25 results about "Otic Agents" patented technology

This application relates to the field of biological control, specifically disclosing a compound bacterial agent containing Bacillus thuringiensis, its preparation method, and its application. A method involves fermenting Bacillus thuringiensis HP-SYJ2 to a concentration of (3-8) × 10⁻⁶. 9 A Bacillus thuringiensis HP-SYJ2 bacterial suspension was obtained by mixing cfu / ml with hydroxyapatite and biochar, then mixing the mixture with the Bacillus thuringiensis HP-SYJ2 bacterial suspension, soaking, and air-drying until the moisture content is 30-40%, followed by maturation for 1-2 weeks to obtain the loading material. Fenugreek seed oil, emulsifier, soil penetrant, and water were mixed and sheared to obtain an emulsion with a fenugreek seed oil concentration of 0.1-0.5 wt%. The loading material and emulsion were packaged separately and mixed before application. This compound microbial agent can be used for the prevention and treatment of root rot in medicinal herbs or to promote their growth. It has the advantages of both preventing and treating root rot in medicinal herbs and promoting their growth.

This invention discloses a stress-resistant and yield-increasing plant growth regulator, its preparation method, and its application, belonging to the field of plant growth regulators. The stress-resistant and yield-increasing plant growth regulator of this invention comprises the following raw materials: *Suaeda salsa* extract, a stress-resistant biostimulant, propionyl brassinolide, styracil, polyaspartic acid, γ-aminobutyric acid, emulsifier, penetrant, co-emulsifier, pH buffer, and deionized water; wherein the stress-resistant biostimulant is perilla lactone. This invention significantly improves the tolerance of wheat to salt-alkali stress by strengthening the antioxidant system and osmotic regulation capacity, ensuring its basic survival and normal physiological functions; and effectively reverses stress-induced growth inhibition through mechanisms such as promoting root development, enhancing photosynthesis, and driving product translocation to grains, thereby achieving a significant yield increase under adverse conditions.

The present invention relates to an osmotic agent composition comprising an acid-sensitive polymer in a coating layer. More particularly, the present invention relates to an osmotic agent composition and a method for preparing same, the osmotic agent composition comprising an acid-sensitive polymer that can be dissolved or separated in an acidic condition so as to form a porous osmosis membrane on a coating layer of the osmotic agent composition.

The invention relates to an ultra-low volume liquid containing pyraclostrobin and tebuconazole, which belongs to the field of pesticide preparations and mainly comprises the following components in percentage by weight: 5-15% of pyraclostrobin, 5-15% of tebuconazole and the balance of water. 10%-20% of tebuconazole; 10%-20% of a cosolvent; 3%-8% of a penetrant; 5%-15% of an evaporation inhibitor; 2%-5% of a stabilizer; the total percentage is 100%. Through specific component selection and proportion optimization, the prepared liquid has proper viscosity, surface tension, volatility and specific gravity, and is especially suitable for ultra-low volume spraying and aviation pesticide application. The preparation is excellent in atomization performance, moderate in fogdrop particle size, low in drifting risk and good in deposition effect, the pesticide utilization rate can be remarkably increased, efficient and synergistic control over crop diseases is achieved, and environmental pollution is reduced.

Provided herein are polymer compositions and extended release otic agents. In one aspect, provided herein is a polymer composition including about 5% to about 15% by weight of the polymer composition of a functional polymer, wherein the functional polymer includes a first functional group, about 0.05% to about 0.6% by weight of the polymer composition of a crosslinker, wherein the crosslinker includes a second functional group, and water, wherein a crosslinking reaction can occur between the first functional group and the second functional group to form a gel, and wherein the polymer composition has a gelation time of about 45 seconds to about 60 minutes at a temperature of about 20° C.

