12results about How to "Short reaction path" patented technology

The application discloses a synthesis method of (+)-Dracocephalone A, (+)-Dracocequinone A and (-)-Dracocequinone B, and belongs to the technical field of drug synthesis. The method is to take 2-isopropylanisole as a starting material, and the target product is obtained through a series of reactions including Fletcher asymmetric conjugate addition, intramolecular alpha-arylation, peroxide-mediated C(sp3)-H cyclization and disulfuration-triggered oxygen bridge reorganization. The method has the advantages of simple steps, easy availability of raw materials and catalysts, low cost, high yield, environmental friendliness and facilitation of industrial production.

The invention discloses a method for synthesizing 1-(2-pyrazinyl)ethanol, and belongs to the technical field of organic synthesis. The method for synthesizing provided by the invention comprises the following steps: under an inert atmosphere, pyrazine and dipropionyl peroxide react under the action of a divalent iron catalyst to generate an ethylpyrazine intermediate; under an inert atmosphere, the ethylpyrazine intermediate and p-nitrobenzonitrile undergo an oxidation reaction under the action of ultraviolet light to generate 1-(2-pyrazinyl)ethanol. The invention can obtain 1-(2-pyrazinyl)ethanol by a two-step method, which is simple to operate, has a short reaction route, mild conditions, low reaction raw material cost, and a two-step total yield of 1-(2-pyrazinyl)ethanol of more than 65%.

The invention discloses a method for preparing 5-methoxytryptamine by a one-pot method, which comprises the following steps: by taking 1, 2, 3, 4-tetrahydro-6-methoxy-1-oxo-beta-carboline as a raw material, neutralizing by using strong acid instead of traditional acetic acid during ring-opening reaction, and carrying out decarboxylation reaction on a ring-opening product without separating to prepare the 5-methoxytryptamine. The method can completely avoid the generation of sodium acetate in the ring-opening reaction in the traditional technology, reduces the influence on the next decarboxylation reaction, and can directly perform the decarboxylation reaction without separating the ring-opening product, thereby effectively solving the problem that the decarboxylation reaction needs to be directly performed in the prior art. According to the method for preparing the 5-methoxytryptamine by using the 2, 3, 4-tetrahydro-6-methoxy-1-oxo-beta-carboline as the raw material, the defects that weak acid is left and an intermediate needs to be separated in the method are overcome, and the reaction route is shortened. The method improves the product yield and purity, has the advantages of simplicity and convenience in operation, high product purity, less three wastes and low cost, and is suitable for large-scale industrial production.

This invention belongs to the field of organic light-emitting materials and semiconductor technology, and provides a multi-aryl aromatic heterocyclic compound, its preparation method, and an electroluminescent device. The structural formula of the multi-aryl aromatic heterocyclic compound is: [structure omitted]. Using this multi-aryl aromatic heterocyclic compound as the guest light-emitting material, the luminous efficiency of the electroluminescent device is effectively improved, its lifespan is extended, and the purity of the emitted color is significantly improved. The light emitted by the electroluminescent device is in the green to red light range.

The invention discloses a preparation method of 4 '; the novel preparation process comprises the following steps: under the protection of inert gas, dissolving a chiral ligand and a metal salt in an organic solvent, stirring the mixture for 30 minutes to 1 hour at room temperature, adding a solution of a compound II into a catalyst solution, stirring for 15-30 minutes at a low temperature of-40 DEG C, adding a compound I, an activating agent and an alkali reagent, stirring for 15-30 minutes at a low temperature of-40 DEG C, and reacting for 1-2 hours to obtain a compound I; and continuously stirring at-40 DEG C to react for 6-8 hours, monitoring the proceeding of the reaction by HPLC (High Performance Liquid Chromatography), and separating a product after the reaction is completed to obtain a compound III. The method has the beneficial effects that the operation is simple, the reaction steps can be effectively reduced, the reaction route is short, the raw materials are easy to obtain, the reaction time is short, and the production cost and the labor cost can be effectively reduced; the product yield is high, the reaction selectivity is good, the product purity is high, the reaction product yield is high, the selectivity is good, the target product can be obtained at a high yield, and meanwhile, the post-treatment difficulty of the product is reduced.

The application provides a composite manganese-based positive electrode material, a preparation method thereof and a lithium ion battery, and the composite manganese-based positive electrode material comprises a manganese-containing positive electrode material and a coating layer coated on the surface of the manganese-containing positive electrode material, and the coating layer comprises a dioxole-containing organic matter and a 2-oxazolidone-containing organic matter. The manganese-containing positive electrode material is modified by the dioxole-containing organic matter and the 2-oxazolidone-containing organic matter, and the surface of the manganese-containing positive electrode material is physically formed into a film under the action of physical adsorption, which makes the ethylene oxide free radicals in the dioxole-containing organic matter and the 2-oxazolidone in the 2-oxazolidone-containing organic matter rapidly crosslink with each other in the charging and discharging process, so that a uniform, thin and stable CEI film with small polarization degree is formed on the surface of the positive electrode material, the dissolution of manganese is effectively inhibited, the interface resistance is reduced, and the cycle and rate performance of the positive electrode material are improved.

