46 results about "Otic Agents" patented technology

The invention discloses a moxidectin pouring solution and a preparation method thereof, and belongs to the technical field of veterinary drug preparations. Every 500 ml of the moxidectin pouring solution comprises 0.1%-10% of moxidectin, an antioxidant, a penetrating agent, a tackifier, a cosolvent, a coloring agent and the balance of a fat solvent, and preferably, soybean oil is used as the fat solvent. The preparation method comprises the following steps: mixing and dissolving the components according to a specific sequence, filtering and sub-packaging. The moxidectin pouring solution disclosed by the invention has the advantages of low cost, convenience in preparation, good quality stability, no influence on impurity detection and the like, effectively solves a plurality of problems of the moxidectin pouring solution in the prior art, and has a good application prospect.

The invention relates to the technical field of skin care product raw materials, and particularly discloses a whitening composition as well as a preparation method and application thereof. The whitening composition is prepared from the following components in parts by mass: 29.6 to 35.4 parts of a solvent; 54 to 56 parts of a humectant; 0.9 to 1.1 parts of a whitening agent; 4.5 to 5.5 parts of a penetrating agent; 0.4 to 0.6 part of an antioxidant; 4.8 to 7.2 parts of a composite plant extract; the composite plant extract is prepared by compounding a polygonatum odoratum root extract, a glycyrrhiza glabra root extract and a rhodiola rosea root extract. The whitening mask has the advantage of further improving the whitening effect.

The present invention relates to an anti-allergy, whitening and freckle-removing composition and a preparation method thereof. The anti-allergy, whitening and freckle-removing composition is composed of the following components in mass fractions: 0.5-2% of Kalanchoe extract, 0.5-2% of Cornus controversa Hance extract, 0.5-2% of Yucca filamentosa extract, 0.5-2% of Chrysanthemum cinerariifolium extract, 1-3% of VC ethyl ether, 0.5-5% of arbutin, 0.1-2% of 4-butylresorcinol, 1-10% of niacinamide, 3-15% of humectant, 3-15% of emollient, 0.5-2% of penetrant, and the balance being water. The anti-allergy, whitening and freckle-removing composition is added with Kalanchoe extract, Cornus controversa Hance extract, Yucca filamentosa extract and Chrysanthemum cinerariifolium extract. Through the synergistic effect of the four extracts, the anti-allergy, whitening and freckle-removing composition has little irritation while maintaining excellent whitening and freckle-removing effects.

This application relates to the field of biological control, specifically disclosing a compound bacterial agent containing Bacillus thuringiensis, its preparation method, and its application. A method involves fermenting Bacillus thuringiensis HP-SYJ2 to a concentration of (3-8) × 10⁻⁶. 9 A Bacillus thuringiensis HP-SYJ2 bacterial suspension was obtained by mixing cfu / ml with hydroxyapatite and biochar, then mixing the mixture with the Bacillus thuringiensis HP-SYJ2 bacterial suspension, soaking, and air-drying until the moisture content is 30-40%, followed by maturation for 1-2 weeks to obtain the loading material. Fenugreek seed oil, emulsifier, soil penetrant, and water were mixed and sheared to obtain an emulsion with a fenugreek seed oil concentration of 0.1-0.5 wt%. The loading material and emulsion were packaged separately and mixed before application. This compound microbial agent can be used for the prevention and treatment of root rot in medicinal herbs or to promote their growth. It has the advantages of both preventing and treating root rot in medicinal herbs and promoting their growth.

The invention belongs to the technical field of cleaning, particularly relates to a pretreatment agent special for a soft endoscope, and provides the following scheme aiming at the problems that an existing pretreatment agent does not have moisturizing and bacteriostatic functions, needs to be used after being diluted and does not allow foams to exist. The special pretreatment agent for the soft endoscope comprises the following raw materials in parts by weight: 5-10 parts of a PH buffer agent, 4-8 parts of modified grease, 5-15 parts of multienzyme, 1-5 parts of an enzyme stabilizer, 1-3 parts of a complexing agent, 1.00-3.00 parts of a penetrating agent, 2-5 parts of a foaming agent, 0.50-1.50 parts of a color, 0.05-0.10 part of essence and the balance of water, has certain foam, can be fully filled in a cavity of the endoscope, and can be used for preparing the soft endoscope. In the use process, dilution is not needed, direct use is achieved, the pretreatment efficiency is improved, bacteria are effectively inhibited, cross infection is prevented, and protein, fat, fiber, starch, sugar and other pollutants can be effectively decomposed.