An aqueous formulation includes a PEDF-derived short peptide (PDSP) having the sequence of one of SEQ ID NO: 1, 2, 3, 5, 6, 8, or 9; histidine having a concentration of 1 mM – 100 mM; and an antioxidant and optionally a non-ionic tonicity agent. The pH value is around 5–9. The antioxidant is nicotinamide, which is at a concentration of 50 mM – 1000 mM. The non-ionic tonicity agent is sorbitol, which is at a concentration of 0 mM – 500 mM. A concentration of the PDSP is 0.01% - 1% w / v.

This invention belongs to the field of ornamental horticulture cultivation technology, and relates to a cultivation method for promoting wound healing in bonsai using a plant hormone repair agent. This method addresses the problems of slow wound healing and susceptibility to infection during grafting and pruning of bonsai. It constructs a plant hormone repair agent composed of hormone components, antibacterial components, repair aids, penetrants, and a carrier, and integrates it with a complete "pretreatment—grafting—application—bandaging—maintenance" process. The repair agent creates a synergistic microenvironment of physiological regulation and antibacterial activity at the graft union and various cuts. Combined with sterile gauze and mulch wrapping, it reduces water loss and pathogen infection. Through temperature and humidity control during the healing period and light, water, and nutrient management during the growing season, the wound can complete continuous healing and gradual lignification in a short time. This invention significantly improves healing speed, infection control, grafting survival rate, and lignification stability, and is suitable for the standardized and large-scale cultivation of various bonsai materials.

A pharmaceutical composition to be applied to an ocular surface is disclosed that includes a quaternized chitosan derivative to provide antimicrobial activity against gram-negative bacteria, gram-positive bacteria, fungi, and viruses as an active ingredient. This is combined with a cellulose compound acting as a viscosity agent and demulcent to protect and lubricate mucous membrane surfaces. This is further combined with a humectant and tonicity agent to retain moisture on the ocular surface and maintain a comfortable osmolarity for the eye. This is further combined with a buffer / pH adjuster system configured to support a physiologically tolerable pH of about 6.0 to 8.0. Finally, this is combined with purified water as a diluent.

The invention relates to an external pain-relieving composition and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines. A formula of the external pain-relieving composition comprises the following components in parts by weight: 10-20 parts of loquat extract, 10-20 parts of folium artemisiae argyi extract, 0.3-0.5 part of radix sophorae flavescentis extract, 5-10 parts of a composite penetrant and 3-5 parts of fermented organic acid. Wherein the compound penetrating agent is prepared from the following components in parts by weight: 0.5 to 1 part of baicalein-glycyrrhetinic acid nano eutectic crystal, 6 to 10 parts of chemical penetration enhancer, 0.5 to 2 parts of carbomer and 0.1 to 0.3 part of betaine; the composition prepared by the invention has the characteristics of efficient permeability and effective relief of local pain.

Provided herein are polymer compositions and extended release otic agents. In one aspect, provided herein is a polymer composition including about 5% to about 15% by weight of the polymer composition of a functional polymer, wherein the functional polymer includes a first functional group, about 0.05% to about 0.6% by weight of the polymer composition of a crosslinker, wherein the crosslinker includes a second functional group, and water, wherein a crosslinking reaction can occur between the first functional group and the second functional group to form a gel, and wherein the polymer composition has a gelation time of about 45 seconds to about 60 minutes at a temperature of about 20° C.

A pharmaceutical composition to be applied to an ocular surface is disclosed that includes a quaternized chitosan derivative to provide antimicrobial activity against gram-negative bacteria, gram-positive bacteria, fungi, and viruses as an active ingredient. This is combined with a cellulose compound acting as a viscosity agent and demulcent to protect and lubricate mucous membrane surfaces. This is further combined with a humectant and tonicity agent to retain moisture on the ocular surface and maintain a comfortable osmolarity for the eye. This is further combined with a buffer / pH adjuster system configured to support a physiologically tolerable pH of about 6.0 to 8.0. Finally, this is combined with purified water as a diluent.

