34 results about "Otic Agents" patented technology

The invention discloses a moxidectin pouring solution and a preparation method thereof, and belongs to the technical field of veterinary drug preparations. Every 500 ml of the moxidectin pouring solution comprises 0.1%-10% of moxidectin, an antioxidant, a penetrating agent, a tackifier, a cosolvent, a coloring agent and the balance of a fat solvent, and preferably, soybean oil is used as the fat solvent. The preparation method comprises the following steps: mixing and dissolving the components according to a specific sequence, filtering and sub-packaging. The moxidectin pouring solution disclosed by the invention has the advantages of low cost, convenience in preparation, good quality stability, no influence on impurity detection and the like, effectively solves a plurality of problems of the moxidectin pouring solution in the prior art, and has a good application prospect.

The invention relates to the technical field of skin care product raw materials, and particularly discloses a whitening composition as well as a preparation method and application thereof. The whitening composition is prepared from the following components in parts by mass: 29.6 to 35.4 parts of a solvent; 54 to 56 parts of a humectant; 0.9 to 1.1 parts of a whitening agent; 4.5 to 5.5 parts of a penetrating agent; 0.4 to 0.6 part of an antioxidant; 4.8 to 7.2 parts of a composite plant extract; the composite plant extract is prepared by compounding a polygonatum odoratum root extract, a glycyrrhiza glabra root extract and a rhodiola rosea root extract. The whitening mask has the advantage of further improving the whitening effect.

This application relates to the field of biological control, specifically disclosing a compound bacterial agent containing Bacillus thuringiensis, its preparation method, and its application. A method involves fermenting Bacillus thuringiensis HP-SYJ2 to a concentration of (3-8) × 10⁻⁶. 9 A Bacillus thuringiensis HP-SYJ2 bacterial suspension was obtained by mixing cfu / ml with hydroxyapatite and biochar, then mixing the mixture with the Bacillus thuringiensis HP-SYJ2 bacterial suspension, soaking, and air-drying until the moisture content is 30-40%, followed by maturation for 1-2 weeks to obtain the loading material. Fenugreek seed oil, emulsifier, soil penetrant, and water were mixed and sheared to obtain an emulsion with a fenugreek seed oil concentration of 0.1-0.5 wt%. The loading material and emulsion were packaged separately and mixed before application. This compound microbial agent can be used for the prevention and treatment of root rot in medicinal herbs or to promote their growth. It has the advantages of both preventing and treating root rot in medicinal herbs and promoting their growth.

The invention belongs to the field of pesticide preparations, and particularly relates to a pydiflumetofen-epoxiconazole suspending agent as well as a preparation method and application thereof. The preparation consists of the following raw materials in percentage by mass: 3-40% of an active component, 6-10% of a dispersing agent, 1-3% of a penetrating agent, 1-3% of a thickening agent, 1.5-2% of a synergist, 3-5% of an anti-freezing agent, 0.2-0.3% of a defoaming agent, 0.2-0.5% of a pH regulator, 0.1-0.3% of an antioxidant and the balance of water. By screening a suspending agent system, the prepared pydiflumetofen-epoxiconazole suspending agent is excellent in stability, the influence of environmental change on the preparation in the storage process is effectively reduced, and the traditional problems of caking, devitrification and the like of the preparation are avoided to the greatest extent.

This invention discloses a stress-resistant and yield-increasing plant growth regulator, its preparation method, and its application, belonging to the field of plant growth regulators. The stress-resistant and yield-increasing plant growth regulator of this invention comprises the following raw materials: *Suaeda salsa* extract, a stress-resistant biostimulant, propionyl brassinolide, styracil, polyaspartic acid, γ-aminobutyric acid, emulsifier, penetrant, co-emulsifier, pH buffer, and deionized water; wherein the stress-resistant biostimulant is perilla lactone. This invention significantly improves the tolerance of wheat to salt-alkali stress by strengthening the antioxidant system and osmotic regulation capacity, ensuring its basic survival and normal physiological functions; and effectively reverses stress-induced growth inhibition through mechanisms such as promoting root development, enhancing photosynthesis, and driving product translocation to grains, thereby achieving a significant yield increase under adverse conditions.

