378 results about "Ethylamines" patented technology

The invention discloses an acetonitrile hydrogenation catalyst and a preparation method and application thereof. The acetonitrile hydrogenation catalyst is a transition metal modified Pt supported catalyst. A transition metal precursor adopted in the transition metal improvement is an oxide containing transition metal elements; the transition metal element is selected from at least one of titanium, vanadium, manganese, iron, cobalt, nickel and copper; the acetonitrile hydrogenation catalyst also comprises a carrier; the carrier is selected from at least one of gamma-Al2O3, SiO2, an MOR molecular sieve and a ZSM-5 molecular sieve. The catalyst can effectively catalyze acetonitrile hydrogenation to prepare ethylamine under mild reaction conditions. The supported catalyst provided by the invention has excellent reaction performance such as high acetonitrile conversion rate in acetonitrile hydrogenation reaction, the reaction condition is mild, the operation is simple, and the catalyst is easy to prepare and can be recycled.

The invention discloses a method for preparing calcium hydroxide slurry with high specific surface area and high pore volume, which comprises the following steps: S1, adding an alcohol reagent into water to obtain a solution A; s2, adding an inorganic salt solution into the solution A, and uniformly mixing to obtain a solution B; s3, a reagent X is added into the solution B, ultrasonic mixing is performed to obtain a solution C, and the reagent X is a mixture of phenol or triethanolamine, ethidene diamine and ethylamine; and S4, adding calcium oxide powder into the solution C, continuously stirring, and reacting to obtain calcium hydroxide slurry. The invention provides a method for preparing calcium hydroxide slurry with high specific surface area and high pore volume, the calcium hydroxide slurry prepared by the method can form calcium hydroxide with high specific surface area and high pore volume when in use, and the method aims to solve the problems of low specific surface area and low pore volume of the existing calcium hydroxide. Therefore, the problem of desulfurization performance inactivation caused by blockage of calcium hydroxide (desulfurizer) pores by generated CaSO3 and CaSO4 in the desulfurization process is avoided.

The present invention discloses an imidazole derivative, a preparation method thereof, and an application, belonging to the field of organic chemistry. The preparation method of the imidazole derivative of the present invention includes: adding compound 2a and dimethyl sulfate into an organic solvent, heating and reacting to obtain compound 3a; wherein, compound 2a is prepared by adding compound 1a, TrtCl, and a base reagent into a solvent, controlling the temperature at 0-10 °C, mixing evenly and reacting. The present invention also further prepares 2-(1-methylimidazol-5-yl)ethylamine (4a) by using the imidazole derivative. The present invention selects dimethyl sulfate as a methylation reagent and cooperates with a specific protecting group design to achieve the efficient preparation of 2-(1-methylimidazol-5-yl)ethylamine, with a total yield of 82.4%.

The invention relates to a green preparation method of fluopyram intermediate 3-chloro-5-(trifluoromethyl)-2-ethylaminopyridine, which comprises the following steps: step 1, Ullmann reaction: coupling 3-chloro-2-methyl-5-trifluoromethylpyridine (C1) and N-bromomethyl phthalimide (C2) in the presence of a copper catalyst and potassium tert-butoxide to generate an intermediate (C3); and step 2, hydrolysis reaction: hydrolyzing the intermediate (C3) in the presence of hydrazine sulfate and an alkaline condition to generate the fluopyram intermediate 3-chloro-5-(trifluoromethyl)-2-ethylamino pyridine. The method has the advantages of short synthesis steps, easily available raw materials, no use of high-toxicity cyanogen compounds, low catalyst cost, difficult poisoning, recycling, simple post-treatment process, and less waste liquid generation, greatly reduces the production cost, improves the production safety, reduces the waste liquid discharge amount, and accords with the idea of green synthesis.

