30results about "Quinone preparation" patented technology

The invention discloses a synthesis method of 9-dichloromethylene-5-amino-benzonorbornene and an intermediate product, the synthesis method comprises the following steps: firstly, synthesizing a cyclization compound 1 as shown in a formula 1 from a cold solution of 6, 6-dichlorofulvene and 1, 4-benzoquinone under the action of a solution of a catalyst I, carrying out oximation reaction on the cyclization compound 1 prepared in the step a and hydroxylamine salt under an alkaline condition, and carrying out post-treatment to obtain the 9-dichloromethylene-5-amino-benzonorbornene. Under the action of a catalyst II, adding the oximate 2 prepared in the step b into a closed container, carrying out hydrogenation reduction to obtain 9-dichloromethylene-5-amino-benzo norbornene, and directly treating the reduction product with acid to obtain 9-dichloromethylene-5-amino-benzo norbornene, namely the 9-dichloromethylene-5-amino-benzo norbornene, namely the 9-dichloromethylene-5-amino-benzo norbornene. According to the method, the cyclization compound is oximated firstly, then the residual carbonyl and two double bonds on the ring are subjected to one-step reduction through catalytic hydrogenation, the working procedure is optimized, meanwhile, reduction by using expensive sodium borohydride is avoided, the method is short in synthesis route and suitable for industrialization, and the production cost is reduced.

The invention discloses a non-planar pi-conjugated naphthoquinone derivative with an asymmetric structure, a preparation method of the non-planar pi-conjugated naphthoquinone derivative and application of the non-planar pi-conjugated naphthoquinone derivative in an aqueous flow battery, and relates to the technical field of electrochemical energy storage. Methyl 4-aminobenzoate is added into hydrochloric acid, then the mixture and sodium nitrite are dissolved in water to be mixed to obtain a diazonium salt solution, and 2-hydroxy-1, 2, 4-triazole is added into the diazonium salt solution to be mixed to obtain a diazonium salt solution; 2, 4-naphthoquinone is dissolved in a KOH solution and mixed with a diazonium salt solution, after hydrochloric acid acidification, acetic acid recrystallization purification is conducted, and BANQ is obtained; the capacity fading rate of the modified naphthoquinone derivative BANQ is as low as 0.00018% per circle, the modified naphthoquinone derivative BANQ shows excellent cycling stability and redox reversibility, the BANQ molecule has an asymmetric non-planar pi conjugation characteristic, and the sensitivity of a redox core to nucleophilic / electrophilic attack is greatly reduced, so that the cycling stability is improved, and the service life is prolonged. And a new direction and possibility are provided for constructing green sustainable large-scale organic redox active molecules for energy storage through artificial modification of natural products.

The present invention relates to the synthetic functionalization of an anthraquinone molecule substituted with at least one hydroxyl or amino group. In some aspects of the invention, a mixture containing the anthraquinone starting material, an aldehyde, a base, an optional solvent, and an optional catalyst is reacted with hydrogen, and then with an oxidizing agent. In other aspects of the invention, the synthetic functionalization of the anthraquinone molecule is carried out electrochemically, rather than chemically, using a divided electrolytic cell.

The application belongs to the field of medicine synthesis, and specifically provides a daunorubicin intermediate compound. The daunorubicin can be synthesized by pure chemical synthesis by using the intermediate compound. The daunorubicin is synthesized by taking 2,5-dihydroxybenzyl alcohol as a raw material. The route has low raw material cost, mild reaction condition, convenient post-treatment, high total yield, and good industrial application prospect.

The utility model discloses a kettle type and pipe type 2-alkylanthraquinone synthesis device for continuous ring-closure reaction, which is characterized in that BE acid and fuming sulfuric acid can be slowly dissolved and prepared and temporarily stored through a dissolving kettle at low temperature, so that unnecessary organic matters possibly derived in the dissolving step are reduced; steam with stable temperature circulates in an interlayer of the reaction tube, compared with containers such as tanks and cylinders, the reaction tube can quickly heat a dissolving solution in a smaller and more uniform heat exchange volume and a larger heat exchange area ratio, the dissolving solution can be quickly switched to a required reaction temperature and then is stabilized at the reaction temperature, and the product yield is increased by 10-15%; the closed-loop liquid obtained by the tubular reactor can be immediately cooled by the cooler, and the quickly cooled closed-loop liquid can be immediately collected.