This application belongs to the field of plant protection technology and relates to a penetrating composition and its use, comprising a penetrant, a surfactant, an adjuvant, and a solvent. The penetrant comprises at least one nanopolymer material selected from the group consisting of a linear aliphatic monoglycidyl ether containing at least 12 carbon atoms, sodium hydroxyethylammonium alkylbenzenesulfonate, and alkylphenoxypolyethyleneoxyethanol. The application also relates to an insecticide composition. This composition can penetrate the trunks of woody plants, facilitating the delivery of the drug to the affected area, effectively preventing and controlling pests, fungal infections, and other diseases.

The invention belongs to the field of pesticide preparations, and particularly relates to a pydiflumetofen-epoxiconazole suspending agent as well as a preparation method and application thereof. The preparation consists of the following raw materials in percentage by mass: 3-40% of an active component, 6-10% of a dispersing agent, 1-3% of a penetrating agent, 1-3% of a thickening agent, 1.5-2% of a synergist, 3-5% of an anti-freezing agent, 0.2-0.3% of a defoaming agent, 0.2-0.5% of a pH regulator, 0.1-0.3% of an antioxidant and the balance of water. By screening a suspending agent system, the prepared pydiflumetofen-epoxiconazole suspending agent is excellent in stability, the influence of environmental change on the preparation in the storage process is effectively reduced, and the traditional problems of caking, devitrification and the like of the preparation are avoided to the greatest extent.

This invention discloses a stress-resistant and yield-increasing plant growth regulator, its preparation method, and its application, belonging to the field of plant growth regulators. The stress-resistant and yield-increasing plant growth regulator of this invention comprises the following raw materials: *Suaeda salsa* extract, a stress-resistant biostimulant, propionyl brassinolide, styracil, polyaspartic acid, γ-aminobutyric acid, emulsifier, penetrant, co-emulsifier, pH buffer, and deionized water; wherein the stress-resistant biostimulant is perilla lactone. This invention significantly improves the tolerance of wheat to salt-alkali stress by strengthening the antioxidant system and osmotic regulation capacity, ensuring its basic survival and normal physiological functions; and effectively reverses stress-induced growth inhibition through mechanisms such as promoting root development, enhancing photosynthesis, and driving product translocation to grains, thereby achieving a significant yield increase under adverse conditions.

The present invention relates to an osmotic agent composition comprising an acid-sensitive polymer in a coating layer. More particularly, the present invention relates to an osmotic agent composition and a method for preparing same, the osmotic agent composition comprising an acid-sensitive polymer that can be dissolved or separated in an acidic condition so as to form a porous osmosis membrane on a coating layer of the osmotic agent composition.

The invention relates to an ultra-low volume liquid containing pyraclostrobin and tebuconazole, which belongs to the field of pesticide preparations and mainly comprises the following components in percentage by weight: 5-15% of pyraclostrobin, 5-15% of tebuconazole and the balance of water. 10%-20% of tebuconazole; 10%-20% of a cosolvent; 3%-8% of a penetrant; 5%-15% of an evaporation inhibitor; 2%-5% of a stabilizer; the total percentage is 100%. Through specific component selection and proportion optimization, the prepared liquid has proper viscosity, surface tension, volatility and specific gravity, and is especially suitable for ultra-low volume spraying and aviation pesticide application. The preparation is excellent in atomization performance, moderate in fogdrop particle size, low in drifting risk and good in deposition effect, the pesticide utilization rate can be remarkably increased, efficient and synergistic control over crop diseases is achieved, and environmental pollution is reduced.

