50 results about "Selective modulation" patented technology

The present invention provides methods and compositions for selective modulation of certain protein kinases, and especially mTor complexes. The methods and compositions are particularly useful in inhibiting mTor selectively for therapeutic applications.

A system and method for selectively treating aberrant cells such as cancer cells through administration of a train of electrical pulses is described. The pulse length and delay between successive pulses is optimized to produce effects on intracellular membrane potentials. Therapies based on the system and method produce two treatment zones: an ablation zone surrounding the electrodes within which aberrant cells are non-selectively killed and a selective treatment zone surrounding the ablation zone within which target cells are selectively killed through effects on intracellular membrane potentials. As a result, infiltrating tumor cells within a tumor margin can be effectively treated while sparing healthy tissue. The system and method are useful for treating various cancers in which solid tumors form and have a chance of recurrence from microscopic disease surrounding the tumor.

The invention relates to a single chip integrated optical matrix-vector multiplier which is characterized by comprising a silicon base, wherein a multi-wavelength light source module, a wavelength selecting modulating module, a power beam splitting module, a micro-ring modulator matrix module and a detector array module are integrated on the silicon base; the multi-wavelength light source module is used for outputting multi-wavelength optical signals with n+1different wavelengths to the wavelength selecting modulating module; the wavelength selecting modulating module is used for selectively modulating each wavelength optical signal in the multi-wavelength optical signals and then sending to the power beam splitting module; the power beam splitting module is used for performing 1:m equal power beam splitting on the multi-wavelength optical signals and sending the multi-wavelength optical signals after being subjected to the beam splitting to the micro-ring modulator matrix module; the micro-ring modulator matrix module is used for processing m paths of multi-wavelength optical signals and sending a processing result to the detector array module; and the detector array module is used for detecting the outputted optical signals. The single chip integrated optical matrix-vector multiplier can be widely applied to the processing process of mass data.

Disclosed are nicotine-related compounds that selectively inhibit cytochrome P-450 2A6 (CYP2A6), selectively inhibit cytochrome P-450 2A13 (CYP2A13), and / or selectively modulate a nicotinic acetylcholine receptor (nAChR). Also disclosed are pharmaceutical compositions comprising a compound of the invention, as well as methods of using the pharmaceutical compositions for treating or preventing a disease or disorder associated with nicotine-ingestion, or a disease or disorder amenable to treatment by selective modulation of nAChRs.

The present invention relates to methods and compositions for modulating levels of amyloid-β peptide (Aβ) exhibited by non-neuronal (i.e., peripheral) cells, fluids, or tissues. The invention also relates to modulation of Aβ levels via selective modulation (e.g., inhibition) of γ-secretase activity. The invention also relates to methods of preventing, treating or ameliorating the symptoms of a disorder, including but not limited to an Aβ-related disorder, by administering a compound that result in the modulation of γ-secretase in a non-neuronal tissue, either directly or indirectly to prevent, treat or ameliorate the symptoms of a brain Aβ disorder, such as Alzheimer's disease.

The present invention relates to methods of selective modulation of peroxisome proliferator activated receptors (PPARs) over G-protein coupled receptor 40 (GPR40), and the use of therapeutically effective amounts of compounds and pharmaceutical compositions which selectively modulate PPAR over GPR40 for the treatment of diseases in patients in need thereof. The methods disclosed herein are exceptionally useful in treating metabolic diseases whilst avoiding certain side effects common to modulators of PPAR previously disclosed in the art.

The invention discloses electronic control terahertz polaroid based on graphene, the electronic control terahertz polaroid includes at least two layers of graphene layers, each layer of graphene is of a grid band structure, a dielectric layer is arranged between each two layers of adjacent graphene layers, and the dielectric layer separates the two layers of graphene layers; an even number of layers of graphene layers are jointly connected to an electrode, an odd number of layers of graphene layers are jointly connected to the other electrode, and the two electrodes are loaded with voltage and voltage regulation can be realized. The polaroid prepared by use of a multilayer film structure can regulate performance parameters such as a response frequency band and the degree of polarization through structure parameters of grid bands such as the width and space periods of the grid bands and the number of layers of graphene; and through voltage regulation, the degree of polarization penetrating through terahertz waves can be actively regulated, and the function of selective modulation of terahertz waves in different directions of polarization can also be realized.

