112 results about "Benzodioxoles" patented technology

The present invention provides a compound having a particular chemical structure or a pharmacologically acceptable salt thereof which has an excellent inhibitory effect on EZH1 and/or EZH2 activity. The present invention provides a compound having a 1,3-benzodioxole structure represented by the general formula (I) or a pharmacologically acceptable salt thereof, or a pharmaceutical composition comprising the compound (wherein R¹, R², R³, R⁴, R⁵, R⁶, and V in the formula (I) are each as defined in the present specification).

The invention discloses a synthetic method of 4-(2,2-difluoro-1,3-benzodioxole-4-yl)pyrrole-3-nitrile. The method comprises the following steps of: preparing an intermediate 2,2-difluorobenz-1,3-dioxole through reacting catechol with dibromodifluoromethane, and preparing an intermediate 2-cyano-3-(2,2-difluorobenz-1,3-dioxole-4-yl)-2-acrylate. The fludioxonil prepared by the synthetic method provided by the invention has the purity of more than 99.0% and the total yield of more than 45.0%; the synthetic method has the advantages of cheap and easily available raw materials, simple process, high product yield in each step, good purity, low production cost, applicability to batch industrial production and the like.

The invention discloses a synthetic process of berberine. The synthetic process comprises the following synthetic route: pyrocatechol and dichloromethane are taken as raw materials and dimethyl sulphoxide is taken as a solvent to synthesize 1,3-benzodioxole; 1,3-benzodioxole is subjected to ViLsmeiar formylation to synthesize heliotropin; heliotropin undergoes nitration through a Henry reaction to generate beta-nitro-3,4-dioxomethenyl styrene; beta-nitro-3,4-dioxomethenyl styrene is subjected to Clemmensen reduction to generate 3,4-(methylenedioxyphenyl)ethylamine; and 3,4-(methylenedioxyphenyl)ethylamine and 2,3-dimethoxy benzaldehyde condense, and the obtained product is reduced to generate N-2,3-dimethoxybenzyl [3,4-(methylenedioxy)phenyl]ethylamine hydrochloride. N-2,3-dimethoxybenzyl [3,4-(methylenedioxy)phenyl]ethylamine hydrochloride is cyclized in a condition of glyoxal, formic acid and copper sulphate to generate berberine hydrochloride. According to the synthetic route, cyanation is avoided and toxicity is reduced. Zinc amalgam is adopted to replace H2Ni and LiAlH4, so that the cost is greatly reduced, the process difficulty is reduced, and the product yield is increased.

The invention discloses a green synthesis process of berberine. The synthesis process comprises the following steps: firstly, introducing dichloromethane into N,N-dimethylformamide by adopting catechol under the alkaline condition and reacting to synthesize benzodioxole; secondly, preparing pepper propionitrile by utilizing the obtained benzodioxole, preparing pepper propionamide by utilizing obtained pepper propionitrile, preparing homopiperony lamine by utilizing pepper propionamide and then synthesizing N-2,3-dimethoxybenzyl homopiperony lamine hydrochloride; finally, synthesizing berberinehydrochloride by utilizing the N-2,3-dimethoxybenzyl homopiperony lamine hydrochloride under the condition of glyoxal, formic acid and copper sulfate. The green synthesis process of the berberine, disclosed by the invention, has the advantages that the formation of black polymers is reduced, the reaction yield is improved, the problem that environmental pollution caused by a large amount of the black polymers produced in the original process production is solved and the requirements of green chemical synthesis required by China are met.

The invention discloses a reaction treatment method of heliotropin intermediate 3,4- dioxymethylene mandelic acid. The method comprises the following reaction treatment steps: firstly, adding glyoxylic acid in a reaction kettle, adding 1,3-benzodioxole under stirring action, and cooling the glyoxylic acid and 1,3-benzodioxole mixed liquid with brine ice; adding a catalyst, namely concentrated sulfuric acid; then dripping a water-insoluble inert solvent, namely dichloromethane, into a head tank, carrying sampling detection on a reaction mixture, and stopping reaction when the content of 1,3-benzodioxole in the reaction mixture is not reduced any more; and finally, adding water into the reaction kettle, uniformly stirring, discharging and filtering by suction to obtain the solid material, namely 3,4- dioxymethylene mandelic acid. According to the reaction treatment method, the feeding sequence is regulated in the early stage to improve the mixing effect and increase the reaction speed, and the water-insoluble inert solvent is added to dilute the reaction mixture, so that the stirring effect is not influenced, the reaction time is shortened, and the problem of hard stirring in the late reaction stage can be solved.

