32 results about "Ethylamine hydrochloride" patented technology

The invention discloses a preparation process of berberine hydrochloride, and belongs to the technical field of berberine production. The invention relates to a berberine hydrochloride preparation process, which comprises: S1, mixing a ferric sulfate-aluminum sulfate composite salt, sodium chloride, zinc chloride and anhydrous formic acid, pre-activating, adding N-2, 3-dimethoxybenzyl homopiperony lamine hydrochloride, dropwise adding a glyoxal mixed solution, and carrying out a reflux reaction. And S2, cooling the reaction liquid until a solid is separated out, filtering, adding a filter cake and diatomite into purified water, stirring, adjusting alkali, heating, and continuously stirring for 0.5-1 hour. Cooling and filtering, and reserving filtrate; s3, adjusting the acidity of the filtrate, cooling and growing crystals; and filtering, rinsing a filter cake, and carrying out vacuum drying on the filter cake to obtain berberine hydrochloride. The berberine hydrochloride prepared by the method is high in yield and purity, and the preparation process is safe, short in flow and friendly to human bodies and environment.

The invention provides a preparation method of diphenyl ethyoxyl phosphine and a product thereof. Taking diphenyl phosphonium chloride and absolute ethyl alcohol as raw materials, petroleum ether as a solvent and triethylamine as an acid-binding agent; the reaction process comprises the following steps: reacting diphenyl phosphine chloride with ethanol to generate diphenyl ethyoxyl phosphine and hydrogen chloride, and reacting hydrogen chloride with triethylamine to generate triethylamine hydrochloride. And after the reaction is finished, separating triethylamine hydrochloride separated by crystallization from the liquid organic phase through centrifugation, taking the obtained triethylamine hydrochloride as a co-product, carrying out desolvation treatment on the obtained liquid organic phase to obtain a diphenylethoxyphosphine crude product, and rectifying to obtain the high-quality diphenylethoxyphosphine. The preparation process provided by the invention is mild in reaction condition, simple and convenient to operate and low in requirements on equipment and energy consumption; the raw materials are wide in source and low in cost, and the solvent and the acid-binding agent can be recycled, so that the method has the advantage of environmental protection. The prepared diphenyl ethyoxyl phosphine is high in purity and good in yield, and has a wide industrial application prospect.

The invention relates to an organic crystalline piezoelectric material based on chiral 4-bromophenylethylamine hydrochloride, which is synthesized by using hydrochloric acid as an anion and protonated (R / S)-4-bromophenylethylamine as a cation according to the stoichiometric ratio of (R / S)-4-bromophenylethylamine to hydrochloric acid of 1: 1. The invention provides an organic crystalline piezoelectric material based on chiral 4-bromophenylethylamine hydrochloride and a preparation method, and provides a two-dimensional hydrogen bond network construction strategy based on protonated chiral amine: protonated (R / S)-4-bromophenylethylamine cations are used as structural elements, chloride ions are used as charge balance bodies, and the chiral 4-bromophenylethylamine hydrochloride is prepared by precisely regulating the interaction of intermolecular hydrogen bonds. Constructing a two-dimensional hydrogen bond network with high orientation; by enhancing ordered arrangement of molecular dipoles and optimizing a lattice strain-polarization response collaborative mode, breakthrough improvement of piezoelectric performance is successfully realized, and a new normal form is provided for developing high-performance organic piezoelectric materials.

The invention belongs to the technical field of medicine synthesis, and particularly relates to a synthesis method of upatinib and an intermediate Up-3 thereof. The preparation method comprises the following steps: dissolving a compound Up-1 and a compound Up-2 in a solvent A, adding alkali 1, and reacting to obtain an intermediate Up-3; dissolving the intermediate Up-3 in a solvent B, adding an acid a, removing Boc protection and closing a ring to obtain an intermediate Up-6, and reacting under the action of an acid b to obtain a compound Up-14; the preparation method comprises the following steps: dissolving carbonyl diimidazole, trifluoroethylamine hydrochloride and alkali 2 in a solvent C, stirring, mixing with a compound Up-14 solution, reacting to obtain a compound Up-13, adding an alkali 3 solution, and removing Tos protecting groups to obtain upatinib. According to the method disclosed by the invention, the upatinib crude product is simply synthesized by taking Up-3 as a starting material through a two-pot method for the first time, the time of the whole process is saved, the total yield is relatively high, the purity of the obtained product is also relatively high, and the method is suitable for large-scale production.

