An anti-allergy, whitening and freckle-removing composition and its preparation method

Abstract

The present invention relates to an anti-allergy, whitening and freckle-removing composition and a preparation method thereof. The anti-allergy, whitening and freckle-removing composition is composed of the following components in mass fractions: 0.5-2% of Kalanchoe extract, 0.5-2% of Cornus controversa Hance extract, 0.5-2% of Yucca filamentosa extract, 0.5-2% of Chrysanthemum cinerariifolium extract, 1-3% of VC ethyl ether, 0.5-5% of arbutin, 0.1-2% of 4-butylresorcinol, 1-10% of niacinamide, 3-15% of humectant, 3-15% of emollient, 0.5-2% of penetrant, and the balance being water. The anti-allergy, whitening and freckle-removing composition is added with Kalanchoe extract, Cornus controversa Hance extract, Yucca filamentosa extract and Chrysanthemum cinerariifolium extract. Through the synergistic effect of the four extracts, the anti-allergy, whitening and freckle-removing composition has little irritation while maintaining excellent whitening and freckle-removing effects.

Description

Technical Field

[0001] The present invention relates to the technical field of skin care products, and more specifically, to an anti-allergic, whitening and freckle-removing composition and a preparation method thereof. Background Art

[0002] The formation of skin pigmentation is the result of pigment deposition on the skin under the influence of factors such as ultraviolet rays, hormones, genetics, and aging. Whitening and freckle-removing creams are commonly used whitening and freckle-removing products. A whitening and freckle-removing cream refers to an emulsified cream for skin that has a certain inhibitory, dissolving, and removing effect on dull skin, uneven skin tone, and skin surface pigmentation. Such products mainly achieve the purpose of freckle removal by adding whitening and freckle-removing additives that inhibit and reduce melanin in the cream matrix. Currently, commonly used whitening and freckle-removing additives include arbutin, kojic acid, vitamin C derivatives, fruit acids, and some traditional Chinese medicine extracts. For example, a Chinese patent named a whitening and anti-aging skin care composition provides a skin care product using arbutin, vitamin C ethyl ether, and niacinamide as whitening ingredients.

[0003] With the change of the external environment (such as ultraviolet rays, pollution, etc.) and the use of a large number of cosmetics, a series of skin problems follow, such as irritation, allergy, redness and swelling, and gradually form sensitive skin. For sensitive skin, if a skin care product with high content and multiple whitening and freckle-removing additives is used for freckle removal, the irritation is too large, making the fragile skin more intolerant, and even easily leading to disfigurement.

[0004] Therefore, it is necessary to solve the problems of large irritation, inapplicability to sensitive skin, and instability of current skin care products with high content of whitening and freckle-removing additives. Summary of the Invention

[0005] The primary object of the present invention is to overcome the problems of large irritation and inapplicability to sensitive skin of current skin care products with high content of whitening and freckle-removing additives, and to provide an anti-allergic, whitening and freckle-removing composition.

[0006] A further object of the present invention is to provide a preparation method of the above anti-allergic, whitening and freckle-removing composition.

[0007] The above objects of the present invention are achieved by the following technical solutions:

[0008] An anti-allergic, whitening and freckle-removing composition is composed of the following components in mass fractions:

[0009] 0.5 - 2% of Kalanchoe extract, 0.5 - 2% of Alstonia scholaris extract, 0.5 - 2% of Yucca filamentosa extract, 0.5 - 2% of Chrysanthemum coccineum extract, 1 - 3% of VC ethyl ether, 0.5 - 5% of arbutin, 0.1 - 2% of 4-butylresorcinol, 1 - 10% of niacinamide, 3 - 15% of humectant, 3 - 15% of emollient, 0.5 - 2% of penetrant, and the balance is water.

[0010] Kalanchoe extract. Kalanchoe (NARCISSUS JONQUILLA), also known as Christmas kalanchoe, contains carotenoids, papilioxanthin, flavoxanthin, rubixanthin, volatile oil, malic acid, pentadecanoic acid, salicylic acid, alkaloids, organic enzymes, etc. The roots of Kalanchoe contain triterpenoid components, etc. The seeds contain fatty oil, lauric acid, glyceride, sterol, alkaloids, etc. The Kalanchoe extract selected in the present invention is from the petals of Kalanchoe.

