151 results about "Ethylamine hydrochloride" patented technology

The invention belongs to the technical field of drug synthesis, and relates to position selective synthesis of alpha-narcotine with participation of a blockage group, preparation of serial phthalide tetrahydroisoquinoline compounds and preparation of various phthalide-3-carboxylic acid compounds and various 3-oxo isochroman-1-carboxylic acid compounds through a universal mode. In the method, 2, 3-dimethoxy benzoic acid is used as a raw material and condensed with glyoxylate through the universal mode to obtain 6, 7-dimethoxy phthalide-3-carboxylic acid, the carboxylic acid and 2-(2-bromo-3, 4-methylenedioxy-5-methoxy-phenyl)-ethylamine hydrochloride are condensed to prepare amide, the amide reacts with Bischler-Napieralski to prepare bromo-alpha-narcotine through reaction, methylation and salt formation, and (-)-alpha-narcotine is then prepared through dehalogenation and resolution. Due to the positioning function of the blockage group, the invention effectively reduces the position selectivity of Bischler-Napieralski cyclization, and realizes the simple and efficient synthesis of alpha-narcotine through removal of the blockage group and the chiral resolution.

The invention relates to one-step synthesis of ethyl isocyanate, which belongs to the chemical technical field. The method abandons a process of phosgene feeding in routine techniques, and uses xylene as a solvent.150-200 kg ethylamine hydrochloride is dissolved in 400-600 L xylene; the xylene solution containing 200-300 kg trichloromethyl carbonate is added into a reaction vessel in a dropwise manner with the presence of 5-10 kg of a catalyst; and the following steps are carried out: preparation of a catalyst, synthesis of a target product, separation of the target product, synthesis of ethyl isocyanate, and preparation of the product after separation. The method in the invention abandons the process of phosgene feeding in the routine techniques, and uses xylene as the solvent. The method effectively solves the problems of high risk, severe pollution, high cost and poor quality and the like in the process of phosgene feeding in the productive process in the routine techniques that use phosgene.

The invention relates to a production process for synthetizing L-theanine through biological immobilized enzyme catalysis, which belongs to the technical field of biosynthesis. The L-theanine is synthetized through the biological immobilized enzyme catalysis by taking sodium glutamate, magnesium chloride hexahydrate, sodium hexametaphosphate, ethylamine hydrochloride and triphosadenine to serve as raw materials. The production process for synthetizing the L-theanine through the biological immobilized enzyme catalysis comprises the following process steps: (1) performing catalytic synthesis on a substrate and an immobilized enzyme to generate the L-theanine, and then, centrifugally separating the biological immobilized enzyme from reaction liquid; (2) removing anions and cations in the reaction liquid through cation exchange resin to generate purified L-theanine; (3) decoloring an L-theanine aqueous solution through activated carbon, and performing vacuum film concentrating to obtain an L-theanine concentrated solution; and (4) adding 95 percent of alcohol to the L-theanine concentrated solution to separate out white L-theanine precipitation crystals; centrifugally separating; and performing vacuum drying to obtain white L-theanine powder. The production process for synthetizing the L-theanine through the biological immobilized enzyme catalysis has the advantages of specific process reaction, high yield, high purity, short period, low energy consumption and the like and is suitable for industrial production.

The invention discloses a novel preparation method of a ramelteon intermediate 2-(1, 2, 6, 7-tetrahydro-8H-indeno[5, 4-b] furan-8-yl) ethylamine hydrochloride (I). The method is characterized by comprising the following steps: dehydrating and condensing and heating and decarboxylating 4, 5-dibromo-1, 2, 6, 7-tetrahydro-8H-indeno[5, 4-b] furan-8-one (II) and cyanoacetic acid (III) under the effect of a catalyst to obtain a compound (IV); then, hydrogenating the (IV) and salifying to obtain the ramelteon intermediate hydrochloride (I). The invention provides a novel preparation of the ramelteon intermediate hydrochloride (I). According to the method, cyanoacetic acid (II) which is cheap and easily available is used, so that the method is simplified in synthetic step, high in efficiency and simple and convenient to operate, and the method is a preparation method which is more suitable for industrialized production.