A process for creating a flexographic plate or a mask for producing a flexographic plate, including providing a screen having a resolution defined by a base pattern of equally sized screen spots, each screen spot comprising a smallest exposed discrete element represented on the screen. In at least a non-solid tonal portion of the plate or mask, the size of physical spots are selectively modulated such that each set of four neighboring physical spots in the base pattern has an unexposed area centered therebetween. Each screen spot in the base pattern may be an exposed pixel surrounded by 8 unexposed pixels, each physical spot corresponding to the resolution of a laser beam for exposing the spots on the mask, in which the imaging step includes boosting power of the laser beam for isolated pixels relative to non isolated pixels. Mask and plates, and imaging systems for creating them, are also disclosed.

The invention relates to compounds and composition for the treatment and prevention of cancer. The invention also covers all diseases that may be treated by selective modulation of levels of reactive oxygen species in diseased cells versus normal cells. Methods for the preparation and administration of such compositions are also disclosed.

The invention discloses a prussian blue / tungsten trioxide electrochromic film and a preparation method thereof. The film has a double-array ordered structure and large specific surface area and can increase ordered ion diffusion channels for electrolyte ions and selectively modulate near infrared light bands and visible light bands. The preparation method comprises the steps as follows: firstly, taking a polystyrene template as a working electrode and an aqueous solution of sodium tungstate, hydrogen peroxide and hydrochloric acid as an electrodeposition solution, removing the polystyrene template after electrochemical deposition to obtain a tungsten trioxide electrochromic film with a bowl-like ordered structure, then, taking the obtained tungsten trioxide electrochromic film with the bowl-like ordered structure as a working electrode and an aqueous solution of FeCl3, K3[Fe(CN)]6 and KCl as an electrodeposition solution, and performing electrochemical deposition to obtain the prussianblue / tungsten trioxide electrochromic film. The preparation method requires no roasting and has the advantages that the method is convenient to operate, efficient and energy-saving, the product is controllable and the like.

The present invention provides methods and compositions for selective modulation of certain protein kinases, and especially mTor complexes. The methods and compositions are particularly useful in inhibiting mTor selectively for therapeutic applications.

The invention relates to a power control method of an orthogonal frequency division multiplexing access system, comprising the following steps of: acquiring cell interference parameters, a maximum path loss difference threshold value and a minimum path loss difference threshold value sent by a service base station by a mobile terminal; determining a target signal interference noise ratio value of the mobile terminal according to the acquired cell interference parameters, the maximum path loss difference threshold value, the minimum path loss difference threshold value and base station signal path loss acquired by measurement by the mobile terminal; and selecting a modulation encoding manner by the mobile terminal according to the confirmed target signal interference noise ratio value and regulating the transmitting power thereof so as to carry out signal transmission. By applying the power control method, the problem that the current power control method can not cover all selective modulation encoding manners is solved, the power control efficiency can be improved under the condition of lesser expenses and the performance and the frequency spectrum utilization ratio of the system are further enhanced.

The present invention relates to novel uses of 1-amino-3-(N,N-dimethylamino)-propylidene-1,1-bisphosphonic acid or any of its soluble salts or any of its hydrates, in particular its use for the manufacture of a medicament for selective modulation of osteoblasts.

The present invention provides methods and compositions for modulating levels of amyloid-β peptide (Aβ) exhibited by cells or tissues. The invention also provides pharmaceutical compositions and methods of screening for compounds that modulate Aβ levels. The invention also provides modulation of Aβ levels via selective modulation (e.g., inhibition) of ATP-dependent γ-secretase activity. The invention also provides methods of preventing, treating or ameliorating the symptoms of a disorder, including but not limited to an Aβ-related disorder, by administering a modulator of γ-secretase, including, but not limited to, a selective inhibitor of ATP-dependent γ-secretase activity or an agent that decreases the formation of active (or optimally active) γ-secretase. The invention also provides the use of inhibitors of ATP-dependent γ-secretase activity to prevent, treat or ameliorate the symptoms of Alzheimer's disease.

The present invention relates to a method of selectively modulating a signalling pathway of interest controlled by a cell receptor involved in signalling through multiple signalling pathways The method includes exposing the receptor to an agent that modulates signalling by the receptor through the signalling pathway of interest and does not substantially modulate signalling through one or more other signalling pathways controlled by the receptor.