The invention relates to the technical field of medicine, in particular to a vagina tightening bacteriostatic preparation and a preparation method thereof.The vagina tightening bacteriostatic preparation is prepared from, by mass, 0%-0.5% of carbomer, 5%-13% of galactomannan, 1%-6% of transient pink regulator, 0.1% of tetrahydropiperine, 4% of physalis alkekengi extracting solution and 10% of composite plant fungicide; the amount of the neutralizer is the amount which enables the pH value of the preparation to be 6.0-6.5. According to the invention, the galactomannan instantly forms a film to tighten and shrink vagina, the instant plicatin rapidly thickens vagina mucosa, the plant penetrant tetrahydropiperine promotes permeation of effective components and increases the mucosa absorbance of the effective components, so that the vagina shrinking effect is multiplied, and the plant penetrant tetrahydropiperine cooperates with other various components to achieve a synergistic effect, so that the vagina shrinking effect is improved. And a rapid and efficient vagina contracting effect is achieved.

The application belongs to the technical field of pesticide preparation, and particularly relates to a pesticide bactericide, a preparation method and application thereof. The pesticide bactericide comprises the following raw materials in percentage by weight: manganese zinc maneb 6.5%-8.5%, metalaxyl 6.5%-8.5%, amaranth fat 6.5%-8.5%, penetrating agent 5.2%-7.2% and water 67.3%-75.3%. The pesticide bactericide is prepared by compounding the above-mentioned percentage by weight of manganese zinc maneb, metalaxyl and amaranth fat with the penetrating agent and water. The bactericide can prevent and control various pathogenic diseases of tobacco seedlings and adult plants, has low toxicity and drug resistance, and has a significant prevention and control effect after being applied to tobacco seedlings, and can increase the maturation rate after being applied to adult plants.

The application belongs to the technical field of biological medicine preparation, and particularly relates to an external use ear drop for promoting auditory nerve growth and a preparation method thereof. The composition raw materials comprise the following components: active small molecules, glyceryl stearate, glyceryl monostearate, soybean lecithin, vitamin E succinate, Tween-80, chitosan quaternary ammonium salt, diethylene glycol monoethyl ether, penetration aid, penetrant, sodium cholate, N-acetyl cysteine, F127 surfactant, F68 surfactant and sodium hyaluronate. Through the synergistic effect of the crystalline lipid core, the positive chitosan quaternary ammonium salt shell, the heat-sensitive in-situ gel outer layer and the mild penetration system, the drug is long-acting retained, smoothly released and efficiently penetrated into the inner ear target area under the condition of not puncturing the eardrum, and the synergistic system significantly improves the stability, local exposure and treatment efficiency of the drug.

This invention discloses a bactericidal, scale-inhibiting, and penetrant compounded from anionic and cationic surfactants and its application, belonging to the field of water treatment science. The single-tailed, double-headed quaternary ammonium salt of this invention exhibits highly efficient bactericidal and algicidal properties. At concentrations greater than 100 mg / L, the bactericidal rate can reach over 99.1%; at concentrations greater than 120 mg / L, the algicidal rate can reach 99.8% after three days. Furthermore, this bactericide adsorbs onto the bacterial surface through strong electrostatic attraction, making it less likely for bacteria to develop drug resistance. The bactericidal, scale-inhibiting, and penetrant prepared by compounding the single-tailed, double-headed quaternary ammonium salt surfactant of this invention can adsorb onto the surface of CaCO3 crystals, preventing normal crystal growth and ultimately dispersing them in the water as loose, broken, microcrystalline particles, thus exhibiting excellent scale inhibition effects.

The application provides a low-eutectic bio-adhesive based on mixed polypeptides of Periplaneta americana and snake slough and a preparation method. Based on the application status of Periplaneta americana and snake slough in surgical diseases and external use drugs, the bio-adhesive fuses the optimal proportion of two animal polypeptide extracts and a low-eutectic solvent, and the three form a uniform composite system through a low-eutectic effect and a self-assembly process, is solidified at a diseased part through a preheating-cooling mode and plays a role. The low-eutectic solvent plays multiple roles as a cosolvent, a plasticizing excipient, a penetration enhancer, a bacteriostatic agent and an auxiliary functional substance. The preparation process is fast, the conditions are mild, special equipment is not needed and the process is easy to scale. The adhesive formula is simplified to the maximum extent, the raw materials are green, the system is stable, no other components are specially added, the operation is simple during use and the bio-adhesive is friendly and safe as an auxiliary treatment means. The whole system fully utilizes the unique activity and nursing efficacy of various components and can play a synergistic treatment role.