[0011] Cornus controversa extract. Cornus controversa contains relatively more indole alkaloids, and also contains α-amyrin acetate, lupeol acetate, and volatile oil components. In the folk of our country, the bark can be used to treat headache, cold, whooping cough, bronchitis, pregnancy vomiting, ulcer bleeding, etc.

[0012] Yucca vera extract. The main functions of Yucca vera are skin conditioner, antioxidant, and it has a certain effect on eliminating free radicals, indicating its antioxidant effect; it has a promoting effect on the decomposition of fat and can be used as a weight loss product. In addition, it can be used as an antibacterial agent and a mite allergy inhibitor. The components of Yucca vera extract are suitable for 8 types of skin, namely wrinkled skin, pigmented skin, firming skin, dry skin, oily skin, sensitive skin, tolerant skin, and non-pigmented skin.

[0013] Chrysanthemum coccineum extract. 27 kinds of triterpenoid compounds with anti-inflammatory effects can be isolated from the flowers of Chrysanthemum coccineum. The inflorescence contains pyrethrin, apigenin, and luteolin. Apigenin is a natural flavonoid compound, which is widely distributed in various food-derived plant foods such as vegetables, fruits, leguminous plants, and tea. A large number of studies on apigenin have shown that this special natural compound has potential antioxidant, anti-cancer, antiviral, and autoimmunity-enhancing and other biological activity characteristics. Luteolin is a flavonoid compound with various pharmacological activities, which can be anti-tumor, antioxidant, and antibacterial.

[0014] The anti-allergic, whitening and freckle-removing composition of the present invention is compounded with four whitening agents, namely VC ethyl ether, arbutin, 4-butylresorcinol, and niacinamide, and has excellent whitening and freckle-removing effects; on this basis, the present invention also adds Kalanchoe extract, Cornus controversa extract, Yucca vera extract, and Chrysanthemum coccineum extract. Through the synergistic effect of the four extracts, the anti-allergic, whitening and freckle-removing composition has less irritation while maintaining excellent whitening and freckle-removing effects. In particular, when the content of the whitening agent is relatively high (the content of VC ethyl ether is higher than 2%, the content of arbutin is higher than 2%, the content of 4-butylresorcinol is higher than 1%, and the content of niacinamide is higher than 5%), the irritation of the anti-allergic, whitening and freckle-removing composition is still relatively low and is suitable for sensitive skin.

[0015] Preferably, the anti-allergy, whitening and freckle-removing composition is composed of the following components by mass fraction: 1-2% of Kalanchoe extract, 1-2% of Cornus controversa Hance extract, 1-2% of Yucca gloriosa extract, 1-2% of Chrysanthemum cinerariifolium extract, 2.5-3% of VC ethyl ether, 3-5% of arbutin, 1.5-2% of 4-butylresorcinol, 7-10% of niacinamide, 4-12% of humectant, 4-12% of emollient, 1-2% of penetrant, and the balance being water.

[0016] Preferably, the arbutin is α-arbutin.

[0017] By regulating the dosage of each component, the dosage of the whitening agents (VC ethyl ether, arbutin, 4-butylresorcinol and niacinamide) is at a relatively high level, so that the anti-allergy, whitening and freckle-removing composition has better whitening and freckle-removing effects and still has relatively low irritation.

[0018] Preferably, the humectant is at least one of sodium hyaluronate, glycerol polyether-26, glycerol, butanediol or filtrate of yeast fermentation product.

[0019] More preferably, the humectant comprises the following components in parts by weight: 0.01-1 part of sodium hyaluronate, 1-5 parts of glycerol polyether-26, 3-10 parts of glycerol, 3-10 parts of butanediol and 0.1-1 part of filtrate of yeast fermentation product.

[0020] Selecting a compound humectant can make the anti-allergy, whitening and freckle-removing composition have better whitening effect and less irritation.