The invention provides a device for generating rotating hexagonal plasma photonic crystals and a method thereof. The device comprises a vacuum reaction chamber, two water electrodes which are arranged in the vacuum reaction chamber and a plasma generation power supply which is electrically connected with the water electrodes. A frame is arranged between the two water electrodes. The internal edge of the frame is formed by multiple ratchets which are arranged in turn, and the internal edge of the frame forms the boundary of a discharge gap. When voltage of the plasma generation power supply is certain, the rotating hexagonal plasma photonic crystals are generated in the discharge gap between the two water electrodes. The generated plasma photonic crystals enable the dispersion curve, the band gap center frequency and the band gap width to be changed due to their own rotation under the condition of constant incident light; and the rotating speed can be enhanced by increasing pressure intensity or reducing the content of argon gas and the rotating speed can be reduced in a reverse way so that light propagation selective modulation can be further enriched.

The parallel electrooptical modulator has two reflecting electrooptical modulators connected serially and connected to two electric signal sources separately. The laser beams two lasers generate in different wavelengths are combined into one beam with the light beam splitter, formed into TM light in the polarizer, and modulated separately with two reflecting electrooptical modulators; and the modulated output light beams are separated into light beams of different wavelengths with the grating spectrometer and received with two detectors. The reflecting electrooptical modulator includes prism with four layers of deposited film, upper metal electrode, wave conducting organic polymer layer, isolating layer and lower metal electrode, and the film layers has such thickness that the attenuation total reflection curve of the modulator has width matching the spectral width of the incident laser pulse. The present invention can perform selective modulation of light wave with different wavelength components.

The invention relates to compounds and composition for the treatment and prevention of cancer. The invention also covers all diseases that may be treated by selective modulation of levels of reactive oxygen species in diseased cells versus normal cells. Methods for the preparation and administration of such compositions are also disclosed.

The invention relates to compounds and composition for the treatment and prevention of cancer. The invention also covers all diseases that may be treated by selective modulation of levels of reactive oxygen species in diseased cells versus normal cells. Methods for the preparation and administration of such compositions are also disclosed.

The invention relates to compounds and composition for the treatment and prevention of cancer. The invention also covers all diseases that may be treated by selective modulation of levels of reactive oxygen species in diseased cells versus normal cells. Methods for the preparation and administration of such compositions are also disclosed.

Methods, uses, kits and products are described for the prevention and treatment of ischemia-associated cardiopathies such as myocardial ischemia / reperfusion (I / R) injury, based on the selective modulation of CD36.

The invention relates to a CO2 electroreduction reaction control method based on an electrode solution system. The CO2 electroreduction reaction control method can realize selective modulation of a product CH4. The electrode solution system is an interface system in which a copper-based electro-catalytic material (including copper foil, a copper net, nano-copper and carbon-loaded nano-copper particles) is in contact with an electrolyte solution. According to the interface system, the periodic step change of the potential is controlled within the temperature range of 0-60 DEG C, the selective preparation of the crystal face of the catalyst and the controllable preparation of the grain size can be realized, and the selective modulation of the CO2 electroreduction product is further realized.The modulation range of the methane Faraday efficiency is 5.5%-79%. The control method of the CO2 electroreduction reaction not only can modulate the selectivity of the product CH4, but also can improve the stability of the CO2 electroreduction reaction, and is suitable for large-scale application of the CO2 electroreduction technology.

The present invention relates to compounds of the general formula and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and / or prophylaxis of diseases such as obesity by selective modulation of CB1 receptors.

The invention discloses a UDWDM-PON transmitter based on the wavelength automatic locking and tracking technology. The UDWDM-PON transmitter includes a laser, an attenuator and a first 1x8 coupler which are connected in sequence to a microwave source; 8 channels are formed after the first 1x8 coupler. All the channels are concentrated on an optical fiber through a second 8x1 coupler; the laser isa mode-locked laser; the first, third, fifth, and seventh channels are odd-numbered channels, and the second, fourth, sixth, and eighth channels are even-numbered channels. The odd-numbered channels are used as the downlink optical carrier to carry the downlink data, and the even-numbered channels are used as the uplink optical carrier to complete the transmission of the user information. An optical frequency comb generated by the mode-locked laser is used as a wavelength reference, and the injection locking is performed on the plurality of DFB lasers to complete the separation of the wavelength reference, so that the problem of wavelength synchronization in the access network is solved; and selective modulation is performed on the separated multiple channels to track the wavelength reference of the mode-locked laser, and the stability of the small channel spacing in the access network can be ensured.

