177 results about "Otic Agents" patented technology

Transdermal delivery compositions and topical compositions for application to the skin are provided. The transdermal delivery composition includes at least two penetrants working synergistically but by disparate biochemical pathways. In one embodiment, the transdermal delivery system includes benzyl alcohol and lecithin organogel. The transdermal delivery compositions are used in a variety of topical compositions as a means of transdermally delivering and topically administering different drugs and agents, including compositions promoting collagen biosynthesis, retinoids and skin lighteners, chemical denervation agents such as BOTOX®, anti-fungal agents, anesthetics and non-steroidal anti-inflammatory drugs (NSAIDs). In addition, these topical compositions may be used in combination with non-ablative treatment modalities, such as microdermabrasion, laser-based skin remodeling and radio-frequency-based skin remodeling.

Compositions and methods are provided that include a biologically active agent and a permeabilizing agent effective to enhance mucosal delivery of the biologically active agent in a mammalian subject, in which the permeabilizing peptide is PN159, PN159 analogues, conjugates of PN159, conjugates of PN159 analogues, or complexes thereof. The permeabilizing agent reversibly enhances mucosal epithelial paracellular transport, typically by modulating epithelial junctional structure and/or physiology at a mucosal epithelial surface in the subject.

The present invention relates to methods and compositions for treating diseases ameliorated by increased mucociliary clearance and mucosal hydration by administering an effective amount of a sodium channel blocker as defined herein and an osmolyte to a subject to a subject in need of increased mucociliary clearance and mucosal hydration.

A formulation and method for delivery of bioactive substances when applied to, or within, the skin or other exterior region of a mammal. for example, a patient, includes a vasoactive agent; an osmolyte; and an active ingredient. The formulation is sufficiently hygroscopic so as to create a condition of hypertonicity when absorbed by the skin. When the formulation is applied to the skin, the vasoactive agent can be delivered to the dermis so as to contact the vasculature of a patient.

The invention provides a disinfectant with low corrosiveness. The disinfectant comprises the following components by weight percent: 0.2-2.0% of ortho-phthalaldehyde, 1-10% of a synergist, 10-50% of a cosolvent, 0.5-5% of a buffering agent, 1-10% of a penetrant, 0.2-2% of a corrosion inhibitor, 0.1-5% of a chelating agent, 0.1-3% of a stabilizing agent and 45-80% of purified water. After the disinfectant is used, intestinal tract pathogenic bacteria, pyogenic coccus, hepatitis virus, H7N9 avian influenza virus, black variant spores of bacillus subtilis and other pathogenic microorganisms can be killed within a short time. Furthermore, the disinfectant adopts a slow release technique, thus having extremely low corrosiveness on metal and being very suitable for disinfecting medical equipment.

The use of L-carnitine and its alkanoyl devivatives, optionally in the form of a pharmaceutically acceptable salt, as osmotic agents in the preparation of solutions for medical use, particularly for peritoneal dialysis, is described.

The invention discloses a disease treatment agent for fruit tree and forest tree limb, and is composed of the following compositions by mass percent: 0.5-5% of tebuconazole, 1-30% of thiophanate methyl, 1-3% of dispersant, 1-3% of wetting agent, 1-4%of antifreezing agent, 3-20% of film forming agent polyvinyl alcohol, 0.1-2.0% of colouring agent methylrosanilinium chloride, 0.5-2%of osmotic agent, 0.002-0.008% of plant growth regulation hormone naphthylacetic acid, 0.0002-0.002% of gibberellin, and 40-90% of water. The invention solves the problems of large preparation residual toxicity, short drug effect stage, slow healing, easy relapse or the like, and is used as a new medicament for protection, treatment and promoting plant growth.