The invention discloses a methylamine-free perovskite thin film with high thermal stability and a preparation method of the methylamine-free perovskite thin film. The perovskite thin film is prepared from an FAPbI3 perovskite precursor solution doped with 2-(methylsulfonyl) ethylamine hydrochloride. A proper amount of 2-(methylsulfonyl) ethylamine hydrochloride is added into the perovskite precursor solution, the compact and uniform FAPbI3 perovskite thin film with photovoltaic activity is obtained under the condition that methylamine ions are not introduced, the thin film has excellent thermal stability, the service life of a perovskite solar cell can be prolonged, and the service life of the perovskite solar cell is prolonged. And the positive significance is realized on the commercialized application of the perovskite battery.

According to the invention, a novel ternary acidic deep eutectic solvent (DES) is prepared, ethylamine hydrochloride (EH) is used as a hydrogen bond acceptor (HBD), and DL-malic acid (MA) and polyethylene glycol-400 (PEG-400) are used as hydrogen bond donors (HBA). The DES solvent has good performance on wood fiber biomass refining pretreatment, and three major components of lignocellulose can be efficiently separated. The ternary acidic DES disclosed by the invention is easy to synthesize, good in stability and simple in use method, and an ideal separation effect can be achieved when high biomass solid content is treated, that is, most cellulose is reserved in a solid form, and most hemicellulose and lignin are converted into a liquid form through dissolution or partial degradation to be separated; and separating the lignin component from the hemicellulose by anti-solvent precipitation. The prepared DES can be recycled after being filtered and subjected to rotary evaporation, still has a separation effect equivalent to that of an original solvent after being recycled for six times, and has good industrial application prospect and value.

This invention discloses a highly selective method for preparing triethylenetetramine. The method uses 2-chloroethylamine hydrochloride and ethylenediamine as raw materials, reacting them in an aqueous solution. An aqueous solution of ethylenediamine with a concentration of 1-100 wt% is added dropwise to an aqueous solution of 2-chloroethylamine hydrochloride with a concentration of 1-100 wt%. The dropping rate of the ethylenediamine solution is 5% to 100% of its own mass per hour. The reaction temperature is 30-200 °C (oil bath temperature), and the reaction time is 2-20 hours (including the dropping time). The molar ratio of 2-chloroethylamine hydrochloride to ethylenediamine is 2:1 to 40:1. This invention is the first to propose a direct synthesis of triethylenetetramine from the bulk chemicals 2-chloroethylamine hydrochloride and ethylenediamine. Compared with the previously reported dichloroethane amination method and the nucleophilic substitution method between dichloroethane and ethylenediamine, this method offers milder reaction conditions, simpler operation, and higher selectivity, making it suitable for industrial production.

The utility model relates to a device for recovering DMC in triethylamine hydrochloride. The device comprises a first phase splitter, a first recovery system, a rectifying tower, a condenser, a second phase splitter and a second recovery system, an oil phase outlet of the first phase splitter is communicated with a material inlet of the first recovery system through a pipeline; a liquid phase outlet of the first phase splitter is communicated with a material inlet of the rectifying tower through a pipeline; a steam outlet in the rectifying tower is communicated with an inlet of the condenser through a pipeline, an outlet of the condenser is communicated with the second phase splitter through a pipeline, and a water outlet of the second phase splitter is communicated with a water inlet of the rectifying tower through a channel. And a DMC outlet of the second phase splitter is communicated with the second recovery system through a pipeline. The DMC recovery device has the beneficial effects that DMC is recovered through the device with a simple structure, continuous production can be realized, the production stability is high, and the equipment maintenance period is prolonged.