The present invention relates to an osmotic agent composition comprising an acid-sensitive polymer in a coating layer. More particularly, the present invention relates to an osmotic agent composition and a method for preparing same, the osmotic agent composition comprising an acid-sensitive polymer that can be dissolved or separated in an acidic condition so as to form a porous osmosis membrane on a coating layer of the osmotic agent composition.

The invention relates to an ultra-low volume liquid containing pyraclostrobin and tebuconazole, which belongs to the field of pesticide preparations and mainly comprises the following components in percentage by weight: 5-15% of pyraclostrobin, 5-15% of tebuconazole and the balance of water. 10%-20% of tebuconazole; 10%-20% of a cosolvent; 3%-8% of a penetrant; 5%-15% of an evaporation inhibitor; 2%-5% of a stabilizer; the total percentage is 100%. Through specific component selection and proportion optimization, the prepared liquid has proper viscosity, surface tension, volatility and specific gravity, and is especially suitable for ultra-low volume spraying and aviation pesticide application. The preparation is excellent in atomization performance, moderate in fogdrop particle size, low in drifting risk and good in deposition effect, the pesticide utilization rate can be remarkably increased, efficient and synergistic control over crop diseases is achieved, and environmental pollution is reduced.

Provided herein are polymer compositions and extended release otic agents. In one aspect, provided herein is a polymer composition including about 5% to about 15% by weight of the polymer composition of a functional polymer, wherein the functional polymer includes a first functional group, about 0.05% to about 0.6% by weight of the polymer composition of a crosslinker, wherein the crosslinker includes a second functional group, and water, wherein a crosslinking reaction can occur between the first functional group and the second functional group to form a gel, and wherein the polymer composition has a gelation time of about 45 seconds to about 60 minutes at a temperature of about 20° C.

An aqueous formulation includes a PEDF-derived short peptide (PDSP) having the sequence of one of SEQ ID NO: 1, 2, 3, 5, 6, 8, or 9; histidine having a concentration of 1 mM – 100 mM; and an antioxidant and optionally a non-ionic tonicity agent. The pH value is around 5–9. The antioxidant is nicotinamide, which is at a concentration of 50 mM – 1000 mM. The non-ionic tonicity agent is sorbitol, which is at a concentration of 0 mM – 500 mM. A concentration of the PDSP is 0.01% - 1% w / v.

This invention belongs to the field of ornamental horticulture cultivation technology, and relates to a cultivation method for promoting wound healing in bonsai using a plant hormone repair agent. This method addresses the problems of slow wound healing and susceptibility to infection during grafting and pruning of bonsai. It constructs a plant hormone repair agent composed of hormone components, antibacterial components, repair aids, penetrants, and a carrier, and integrates it with a complete "pretreatment—grafting—application—bandaging—maintenance" process. The repair agent creates a synergistic microenvironment of physiological regulation and antibacterial activity at the graft union and various cuts. Combined with sterile gauze and mulch wrapping, it reduces water loss and pathogen infection. Through temperature and humidity control during the healing period and light, water, and nutrient management during the growing season, the wound can complete continuous healing and gradual lignification in a short time. This invention significantly improves healing speed, infection control, grafting survival rate, and lignification stability, and is suitable for the standardized and large-scale cultivation of various bonsai materials.

A pharmaceutical composition to be applied to an ocular surface is disclosed that includes a quaternized chitosan derivative to provide antimicrobial activity against gram-negative bacteria, gram-positive bacteria, fungi, and viruses as an active ingredient. This is combined with a cellulose compound acting as a viscosity agent and demulcent to protect and lubricate mucous membrane surfaces. This is further combined with a humectant and tonicity agent to retain moisture on the ocular surface and maintain a comfortable osmolarity for the eye. This is further combined with a buffer / pH adjuster system configured to support a physiologically tolerable pH of about 6.0 to 8.0. Finally, this is combined with purified water as a diluent.