[0021] Preferably, the emollient is at least one of hydrogenated lecithin, cyclopentasiloxane, caprylic / capric triglyceride, cetearyl alcohol, glyceryl stearate, PEG-100 stearate or behenyl alcohol.

[0022] Preferably, the penetrant is isosorbide dimethyl ether.

[0023] The Kalanchoe extract, Cornus controversa Hance extract, Yucca gloriosa extract and Chrysanthemum cinerariifolium extract can be obtained by commercial purchase or can be prepared by oneself.

[0024] Preferably, the Kalanchoe extract, Cornus controversa Hance extract, Yucca gloriosa extract and Chrysanthemum cinerariifolium extract are obtained by microwave extraction method.

[0025] The mechanism of microwave extraction can be considered from two aspects. On the one hand, in the process of microwave radiation, high-frequency electromagnetic waves penetrate the extraction medium and reach the vascular bundles and alveolar systems inside the material. Due to the absorption of microwave energy, the temperature inside the cells rises rapidly, causing the internal pressure of the cells to exceed the expansion tolerance of the cell wall, and the cells rupture. The effective components inside the cells flow out freely and are captured and dissolved by the extraction medium under lower temperature conditions. Through further filtration and separation, the extracted material is obtained. On the other hand, the electromagnetic field generated by the microwave accelerates the diffusion rate of the components to be extracted towards the interface of the extraction solvent. When using an aqueous extraction solvent, under the microwave field, water molecules rotate at high speed and enter the excited state, which is a high-energy unstable state. Or the water molecules vaporize, strengthening the driving force of the extraction components; or the water molecules themselves release energy and return to the ground state, and the released energy is transferred to other substance molecules, accelerating their thermal motion, shortening the time for the molecules of the extraction components to diffuse from inside the material to the interface of the extraction solvent, thus increasing the extraction rate by several times. At the same time, the extraction temperature is also reduced, ensuring the quality of the extraction to the greatest extent.

[0026] More preferably, the extractant for the microwave extraction method is an aqueous solution of butanediol with a mass fraction of 45-55%.

[0027] More preferably, the microwave frequency of the microwave extraction method is 400-250000 MHz.

[0028] The preparation method of the above anti-allergy, whitening and freckle-removing composition includes the following steps:

[0029] S1. Mix the extracts of Kalanchoe blossfeldiana, extracts of Alstonia scholaris, extracts of Yucca gloriosa, extracts of Chrysanthemum coccineum, VC ethyl ether, arbutin, 4-butylresorcinol, niacinamide, humectant, penetrant and water, and heat to 70-85 °C to obtain a mixture for standby; heat the emollient to 70-85 °C for standby.

[0030] S2. Homogenize the mixture and the heated emollient to obtain the anti-allergy, whitening and freckle-removing composition.

[0031] Preferably, in step S1, mix the extracts of Kalanchoe blossfeldiana, extracts of Alstonia scholaris, extracts of Yucca gloriosa, extracts of Chrysanthemum coccineum, VC ethyl ether, arbutin, 4-butylresorcinol, niacinamide, humectant, penetrant and water, and heat to 80-85 °C to obtain a mixture for standby; heat the emollient to 80-85 °C for standby.

[0032] Compared with the prior art, the beneficial effects of the present invention are:

[0033] The anti-allergy, whitening and freckle-removing composition of the present invention is compounded with four whitening agents, namely VC ethyl ether, arbutin, 4-butylresorcinol and niacinamide, and has excellent whitening and freckle-removing effects. On this basis, the present invention also adds extracts of Kalanchoe blossfeldiana, Cornus controversa Hance, Yucca gloriosa and Chrysanthemum cinerariifolium, and through the synergistic effect of the four extracts, the anti-allergy, whitening and freckle-removing composition has less irritation while maintaining excellent whitening and freckle-removing effects. In particular, when the content of the whitening agent is relatively high (when the content of VC ethyl ether is higher than 2%, the content of arbutin is higher than 2%, the content of 4-butylresorcinol is higher than 1%, and the content of niacinamide is higher than 5%), the irritation of the anti-allergy, whitening and freckle-removing composition is still relatively low, and it is suitable for sensitive skin. Description of the Drawings

[0034] Figure 1 It is a photograph of a certain zebrafish after incubation in the melanin inhibition rate test experiment of the anti-allergy, whitening and freckle-removing composition of Example 1.