The invention belongs to the technical field of organic synthesis, and relates to a preparation method of cimetidine, in particular to a process for synthesizing cimetidine through continuous flow reaction. According to the process, cyanamide and methyl isocyanate are taken as initial raw materials and are accurately pumped into a microchannel continuous flow reactor according to a certain molar ratio, and the N-cyano-N '-methylurea intermediate is efficiently and controllably synthesized at a specific temperature. And then, synchronously pumping a 2-(((5-methyl-1H-imidazole-4-yl) methyl) sulfo) ethyl-1-amine hydrochloride solution and the N-cyano-N '-methylurea intermediate into a subsequent continuous flow reaction module, introducing the reaction liquid into an online drying device with a molecular sieve in real time, and promoting efficient nucleophilic addition reaction through continuous water removal, thereby obtaining the N-cyano-N'-methylurea intermediate. Finally, the cimetidine is obtained at a high yield. The method has the outstanding advantages of mild conditions, high yield, stable product quality, easiness in large-scale amplification and the like, and is a new generation of cimetidine preparation technology which is green, safe and efficient and has important industrial application value.

The application belongs to the technical field of electrolysis of water, and particularly relates to a NiFe bimetallic MOF self-supporting bifunctional electrode for electrolysis of water and a method for electrolysis of water. The electrode takes foamed nickel as a substrate, and the surface of the substrate is uniformly coated with NiFe bimetallic MOF. The coating method comprises the following steps: two pieces of foamed nickel after cleaning and pretreatment are taken as anodes, one piece of foamed nickel after cleaning and pretreatment is taken as a cathode, and the anodes and the cathode are immersed in an electrolyte; under the condition of a constant current of 14-16 mA of a direct current power supply, electrodeposition is performed for 15-55 min; the area of the anode foamed nickel is larger than that of the cathode; in the electrolyte, N,N-dimethylformamide is taken as a solvent, and nickel salt, iron salt, 1,3,5-benzene tricarboxylic acid and triethylamine hydrochloride are uniformly dissolved in the solvent; the molar ratio of Ni to Fe is 40-75:1; and the concentration of triethylamine hydrochloride is 0.01-0.1 mol L⁻¹. The application adopts a double-anode electrodeposition process to improve deposition uniformity, fully expose active sites and reduce electrodeposition energy consumption; and the synergistic effect of the Ni-Fe bimetallic MOF optimizes the HER and OER catalytic performance of the electrode.

The application belongs to the field of organic chemistry and particularly relates to a synthesis method of berberine hydrochloride. The method comprises the following steps: taking 3,4-dimethoxyphenethylamine hydrochloride and 3,4-methylenedioxybenzaldehyde as starting materials, sequentially undergoing oxidative cyclization, selective reduction and quaternary ammonium ring closure through three-step reactions, and finally directly obtaining the target product berberine hydrochloride through acid treatment. The technical scheme has the characteristics of high efficiency, simplicity, and high industrial cost ratio in the synthesis of berberine hydrochloride, the overall reaction is more green and safe, the reaction condition is more mild, the reaction process has high selectivity, and the berberine hydrochloride product with higher purity can be obtained.

The present invention provides 1,4-dimethylpiperazine and a preparation method thereof. The preparation method comprises the following steps: (1) reacting N-methyl ethylamine salt to obtain a reactant; (2) purifying the reactant to obtain the 1,4-dimethylpiperazine; the N-methyl ethylamine salt is 2-chloro-N-methyl ethylamine hydrochloride or 2-bromo-N-methyl ethylamine bromate; the process for preparing 1,4-dimethylpiperazine provided by the present invention has high reaction activity, high stability, high selectivity, simple reaction steps, mild reaction conditions, low requirements for reaction equipment, low potential safety hazards in production, and the purity of the 1,4-dimethylpiperazine prepared by the preparation method provided by the present invention can reach 99.5%.

The invention discloses a novel preparation method of dimethyl diethyl ammonium chloride. The method comprises the following specific steps: adding diethylamine hydrochloride, dimethyl carbonate and a reaction solvent into a pressure reaction kettle, reacting at 90-180 DEG C for 8-24 hours, cooling to release gas produced by the reaction when the pressure of the reaction kettle reaches a certain value during the reaction, and concentrating, crystallizing, filtering and drying the reaction liquid after the reaction is finished, thereby obtaining the methylation and quaternization of amines. The high-purity dimethyl diethyl ammonium chloride is obtained. According to the method, expensive reagents N, N-dimethylethylamine and N, N-diethyl methylamine are not used, meanwhile, reagents chloroethane and chloromethane which are high in harm and toxicity are also not used, the problem that the pressure of a reaction kettle is too high in the methylation process of the reaction is solved by releasing gas generated in the reaction process, the obtained product is high in purity, the yield is high, and the method is suitable for industrial production. And the halogen ion and metal ion residues are very low. The novel method for preparing dimethyl diethyl ammonium chloride is green, safe, low in cost and high in product quality.