This invention belongs to the technical field of 2-pentylanthraquinone production equipment, specifically a continuous closed-loop reaction device for preparing 2-pentylanthraquinone and its usage method. Addressing the problems of low preparation efficiency, long preparation time, high labor intensity for employees, and air pollution caused by released gases in existing technologies, the following solution is proposed: a workbench, with a gas conversion box rotatably connected to the top of the workbench, a rotating disk fixedly connected to the top of the gas conversion box, multiple connecting plates fixedly connected to the outer wall of the rotating disk, and gaskets fixedly connected to the top of the connecting plates. In this invention, the cooperation of a first magnet and a second magnet can drive the rotating shaft, a first slide rod, and a second slide rod to move up and down, thereby automatically completing stirring, depressurization, gas collection, and mixed liquid collection operations without manual operation, reducing the labor intensity of workers. Furthermore, multiple closed-loop reaction vessels react sequentially, improving the preparation efficiency of the mixed liquid.

The application belongs to the field of medicine synthesis, and particularly relates to a chemical synthesis method of an epirubicin intermediate, daunorubicin. The daunorubicin is synthesized by taking 2,5-dihydroxybenzyl alcohol as raw material, the route has low raw material cost, mild reaction condition, convenient post-treatment, high total yield, and has a good industrial application prospect.

The invention discloses a synthesis method of 1, 1-diarylethene, which comprises the following steps: by taking aryl fluorosulfonate and sulfonyl hydrazone as raw materials, in the presence of a palladium catalyst, a ligand, alkali and an organic solvent, heating to carry out coupling reaction, and after the reaction is finished, carrying out post-treatment to obtain a 1, 1-diarylethene compound. The method has the advantages that the aryl fluorosulfonate reagent is easy to prepare and store, the reaction selectivity is high, the functional group compatibility is good, the substrate application range is wide and the like, and the yield is as high as 91%. As the 1, 1-diarylethene compound is an important functional molecular skeleton structure, the 1, 1-diarylethene compound has very wide application in the fields of fine chemical engineering and pharmacy; therefore, the method has great application value and social and economic benefits.

The invention relates to the technical field of synthesis, and provides a buparvaquone preparation method, which comprises: S1, carrying out a reaction on tetrahydrofuran, sodium hydride, p-tert-butyl cyclohexanone and triethyl phosphoryl acetate to prepare an intermediate 1; s2, carrying out hydrogenation reaction on the intermediate 1 under the action of a catalyst to obtain an intermediate 2; s3, carrying out hydrolysis reaction on the intermediate 2 to obtain an intermediate 3; and S4, carrying out C-C coupling reaction on the intermediate 3, and finally, carrying out heating reaction under the catalysis of potassium hydroxide to obtain buparvaquone. The intermediate 1 is 4-tert-butyl cyclohexane subunit ethyl acetate; the intermediate 2 is 4-tert-butyl cyclohexyl ethyl acetate; the intermediate 3 is 4-tert-butyl cyclohexyl acetic acid; the carrier of the catalyst is diatomite, and the active components are alloyed Pd and Fe. Through the technical scheme, the problem of low total yield of buparvaquone in the prior art is solved.

The application is suitable for the technical field of reaction devices, and provides a reaction device for synthesizing 2-pentylanthraquinone, which comprises a bottom plate, a support frame fixed on the bottom plate, and a reaction barrel fixed on the support frame, and further comprises a sealing cover, a first rotating disc, a guide sliding block, a stirring shaft, a motion track adjusting mechanism and a rotating assembly; a discharge pipe is communicatively arranged at the bottom of the reaction barrel. The motion track adjusting mechanism drives the first rotating disc to rotate, the first rotating disc drives the guide sliding block to revolve, the guide sliding block drives the stirring shaft to revolve, the stirring shaft drives the stirring blade to revolve, and then the stirring shaft and the stirring blade revolve to stir the raw materials, at the same time, the motion track adjusting mechanism changes the revolution radius of the stirring shaft, and then changes the motion track of the stirring shaft and the stirring blade, so that the stirring shaft and the stirring blade move reversely to the reaction barrel shaft or the reaction barrel side wall when revolving, and the stirring shaft and the stirring blade can stir any position in the reaction barrel.

This invention relates to a class of naphthoquinone derivatives, their preparation, and their application in the prevention and control of plant diseases and pests. This invention is the first to discover that juglone derivatives I-1 to I-13 and lancione derivatives II-1 to II-6 can effectively inhibit 14 plant pathogens, including tobacco mosaic virus (TMV), cucumber wilt, peanut brown spot, apple ring rot, wheat sheath rot, corn small spot, watermelon anthracnose, rice seedling blight, tomato early blight, wheat scab, rice blast, pepper blight, rapeseed sclerotium, cucumber gray mold, and rice sheath rot. Furthermore, it exhibits good activity against eight plant pests: armyworm, cotton bollworm, corn borer, cabbage moth, mosquito larvae, aphids, spider mite, and diamondback moth.