The invention discloses a composition with a permeation promoting effect as well as a preparation method and application thereof, and relates to the technical field of cosmetics. The composition disclosed by the invention is obtained by fermenting a fermentation substrate by thalli; the fermentation substrate is prepared from the following raw materials: a dogwood extract, creatinine and polyhydric alcohols. The composition provided by the invention has an excellent penetration promoting effect, can promote the absorption of active ingredients by skin, is free of irritation to skin temperature, is suitable for being used as a penetration promoting agent for preparing cosmetics, and improves the utilization rate of the active ingredients of the cosmetics.

Provided herein are compositions and methods for clearing mucus (e.g., excess mucus) from the lungs. In one aspect, provided herein are methods of clearing mucus from the lungs of a subject in need thereof comprising instilling into the lungs of the subject an effective amount of a liquid pharmaceutical composition comprising an isotonic osmolyte. The liquid pharmaceutical composition (e.g., aqueous, isotonic sodium gluconate solution) may further comprise one or more additional agents selected from epithelial sodium channel (ENaC) inhibitors, osmolytes mucolytic agents, surfactants, DNases, anti-infectives, and anti-inflammatory agents. Also provided herein are liquid pharmaceutical compositions (i.e., "instillation solutions," "lavage solutions") useful in the methods described herein.

This invention relates to a method for preparing a high-fluorine chlorpyrifos-imidacloprid suspension, belonging to the field of pesticide technology. In preparing this high-fluorine chlorpyrifos-imidacloprid suspension, an synergist is added to form a water-retaining film on the surface of the droplets during residual spraying. This allows the droplets to be evenly dispersed on the object surface, preventing the liquid moisture from evaporating or being absorbed, thus improving the adhesion of the product to the target surface and prolonging its effect. The pesticide adheres to the object surface at a size of less than 5 micrometers. Upon contact with the target organism, a trace amount of penetrant promotes the absorption and activation of the active ingredient, thereby improving the efficacy. The product prepared by this invention is environmentally friendly, highly safe, and has a long-lasting effect on sanitary pests with a high contact kill rate.

The invention discloses a stress-resistant yield-increasing plant growth regulator as well as a preparation method and application thereof, and belongs to the field of plant growth regulators. The stress-resistant and yield-increasing plant growth regulator comprises the following raw materials: a suaeda glauca extract, a stress-resistant biological stimulant, propionyl brassinolide, coronatine, polyaspartic acid, gamma-aminobutyric acid, an emulsifier, a penetrant, a co-emulsifier, a pH buffer agent and deionized water. The stress resistance biological stimulant is sclareolide. By strengthening an anti-oxidation system and the osmotic regulation capability, the tolerance of wheat to saline-alkali stress is remarkably improved, and the basic survival and normal physiological functions of wheat are guaranteed; growth inhibition caused by stress is effectively reversed through the mechanisms of promoting root development, enhancing photosynthesis, driving products to be transferred to grains and the like, so that the yield is remarkably increased under the adverse situation.

The invention discloses a fosthiazate and ethylicin-based rice aphelenchoides besseyi disease environment-friendly treatment agent and a preparation method thereof, the fosthiazate and ethylicin-based rice aphelenchoides besseyi disease environment-friendly treatment agent comprises fosthiazate, ethylicin, an auxiliary agent and powder, the mass ratio of fosthiazate to ethylicin is 30: 1-1: 30, the auxiliary agent is selected from one of a filler, a dispersant, a wetting agent, a penetrant, a film-forming agent and a stabilizer, and the powder is powder. The powder is prepared from prothioconazole, imazalil, cartap and a dispersing agent; through scientific compounding of fosthiazate and ethylicin, the contact killing and systemic absorption effects on aphelenchoides besseyi are remarkably enhanced, meanwhile, the use concentration of the pesticide is reduced, damage to soil microbial communities is reduced, the environmental pressure is effectively relieved, and the prevention and control safety is improved; the photolysis stability and slow release performance of active ingredients are remarkably improved, the pesticide effect lasting time is prolonged, the pesticide application frequency is reduced, the adhesion capacity and permeation efficiency of the pesticide on the surfaces of rice leaves are enhanced through the nanometer silicon carrier, and the pesticide utilization rate is increased.