The invention belongs to the technical field of chemical preparations and in particular relates to a catching agent of benzene series compounds and a preparation method thereof. The catching agent of the benzene series compounds comprises the following raw materials in parts by weight: 5-8 parts of polyacrylamide, 10-20 parts of starch, 8-15 parts of sorbic acid, 10-15 parts of sodium sorbate, 30-45 parts of plant flower extractive, 5-10 parts of penetrating agent, 15-20 parts of sepiolite powder, 1-3 parts of cerium manganese compound oxide catalyst, 5-10 parts of cross-linked rectorite, 10-20 parts of chitosan and 80-100 parts of deionized water. The catching agent of the benzene series compounds is good in absorption and long in service life, so that the pollution caused by the benzene series compounds after decoration of a house is solved; meanwhile, the catching agent of the benzene series compounds is also capable of effectively inhibiting or killing some bacteria and viruses in influenza, intestinal tract and skin; the catching agent of the benzene series compounds is beneficial to the health of people.

The invention provides anti-mosquito cloth, which is prepared after an anti-mosquito medicament is attached to cloth to be dried. The anti-mosquito medicament is formed by mixing an anti-mosquito liquid medicament and accessory ingredient solution which at least comprises a penetrating agent and a sustained release agent, wherein the mass volume concentration and the volume ratio of each composition are that: the anti-mosquito liquid medicament has over 60 percent of medicinal mass volume concentration of the liquid medicament body, and accounts for 10 to 20 percent of the anti-mosquito medicament by volume; the accessory ingredient solution accounts for 80 to 90 percent in the anti-mosquito medicament by volume; the accessory ingredient solution at least comprises the following compositions in mass volume concentration by percentage: 0.1 to 2.9 percent of the penetrating agent, and 3.7 to 11.3 percent of the sustained release agent; and the sum of the volume percentages of all components of the anti-mosquito medicament is 100 percent. The anti-mosquito liquid medicament can quickly penetrate clearances among the cloth to form excellent pull-out capacity, good washability and sustained anti-mosquito effect.

A topical oil-in-water composition of ivermectin is provided. The topical oil-in-water composition contains an oily phase, an aqueous phase and a surfactant emulsifier. The emulsion is essentially devoid of any solvents or propenetrating agents for ivermectin and any gelling agent.

The invention relates to preparation for a pinus koraiensis phytoncide finishing agent, a fabric finished by same and a finishing method thereof. The formula of the finishing agent contains 10-40g/L of pinus koraiensis phytoncide microcapsule, 10-35g/L of chitosan cross-linking agent, 2-5g/L of organic silicon soft finishing agent and 1-3g/L of penetrant. The pinus koraiensis phytoncide finishing agent is prepared according to the steps of extracting pinus koraiensis phytoncide, preparing the pinus koraiensis phytoncide microcapsule, preparing the pinus koraiensis phytoncide finishing agent, bottling and packaging. The finishing agent is applied to the finishing of the cotton fabric. The cotton fabric has the antibacterial rate for staphylococcus aureus of above 98.2%, antibacterial rate for escherichia coli of above 92.3%, antibacterial rate for candida albicans of above 90.5%, deodorization rate of above 97.2%, mite-proof rate of above 90.6% and the reducing rate of sterilizing, deodorizing and mite-proof effects of below 10% after being cleaned for more than 20 times.

The invention relates to an antifungal and antibacterial agent for a waterproof leather product and a preparation method of the antifungal and antibacterial agent. The antifungal and antibacterial agent for the waterproof leather product comprises the following components in percentage by weight: 1-6.5 percent of antifungal agent, 2-5 percent of antibacterial agent, 1-4 percent of penetrating agent, 1-4 percent of dispersion emulsion, 1-3 percent of thickening agent, 2-5 percent of anti-freezing agent, 0.05-0.1 percent of antifoaming agent and the balance of solvent. By adopting the antifungal and antibacterial agent for the waterproof leather product and the preparation method of the antifungal and antibacterial agent, provided by the invention, an efficient, low-toxicity, convenient (soaking, padding or direct spraying), water soaking-resistant and water washing-resistant antifungal effect can be achieved. In the antifungal and antibacterial agent for the waterproof leather product, a grafted quaternary ammonium salt cation antibacterial agent is added and can be organically combined with the leather product for forming a layer of antibacterial film on the surface of the leather product, so that an excellent water-resistant antibacterial effect is achieved.