The invention relates to an external pain-relieving composition and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines. A formula of the external pain-relieving composition comprises the following components in parts by weight: 10-20 parts of loquat extract, 10-20 parts of folium artemisiae argyi extract, 0.3-0.5 part of radix sophorae flavescentis extract, 5-10 parts of a composite penetrant and 3-5 parts of fermented organic acid. Wherein the compound penetrating agent is prepared from the following components in parts by weight: 0.5 to 1 part of baicalein-glycyrrhetinic acid nano eutectic crystal, 6 to 10 parts of chemical penetration enhancer, 0.5 to 2 parts of carbomer and 0.1 to 0.3 part of betaine; the composition prepared by the invention has the characteristics of efficient permeability and effective relief of local pain.

Provided herein are polymer compositions and extended release otic agents. In one aspect, provided herein is a polymer composition including about 5% to about 15% by weight of the polymer composition of a functional polymer, wherein the functional polymer includes a first functional group, about 0.05% to about 0.6% by weight of the polymer composition of a crosslinker, wherein the crosslinker includes a second functional group, and water, wherein a crosslinking reaction can occur between the first functional group and the second functional group to form a gel, and wherein the polymer composition has a gelation time of about 45 seconds to about 60 minutes at a temperature of about 20° C.

The invention discloses a disinfectant with a long-acting disinfection effect and a preparation method thereof, and belongs to the technical field of disinfection materials, the disinfectant is prepared from the following raw materials by weight: 0.2%-0.5% of a bactericide, 1%-5% of a waterproof agent, 0.1%-1% of a synergist, 0.5%-2% of a corrosion inhibitor, 1%-5% of a penetrant, and the balance purified water. The weight ratio of the waterproof agent to the penetrating agent is (0.9-1.1): 2. According to the disinfectant with the long-acting disinfection effect and the preparation method of the disinfectant, through the synergistic effect of all the components, the disinfectant can continuously disinfect for more than 24 hours, the killing logarithm value is larger than or equal to 3.00 after 24 hours, the sterilization effect can still be met by only conducting common cleaning within the long-acting disinfection time of the disinfectant, and the disinfectant has the long-acting disinfection effect. The problem that a traditional disinfectant can only resist bacteria for a long time and cannot achieve a long-acting disinfection effect is solved.

A pharmaceutical composition to be applied to an ocular surface is disclosed that includes a quaternized chitosan derivative to provide antimicrobial activity against gram-negative bacteria, gram-positive bacteria, fungi, and viruses as an active ingredient. This is combined with a cellulose compound acting as a viscosity agent and demulcent to protect and lubricate mucous membrane surfaces. This is further combined with a humectant and tonicity agent to retain moisture on the ocular surface and maintain a comfortable osmolarity for the eye. This is further combined with a buffer / pH adjuster system configured to support a physiologically tolerable pH of about 6.0 to 8.0. Finally, this is combined with purified water as a diluent.

The invention relates to the technical field of food microorganisms, in particular to a long-acting slow-release antibacterial preparation targeting clostridium botulinum spores as well as a preparation method and application of the long-acting slow-release antibacterial preparation. The long-acting slow-release bacteriostatic preparation comprises a wall material and a core material, the core material comprises a lactic acid bacteria metabolite and a spore coating penetrant; the wall material is prepared from konjac glucomannan, tannic acid, polylysine salt and hyaluronic acid. By preparing a core material compound and embedding the core material compound in a wall material microcapsule, a three-layer action system of spore coating damage, skin layer degradation and core metabolism inhibition is constructed. The preparation can significantly improve the targeting and stability of antibacterial components, realizes complete substitution of nitrite in meat products, has the characteristics of safety, high efficiency and long acting, and conforms to the national food safety and health industrial policy.