The application provides an alpha-cyclodextrin derivative, a preparation method, a demulsifying agent and a preparation method and application, and belongs to the technical field of fine chemical industry and oil and gas field development chemicals. The alpha-cyclodextrin derivative provided by the application comprises a main skeleton alpha-cyclodextrin and a long-chain hydrophobic structure from vinyl stearate, and the molecular formula of the alpha-cyclodextrin derivative is C 54 H 94 O 31 The application takes alpha-cyclodextrin as a skeleton, introduces a long-chain hydrophobic structure from vinyl stearate through long-chain acylation, thereby improving the lipophilic chain segment characteristics of alpha-cyclodextrin, and improving the oil phase dispersibility and interface regulation capacity of alpha-cyclodextrin to a certain extent. The provided demulsifying agent has lipophilicity and CO2 affinity, and improves the CO2 flooding effect.

This invention provides a method for preparing 1,1'-ethylene-2,2'-bipyridine dichlorosalt, belonging to the field of chemical synthesis. The method includes: dissolving 1,2-dichloroethane and an organic amine in a first solvent, and carrying out a first reaction under first reaction conditions to obtain a geminal quaternary ammonium chloride; dissolving the geminal quaternary ammonium chloride and 2,2-bipyridine in a second solvent, and carrying out a second reaction under second reaction conditions to obtain 1,1'-ethylene-2,2'-bipyridine dichlorosalt. Using a dichlorosalt with two quaternized ends, which is relatively easy to synthesize from 1,2-dichloroethane and an organic amine, as a precursor, and utilizing the high boiling point and the ability to dissociate and release carbocations at certain temperatures, this substance is reacted with 2,2-bipyridine via ion exchange as an intermediate medium to generate low-cost diquat dichlorosalt. This method has mild reaction conditions and does not introduce catalysts that are difficult to process laterally. Under optimal reaction conditions, the yield of diquat dichlorosalt is as high as 95%.

The invention belongs to the technical field of organic synthesis, and particularly relates to an addition product of alkyl free radicals and a capture reagent as well as an addition method and application of the addition product. Dissolving secondary alkyl ethylbenzene A, a capture reagent B, an acridinium salt photocatalyst and an additive into an organic solvent, and carrying out an illumination reaction to obtain an addition product of the alkyl free radical and the capture reagent; wherein the structural general formula of the secondary alkyl ethylbenzene A is # imgabs0 # formula I; the capture reagent B is selected from at least one of # imgabs1 # imgabs2 # TsCN; the structural formula of the addition product of the alkyl free radical and the capture reagent comprises at least one of # imgabs3 #. The invention provides a method for oxidizing secondary alkyl ethylbenzene through single electron transfer to induce the secondary alkyl ethylbenzene to generate carbon-carbon bond breakage and react with a capture reagent to generate a product. Reactants and raw materials are easy to obtain, the reaction process is safe and controllable, the operation is simple, and the production cost is low. And the addition product has high functional group property and is more diversified in application.

This invention discloses a method for preparing 6-bromo-6,6-difluoro-1-hexanol, belonging to the field of organic synthesis. The method uses 4-penten-1-ol as a starting material, reacting it with dibromodifluoromethane via an addition reaction to prepare 4,6-dibromo-6,6-difluoro-1-hexanol; then, a dehalogenation reaction is carried out using a second metal reagent to obtain 6-bromo-6,6-difluoro-1-hexanol. In this method, the reactants and reagents are inexpensive and readily available, the reaction steps are short, and production control is convenient; the reaction conditions are mild, ensuring high safety; the process is simple, and the product has high purity.

The application discloses a boron-nitrogen doped polycyclic aromatic compound and a synthesis method thereof, and relates to the technical field of organic synthesis. The application takes o-bromonitrobenzene as raw material, and first carries out a Bartoli reaction with vinyl magnesium bromide to synthesize 7-bromoindole; then carries out twice coupling reactions under the action of a metal catalyst to form a dimer of indole; carries out a reaction of the dimer of indole with di-tert-butyl dicarbonate to obtain a single Boc dimer of indole; carries out a borohydration reaction on the single Boc dimer of indole to obtain a boron-containing intermediate; and finally carries out a reaction with a Grignard reagent to obtain the boron-nitrogen doped polycyclic aromatic compound. The synthesis method has the characteristics of a relatively short reaction path, simple operation method and mild reaction conditions. Meanwhile, the compound synthesized by the application is sensitive to fluoride ions and has a high fluorescence quantum yield, and can be applied to the fields of fluoride ion sensors and organic photoelectric materials, and has a wide application prospect.

The invention belongs to the technical field of drug synthesis, and particularly relates to a preparation method of a ticagrelor intermediate, which comprises the following five steps: S1, preparing an intermediate II; s2, preparing an intermediate III; s3, preparing an intermediate IV; s4, preparing an intermediate V; and S5, preparing an intermediate VI. Compared with a multi-step and complex synthesis process in the prior art, the method has the advantages that the route of the ticagrelor key intermediate V is greatly shortened, the synthesis process of the intermediate V is simplified, the production efficiency and the yield are remarkably improved, the production period is shortened, the raw material consumption and the generation of byproducts are reduced, and the requirements of industrial production are met.