[0035] Figure 2 It is a photograph of a certain zebrafish after incubation in the melanin inhibition rate test experiment of the anti-allergy, whitening and freckle-removing composition of Example 2. Detailed Embodiments

[0036] In order to more clearly and completely describe the technical solution of the present invention, the following further details the present invention through specific examples. It should be understood that the specific examples described herein are only used to explain the present invention and are not used to limit the present invention, and various changes can be made within the scope defined by the claims of the present invention.

[0037] The descriptions of the raw materials selected in the examples and comparative examples of the present invention are as follows:

[0038] Extracts of Kalanchoe blossfeldiana, Cornus controversa Hance, Yucca gloriosa and Chrysanthemum cinerariifolium are obtained by microwave extraction method: the raw materials are Kalanchoe blossfeldiana petals, Cornus controversa Hance, Yucca gloriosa petals and Chrysanthemum cinerariifolium petals respectively, the extraction solvent is 50% butylene glycol solution, and the microwave frequency is 2450 MHz;

[0039] VC ethyl ether: the purity is 99%;

[0040] Arbutin: α-arbutin, the purity is 99%;

[0041] 4-butylresorcinol: the purity is 99%;

[0042] Niacinamide: the purity is 99%;

[0043] Humectant: includes the following components by weight: 0.1 part of sodium hyaluronate, 5 parts of glycerol polyether-26, 3 parts of glycerol, 3 parts of butylene glycol and 0.2 part of yeast fermentation product filtrate;

[0044] Emollient: Cyclopentasiloxane, with a purity of 100%;

[0045] Water: Deionized water;

[0046] Unless otherwise specified, other raw materials and reagents are those that can be obtained from commercial channels such as the conventional market.

[0047] Examples 1 - 5

[0048] Examples 1 - 5 provide a series of anti - allergic, whitening, and freckle - removing compositions, and their formulations are shown in Table 1.

[0049] The preparation methods of the anti - allergic, whitening, and freckle - removing compositions in each example include the following steps:

[0050] S1. Mix the extracts of Kalanchoe blossfeldiana, Alstonia scholaris, Yucca filamentosa, Chrysanthemum cinerariifolium, VC ethyl ether, arbutin, 4 - butylresorcinol, niacinamide, humectant, and water, and heat to 70 - 85°C to obtain a mixture for standby; heat the emollient to 70 - 85°C for standby;

[0051] Among them, in Examples 1 - 3, the extracts of Kalanchoe blossfeldiana, Alstonia scholaris, Yucca filamentosa, Chrysanthemum cinerariifolium, VC ethyl ether, arbutin, 4 - butylresorcinol, niacinamide, humectant, and water are mixed and heated to 80°C; the emollient is heated to 80°C. In Example 4, the extracts of Kalanchoe blossfeldiana, Alstonia scholaris, Yucca filamentosa, Chrysanthemum cinerariifolium, VC ethyl ether, arbutin, 4 - butylresorcinol, niacinamide, humectant, and water are mixed and heated to 70°C; the emollient is heated to 70°C. In Example 5, the extracts of Kalanchoe blossfeldiana, Alstonia scholaris, Yucca filamentosa, Chrysanthemum cinerariifolium, VC ethyl ether, arbutin, 4 - butylresorcinol, niacinamide, humectant, and water are mixed and heated to 85°C; the emollient is heated to 85°C.

[0052] S2. Homogenize the mixture and the heated emollient to obtain the anti - allergic, whitening, and freckle - removing composition.

[0053] Table 1 Formulations of the anti - allergic, whitening, and freckle - removing compositions in Examples 1 - 5 (mass fraction %)

[0054]

[0055]

[0056] Comparative Examples 1 - 5

[0057] Comparative Examples 1 - 5 provide a series of anti - allergic, whitening, and freckle - removing compositions, and their formulations are shown in Table 2.

[0058] The preparation methods of the anti-allergy, whitening and freckle-removing compositions of each proportion include the following steps:

[0059] S1. Mix the components except the emollient, heat to 80 °C to obtain a mixture, and set aside; heat the emollient to 80 °C and set aside.