The invention relates to the technical field of medicine, in particular to a vagina tightening bacteriostatic preparation and a preparation method thereof.The vagina tightening bacteriostatic preparation is prepared from, by mass, 0%-0.5% of carbomer, 5%-13% of galactomannan, 1%-6% of transient pink regulator, 0.1% of tetrahydropiperine, 4% of physalis alkekengi extracting solution and 10% of composite plant fungicide; the amount of the neutralizer is the amount which enables the pH value of the preparation to be 6.0-6.5. According to the invention, the galactomannan instantly forms a film to tighten and shrink vagina, the instant plicatin rapidly thickens vagina mucosa, the plant penetrant tetrahydropiperine promotes permeation of effective components and increases the mucosa absorbance of the effective components, so that the vagina shrinking effect is multiplied, and the plant penetrant tetrahydropiperine cooperates with other various components to achieve a synergistic effect, so that the vagina shrinking effect is improved. And a rapid and efficient vagina contracting effect is achieved.

The invention discloses a multipurpose medical dressing based on triatomic oxidized oil and a preparation method thereof. The multipurpose medical dressing comprises the following raw materials in parts by weight: 160-170 parts of triatomic oxidized oil, 30-40 parts of modified thickener and 2-7 parts of penetrant; the modified penetrant has a good bactericidal effect, and the side chain contains a long-chain quaternary ammonium salt structure and the long-chain quaternary ammonium salt is a spirocyclic structure, so that in the process of the quaternary ammonium salt inserting into the bacterial cell membrane, the perforated gap of the cell membrane is expanded, and then the cells are caused to flow out. The medical dressing has a killing effect on pathogenic microorganisms, can reduce inflammation and relieve pain, and promote wound healing. It has obvious therapeutic effects on joint pain and intractable skin diseases. It is a non-toxic product and has no irritation to skin, mucous membranes, eyes, etc. at low concentrations. Due to the small molecular weight of O3, it has a strong permeation effect on cells and tissues, and can penetrate into the 2mm below the mucosa to kill the pathogenic microorganisms in the cells and tissues.

The application belongs to the technical field of pesticide preparation, and particularly relates to a pesticide bactericide, a preparation method and application thereof. The pesticide bactericide comprises the following raw materials in percentage by weight: manganese zinc maneb 6.5%-8.5%, metalaxyl 6.5%-8.5%, amaranth fat 6.5%-8.5%, penetrating agent 5.2%-7.2% and water 67.3%-75.3%. The pesticide bactericide is prepared by compounding the above-mentioned percentage by weight of manganese zinc maneb, metalaxyl and amaranth fat with the penetrating agent and water. The bactericide can prevent and control various pathogenic diseases of tobacco seedlings and adult plants, has low toxicity and drug resistance, and has a significant prevention and control effect after being applied to tobacco seedlings, and can increase the maturation rate after being applied to adult plants.

The application belongs to the technical field of biological medicine preparation, and particularly relates to an external use ear drop for promoting auditory nerve growth and a preparation method thereof. The composition raw materials comprise the following components: active small molecules, glyceryl stearate, glyceryl monostearate, soybean lecithin, vitamin E succinate, Tween-80, chitosan quaternary ammonium salt, diethylene glycol monoethyl ether, penetration aid, penetrant, sodium cholate, N-acetyl cysteine, F127 surfactant, F68 surfactant and sodium hyaluronate. Through the synergistic effect of the crystalline lipid core, the positive chitosan quaternary ammonium salt shell, the heat-sensitive in-situ gel outer layer and the mild penetration system, the drug is long-acting retained, smoothly released and efficiently penetrated into the inner ear target area under the condition of not puncturing the eardrum, and the synergistic system significantly improves the stability, local exposure and treatment efficiency of the drug.

This invention discloses a bactericidal, scale-inhibiting, and penetrant compounded from anionic and cationic surfactants and its application, belonging to the field of water treatment science. The single-tailed, double-headed quaternary ammonium salt of this invention exhibits highly efficient bactericidal and algicidal properties. At concentrations greater than 100 mg / L, the bactericidal rate can reach over 99.1%; at concentrations greater than 120 mg / L, the algicidal rate can reach 99.8% after three days. Furthermore, this bactericide adsorbs onto the bacterial surface through strong electrostatic attraction, making it less likely for bacteria to develop drug resistance. The bactericidal, scale-inhibiting, and penetrant prepared by compounding the single-tailed, double-headed quaternary ammonium salt surfactant of this invention can adsorb onto the surface of CaCO3 crystals, preventing normal crystal growth and ultimately dispersing them in the water as loose, broken, microcrystalline particles, thus exhibiting excellent scale inhibition effects.