The present invention discloses a compound foam-type long-acting disinfectant containing citric acid, its preparation method and application. The disinfectant includes the following components by weight percentage: citric acid 0.5% to 5.0%, benzalkonium bromide 0.5% to 5.0%, decanium bromide 0.5% to 5.0%, glutaraldehyde 0.25% to 2.5%, polyhexamethylene biguanide 0.5% to 5.0%, cosolvent 3.0% to 15.0%, penetrant 0.1% to 0.5%, foam emulsifier 0.5% to 5.0%, stabilizer and citric acid can form a buffer system, maintain a pH value of 3.0 to 5.0, and sterile water is supplemented to 100%. The compound disinfectant of the present invention has a synergistic or additive effect, killing all pathogenic microorganisms of animal origin including bacteria, viruses, mycoplasmas, fungi, etc. in the breeding environment, with a sterilization efficiency of 100%.

Provided herein are polymer compositions and extended release otic agents. In one aspect, provided herein is a polymer composition including about 5% to about 15% by weight of the polymer composition of a functional polymer, wherein the functional polymer includes a first functional group, about 0.05% to about 0.6% by weight of the polymer composition of a crosslinker, wherein the crosslinker includes a second functional group, and water, wherein a crosslinking reaction can occur between the first functional group and the second functional group to form a gel, and wherein the polymer composition has a gelation time of about 45 seconds to about 60 minutes at a temperature of about 20° C.

An aqueous formulation includes a PEDF-derived short peptide (PDSP) having the sequence of one of SEQ ID NO: 1, 2, 3, 5, 6, 8, or 9; histidine having a concentration of 1 mM – 100 mM; and an antioxidant and optionally a non-ionic tonicity agent. The pH value is around 5–9. The antioxidant is nicotinamide, which is at a concentration of 50 mM – 1000 mM. The non-ionic tonicity agent is sorbitol, which is at a concentration of 0 mM – 500 mM. A concentration of the PDSP is 0.01% - 1% w / v.

This invention belongs to the field of ornamental horticulture cultivation technology, and relates to a cultivation method for promoting wound healing in bonsai using a plant hormone repair agent. This method addresses the problems of slow wound healing and susceptibility to infection during grafting and pruning of bonsai. It constructs a plant hormone repair agent composed of hormone components, antibacterial components, repair aids, penetrants, and a carrier, and integrates it with a complete "pretreatment—grafting—application—bandaging—maintenance" process. The repair agent creates a synergistic microenvironment of physiological regulation and antibacterial activity at the graft union and various cuts. Combined with sterile gauze and mulch wrapping, it reduces water loss and pathogen infection. Through temperature and humidity control during the healing period and light, water, and nutrient management during the growing season, the wound can complete continuous healing and gradual lignification in a short time. This invention significantly improves healing speed, infection control, grafting survival rate, and lignification stability, and is suitable for the standardized and large-scale cultivation of various bonsai materials.

The invention relates to a microcapsule composition as well as a preparation method and application thereof. The microcapsule composition comprises the following components: PEI-modified silicon dioxide sustained-release capsule powder, coconut charcoal powder, a thickening agent, a penetrating agent, a defoaming agent, a cross-linking agent and water. The composition is used for textile processing and has the comprehensive effects of resisting bacteria, preventing mites and relieving fatigue, and due to modification of PEI, the number of times of washing of fabrics is remarkably increased, and the comprehensive effects of resisting bacteria, preventing mites and relieving fatigue are good.

The invention discloses a special auxiliary agent suitable for flight control mixing, a preparation method and application thereof. The special auxiliary agent suitable for flight control mixing comprises the following components in percentage by weight: 30-40% of plant essential oil, 10-20% of a dispersing agent, 10-15% of a wetting agent, 5-10% of a penetrating agent, 2-4% of an anti-freezing agent, 5-10% of a modified anti-drifting agent and 15-25% of water. Compared with the prior art, the special auxiliary agent prepared by the invention has the advantages that the particle size of fog drops can be increased within a certain range, fog drop sedimentation is promoted, and spray drift is slowed down; and the composition has good wettability and stability, improves the versatility of being matched with pesticides, prevents the liquid medicine from being sticky, thick and flocculated, and is suitable for corn lodging resistance, rice and wheat flying prevention.