The invention relates to a carbon-based organic-inorganic perovskite solar cell based on modification of 2-methylthio-1-ethylamine hydrochloride and a preparation method of the carbon-based organic-inorganic perovskite solar cell based on modification of 2-methylthio-1-ethylamine hydrochloride. The solar cell sequentially comprises a transparent conductive substrate, an electron transport layer, a perovskite layer, a 2-methylthio-1-ethylamine hydrochloride modification layer and a carbon electrode from bottom to top, the thickness of the 2-methylthio-1-ethylamine hydrochloride modification layer ranges from 5 nm to 10 nm. The preparation method is efficient, the preparation process is simple, the carrier transport performance of the prepared perovskite solar cell based on the carbon electrode is improved, the photoelectric conversion efficiency is remarkably improved, and the perovskite solar cell has good application prospects in the future.

The invention discloses a preparation method of amiodarone hydrochloride, which comprises the following steps: carrying out substitution reaction on (2-butyl-3-benzofuryl) (4-hydroxy-3, 5-diiodophenyl) ketone and 2-chloroethanol, then carrying out chlorination, carrying out amination reaction with diethylamine to obtain free amiodarone, salifying and crystallizing in a hydrochloric acid ethanol solution, and purifying to obtain the amiodarone hydrochloride. The amiodarone hydrochloride is obtained. According to the method, use of 2-chloro-N, N-diethyl ethylamine hydrochloride in a traditional route is avoided, the process conditions are mild, the total yield of the route is high, and the method is suitable for industrial production.

This invention provides a method for preparing androstane-3,6,17-trione (E,Z)-3-[O-(2-aminoethyl)]oxime hydrochloride, comprising the following steps: benzophenone oxime reacts with 2-chloroethylamine hydrochloride in dimethyl sulfoxide, followed by acid-base adjustment, toluene extraction, hydrolysis with concentrated hydrochloric acid to remove the protecting group, and crystallization to obtain high-purity 2-aminoethylamine hydrochloride; androstane-3,6,17-triol is used as a raw material and oxidized under the catalysis of sodium bromate and ruthenium oxide (IV), quenched, separated, washed with water, and crystallized by solvent replacement with isopropanol to obtain androstane-3,6,17-trione; the 2-aminoethylamine hydrochloride solution is mixed and reacted with the trione in tetrahydrofuran solution at low temperature, followed by salting out, filtration, separation, washing with saturated brine and drying with magnesium sulfate, and purification by solvent replacement, water dissolution and concentration, and cooling crystallization to obtain the high-purity target product. This invention significantly improves the yield of the target product by optimizing reaction conditions, while achieving readily available raw materials, low cost, and industrialized production through traditional chemical reaction pathways.

The invention belongs to the technical field of medicine preparation, and particularly relates to a preparation method of high-optical-purity litamilast. According to the method, an acetonitrile aqueous solution with a specific concentration is taken as a solvent, a litamilast crude product and (S)-(-)-N-benzyl-1-phenyl-ethylamine are salified, and litamilast (S)-(-)-N-benzyl-1-phenyl-ethylamine salt is separated out by utilizing the solubility difference of the salified isomer in the solvent, so that the litamilast (S)-(-)-N-benzyl-1-phenyl-ethylamine salt is obtained. (S)-(-)-N-benzyl-1-phenyl-ethylamine salt of an isomer impurity A of the compound is dissolved in a solvent. And dissociating by using (S)-(-)-N-benzyl-1-phenyl-ethylamine hydrochloride of the litamilast hydrochloride, so as to obtain the litamilast with high optical purity. The method is simple in technological process, high-optical-purity litamilast can be obtained through one-time preparation, operation is easy, the solvent can be recycled, cost is low, and the method is environmentally friendly and suitable for large-scale industrial production and has excellent industrial application prospects.