The invention relates to a semi-continuous preparation method of poly-p-phenylene benzobisoxazazole polymer, belonging to the production field of high-performance fibers. The semi-continuous preparation method comprises the steps of adding raw materials into a kneading kettle, and conducting dehydrochlorination on a monomer in the kneading kettle to increase the surface updating capability of a high-viscosity system and accelerate the dehydrochlorination; then entering the materials into a mixing kettle, removing bubbles of a polymer, mixing, pumping the materials into a filter by a metering pump, directly connecting the filter with more than two screw extruders which are connected in series, filtering the materials subjected to dehydrochlorination and bubble removal, and then polymerizing. According to the preparation method, the continuity of operation is improved.

An article comprising a fabric comprising:

• • (a) a blended yarn comprising:
    • (i) from about 10% to about 85% by weight of at least one biregional fiber comprising an oxidized polymer selected from the group consisting of acrylonitrile based homopolymers, acrylonitrile based copolymers, acrylonitrile based terpolymers, and combinations thereof;
    • (ii) at least one companion fiber selected from the group consisting of FR polyester, FR nylon, FR rayon, FR treated cellulose, m-aramid, p-aramid, modacrylic, novoloid, melamine, wool, nylon, regenerated cellulose, polyvinyl chloride, antistatic fiber, poly(p-phenylene benzobisoxazole) (PBO), polybenzimidazole (PBI), polysulphonamide (PSA), and combinations thereof; and
  • (b) optionally including a companion yarn different from said blended yarn; wherein said companion yarn includes p-aramid in an amount less than 20% of the fabric weight; and wherein the fabric has a weight from about 3 oz/yd² to about 12 oz/yd².

The present invention relates a compound for inhibiting the growth of tumor cells. More specifically, the compound of the present invention is 4,7-dimethoxy-5-methy-1,3-benzodioxole. 4,7-dimethoxy-5-methy-1,3-benzodioxole of the present invention is used for inhibiting the growth of tumor cells of breast cancer, liver cancer, and prostate cancer, and the pharmaceutical composition comprises an effective dose of 4,7-dimethoxy-5-methy-1,3-benzodioxole.

The present invention relates to compounds of the general formula

and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases such as obesity by selective modulation of CB1 receptors.

The invention provides a benzodioxole preparation method, and belongs to the technical field of organic synthesis. The preparation method comprises: mixing catechol, sodium hydroxide, water and dimethyl silicone oil, and carrying out a first reaction to obtain a sodium catechol solution; and mixing the sodium catechol solution, tetrabutylammonium chloride and dichloromethane, and carrying out a condensation reaction to obtain the benzodioxole. According to the present invention, during the preparation of the sodium phenolate solution, dimethyl silicone oil is added, so that the sodium phenolate solution is protected from being oxidized so as to improve the yield of subsequent product; by using tetrabutylammonium chloride as the catalyst, the yield of the benzodioxole is increased comparedwith the use of tetrabutylammonium bromide as the catalyst; and the data of the embodiments show that the preparation method can achieve the molar yield of the benzodioxole of 92-95% and the purity ofthe benzodioxole of greater than 99.9%.

A transmission belt comprising a belt body and a cord. The belt body is made of a rubber composition. The cord is comprised of poly-p-phenylene benzobisoxazole fiber. The cord is embedded in the belt body. The belt body and the cord are formed into an integral whole by vulcanizing the rubber composition. The surface of the cord is subjected to a primary treatment involving coating a mixture of an epoxy compound and latex and heat treating, and a secondary treatment involving coating a resorcinol-formalin-latex adhesive and heat treating.

The invention provides a preparation method for fluoride aromatic organic compound. The preparation method includes the steps of providing fluoride aromatic organic compound containing aldehyde group, and taking 2, 2-difluoro-1,3 benzodioxole as a fluorinating agent, conducting fluoridation reaction on the fluorinating agent and fluoride aromatic organic compound containing the aldehyde group so as to obtain the fluoride aromatic organic compound. The invention provides a new process route for improving the utilization rate of fluorine.