The application provides a low-eutectic bio-adhesive based on mixed polypeptides of Periplaneta americana and snake slough and a preparation method. Based on the application status of Periplaneta americana and snake slough in surgical diseases and external use drugs, the bio-adhesive fuses the optimal proportion of two animal polypeptide extracts and a low-eutectic solvent, and the three form a uniform composite system through a low-eutectic effect and a self-assembly process, is solidified at a diseased part through a preheating-cooling mode and plays a role. The low-eutectic solvent plays multiple roles as a cosolvent, a plasticizing excipient, a penetration enhancer, a bacteriostatic agent and an auxiliary functional substance. The preparation process is fast, the conditions are mild, special equipment is not needed and the process is easy to scale. The adhesive formula is simplified to the maximum extent, the raw materials are green, the system is stable, no other components are specially added, the operation is simple during use and the bio-adhesive is friendly and safe as an auxiliary treatment means. The whole system fully utilizes the unique activity and nursing efficacy of various components and can play a synergistic treatment role.

The invention discloses a composition with a permeation promoting effect as well as a preparation method and application thereof, and relates to the technical field of cosmetics. The composition disclosed by the invention is obtained by fermenting a fermentation substrate by thalli; the fermentation substrate is prepared from the following raw materials: a dogwood extract, creatinine and polyhydric alcohols. The composition provided by the invention has an excellent penetration promoting effect, can promote the absorption of active ingredients by skin, is free of irritation to skin temperature, is suitable for being used as a penetration promoting agent for preparing cosmetics, and improves the utilization rate of the active ingredients of the cosmetics.

The invention provides a macrocyclic polyamine supramolecular scale removal and prevention agent which comprises the following components in percentage by mass based on the total mass of the macrocyclic polyamine supramolecular complex aqueous solution: 4-6% of a solubilizer, 2-3% of a penetrant and the balance of a slow release agent, and the sum of the mass percentage of the solubilizer, the mass percentage of the penetrant and the mass percentage of the slow release agent is 100%. The mass percentage of the macrocyclic polyamine supramolecular complex aqueous solution is 0.5-2%, the macrocyclic polyamine supramolecular complex aqueous solution comprises macrocyclic polyamine, quaternary ammonium salt and water which are mixed according to the mass ratio of 1: (1-1.5): (4-6), the macrocyclic polyamine has a structure shown as a formula (I), and R1, R2, R3 and R4 are independently selected from groups of-H,-CH3,-CH2CH3 and-CH2COOH respectively. According to the macrocyclic polyamine supramolecular descaling and antiscaling agent disclosed by the invention, the descaling rate of barium sulfate can reach 88-95%, and the scale inhibition rate can reach 90-95%.

Provided herein are compositions and methods for clearing mucus (e.g., excess mucus) from the lungs. In one aspect, provided herein are methods of clearing mucus from the lungs of a subject in need thereof comprising instilling into the lungs of the subject an effective amount of a liquid pharmaceutical composition comprising an isotonic osmolyte. The liquid pharmaceutical composition (e.g., aqueous, isotonic sodium gluconate solution) may further comprise one or more additional agents selected from epithelial sodium channel (ENaC) inhibitors, osmolytes mucolytic agents, surfactants, DNases, anti-infectives, and anti-inflammatory agents. Also provided herein are liquid pharmaceutical compositions (i.e., "instillation solutions," "lavage solutions") useful in the methods described herein.

This invention relates to a method for preparing a high-fluorine chlorpyrifos-imidacloprid suspension, belonging to the field of pesticide technology. In preparing this high-fluorine chlorpyrifos-imidacloprid suspension, an synergist is added to form a water-retaining film on the surface of the droplets during residual spraying. This allows the droplets to be evenly dispersed on the object surface, preventing the liquid moisture from evaporating or being absorbed, thus improving the adhesion of the product to the target surface and prolonging its effect. The pesticide adheres to the object surface at a size of less than 5 micrometers. Upon contact with the target organism, a trace amount of penetrant promotes the absorption and activation of the active ingredient, thereby improving the efficacy. The product prepared by this invention is environmentally friendly, highly safe, and has a long-lasting effect on sanitary pests with a high contact kill rate.