The invention discloses an integral centrifugal column for enriching S-nitrosopeptide as well as a preparation method and application of the integral centrifugal column, and belongs to the technical field of SNO proteomics analysis. The method disclosed by the invention comprises the following steps: adding an integral material pre-polymerization solution into a closed blank centrifugal column, and carrying out in-situ thermal initiation polymerization reaction to obtain a substrate integral material centrifugal column; and swelling the substrate integral material centrifugal column, adding a phosphate buffer solution of pyridine dithio ethylamine hydrochloride, standing and cleaning to obtain the integral material centrifugal column for enriching the SNO peptide. The centrifugal column can realize integrated reduction, marking and enrichment of SNO peptides, and is applied to SNO proteomics analysis in complex biological samples. The method solves the technical problem that the existing method is difficult to simultaneously reduce / mark / enrich SNO protein or peptide in a complex sample, effectively reduces the loss and degradation of the SNO peptide in the sample treatment process through the integrated sample treatment process, and obviously improves the identification scale of the SNO protein and the modification site.

The invention discloses metal surface anticorrosive paint and a preparation method thereof, and relates to the field of metal anticorrosive paint. When the metal surface anticorrosive paint is prepared, modified castor oil and triethylamine hydrochloride react to prepare a castor oil-based cross-linking agent; the preparation method comprises the following steps: carrying out epoxidation reaction on hexafluorobisphenol A and epoxy chloropropane to prepare an epoxy prepolymer; reacting the epoxy prepolymer with protocatechuic acid to obtain modified epoxy resin; the preparation method comprises the following steps: reacting 2-aminobenzothiazole with isocyanate propyl triethoxy silane to prepare modified silane; and uniformly mixing the modified epoxy resin, the modified silane and the mixed solvent, and adding the flatting agent and the castor oil-based cross-linking agent to prepare the metal surface anticorrosive paint. The metal surface anticorrosive paint prepared by the invention has excellent corrosion resistance, antibacterial property and high adhesive force.

The application discloses a method for producing berberine by using recycled formic acid, and belongs to the technical field of preparation of medical chemical raw materials. The method comprises the following steps: 1, adding diatomite powder to a dilute hydrochloric acid solution to remove impurities, and preparing a water removing agent by acid pickling, roasting and dropwise adding phosphorus oxychloride; 2, adding anhydrous sodium sulfate to crude formic acid to pre-dehydrate, adding the water removing agent to remove water after filtering out the precipitate, and obtaining refined recycled formic acid; 3, adding copper chloride, refined recycled formic acid, N-2,3-dimethoxybenzyl piperidyl ethylamine hydrochloride into a reactor, dropwise adding 40% glyoxal, and performing cyclization reaction for 3-4 hours; 4, removing the cyclization mother liquor by suction filtration, retaining the solid, adjusting the alkali and heating, filtering out the precipitate and retaining the filtrate, adjusting the acid, cooling and crystallizing, filtering and retaining the solid, rinsing and drying, and obtaining berberine. The application realizes preparation of berberine by using recycled formic acid, and the production process is safe, and the product has high purity and high yield.

The invention discloses an acid-base bifunctional solid catalyst and a synthetic method of chlorphenesin, and belongs to the technical field of organic chemical preparation. The acid-base bifunctional solid catalyst is prepared by the following steps: 1) dispersing UiO-66-NH2 in dimethylformamide, adding 2-chloroethylamine hydrochloride, and carrying out a reaction, so as to obtain imidization modified UiO-66-NH2; 2) dispersing the imidization modified UiO-66-NH2 in methanol, adding formaldehyde, and carrying out a reaction to obtain a solid product; and 3) dispersing the solid product in acetonitrile, adding hypophosphorous acid, and carrying out a reaction to obtain the acid-base bifunctional solid catalyst. When the acid-base bifunctional catalyst provided by the invention is used for synthesizing chlorphenesin, the catalyst is easy to recover, environment-friendly and non-corrosive to production equipment, the loss of raw materials and equipment can be effectively reduced, and side reaction can be effectively inhibited.