The invention relates to the technical field of non-woven fabric production and application, in particular to an antibacterial finishing agent as well as an antibacterial all-cotton spunlace non-wovenfabric and a product thereof. The antibacterial finishing agent comprises organosilicon quaternary ammonium salt and a penetrant. The antibacterial all-cotton spunlace non-woven fabric comprises thefollowing preparation steps of 1, mixing the antibacterial finishing agent and water and uniformly stirring to prepare an antibacterial finishing liquid; and 2, performing antibacterial finishing on cloth by adopting the antibacterial finishing liquid; preforming drying treatment on the finished cloth, and finally winding to obtain the antibacterial all-cotton spunlace non-woven fabric. The non-woven fabric has good hydrophilic performance and does not damage the beneficial flora on the surface of a human body.

A hydrophilic liquid disinfectant for surgical operation, trauma, burn, perineal mucosa, oral mucosa, vaginal mucosa, etc is prepared through adding iodine, chlorhexidine and polyhexamthylene guanidine to non-ionic surfactant, heating, stirring, adding penetrant, phosphoric acid and water, and stirring.

The invention provides a cleaning-free compound hand sanitizer. The cleaning-free compound hand sanitizer is characterized by comprising the following components by mass-to-volume ratio: 0.45-0.55% of chlorhexidine, 0.05-0.15% of triclosan, 0.12-12% of Chinese herb extract compound, 50-60% of alcohols, 0.1-3% of nonionic surfactant, 0.5-2% of penetrant, and the balance of water. The cleaning-free compound hand sanitizer is stable in performance, broad-spectrum antibacterial, fast in sterilization, free of gooey feeling after hands are washed, good in moisturizing effect, mild in odor, and free of stimulation. The invention also discloses a preparation method of the cleaning-free compound hand sanitizer. The preparation method is simple and applicable to large-scale production and application.

Compositions for inducing a natural tan of the skin is disclosed. The compositions contain D-ribose as the active ingredient plus a penetrant to deliver D-ribose to the basal cells and dermis of the skin. Compositions further containing emollients and emulsifiers are preferred.

The invention provides an anti-crease and anti-microbial clothing finishing agent and an application method thereof. The anti-crease and anti-microbial clothing finishing agent comprises 5 to 8 parts of Blumea oil, 25 to 35 parts of chitosan, 55 to 65 parts of water-based polyurethane, 12 to 18 parts of a softening agent, 3 to 6 parts of a penetrating agent JFC and 2 to 8 parts of a catalyzer. The anti-crease and anti-microbial clothing finishing agent provided by the invention can be used for treating natural fiber and synthetic fiber fabrics as well as natural fiber and synthetic fiber blended fabric clothing, can improve the anti-crease performance of the clothing, and can further improve the biodegradability of the fabric. The clothing is soaked into the finishing agent, then pressed until the liquid take-up rate reaches 55 to 70 percent, preheated in a heat-setting machine, and then baked. The wrinkle recovery angles, in the warp direction and in the weft direction, of treated clothing are 200 to 220 degrees, the growth of staphylococcus aureus and escherichia coli is restrained remarkably, and the anti-crease and anti-microbial clothing finishing agent has an antibacterial property, and remarkable economic benefit and environmental benefit.

The invention discloses a compound disinfectant for circulating water systems, comprising benzyltribenzyl phosphonium chloride, dithiocyano-methane and copper sulfate. When the compound disinfectant is used, if certain amount of penetrant is added, the synergistic effect among drugs can be brought into full play, and not only the antibacterial activity can be effectively improved but also microorganisms can be avoided from generating resistance to drugs due to long-term use of single variety of disinfectants. The compound disinfectant of the invention has good disinfection and algae elimination effects and low use cost, simultaneously solves the problem of resistance of bacteria to common disinfectants and is suitable for circulating cooling water systems, reclaimed water circulating systems, clean drainage recycling systems or other circulating water systems.