The invention relates to a multi-channel terahertz wave modulation method. Incident terahertz waves pass through a terahertz wave collimator to become a collimated wave beam, the collimated wave beam sequentially enters multiple overlapped independent modulation channel modules to be independently modulated, each independent modulation channel module outputs an independent modulation signal, then all the output independent modulation signals are sequentially combined through terahertz wave channel combiners in the modulation channel modules and output uniformly from a system output opening, and clutter absorption devices are arranged in the independent modulation channel modules with the terahertz wave channel combiners. A system is composed of multiple terahertz wave modulator module units of different types in a free combination mode, and the purpose of increasing or decreasing the number of channels of modulation terahertz waves is quite easy and convenient to achieve; the function of performing selective modulation on specific channels (wave bands) is achieved, wave absorbers are used, in this way, disturbance of clutters or terahertz waves of non-attention wave bands is further reduced, and then the signal-to-noise ratio is further optimized.

A frequency selective modulation apparatus and method using re-spreading codes are disclosed. The frequency selective modulation apparatus includes: a serial-to-parallel converter receiving transmission data and performing serial-to-parallel conversion on the transmission data at a pre-set ratio; one or more sub-frequency selective spreaders selecting one spreading code by using data bits received from the serial-to-parallel converter; a majority value selection unit selecting a majority value from one or more spreading codes which have been selected by each of the one or more of the sub-frequency selective spreaders; and a first XOR logic circuit XORing an output of the majority value selection unit and a re-spreading code Wn to re-spread a frequency selective baseband to a frequency selective passband.

The invention provides a single-state semi-quantum key distribution system and method.The system comprises a sending end and a receiving end, the sending end comprises a signal light unit, a light transmission unit, a phase modulator unit and a detector unit, and the signal light unit, the light transmission unit and the phase modulator unit are sequentially connected; the detector unit is connected with the phase modulator unit and the light transmission unit, and the phase modulator unit is a non-equal-arm interferometer; the receiving end comprises an intensity modulator unit, the intensity modulator unit is connected with the phase modulator unit, and the intensity modulator unit is an interference loop; and the interference loop is used for loading voltage to the received optical pulse group sent by the non-equal-arm interferometer to obtain a processed optical pulse group, and sending the processed optical pulse group to the non-equal-arm interferometer. According to the system and the method, a selective modulation mode is adopted to realize a single-state semi-quantum key distribution protocol, the problem of unreasonable design of an existing system is solved, and the system and the method have extremely high safety and practical application feasibility.

Particular embodiments of the present disclosure relate systems and methods for evaluating visible light sources. According to one embodiment, a method of evaluating a visible light source including a semiconductor laser having a gain section, a wavelength selective section, and a phase section includes applying a gain drive signal to the gain section of the semiconductor laser at a gain modulation frequency, and applying a triangular wave drive signal to the wavelength selective section of the semiconductor laser at a wavelength selective modulation frequency that is greater than the gain modulation frequency. The light source emits a plurality of optical output pulses. Output power values of the optical output pulses at a selected wavelength are detected. The output power value of one or more selected output pulses is compared with an output power threshold value to generate an indication of whether the visible light source satisfies an output power specification.

The invention discloses a long-service-life electrochromic film capable of selectively regulating and controlling light and heat. Transparent conductive coated glass is used as a substrate, and an FTOnano hole array film and an amorphous WO3 film are sequentially prepared on the substrate to form an embedded amorphous WO3 composite film having an FTO nano array, wherein the array is a regularly-arranged hole array, and the amorphous WO3 film is filled in a circular hole of the FTO nano hole array film and higher than a depth of the circular hole of the FTO nano hole array film. A preparationmethod of the film comprises the following steps: preparing the FTO nano hole array by utilizing laser interference combined with a photosensitive sol-gel technique, and filling an amorphous WO3 matrix on the hole array by utilizing an a sol-gel technique to form the composite film. The composite film disclosed by the invention can maintain a more excellent selective modulation effect on the lightand the heat after 100,000 electrochromic cycles due to ultra-strong chemical stability of FTO; and the preparation method of the film has the characteristics that the process is controllable and thelarge-area film is easy to form, and is suitable for industrialized mass production.