This invention discloses a method for recovering triethylamine hydrochloride and treating wastewater, aiming to solve the problems of recovering vinylene carbonate and triethylamine while reducing the cost of waste treatment. The method includes: Step 1: Soaking triethylamine hydrochloride in an organic solvent, ultrasonically cavitating and pulverizing the triethylamine hydrochloride, dissolving vinylene carbonate, filtering, and drying the triethylamine hydrochloride in stages under reduced pressure to recover vinylene carbonate and triethylamine; Step 2: Mixing the triethylamine hydrochloride with diatomaceous earth and subjecting it to high-temperature heat treatment; Step 3: Dissolving the heat-treated mixture of triethylamine hydrochloride and diatomaceous earth in water, filtering, alkaline hydrolysis, phase separation, and wastewater extraction; Step 4: Using an adsorbent to adsorb the wastewater, resulting in effluent with TOC < 10 ppm and TN < 5 ppm, which can be directly discharged into the sea after meeting the standards. Compared with traditional wastewater evaporation and salt precipitation operations, this method significantly reduces wastewater treatment costs. The recovered vinylene carbonate, after desolventizing and purification, can be sold as a product.

The utility model discloses a triethylamine hydrochloride wastewater pretreatment device, which relates to the technical field of wastewater pretreatment and comprises a stirring tank. A first motor for driving the rotating shaft to rotate is mounted at the top of the stirring tank, a stirring part is mounted on the outer side of the rotating shaft and close to the bottom, a purification box for pretreating wastewater is mounted on the other side of the stirring tank, and a filtering part is mounted on the inner side of the purification box through multiple groups of locking fasteners; according to the sewage treatment device disclosed by the utility model, large-particle impurities in sewage are filtered and purified in advance through the filtering piece in the purification box, and a purified aqueous solution is pumped into the stirring tank by utilizing the liquid pump; the stirring piece is used for fully stirring and mixing the aqueous solution and the medicine, the PH value adjusting speed is increased, the brushing piece can be used for brushing and cleaning the filtering piece, impurity accumulation is avoided, and the filtering piece can be taken out, disassembled, replaced or fixedly installed through the locking piece.

The invention belongs to a chemical synthesis technology. The invention provides a synthesis method of N, N-dimethyl ethanethiol amine hydrochloride, which comprises the following synthesis steps: (1) synthesizing a 2-chloro-N, N-dimethyl ethylamine hydrochloride intermediate; (2) synthesis of N, N-dimethyl ethanethiol amine; and (3) synthesizing the N, N-dimethyl ethanethiol amine hydrochloride. The invention further provides the N, N-dimethyl ethanethiol amine hydrochloride. The invention also provides the N, N-dimethyl ethanethiol amine hydrochloride synthesized by the synthesis method or the application of the N, N-dimethyl ethanethiol amine hydrochloride in measuring the content of a water-soluble metabolite fumonisins generated by fusarium moniliforme. The synthesis method of the N, N-dimethyl ethanethiol amine hydrochloride provided by the invention is simple and efficient, the use of high-leakage risk raw materials such as hydrogen sulfide and ethylene sulfide is avoided, the production cost is effectively reduced, and the environmental pollution is reduced. N, N-dimethyl ethanethiol amine hydrochloride is used for replacing ethanethiol, so that the method is safer and has practical application value.

The invention discloses a rivastigmine derivative based on electron donating effect modification and a preparation method and application thereof, and belongs to the field of medicinal chemistry, the structural formula of the rivastigmine derivative based on electron donating effect modification is shown in the formula (I), and the preparation method comprises the following steps: dissolving triphosgene in dichloromethane, adding a catalyst, and stirring to obtain a solution A; injecting into a reaction bottle protected by nitrogen by an injector, and starting stirring; mixing N-methyl-2-chloroethylamine hydrochloride and triethylamine, diluting with dichloromethane, and then slowly dropwise adding the mixture into the reaction bottle at room temperature by using an injector; after dropwise adding, dissolving 3-[1-(dimethylamino) ethyl] phenol in dichloromethane, slowly dropwise adding into the reaction bottle by using an injector at room temperature, and continuously stirring to react; and after the reaction is finished, evaporating to remove the solvent. The compound provided by the invention can be used for preparing an anti-Alzheimer's disease medicine. # imgabs0 #