The patent relates to a method for preparing marine terpenoid natural products based on a decarboxylation coupling reaction of carboxylic acid salt of sclareolide or carboxylic acid of sclareolide and quinone compounds, and belongs to the field of chemical synthesis. The method takes sclareolide as raw material, and realizes, for the first time, a Minisci decarboxylation coupling reaction of carboxylic acid salt of bicyclic sesquiterpene or carboxylic acid of sclareolide and p-benzoquinone promoted by Selectfluor, so that the synthesis steps of yahazunone are shortened from the previous 6-18 steps to 2 steps, and asymmetric synthesis of multiple yahazunone natural products is realized. The method has the characteristics of good step economy, simple operation and suitability for industrial production.

The present application relates to the technical field of medicine, in particular to a MK-4 analogue, a preparation method and application thereof. The MK-4 analogue provided by the present application is more stable in liver microsomes and has a longer half-life. In the osteogenic experiment of osteoblasts, the osteogenic ability is stronger, which is of great significance for enhancing the specificity, effectiveness and reducing the side effects of drugs, and thus can be used for preparing drugs for preventing and / or treating osteoporosis. As the MK-4 analogue, it is expected to be used for preparing drugs for treating cardiovascular and cerebrovascular diseases, chronic kidney disease, neurodegenerative diseases, diabetes and cancer, etc.

The invention discloses a supramolecular composite electrode for a dual-carbon target. The supramolecular composite electrode is a copper-plated electrode coated with a column [5] quinone modification layer. The supramolecular composite electrode provided by the invention has a special application mode in CO2 reduction, and shows excellent multi-carbon product selectivity in an acidic electrolyte; the Faraday efficiency of reducing CO2 into a multi-carbon product in a flow-type electrolytic cell is excellent at a CO2 flow rate of 30 mL min <-1 > and a current density of 400 mA cm <-2 >. The supramolecular composite electrode is simple to prepare, has excellent selectivity when being used for electrocatalytically reducing greenhouse gas CO2 into a multi-carbon product in an acidic electrolyte, and has important significance for realizing a dual-carbon target.

The invention discloses a method for carrying out difluoromethoxy conversion on alcohol, and relates to the technical field of organic chemical synthesis. According to the invention, under mediation of light and acid, hydroxyl of alcohol can react with bpyCu (CF3) 3 to realize difluoromethoxylation; the alcohol difluoromethoxylation reaction provided by the invention has the advantages that the substrate universality is good, the alcohol difluoromethoxylation of primary alcohol, secondary alcohol, tertiary alcohol and even polyhydroxy compounds can be realized, the compound types of the difluoromethoxylation compounds can be expanded, and the full research of the difluoromethoxylation compounds can be further realized.

This invention discloses a method for preparing quinone compounds. The method comprises the following steps: in the presence of a base, a compound as shown in Formula II and a compound as shown in Formula III undergo a condensation reaction to obtain a quinone compound as shown in Formula I; wherein the base is more basic than sodium phenolate. This method is simple to operate and suitable for industrial production.

The application belongs to the field of medicine synthesis, and specifically provides a daunorubicin intermediate compound. The daunorubicin can be synthesized by pure chemical synthesis by using the intermediate compound. The daunorubicin is synthesized by taking 2,5-dihydroxybenzyl alcohol as a raw material. The route has low raw material cost, mild reaction condition, convenient post-treatment, high total yield, and good industrial application prospect.

The application belongs to the technical field of organic compound preparation, and particularly relates to a method for continuously preparing 2-ethylanthraquinone. The preparation method comprises the following steps: S1, loading a MOF / phosphotungstic acid composite catalyst on the inner wall of a reaction tube of a continuous reactor for standby; S2, using phthalic anhydride and ethylbenzene as raw materials, performing a Friedel-Crafts acylation, acidolysis and purification to prepare 2-(4-ethylbenzoyl)benzoic acid; and S3, in the continuous reactor, 2-(4-ethylbenzoyl)benzoic acid is subjected to dehydration and ring closure under the action of the MOF / phosphotungstic acid composite catalyst to prepare 2-ethylanthraquinone. The application combines a photosensitive ligand, a MOF and phosphotungstic acid to improve the catalytic reaction efficiency and selectivity of 2-ethylanthraquinone. Through optimization of the preparation process of 2-ethylanthraquinone, the operation is simplified, waste acid generation is reduced, and green cleaning, high yield, good production safety and continuous production are realized in the synthesis process of 2-ethylanthraquinone.