The present invention belongs to the field of medicine technology, and is especially oral loratadine disintegrating tablet for treating allergic diseases and its preparation process. The oral loratadine disintegrating tablet includes loratadine as effective medicine component, and excipient mixture comprising disintegrating agent, stuffing, soluble polyol and penetrant. The oral loratadine disintegrating tablet consists of loratadine 20-50 wt%, disintegrating agent 5-15 wt%, stuffing 10-30 wt%, soluble polyol 30-60 wt%, and penetrant 1-5 wt%. The oral loratadine disintegrating tablet, after being disintegrated fast, can cover gastrointestinal mucous membrane widely, and has fast acting, no first pass effect, high bioavailability, and convenient taking.

The invention belongs to the technical field of pesticides and discloses a wettable powder containing fluroxypyr, florasulam and carfentrazone-ethyl. The compounded wettable powder is prepared with the fluroxypyr, the florasulam and the carfentrazone-ethyl as main active components according to the mass ratio of 0.1-60:0.1-40:0.1-80. The total mass percentage content of the fluroxypyr, the florasulam and the carfentrazone-ethyl in the wettable powder is 1-90%. The aqueous agent also includes 1-20% of a dispersing agent, 1-10% of a wetting agent, 0-10% of a speader, 0-15% of a permeating agent and the balanced being filling materials. The wettable powder is safe and convenient to store and transport. By means of combination of the herbicides, the wettable powder is enlarged in weeding spectrum and is improved in weeding effect. The wettable powder is wide in the weeding spectrum, is quick in effects, is long in lasting period, can delay the drug resistance, is complete in weeding, is low in residue, is low in toxicity and is safe and environmental-protective. The wettable powder is an excellent chemical herbicide.

This invention relates to the topical treatment of the Carpal Tunnel Syndrome by the use of a selected protein kinase C inhibitor and an effective penetrating agent selected from lecithin organogel or poloxamer 407 lecithin organogel. The protein kinase C inhibitors may be selected from sphingosine, sphinganine, phytosphingosine, curcumin, tetrahydrocurcumin, curcuminoids or apigenin.

The invention discloses a biological environmental antiviral cold prevention toothpaste and a preparation method thereof. The toothpaste contains the following components of: alkyl polyglucoside (APG), precipitated silica, lysozyme, neutral protease, hydrolyzed protein, immunoglobulin, recombinant human epidermal growth factor, strontium chloride, sorbitol, butylparaben, CMC (Carboxyl methyl Cellulose), xanthan gum, glucolase, enzyme, and a skin penetrating agent, etc. The invention is directed at the pathogenic mechanism that illness finds its way in by the mouth and nose, and the biologicalenvironmental antiviral cold prevention toothpaste with bio-environmental protection, virus resisting, cold prevention, as well as disease prevention and treatment effects is designed and prepared. During use, the toothpaste of the invention has cool, refreshing, icy and fragrant mouthfeel, and decomposes rapidly after entering the mouth. After tooth brushing, the ice-cold and refreshing feel remains for a long time, the bacteriostatic control time is long, the mouthfeel is refreshing, the taste is fragrant and bittersweet, and the spirit can be made cheerful, so that the toothpaste of the invention is beneficial to human health.

A wound nursing liquid for controlling infection and promoting healing of wound contains proportionally Ag ion powder, gelatin, binary acid, penetrant, tartaric acid and purified water. Its preparing process is also disclosed.

The invention relates to a carvacrol emulsion in water and a preparation method thereof. The carvacrol emulsion in water comprises, by weight, 1-20% of carvacrol, 6-15% of a solvent, 1-3% of a penetrating agent, 1-3% of an anti-freezing agent, 0.3-1% of a defoaming agent, 0.05-0.4% of a stabilizing agent, 6-12% of a surfactant, 6-10% of a sustained-release agent and 6-10% of a co-solvent, with the balance being water. The active components and preferable auxiliary agents of the carvacrol emulsion in water are all environment-friendly and has extremely low toxicity and little side effect, and can be applied in any countries all over the world without restriction. The carvacrol emulsion in water has high stability, good bactericidal and insecticidal effects and sustained-release effect; and the preparation method is simple and has no pollution.