The invention discloses a stress-resistant yield-increasing plant growth regulator as well as a preparation method and application thereof, and belongs to the field of plant growth regulators. The stress-resistant and yield-increasing plant growth regulator comprises the following raw materials: a suaeda glauca extract, a stress-resistant biological stimulant, propionyl brassinolide, coronatine, polyaspartic acid, gamma-aminobutyric acid, an emulsifier, a penetrant, a co-emulsifier, a pH buffer agent and deionized water. The stress resistance biological stimulant is sclareolide. By strengthening an anti-oxidation system and the osmotic regulation capability, the tolerance of wheat to saline-alkali stress is remarkably improved, and the basic survival and normal physiological functions of wheat are guaranteed; growth inhibition caused by stress is effectively reversed through the mechanisms of promoting root development, enhancing photosynthesis, driving products to be transferred to grains and the like, so that the yield is remarkably increased under the adverse situation.

The invention relates to the technical field of textile fabrics, in particular to an antibacterial and allergy-free textile fabric and a preparation process thereof.The preparation process includes the following steps that S1, pure cotton or cotton blended base cloth is soaked in a sodium carbonate aqueous solution, washed to be neutral after heat treatment and dried, and pretreated base cloth is obtained; s2, dispersing alkannin nanocapsules in deionized water to obtain dispersion liquid, adding water-soluble epoxy resin and a penetrating agent, and stirring at room temperature to obtain finishing liquid; s3, soaking the pretreated base cloth into the finishing liquid, stirring and soaking at a controlled temperature, soaking twice and rolling twice, and drying to obtain the antibacterial allergy-free textile fabric. Through the pretreatment process, the surface performance of the base cloth is improved, impurities and roughness of the surface of the base cloth are reduced, and irritation to skin is reduced. Meanwhile, the components in the finishing liquid can be tightly combined with fibers of the base cloth, so that the occurrence probability of anaphylactic reaction is reduced, and the wearing comfort and safety are improved.

The invention discloses a fosthiazate and ethylicin-based rice aphelenchoides besseyi disease environment-friendly treatment agent and a preparation method thereof, the fosthiazate and ethylicin-based rice aphelenchoides besseyi disease environment-friendly treatment agent comprises fosthiazate, ethylicin, an auxiliary agent and powder, the mass ratio of fosthiazate to ethylicin is 30: 1-1: 30, the auxiliary agent is selected from one of a filler, a dispersant, a wetting agent, a penetrant, a film-forming agent and a stabilizer, and the powder is powder. The powder is prepared from prothioconazole, imazalil, cartap and a dispersing agent; through scientific compounding of fosthiazate and ethylicin, the contact killing and systemic absorption effects on aphelenchoides besseyi are remarkably enhanced, meanwhile, the use concentration of the pesticide is reduced, damage to soil microbial communities is reduced, the environmental pressure is effectively relieved, and the prevention and control safety is improved; the photolysis stability and slow release performance of active ingredients are remarkably improved, the pesticide effect lasting time is prolonged, the pesticide application frequency is reduced, the adhesion capacity and permeation efficiency of the pesticide on the surfaces of rice leaves are enhanced through the nanometer silicon carrier, and the pesticide utilization rate is increased.

To meet the demand for alternative dosage forms, such as a dosage form that can deliver deutetrabenazine in a controlled manner over an extended period of time.SOLUTION: Provided herein are osmotic dosage forms containing deutetrabenazine for use in the treatment of, e.g., hyperkinetic movement disorders. When orally administered to a subject on a once-daily basis, the dosage forms provide a favorable pharmacokinetic profile for the active agent indicating treatment efficacy over an extended period of time.SELECTED DRAWING: None