The invention relates to a nitrogen-containing heterocyclic compound as well as a preparation method and application thereof, belongs to the technical field of heterocyclic compound synthesis, and solves the problems of low reaction efficiency and high energy consumption caused by the fact that an existing method for synthesizing an indole maleimide derivative needs to be carried out step by step. The preparation method comprises the following steps: step 1, adding indoleacetamide and a nucleophilic reagent into a mixed solution, and reacting; 2, performing post-treatment to obtain a nitrogen-containing heterocyclic compound; the mixed solution comprises alkali, an additive and an organic solvent; the alkali comprises one of triethylamine (Et3N), N, N-diisopropylethylamine, pyridine and 1, 8-diazabicyclo [5.4. 0] undec-7-ene, and the alkali comprises one of 1, 8-diazabicyclo [5.4. 0] undec-7-ene.

The invention discloses a preparation method of a composite flocculant based on efficient water treatment, belongs to the technical field of flocculant processing, and aims to solve the technical problem that the flocculation performance and the settling performance of a flocculant need to be further improved in the prior art. The preparation method specifically comprises the following steps: putting acrylamide, diallyldimethylammonium chloride, 2-hydroxypropyl methacrylate and deionized water into a reaction kettle, and uniformly mixing to obtain a mixed monomer; according to the preparation method, citric acid monohydrate and iron nitrate nonahydrate react under a mild acidic condition to form a Fe < 3 + >-citric acid complex, and then 2-hydroxyethylamine is introduced to further participate in complexing to obtain a citric acid complexing solution, so that not only is the flocculation performance of the composite flocculant improved, but also the settling performance of the composite flocculant is improved.

The invention discloses a triazine desulfurizer and a preparation method thereof, and belongs to the technical field of gas purification. The triazine desulfurizer is mainly prepared from the following raw materials in percentage by weight: 20 to 50 weight percent of triazine derivative, 10 to 15 weight percent of sterically hindered amine, 3 to 7 weight percent of stabilizer, 1 to 3 weight percent of synergist, 0.5 to 1.5 weight percent of penetrant, 0.5 to 1.5 weight percent of inhibitor, 1 to 2 weight percent of additive and the balance of water, the preparation method of the triazine derivative comprises the following steps: adding 2-(diphenylphosphino) ethylamine into a toluene solvent, adding a paraformaldehyde aqueous solution in batches under a stirring condition, and reacting for 2-8 hours to obtain the triazine derivative. According to the triazine desulfurizer and the preparation method thereof provided by the invention, the triazine derivative and the sterically hindered amine are taken as a host, and the stabilizer, the synergist, the penetrant, the inhibitor and the assistant are compounded, so that the scaling trend of the triazine desulfurizer in an oil and gas well can be slowed down, the dissolution rate of hydrogen sulfide and the mass transfer rate in a solution are increased, and the desulfurization reaction is promoted; the desulfurization effect and the desulfurization rate are improved, and meanwhile, a very good scale inhibition effect is also achieved.

The invention discloses a preparation process of berberine hydrochloride, and belongs to the technical field of berberine production. The invention relates to a berberine hydrochloride preparation process, which comprises: S1, mixing a ferric sulfate-aluminum sulfate composite salt, sodium chloride, zinc chloride and anhydrous formic acid, pre-activating, adding N-2, 3-dimethoxybenzyl homopiperony lamine hydrochloride, dropwise adding a glyoxal mixed solution, and carrying out a reflux reaction. And S2, cooling the reaction liquid until a solid is separated out, filtering, adding a filter cake and diatomite into purified water, stirring, adjusting alkali, heating, and continuously stirring for 0.5-1 hour. Cooling and filtering, and reserving filtrate; s3, adjusting the acidity of the filtrate, cooling and growing crystals; and filtering, rinsing a filter cake, and carrying out vacuum drying on the filter cake to obtain berberine hydrochloride. The berberine hydrochloride prepared by the method is high in yield and purity, and the preparation process is safe, short in flow and friendly to human bodies and environment.