The invention belongs to the technical field of veterinary drugs, particularly relates to a preparation method of a 2, 3-disubstituted naphthoquinone compound for preventing and treating animal ectoparasites, and aims to solve the problem that a preparation method of related compounds convenient for industrialization is lacked in the prior art. According to the preparation method, different reaction general formulas are matched with differentiated preparation processes, so that the performance of the finally prepared compound is ensured; the preparation method disclosed by the invention is simple in process and mild in reaction condition, diverse 2, 3-disubstituted naphthoquinone compounds can be efficiently prepared, and the prepared compounds have high fatality rate on various animal ectoparasites and are convenient for industrial popularization and synthesis.

To realize synthetic functionalization of anthraquinone molecules substituted with at least one hydroxyl group or amino group.SOLUTION: According to part of embodiments of the present invention, synthetic functionalization of anthraquinone molecules occurs not chemically but electrochemically by using a divided electrolytic tank.SELECTED DRAWING: Figure 2

The application belongs to the field of medicine synthesis, and specifically provides a daunorubicin intermediate compound. The daunorubicin can be synthesized by pure chemical synthesis by using the intermediate compound. The daunorubicin is synthesized by taking 2,5-dihydroxybenzyl alcohol as a raw material. The route has low raw material cost, mild reaction condition, convenient post-treatment, high total yield, and good industrial application prospect.

The present application belongs to the technical field of industrial analysis and detection, and provides a chrysophanol-based natural perfume reconstituted molecular tool, a preparation method and application thereof. The method comprises the following steps: mixing a natural perfume solution and a chrysophanol solution to perform a dehydration condensation reaction, and obtaining the chrysophanol-based natural perfume reconstituted molecular tool. The raw material is abundant and belongs to a natural plant extract, the cost is low, the reagent required in the whole process is single, is non-toxic and harmless, and the final yield is also high. The obtained molecular tool has a stable chemical structure, can exist in a complex wax emulsion for a long time, has stable light signal release performance, can effectively release a light signal in a wax emulsion with various pH values, can maintain good light signal output in a long-term irradiation process, has a high viscosity sensitivity coefficient, and has a detection lower limit of viscosity as low as 1.23 cP, is suitable for measuring wax emulsion micro-area viscosity changes, and is helpful to realize rapid, efficient and visual preparation of wax emulsion consistency.

This invention discloses a pyridone palladium catalyst with the structure shown in Formula I, wherein R1, R2, R3, R4, R5, and R6 are independently selected from H, -CF3, -NO2, -OH, -F, -Cl, -Br, -CN, -CH3, and -OCH3, respectively. R1, R2, R3, R4, R5, and R6 may be the same or different, and R1, R2, R3, R4, R5, and R6 are independently substituted at positions 3, 4, 5, or 6 of the pyridone. This invention discloses the application of the described pyridone palladium catalyst in catalytic coupling reactions and C-H bond functionalization reactions. Using the described pyridone palladium catalyst, a high yield is still maintained even when the reaction feed is increased to the gram level.

The present invention relates to a method for the electrosynthesis of substituted 1,4-naphthoquinones in an electrolytic cell, and to a method for the synthesis of substituted 1,4-naphthoquinones in a flow fuel cell. The present invention also relates to the use of said substituted 1,4-naphthoquinones as a redox molecule in the negolyte of a redox flow battery. Lastly, the present invention relates to a redox flow battery comprising a posolyte comprising a redox molecule and a negolyte comprising at least one substituted 1,4-naphthoquinone obtained by one of the methods according to the invention.

The utility model relates to the technical field of 2-ethyl anthraquinone preparation, in particular to a 2-ethyl anthraquinone closed-loop reaction device, which comprises a circulating tank, a feed buffer tank, a toluene condenser, a flash tank and a plurality of groups of reactors arranged in a line, a discharge port of the circulating tank is provided with a delivery pipe V, the delivery pipe V is provided with a circulating heater, and the circulating heater is communicated with the circulating tank. A second material conveying pipe connected with the fifth conveying pipe is arranged at the bottom of each reactor, a third conveying pipe is arranged at a second feeding port of the circulation tank, a first material conveying pipe connected with the third conveying pipe is arranged at the top of each reactor, and a fourth conveying pipe is arranged at a feeding port of the flash tank. The fourth conveying pipe is connected with a fifth conveying pipe through second conveying branch pipes with the same number as the reactors, a reflux tower is arranged on one side of the flash tank, and a discharging port of the reflux tower is connected with a methylbenzene condenser through a pipeline. Through continuous circulation, the materials are fully reacted in the reactor, so that the reaction efficiency and the yield are improved.