The invention belongs to the field of organic chemistry, and particularly relates to a synthetic method of berberine hydrochloride. The method comprises the following steps: taking 3, 4-dimethoxyphenylethylamine hydrochloride and 3, 4-methylenedioxybenzaldehyde as starting raw materials, carrying out three-step reaction in sequence, sequentially carrying out oxidative cyclization, selective reduction and quaternization ring closing, and finally directly obtaining the target product berberine hydrochloride through acid treatment. The technical scheme has the characteristics of high efficiency, simplicity and high industrial cost performance in synthesis of berberine hydrochloride, the whole reaction is green and safe, the reaction conditions are mild, the reaction process has extremely high selectivity, and a berberine hydrochloride product with higher purity can be obtained.

The invention discloses a high-interception seawater desalination polyamide reverse osmosis composite membrane and a preparation method thereof, and relates to the technical field of membrane separation, the high-interception seawater desalination polyamide reverse osmosis composite membrane is prepared from the following raw materials: a polysulfone-based membrane, m-phenylenediamine, triethylamine hydrochloride, trimesoyl chloride and an isoparaffin solvent; wherein the isoparaffin solvent is IsoparG, and the isoparaffin solvent is isoparaffin; by optimizing the concentration ratio of a water-phase monomer m-phenylenediamine, a catalyst triethylamine hydrochloride and an organic-phase monomer trimesoyl chloride and combining an interfacial polymerization and thermal crosslinking process, a polyamide functional layer with high crosslinking degree and a uniform microstructure is constructed. Under the test conditions of 32000 ppm NaCl solution and 800 psi, the permeation flux of the prepared membrane is larger than or equal to 22.0 LMH, the NaCl retention rate is larger than or equal to 99.50%, the core requirement of seawater desalination for the high retention rate is met, and the water treatment efficiency matched with actual engineering is guaranteed.

The invention discloses a triethylamine hydrochloride freezing crystallization device and process, and relates to the technical field of triethylamine hydrochloride preparation. The invention comprises a solution processing component, comprising a processing tank and a tank cover located at an upper port position of the processing tank and flange-connected thereto, a crystallization component, comprising a crystallization tank located inside the processing tank and a stirring motor fixed at an upper end surface position of the tank cover, a distinguishing linkage component, comprising a distinguishing column sliding inside a transverse cylinder and a linkage column located inside the processing tank and arranged parallel to the distinguishing column at the same height, a circulation reflux component, and a freezing and recycling component. The invention realizes that the size of the crystals inside the crystallization tank can be distinguished by sliding the distinguishing column inside the transverse cylinder, thereby moving the curved hole and the vertical hole to the position directly below the lower port of the crystallization tank in different time periods, and small crystals are transported to a heating box through a screw rod, and the recovered small crystals are melted and recrystallized, so as to realize the work of achieving recrystallization by utilizing the waste heat.

The invention relates to the technical field of esterification reaction devices, discloses an esterification reaction device for recycling triethylamine hydrochloride, and solves the problem that when a certain amount of sodium hypochlorite needs to be added in an esterification reaction to promote the reaction process, the sodium hypochlorite is slowly added, so that the reaction time is shortened. The invention relates to a sodium hypochlorite reaction device which solves the problems that sodium hypochlorite is in contact with a solution below a liquid inlet firstly, the solution in the device is possibly not in contact with the sodium hypochlorite completely, and the reaction is not complete, and comprises a reaction barrel, a protective shell is arranged at the upper end of the reaction barrel, the reaction barrel comprises a reaction shell, and a barrel cover is fixedly mounted at the upper end of the reaction shell. A liquid inlet is formed in the outer side of the reaction barrel, a stirring assembly is arranged at the upper end of the barrel cover, a rotating assembly is arranged on one side of the stirring assembly, and when a certain amount of sodium hypochlorite needs to be added to promote the reaction process, the sodium hypochlorite is slowly added into the liquid inlet, flows into the liquid discharging groove and is discharged into a mixed solution in the reaction barrel.