The invention relates to a surface modification processing device for poly(p-phenylene benzobisoxazole) fiber and a use method of the surface modification processing device. The surface modification processing device partially comprises a tension providing device, a yarn guide device, a surface modification processing groove, a drying device and a coiling device. Through the device provided by the invention, the poly(p-phenylene benzobisoxazole) fiber is subjected to surface modification, the poly(p-phenylene benzobisoxazole) fiber can be continuously subjected to surface processing in real time, the surface performance is improved, meanwhile, the original mechanical property of the PBO fiber is not damaged, and in addition, the processing effect is good. The device provided by the invention has the advantages that the structure is simple, the operation is simple and convenient, and the continuous and industrial production can be realized.

The invention relates to a synthesizing method for 2,2-difluoro-1,3-benzodioxole. The method comprises the steps that 1, sodium hydroxide and water are added into a reaction kettle, then liquid paraffin is added, the temperature is increased to control the temperature of the reaction kettle to be under the condition of 85 DEG C, pyrocatechol is added, the temperature is kept at 85 DEG C, reacting is performed for 1 hour, and then pyrocatechol sodium salt is prepared; 2, methylbenzene, water and catalysts are added in a high-pressure kettle, the high-pressure kettle is closed, replacement is performed for three times with nitrogen, the temperature is increased to control the temperature of the high-pressure kettle to be under the condition of 95 DEG C, the pyrocatechol sodium salt prepared in the step 1 and dichlorodifluoromethane are added, the pyrocatechol sodium salt is preheated to 85 DEG C-90 DEG C in advance before being fed, the temperature of the high-pressure kettle is kept at 95 DEG C-105 DEG C, reacting is performed for 1 hour, the high-pressure kettle is cooled to 20 DEG C, an organic layer solution is separated out, washing is performed for one time, the organic layer solution is rectified to collect rectified components, and the 2,2-difluoro-1,3-benzodioxole is obtained. The synthesizing method for the 2,2-difluoro-1,3-benzodioxole has the advantages of being simple and direct in technology, few in technology waste materials, high in yield and suitable for large-scale industrialized production.

It is an object of the present invention to provide a resin gear for an electric power steering apparatus excellent in mechanical strength and durability, in which damage of teeth, for example, does not occur even when the gear is employed in an electric power steering apparatus equipped with a high-power electric actuator. In a resin gear for an electric power steering apparatus in the form of a worm wheel 10, a gear portion 16 thereof is formed of a resin molding material containing a thermosetting resin and polyparaphenylene-benzobisoxazole fibers (PBO fibers) as essential constituents.

Provided is a hydrogen-dispensing hose. At least two reinforcing layers are coaxially layered between an inner surface layer of a thermoplastic resin having a dry hydrogen gas permeability coefficient at 90° C. of 1×10⁻⁸ cc·cm/cm²·sec.·cmHg or less and an outer surface layer of a thermoplastic resin. A wire braided layer formed by braiding metal wires is used as the outermost reinforcing layer. Fiber braided layers formed by braiding high-strength fibers such as polyparaphenylene benzobisoxazole fibers are used as the other reinforcing layers.

The invention relates to a drug composition for treating hepatitis C infection and a unit dosage form. The drug composition and the unit dosage are prepared from KW136(N-[(2S)-1-[(2S)-2-{4-[7-(4-{2-[(2S)-1-[(2S)-2-(methoxycarbonyl)amino]3-methylbutyryl]pyrrolidine-2-yl)-1H-imidazole-4-yl}phenyl}-2H-1,3-benzodioxole-4-yl]-1H-imidazole-2-yl}pyrrolidine-1-yl]-3-methyl-1-oxobutane-2-yl]methyl carbamate dihydrochloride, a compound as shown in a formula (II) and at least one pharmaceutically acceptable excipient which are in therapeutically effective amounts. The invention also discloses a method for preparing the drug composition and the unit dosage form.

(wherein R¹ represents hydroxy or substituted or unsubstituted lower alkoxy; R² represents an aromatic heterocyclic group or the like; Y represents lower alkyl or the like; and n represents an integer of from 1 to 6)

For example, a process for preparing a 1,3-benzodioxole-2-spirocycloalkane derivative represented by the above formula (VII), which comprises adding a base to a mixture containing a compound represented by the above formula (V) and a compound represented by the above formula (VI); and allowing the compound represented by the above formula (V) to react with the compound represented by the above formula (VI), are provided.