This invention relates to a composition containing octenylamine and imazalil and its applications. The composition can be prepared as a wettable powder, microemulsion, soluble liquid, suspension, water dispersible agent, granules, emulsifiable concentrate, or water-in-oil emulsion. When prepared as a soluble liquid, the adjuvants consist of a solvent, surfactant, defoamer, antifreeze, penetrant, pH adjuster, and filler. The efficacy against grape anthracnose is significantly higher than that of a single agent. The soluble liquid prepared by this invention resolves the technical contradiction between the hydrolysis of octenylamine under alkaline conditions and the acidic precipitation of imazalil. It reduces the surface tension of the solution, lowers the contact angle, and reduces solution loss.

The invention discloses a transmembrane drug-loaded delivery system and a preparation method and application thereof, and particularly relates to the technical field of aquaculture disease prevention and control. Wherein the transmembrane drug-loading delivery system is formed by compounding a polyphenol compound with anti-parasitic activity, a drug carrier and a penetration enhancer. Meanwhile, the invention also discloses a preparation method of the transmembrane drug-loaded delivery system, and the method comprises the following steps: adding the polyphenol compound into the drug carrier, and stirring in a water bath until the polyphenol compound is completely dissolved to prepare a drug-containing oil phase; mixing the permeation promoter A, the permeation promoter B and the penetration enhancer, and uniformly stirring to obtain a mixed phase; fully mixing the medicine-containing oil phase with the mixed phase to form a premix; and adding the premix into ultrapure water which is preheated to 35-40 DEG C, and continuously stirring to obtain the transmembrane drug-loading delivery system. The transmembrane drug-loading delivery system can permeate host mucus and a parasite barrier, so that effective components are accurately delivered to a target spot, and the effect of killing parasites in fish bodies is achieved.

Provided herein are polymer compositions and extended release otic agents. In one aspect, provided herein is a polymer composition including about 3% to about 15% by weight of the polymer composition of a functional polymer, wherein the functional polymer includes a first functional group, about 0.03% to about 0.6% by weight of the polymer composition of a crosslinker, wherein the crosslinker includes a second functional group, an active agent, wherein the active agent comprises a neuroprotective agent or a chemoprotective agent, and water, wherein a crosslinking reaction can occur between the first functional group and the second functional group to form a gel, and wherein the polymer composition has a gelation time of about 45 seconds to about 30 minutes at a temperature of about 20 °C.

The invention belongs to the technical field of biological medicine preparations, and particularly relates to external ear drops for promoting auditory nerve growth and a preparation method of the external ear drops. The composition raw materials comprise the following components: active small molecules, glyceryl stearate, glyceryl monostearate, soya bean lecithin, vitamin E succinate, tween-80, chitosan quaternary ammonium salt, diethylene glycol monoethyl ether, a penetration enhancing auxiliary agent, a penetrating agent, sodium cholate, N-acetylcysteine, an F127 surfactant, an F68 surfactant and sodium hyaluronate. Through the synergistic effect of the crystalline lipid core, the chitosan quaternary ammonium salt positive shell, the thermosensitive in-situ gel outer layer and the mild permeation enhancing system, the drug is detained in the auditory meatus for a long time, is stably released and efficiently permeates into an inner ear target region under the condition that the tympanic membrane is not punctured, and the stability, local exposure and treatment efficiency of the drug are remarkably improved through the synergistic system.