The invention belongs to the technical field of chemical pharmacy, and particularly relates to a preparation method and application of an impurity of a beta2 adrenal receptor stimulant and M receptor antagonist bifunctional active compound. According to the impurity preparation method of the beta2 adrenal receptor stimulant and M receptor antagonist bifunctional active compound, acetylation of amino is successfully realized by using acetylation reagents such as acetyl chloride and alkali accelerators such as N, N-diisopropylethylamine, then debenzylation is performed through hydrogenation reaction, and the compound shown in the formula I is successfully prepared. Then, through liquid chromatography purification, a high-purity compound as shown in the formula I is obtained, and the raw material medicine as shown in JKN2304 can meet the requirements of reference substances in the research and development process; the technical problem that in the prior art, an impurity synthesis process of a beta 2 adrenal gland receptor agonist and M receptor antagonist bifunctional active compound is lacked is solved.

The invention discloses a high-strength energetic compound based on a polydopamine and thiourea polymer and a preparation method of the high-strength energetic compound, and the energetic compound is composed of energetic crystal 1, 3, 5-triamino-2, 4, 6-trinitrobenzene, the polydopamine and the thiourea polymer. The preparation method comprises the following steps: modifying an energetic crystal 1, 3, 5-triamino-2, 4, 6-trinitrobenzene through polydopamine in advance; the polythiourea is obtained through reaction of 2, 2 '-(ethylene dioxygen) diethylamine, carbon disulfide and trimethylolpropane tripolypropylene glycol ether, and the addition amount is 2.5 wt.%-10 wt.%; and mixing the two components by a kneading method, and drying to obtain the energetic compound. The obtained compound has the characteristics of strengthening and toughening, the Brazil mechanical strength reaches 14.76 MPa, and the fracture strain reaches 0.474%. By introducing polyphenol polydopamine and polythiourea to achieve a synergistic effect, the mechanical property of the explosive is greatly improved, and a technical support can be provided for the application of the explosive; meanwhile, the preparation method is simple, mild in reaction condition and easy for large-scale production.

The invention discloses a flue gas desulfurization composite synergist and a preparation method thereof, and relates to the technical field of flue gas desulfurization. The desulfurization composite synergist is prepared from the following raw materials in parts by weight: 5 to 10 parts of citric acid, 20 to 30 parts of binary acid, 15 to 20 parts of sodium formate, 15 to 20 parts of sodium salt, 12 to 18 parts of magnesium salt, 2 to 4 parts of surfactant, 2 to 4 parts of pH buffering agent and 5 to 10 parts of calcium oxide. The preparation method comprises the following steps: carrying out a ring-opening reaction on 3-(2-aminoethylamine) propyl methyl dimethoxy silane and glucolactone to obtain an intermediate 1, and then carrying out a two-step quaternization reaction to synthesize the novel surfactant. The prepared desulfurization composite synergist has a good desulfurization effect and is suitable for limestone-gypsum wet flue gas desulfurization.

The invention relates to an organic crystalline piezoelectric material based on chiral 4-bromophenylethylamine hydrochloride, which is synthesized by using hydrochloric acid as an anion and protonated (R / S)-4-bromophenylethylamine as a cation according to the stoichiometric ratio of (R / S)-4-bromophenylethylamine to hydrochloric acid of 1: 1. The invention provides an organic crystalline piezoelectric material based on chiral 4-bromophenylethylamine hydrochloride and a preparation method, and provides a two-dimensional hydrogen bond network construction strategy based on protonated chiral amine: protonated (R / S)-4-bromophenylethylamine cations are used as structural elements, chloride ions are used as charge balance bodies, and the chiral 4-bromophenylethylamine hydrochloride is prepared by precisely regulating the interaction of intermolecular hydrogen bonds. Constructing a two-dimensional hydrogen bond network with high orientation; by enhancing ordered arrangement of molecular dipoles and optimizing a lattice strain-polarization response collaborative mode, breakthrough improvement of piezoelectric performance is successfully realized, and a new normal form is provided for developing high-performance organic piezoelectric materials.