[0060] S2. Homogenize the mixture and the heated emollient to obtain the product.

[0061] Table 2 Formulations of the anti-allergy, whitening and freckle-removing compositions of Comparative Examples 1-5 (mass fraction %)

[0062]

[0063]

[0064] Performance Test

[0065] 1. Human skin irritation test experiment:

[0066] Select 60 female volunteers with healthy skin, aged between 20 and 50 years old, and the flexor side skin of each volunteer's forearm is the test site.

[0067] Adopt the closed patch test method. Each patch tester has 10 slots. Add the anti-allergy, whitening and freckle-removing composition of Example 1 to Slot 1 of the patch tester, the anti-allergy, whitening and freckle-removing composition of Example 2 to Slot 2, the anti-allergy, whitening and freckle-removing composition of Example 3 to Slot 3, the anti-allergy, whitening and freckle-removing composition of Example 4 to Slot 4, the anti-allergy, whitening and freckle-removing composition of Example 5 to Slot 5, the anti-allergy, whitening and freckle-removing composition of Comparative Example 1 to Slot 6, the anti-allergy, whitening and freckle-removing composition of Comparative Example 2 to Slot 7, the anti-allergy, whitening and freckle-removing composition of Comparative Example 3 to Slot 8, the anti-allergy, whitening and freckle-removing composition of Comparative Example 4 to Slot 9, and the anti-allergy, whitening and freckle-removing composition of Comparative Example 5 to Slot 10, and the addition amount is 0.02 g for each; then stick the patch tester firmly on the test site of the volunteer. The patch test time is 48 h; after 48 h, remove the patch tester, and observe and record the test results 30 min later, and count the number of people with different reactions. The identification criteria for different reactions are shown in Table 3.

[0068] Table 3 Identification criteria for the results of the human skin irritation test

[0069]

[0070] The test results are shown in Table 4 below.

[0071] Table 4 Test results of the human skin irritation test

[0072]

[0073]

[0074] As can be seen from Table 4, the irritations of the anti-allergy, whitening and freckle-removing compositions in Examples 1 to 5 are all relatively small; for the anti-allergy, whitening and freckle-removing compositions in Comparative Examples 1 to 4, a certain extract was not added, and there were many suspicious reactions in their test results, and positive reactions or erythema reactions also occurred. This indicates that there is a synergistic effect among Kalanchoe extract, Alstonia scholaris extract, Yucca filamentosa extract and Chrysanthemum cinerariifolium extract, making the anti-allergy, whitening and freckle-removing composition have small irritation while maintaining excellent whitening and freckle-removing effects.

[0075] 2. Melanin inhibition rate test experiment (zebrafish embryo test method)

[0076] The anti-allergy, whitening and freckle-removing compositions of Example 1 and Example 2 were tested according to the group standard T / SHRH 036-2021 "Cosmetics Melanin Inhibition Test - Zebrafish Embryo Test Method". After calculation, the melanin inhibition rate of the anti-allergy, whitening and freckle-removing composition of Example 1 was 84%, and the melanin inhibition rate of the anti-allergy, whitening and freckle-removing composition of Example 2 was 24%; the dosages of the whitening agents (VC ethyl ether, arbutin, 4-butylresorcinol and niacinamide) in the anti-allergy, whitening and freckle-removing compositions of Examples 3 to 5 were higher than those of Example 1, and the melanin inhibition rate was higher.

[0077] For the melanin inhibition rate test of the anti-allergy, whitening and freckle-removing composition of Example 1, a photo of a certain zebrafish after the incubation ended is as Figure 1 shown; for the melanin inhibition rate test of the anti-allergy, whitening and freckle-removing composition of Example 2, a photo of a certain zebrafish after the incubation ended is as Figure 2 shown. From Figure 1 and Figure 2 it can be seen that the colors on the backs of the zebrafish are all very light, among which the color of Example 1 is significantly lighter than that of Example 2.

[0078] The melanin inhibition rate test experiment shows that the anti-allergy, whitening and freckle-removing composition of the present application has good whitening and freckle-removing effects.