The invention belongs to the technical field of medicine, and particularly provides external ointment for treating psoriasis and a preparation method thereof.The external ointment is prepared from, by weight, 1.2-2 parts of antifungal agent, 1-1.6 parts of traditional Chinese medicine sustained-release agent, 8-11 parts of glycerin, 8-10 parts of wax stearyl alcohol, 5-7 parts of mineral oil, 2.5-4 parts of propylene glycol, 1-2 parts of emulsifier and 0.2-0.8 part of penetrant. The formula comprises the following components in parts by weight: 0.2 to 0.5 part of preservative, 0.3 to 0.7 part of triethanolamine, 0.5 to 1 part of carbomer, 0.05 to 0.15 part of essence, 0.005 to 0.01 part of pigment, 0.001 to 0.005 part of fluorometholone acetate and 50 to 70 parts of purified water. Wherein the medicinal component in the traditional Chinese medicine slow-release agent is composite plant essential oil. All the components of the external ointment are compatible with one another, and the external ointment is remarkable in curative effect, quick in effect taking, small in toxic and side effects, free of excessive stimulation and low in recurrence rate after curing, has certain calming and itching relieving properties, slow release properties and antibacterial activity and can effectively solve the problem of treatment of psoriasis.

A pharmaceutical composition to be applied to an ocular surface is disclosed that includes a quaternized chitosan derivative to provide antimicrobial activity against gram-negative bacteria, gram-positive bacteria, fungi, and viruses as an active ingredient. This is combined with a cellulose compound acting as a viscosity agent and demulcent to protect and lubricate mucous membrane surfaces. This is further combined with a humectant and tonicity agent to retain moisture on the ocular surface and maintain a comfortable osmolarity for the eye. This is further combined with a buffer / pH adjuster system configured to support a physiologically tolerable pH of about 6.0 to 8.0. Finally, this is combined with purified water as a diluent.

The invention discloses a traditional Chinese medicine plaster for adjuvant therapy of clostridium difficile infection and reconstruction of intestinal flora balance and a preparation method thereof, and relates to the technical field of traditional Chinese medicine plasters, the traditional Chinese medicine plaster comprises a base material layer, an ointment and a protective layer, the ointment is prepared from effective components, a penetrant, an excipient, an adsorbent and deionized water; the effective components are prepared from rhizoma atractylodis macrocephalae volatile oil, cortex magnoliae officinalis volatile oil, folium artemisiae argyi volatile oil, a rhizoma coptidis extract, a herba taraxaci extract, a radix paeoniae alba extract and a poria cocos extract; according to the present invention, the accurate intervention of the intestinal microenvironment is achieved through the umbilical region targeting drug delivery and the combination of the dual mechanisms of the transdermal absorption and the acupoint stimulation, the drug action time is prolonged through the adsorbent porous slow-release structure, the flora balance is synchronously adjusted, the pathogenic bacterium proliferation is inhibited, and the limitation of the traditional oral administration or injection therapy is broken through; an efficient and convenient traditional Chinese medicine external treatment solution is provided for the drug-resistant clostridium difficile infection.

Provided herein is an osmotic dosage form containing deutetrabenazine, for use, for example, in the treatment of hyperkinetic movement disorders. When administered orally on a once-daily basis to a subject, this dosage form provides a favorable pharmacokinetic profile of the active agent and exhibits a treatment effect over a long period of time.