The present invention belongs to the technical field of veterinary drugs, and specifically relates to use of a 2,3-disubstituted naphthoquinone compound. The compound is applied to the prevention and control of animal ectoparasites; the animal is one or more of cattle, sheep, pigs, rabbits, cats, and dogs; the animal ectoparasites are one or more of psoroptic mites, sarcoptic mites, demodex mites, and ticks. The series of compounds has good anti-ectoparasite activity and can be successfully applied to the field of veterinary drugs, thereby solving the safety and toxicity problems existing in long-term external use.

The application belongs to the technical field of industrial analysis and detection, and provides a cinnamon derivative based on natural mycotoxin, a preparation method and application thereof.The preparation method comprises the following steps: mixing anatumomycin solution and trans-4-methoxy acrylate solution, and then reacting to obtain the cinnamon derivative based on natural mycotoxin; the molar ratio of anatumomycin and trans-4-methoxy acrylate is 1:1-80.The cinnamon derivative based on natural mycotoxin provided by the application can be applied in inorganic powder grinding and dispersing agents containing a large number of pseudoplastic components as a molecular tool, as an in-situ molecular level viscosity sensing tool, the size of relative viscosity can be obtained without the help of external shearing, and the viscosity change can be effectively presented in a visual way, which is helpful to realize the rapid, efficient and controllable preparation of inorganic powder grinding and dispersing agents.

The utility model discloses a hydrolysis reaction device for anthraquinone production, which comprises a reaction kettle I and a reaction kettle II, the surface of the reaction kettle I and the surface of the reaction kettle II are both communicated with a feeding pipe and a discharging pipe, the right end of the discharging pipe is communicated with a convex opening connector, the left end of the feeding pipe is communicated with a connector, and the right end of the discharging pipe is communicated with a convex opening. The first reaction kettle and the second reaction kettle are communicated through a discharging pipe, a convex opening connector, a connector and a bent pipe, a convex opening in the right end of the convex opening connector is connected to an inner cavity of a groove in the left end of the connector in a sliding mode, and then the convex opening connector and the connector are fixed through a bolt and a nut; and under the action of the convex opening connector and the auxiliary sealing ring, the leakproofness between the convex opening connector and the connector is enhanced, so that the purposes that the leakproofness at the connecting pipe joint between the reaction kettles is enhanced, and the condition of gas or liquid leakage between the reaction kettles can be avoided can be achieved.

The invention discloses a method for preparing 2-ethyl anthraquinone through catalysis of ammonium salt ionic liquid, which comprises the following steps: dissolving phthalic anhydride in a solvent, adding first ammonium salt ionic liquid, uniformly stirring, and reacting at the temperature of 40-80 DEG C to obtain reaction liquid containing 2-(4-ethylbenzoyl) benzoic acid; adding phosphorus pentoxide and a second ammonium salt ionic liquid into the reaction liquid containing 2-(4-ethylbenzoyl) benzoic acid, and reacting at 70-130 DEG C; after the reaction is finished, adding a water quenching ionic liquid into a reaction system, filtering a hydrolysis product, adding ethyl acetate into filtrate for multiple times of extraction, combining organic phases obtained after each time of extraction, adding activated carbon into the organic phases for decoloration, filtering the activated carbon, adding a solid dewatering agent, filtering, and evaporating to remove the ethyl acetate to obtain a 2-ethyl anthraquinone crude product. According to the method, the ammonium salt ionic liquid is used as the catalyst to replace fuming sulfuric acid in a traditional preparation process, the amount of generated wastewater is small, the production cost is greatly reduced, and the method is green and environment-friendly.

The invention relates to the field of high-value utilization of biomass, in particular to a method for polymerizing and depolymerizing lignin into a benzoquinone compound and a depolymerizing method of the benzoquinone compound. Lignin or a lignin model compound is used as a raw material and is subjected to lignin oxidative depolymerization reaction under the action of an oxidizing agent and a mixed solvent; benzylic hydroxyl of lignin generates benzylic carbocations under the action of a solvent, then the benzylic carbocations are combined with an oxidizing agent to generate an oxide intermediate, and the benzoquinone compound and byproducts thereof are obtained through an intramolecular rearrangement reaction and oxidation of the oxidizing agent. The depolymerization method for polymerizing and depolymerizing lignin into the benzoquinone compound provided by the invention is low in cost, simple in operation and reaction conditions, green and renewable in raw materials, cheap and green in oxidant, high in depolymerization efficiency and wide in lignin universality, and solves the problems that the preparation raw materials for producing the benzoquinone compound in the current industry are non-renewable and non-sustainable, and the cost is low. The energy consumption is high; the post-treatment is difficult, and the like.