The invention discloses a glyphosate mother liquor comprehensive treatment and resource recycling method which comprises the following steps: adding a pH value regulator into acidic mother liquor M0,standing for layering, and separating the solution to obtain mother liquor M4 at the upper layer and mother liquor M5 at the lower layer; the mother liquor M4 and the mother liquor M5 are treated andapplied, triethylamine hydrochloride, triethylamine, chloride salt, methyltriethylammonium chloride, phosphorous acid or salt thereof, hydroxymethylphosphonic acid or salt thereof, glyphosate or saltthereof, glyphosate or salt thereof and glyphosate or salt thereof are recovered from the mother liquor M4 and the mother liquor M5, and are respectively and correspondingly converted into products with higher additional values for utilization. The glyphosate mother liquor comprehensive treatment and resource recycling method has the advantages that the emission is reduced from the source; the method reduces the total amount and treatment load of the glyphosate mother liquor, reduces environmental pollution, realizes reasonable recycling and appreciation of resources, improves economic benefits, is environment-friendly, outstanding in economic benefits and good in technical implementation effect, and is suitable for large-scale industrial application.

The invention relates to a synthetic method of 2-(7-methoxyl-1-naphthyl) ethylamine hydrochloride. The method comprises the following steps of: reacting 7-methoxyl-1-naphthyl (a compound IV) with cyanoacetic acid to prepare (7-methoxyl-3,4-dihydro-1-naphthyl) acetonitrile (a compound III); performing deep drawing quality (DDQ) dehydrogenation to prepare (7-methoxyl-1-naphthyl) acetonitrile; using sodium borohydride as a reducing agent and reacting sodium borohydride with calcium chloride in anhydrous tetrahydrofuran to react to obtain 2-(7-methoxyl-1-naphthyl) ethylamine; and satisfying with hydrochloric acid to obtain a compound I, wherein the compound is an important intermediate of synthetic agomelatine.

The invention provides a clean production process of glycine. The clean production process can be used for co-producing an ammonium chloride product when being used for producing glycine. In a process of producing glycine, a triethylamine hydrochloride product can be co-produced. After a solvent, namely methanol, and a catalyst are added into a reactor of a glycine ammonolysis reaction, solid ammonium chloroacetate is added; after the temperature is raised to 65 DEG C, triethylamine is added; all triethylamine is added within one and a half hours; and the heat is kept and a reaction is carried out for two and a half hours until the pH (Potential of Hydrogen) value is 7.5. The glycine and triethylamine hydrochloride are separated through cooling and freezing respectively. The triethylamine in the triethylamine hydrochloride is recycled through an ammonia introducing method; and meanwhile, the ammonium chloride product is co-produced.

The invention discloses a preparation method for isocyanate ethyl methacrylate. The preparation method comprises the following steps: (I), reacting by adopting ethanol amine, methacrylic acid and an organic solvent as raw materials in the presence of thionyl chloride, adding distilled water after reaction is ended, stirring, layering, concentrating and drying an obtained water layer to obtain methylacryloyl(2-hydroxyl) ethylamine hydrochloride, and drying and concentrating the organic phase to obtain methacrylic acid (2-hydroxyl) alcohol ester; (II), adding an organic solvent, solid phosgene and a catalyst into the reactor, adding methylacryloyl(2-hydroxyl) ethylamine hydrochloride generated in the step (I), heating to 80-100 DEG C in a reaction process, and collecting the fraction which is isocyanate ethyl methacrylate after the reaction is ended. The preparation method disclosed by the invention serves double purposes, and waste gas generated in the reaction process is absorbed by alkali liquor, so that environmental pollution is almost avoided; the purity of obtained products is over 95%, and the product yield is over 90%.