, the anti-inflammatory and antioxidant effects of the composition are significantly reduced, indicating that perilla lactone, artemisia leaf extract, and sage extract can synergistically enhance the anti-inflammatory and antioxidant effects of the bisabolol-containing composition.

[0041] Compare Application Example 1-5 with Application Example 1-3 The soothing and repairing compositions of Examples 1-5 and Comparative Examples 1-3 were added to shampoos to obtain shampoos of Application Examples 1-5 and Comparative Application Examples 1-3, respectively. The formulations are shown in Table 2.

[0042] The shampoos used in Examples 1-5 and Comparative Examples 1-3 include the following steps: S1. Mix the humectant, chelating agent, thickener and 1 / 2 volume of deionized water, and homogenize at 60°C to obtain an aqueous solution. S2. When the temperature of the aqueous solution in S1 drops to 40°C, add the preservative. When the system temperature drops to 30°C, add the surfactant, the components of the soothing and repairing composition, and the remaining deionized water. Stir well and finally add the pH adjuster to obtain the shampoo.

[0043] Table 2. Shampoo formulations of Application Examples 1-5 compared to Application Examples 1-3

[0044] Comparative Application Example 4 The shampoo in Comparative Application Example 4 does not contain the soothing and repairing composition, but uses an equal amount of deionized water instead of the composition, and the preparation method is the same as in Application Example 1.

[0045] Test Example 3: Evaluation of the moisturizing and anti-itch effects of shampoo Forty-five volunteers were selected, with their age and gender randomly determined to meet the standards of the "Cosmetic Safety Technical Specifications" (2015). The volunteers were randomly divided into nine groups of five, and each group used the shampoos from Application Examples 1-5 and Control Application Examples 1-5, respectively.

[0046] Each group of volunteers used the shampoo once every two days, using the normal amount of shampoo they usually use, for 15 days.

[0047] Moisturizing effect evaluation: Scalp moisture was measured using a skin moisture meter before testing and on day 15 after use. Three points were selected on the back of the head for testing, each measuring 5cm x 5cm. Larger measurements indicated higher skin hydration. The scalp moisture test results for each volunteer were statistically analyzed, and the moisturizing difference rate was calculated. Moisturizing improvement rate = (average post-test skin moisture test result - average pre-test skin moisture test result) / average pre-test skin moisture test result × 100%. The results are shown in Table 3.

[0048] Evaluation of anti-itch effect: Before the test and on day 15 after use, volunteers rated the degree of scalp itching, with a maximum score of 10 and a minimum score of 1. A higher score indicates a lower degree of itching and dandruff. The scores of each volunteer were counted, and the improvement rate of scalp itching and dandruff problems was calculated. Scalp itching improvement rate = (average scalp itching score before the test - average scalp itching score after the test) / average scalp itching score before the test × 100%. The results are shown in Table 3.

[0049] Table 3. Evaluation data on the moisturizing and anti-itch effects of each group of shampoos. Application Example 1 16.4 30.2 Application Example 2 14.2 27.9 Application Example 3 15.7 29.3 Application Example 4 12.4 20.6 Application Example 5 13.9 23.8 Comparative Application Example 1 10.6 16.8 Comparative Application Example 2 9.9 14.4 Comparative Application Example 3 8.2 17.5 Comparative Application Example 4 6.0 9.6 As shown in Table 3, the moisturizing and anti-itch effects of the shampoos in Application Examples 1-5 and Comparative Application Examples 1-3 are better than those in Comparative Application Example 4, indicating that the soothing and repairing composition is an important factor affecting the moisturizing and anti-itch effects of the shampoo.

[0050] Based on the data from Application Examples 1-5, it can be seen that when the weight ratio of bisabolol, sage lactone, artemisia leaf extract, and sage extract in the composition is in the range of (2-6):(0.8-1.5):(0.3-0.6):(0.3-0.6), the moisturizing and antipruritic effects of the shampoo are at a relatively good level.

[0051] Based on the data from Application Example 1 and Comparative Application Examples 1-3, it can be seen that the absence of any one of the components, namely, perilla lactone, Artemisia argyi leaf extract, or Agrimonia pilosa extract, in the composition will reduce the moisturizing and antipruritic properties of the shampoo. This may be because the present invention achieves good anti-inflammatory and antioxidant effects in the shampoo through the synergistic effect of bisabolol, perilla lactone, Artemisia argyi leaf extract, and Agrimonia pilosa extract, thereby realizing the moisturizing and antipruritic effects of the shampoo.

[0052] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit the scope of protection of the present invention. Although the present invention has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can be made to the technical solutions of the present invention without departing from the essence and scope of the technical solutions of the present invention.

Claims

1. A soothing and repairing composition containing bisabolol, characterized in that, It includes the following components: bisabolol, perilla lactone, Artemisia scoparia leaf extract and sage extract; wherein the weight ratio of bisabolol, perilla lactone, Artemisia scoparia leaf extract and sage extract is (2-6):(0.8-1.5):(0.3-0.6):(0.3-0.6).

2. The use of the soothing and repairing composition containing bisabolol as described in claim 1 in the preparation of shampoo and body care products.

3. The application of the soothing and repairing composition containing bisabolol as described in claim 2 in the preparation of personal care products, characterized in that, The soothing and repairing composition is added at a rate of 0.1%-10% of the total weight of the shampoo and conditioner.

4. A shampoo, characterized in that, Including the following raw materials by weight percentage: 0.5%-5% of the soothing and repairing composition containing bisabolol as described in claim 1, 15-25% of surfactant, 0.1-1% of cationic conditioner, 0.05-0.15% of chelating agent, 3-10% of moisturizer, 0.5-1.5% of thickener, 0.5-1.0% of preservative and 0.01-0.3% of pH adjuster, with the balance being deionized water.

5. The shampoo as described in claim 4, characterized in that, (a) The surfactant is at least one of sodium lauroyl sarcosinate, cocamidopropyl betaine, sodium cocoyl methyl taurate, fatty alcohol polyoxyethylene ether, sodium lauroyl amphoteric acid, TEA salt of cocoyl glutamate, TEA salt of dodecylbenzene sulfonate and disodium cocoyl amphoteric acid. (b) The cationic conditioning agent is at least one of polyquaternium-10, polyquaternium-6, polyquaternium-7, polyquaternium-22, polyquaternium-47, and polyquaternium-67; (c) The chelating agent is at least one of disodium EDTA and / or tetrasodium diethylamine glutamate; (d) The moisturizer is at least one of propylene glycol, glycerin, butylene glycol, panthenol, sorbitol and sodium hyaluronate; (e) The thickener is at least one of PEG-120 methyl glucotriethearate and acrylate copolymers; (f) The preservative is at least one of phenoxyethanol, sodium benzoate, p-hydroxyacetophenone, 1,2-hexanediol and ethylhexylglycerin; (g) The pH adjuster is at least one of arginine, tromethamine, citric acid, sodium citrate and lactic acid.

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