[0079] Obviously, the above-mentioned embodiments of the present invention are merely examples for clearly illustrating the present invention, and are not intended to limit the implementation manners of the present invention. For those of ordinary skill in the art, other different forms of changes or modifications can be made on the basis of the above description. It is not necessary and impossible to enumerate all the implementation manners here. Any modifications, equivalent replacements and improvements made within the spirit and principle of the present invention shall be included within the protection scope of the claims of the present invention.

Claims

1. An anti-allergy, whitening and freckle-removing composition, characterized in that, It is composed of the following components by mass fraction: Kalanchoe extract 0.5 - 2%, Alstonia scholaris extract 0.5 - 2%, Yucca filamentosa extract 0.5 - 2%, Chrysanthemum coccineum extract 0.5 - 2%, VC ethyl ether 1 - 3%, arbutin 0.5 - 5%, 4 - butylresorcinol 0.1 - 2%, niacinamide 1 - 10%, humectant 3 - 15%, emollient 3 - 15%, penetrant 0.5 - 2%, and the balance is water; The Kalanchoe extract, Alstonia scholaris extract, Yucca filamentosa extract, and Chrysanthemum coccineum extract are obtained by microwave extraction method; The extractant for the microwave extraction method is an aqueous solution of butanediol with a mass fraction of 45 - 55%; The microwave frequency of the microwave extraction method is 400 - 250000 MHz.

2. The anti-allergy, whitening and freckle-removing composition according to claim 1, characterized in that, It is composed of the following components by mass fraction: Kalanchoe extract 1 - 2%, Alstonia scholaris extract 1 - 2%, Yucca filamentosa extract 1 - 2%, Chrysanthemum coccineum extract 1 - 2%, VC ethyl ether 2.5 - 3%, arbutin 3 - 5%, 4 - butylresorcinol 1.5 - 2%, niacinamide 7 - 10%, humectant 4 - 12%, emollient 4 - 12%, penetrant 1 - 2%, and the balance is water.

3. The anti-allergy, whitening and freckle-removing composition according to claim 1, characterized in that, The arbutin is α - arbutin.

4. The anti-allergy, whitening and freckle-removing composition according to claim 1, characterized in that, The humectant is at least one of sodium hyaluronate, glycerol polyether - 26, glycerol, butanediol, or filtrate of yeast fermentation product.

5. The anti-allergy, whitening and freckle-removing composition according to claim 4, characterized in that, The humectant includes the following components by weight: 0.01 - 1 part of sodium hyaluronate, 1 - 5 parts of glycerol polyether - 26, 3 - 10 parts of glycerol, 3 - 10 parts of butanediol, and 0.1 - 1 part of filtrate of yeast fermentation product.

6. The anti-allergy, whitening and freckle-removing composition according to claim 1, characterized in that, The emollient is at least one of hydrogenated lecithin, cyclopentasiloxane, caprylic / capric triglyceride, cetearyl alcohol, glyceryl stearate, PEG - 100 stearate, or behenyl alcohol; the penetrant is isosorbide dimethyl ether.

7. A method for preparing the anti-allergy, whitening and freckle-removing composition according to any one of claims 1 to 6, characterized in that, It includes the following steps: S1. Mix the Kalanchoe extract, Alstonia scholaris extract, Yucca filamentosa extract, Chrysanthemum coccineum extract, VC ethyl ether, arbutin, 4 - butylresorcinol, niacinamide, humectant, penetrant, and water, and heat to 70 - 85 °C to obtain a mixture for standby; heat the emollient to 70 - 85 °C for standby; S2. Homogenize the mixture and the heated emollient to obtain the anti - allergic, whitening, and freckle - removing composition.

8. The preparation method according to claim 7, characterized in that, In step S1, mix the Kalanchoe extract, Alstonia scholaris extract, Yucca filamentosa extract, Chrysanthemum coccineum extract, VC ethyl ether, arbutin, 4 - butylresorcinol, niacinamide, humectant, penetrant, and water, and heat to 80 - 85 °C to obtain a mixture for standby; heat the emollient to 80 - 85 °C for standby.

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