The invention belongs to the technical field of cosmetic preparation, and particularly relates to a relieving and acne removing spray and application, the spray comprises an agent A and an agent B, wherein the agent A is prepared from the following raw materials in percentage by mass: 2 to 3 percent of humectants, 1 to 1.5 percent of penetrating agents, 0.1 to 0.2 percent of salicylic acid microcapsules, 0.1 to 0.2 percent of preservatives, 0.6 to 0.8 percent of conditioning agents, 0.05 to 0.15 percent of buffering agents, 1.5 to 1.8 percent of plant extracts and the balance of deionized water; the agent B is prepared from the following raw materials in percentage by mass: 10 to 12 percent of chloramphenicol and the balance of solvent. The soothing acne-removing spray prepared by the invention has the advantages of quick effect and no irritation.

The invention relates to an external pain-relieving composition and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines. A formula of the external pain-relieving composition comprises the following components in parts by weight: 10-20 parts of loquat extract, 10-20 parts of folium artemisiae argyi extract, 0.3-0.5 part of radix sophorae flavescentis extract, 5-10 parts of a composite penetrant and 3-5 parts of fermented organic acid. Wherein the compound penetrating agent is prepared from the following components in parts by weight: 0.5 to 1 part of baicalein-glycyrrhetinic acid nano eutectic crystal, 6 to 10 parts of chemical penetration enhancer, 0.5 to 2 parts of carbomer and 0.1 to 0.3 part of betaine; the composition prepared by the invention has the characteristics of efficient permeability and effective relief of local pain.

Provided herein are polymer compositions and extended release otic agents. In one aspect, provided herein is a polymer composition including about 5% to about 15% by weight of the polymer composition of a functional polymer, wherein the functional polymer includes a first functional group, about 0.05% to about 0.6% by weight of the polymer composition of a crosslinker, wherein the crosslinker includes a second functional group, and water, wherein a crosslinking reaction can occur between the first functional group and the second functional group to form a gel, and wherein the polymer composition has a gelation time of about 45 seconds to about 60 minutes at a temperature of about 20° C.

The invention discloses a disinfectant with a long-acting disinfection effect and a preparation method thereof, and belongs to the technical field of disinfection materials, the disinfectant is prepared from the following raw materials by weight: 0.2%-0.5% of a bactericide, 1%-5% of a waterproof agent, 0.1%-1% of a synergist, 0.5%-2% of a corrosion inhibitor, 1%-5% of a penetrant, and the balance purified water. The weight ratio of the waterproof agent to the penetrating agent is (0.9-1.1): 2. According to the disinfectant with the long-acting disinfection effect and the preparation method of the disinfectant, through the synergistic effect of all the components, the disinfectant can continuously disinfect for more than 24 hours, the killing logarithm value is larger than or equal to 3.00 after 24 hours, the sterilization effect can still be met by only conducting common cleaning within the long-acting disinfection time of the disinfectant, and the disinfectant has the long-acting disinfection effect. The problem that a traditional disinfectant can only resist bacteria for a long time and cannot achieve a long-acting disinfection effect is solved.

A pharmaceutical composition to be applied to an ocular surface is disclosed that includes a quaternized chitosan derivative to provide antimicrobial activity against gram-negative bacteria, gram-positive bacteria, fungi, and viruses as an active ingredient. This is combined with a cellulose compound acting as a viscosity agent and demulcent to protect and lubricate mucous membrane surfaces. This is further combined with a humectant and tonicity agent to retain moisture on the ocular surface and maintain a comfortable osmolarity for the eye. This is further combined with a buffer / pH adjuster system configured to support a physiologically tolerable pH of about 6.0 to 8.0. Finally, this is combined with purified water as a diluent.

The invention discloses a compound type rape flowering phase prolonging water-soluble preparation and a preparation method and application thereof, the compound type rape flowering phase prolonging water-soluble preparation comprises 0.035-0.17% of a hormone synergist, 0.15-0.7% of a metabolism regulating agent, 0.15-0.45% of a stress-resistant protective agent, 0.21-0.85% of a synergistic adjuvant and the balance of water; wherein the hormone synergist is prepared from gibberellin (GA3), 6-benayl aminopurine (6-BA) and paclobutrazol (PP333); the metabolism regulator comprises a sucrose signal enhancer and an antioxidant; the stress-resistant protective agent comprises proline and potassium silicate; the synergistic adjuvant comprises a slow-release carrier and a penetrant; % is mass percent. By constructing a compound regulator formula and optimizing an application strategy, neglect of gene-metabolic network coordinated regulation in the prior art is broken through, safe, efficient and lasting prolonging of the flowering phase of the rape is finally realized, and meanwhile, the yield and the quality are also improved.

The invention relates to the technical field of food microorganisms, in particular to a long-acting slow-release antibacterial preparation targeting clostridium botulinum spores as well as a preparation method and application of the long-acting slow-release antibacterial preparation. The long-acting slow-release bacteriostatic preparation comprises a wall material and a core material, the core material comprises a lactic acid bacteria metabolite and a spore coating penetrant; the wall material is prepared from konjac glucomannan, tannic acid, polylysine salt and hyaluronic acid. By preparing a core material compound and embedding the core material compound in a wall material microcapsule, a three-layer action system of spore coating damage, skin layer degradation and core metabolism inhibition is constructed. The preparation can significantly improve the targeting and stability of antibacterial components, realizes complete substitution of nitrite in meat products, has the characteristics of safety, high efficiency and long acting, and conforms to the national food safety and health industrial policy.

The invention relates to the technical field of medicine, in particular to a vagina tightening bacteriostatic preparation and a preparation method thereof.The vagina tightening bacteriostatic preparation is prepared from, by mass, 0%-0.5% of carbomer, 5%-13% of galactomannan, 1%-6% of transient pink regulator, 0.1% of tetrahydropiperine, 4% of physalis alkekengi extracting solution and 10% of composite plant fungicide; the amount of the neutralizer is the amount which enables the pH value of the preparation to be 6.0-6.5. According to the invention, the galactomannan instantly forms a film to tighten and shrink vagina, the instant plicatin rapidly thickens vagina mucosa, the plant penetrant tetrahydropiperine promotes permeation of effective components and increases the mucosa absorbance of the effective components, so that the vagina shrinking effect is multiplied, and the plant penetrant tetrahydropiperine cooperates with other various components to achieve a synergistic effect, so that the vagina shrinking effect is improved. And a rapid and efficient vagina contracting effect is achieved.

The invention discloses a multipurpose medical dressing based on triatomic oxidized oil and a preparation method thereof. The multipurpose medical dressing comprises the following raw materials in parts by weight: 160-170 parts of triatomic oxidized oil, 30-40 parts of modified thickener and 2-7 parts of penetrant; the modified penetrant has a good bactericidal effect, and the side chain contains a long-chain quaternary ammonium salt structure and the long-chain quaternary ammonium salt is a spirocyclic structure, so that in the process of the quaternary ammonium salt inserting into the bacterial cell membrane, the perforated gap of the cell membrane is expanded, and then the cells are caused to flow out. The medical dressing has a killing effect on pathogenic microorganisms, can reduce inflammation and relieve pain, and promote wound healing. It has obvious therapeutic effects on joint pain and intractable skin diseases. It is a non-toxic product and has no irritation to skin, mucous membranes, eyes, etc. at low concentrations. Due to the small molecular weight of O3, it has a strong permeation effect on cells and tissues, and can penetrate into the 2mm below the mucosa to kill the pathogenic microorganisms in the cells and tissues.

The application belongs to the technical field of pesticide preparation, and particularly relates to a pesticide bactericide, a preparation method and application thereof. The pesticide bactericide comprises the following raw materials in percentage by weight: manganese zinc maneb 6.5%-8.5%, metalaxyl 6.5%-8.5%, amaranth fat 6.5%-8.5%, penetrating agent 5.2%-7.2% and water 67.3%-75.3%. The pesticide bactericide is prepared by compounding the above-mentioned percentage by weight of manganese zinc maneb, metalaxyl and amaranth fat with the penetrating agent and water. The bactericide can prevent and control various pathogenic diseases of tobacco seedlings and adult plants, has low toxicity and drug resistance, and has a significant prevention and control effect after being applied to tobacco seedlings, and can increase the maturation rate after being applied to adult plants.