The invention relates to the field of cosmetics, in particular to a blue copper peptide composition with instantaneous cool feeling and infiltration promotion effects and a preparation method and application of the blue copper peptide composition. The composition comprises an active component copper-blue peptide and a cooling and permeation enhancing system formed by compounding at least two of menthane formylethylamine, menthone glyceryl ketal and methyl diisopropyl propionamide, and the active component can further comprise hexapeptide-11, a blue algae extract and a yeast fermentation product. The preparation method of the composition comprises three core steps of providing a water phase, adding the active ingredients and adding the cool and refreshing infiltration promoting system and other components. Through synergistic compounding of specific fresheners, on the premise that the use amount of each single component is remarkably reduced, efficient permeation promotion of the copper-blue peptide is achieved, the layered cool feeling experience which takes effect quickly and is lasting and mild is provided, the common skin irritation problem of a traditional permeation promoter or a high-concentration single freshener is avoided, and the effect is remarkable. And the transdermal patch has excellent transdermal efficiency, active matter stability and use comfort.

The invention relates to the technical field of preparation of cupanicilib, and discloses a novel preparation method of cupanicilib, which comprises the following steps: by taking vanillic acid as an initial raw material, carrying out methyl esterification, nitration, alkylation reaction with N-3-chloropropylmorpholine hydrochloride, ester group hydrolysis, condensation with urea, nitro reduction, intramolecular condensation and condensation with chloroethylamine hydrochloride to obtain cupanicilib. According to the synthetic scheme, the synthetic route is short, the raw materials are easy to obtain, the yield is high, no dangerous reaction process exists in the reaction process, a highly toxic reagent is not used, and the synthetic scheme is green and efficient.

To provide a fine granulated agent replenishing liquid for a plating liquid, with the replenishing liquid being excellent in the initial stability and safety, and the replenished plating liquid being excellent in the aging stability, without damaging the appearance of a plating film when replenished for a long period of time nor dissolving an organic resist film present on a material to be plated.SOLUTION: A fine granulated agent replenishing liquid for a plating liquid, replenishing a fine granulated agent to a tin-based plating solution including one or two or more kinds of compounds selected from the group consisting of benzaldehyde, 1-naphthaldehyde, 1-naphthoic acid, 1-acetonaphthone, DL-1-(1-naphthyl)ethylamine, and benzylidene acetone, includes a phenyl glycol-based surfactant, the fine granulated agent and water, with a content of the fine granulated agent therein being in a range of 0.1 g / L or more and 10.0 g / L or less, a content of the phenyl glycol-based surfactant therein being in a range of 5 g / L more and 50 g / L or less, and a content of alcohol being less than 1 mass%.SELECTED DRAWING: None

The application discloses a preparation method of enciferstat bulk drug and belongs to the field of drug synthesis. 9,10-dimethoxy-2-(2,4,6-trimethylphenylimino)-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-one (SM) is used as a raw material, and the raw material is reacted with cyclohexylamine under alkaline conditions, and the reaction is washed with water, dried, and concentrated to obtain an intermediate I; the intermediate I is reacted with urea under pressurized heating conditions to prepare an enciferstat drug molecule, the two-step yield is more than 67%, and the purity is more than 99%, the method has a simple operation process, the product is easy to purify, the yield is high, the product purity is high, and a new method for preparing enciferstat bulk drug is provided.

This invention belongs to the field of two-dimensional material preparation technology, and provides an MXene material and its preparation method. The preparation method of the MXene material includes: mixing a MAX phase precursor to be etched with an organic halide reagent and a morphology modifier, performing a solvothermal etching reaction, and after the reaction, washing and drying the resulting product to obtain the MXene material; wherein the organic halide reagent is triethylamine trihydrofluoride, triethylamine hydrochloride, or dichloroethylamine hydrochloride, and the morphology modifier is ethylene glycol, dimethyl sulfoxide, or cyclohexane. The method of this invention can effectively control the microstructure and pore structure of the MXene material.

The present invention discloses an electrochemiluminescent compound, a preparation method thereof and an application thereof, wherein the structural formula of the electrochemiluminescent compound is: wherein n is 100-200, R1, R2, R3 and R4 are all selected from one of a Y group and a hydrogen group, and at least one of R1, R2, R3 and R4 is a Y group. The preparation method of the electrochemiluminescent compound comprises the following steps: dissolving an iridium-containing complex, N, N-diisopropylethylamine, N, N, N', N'-tetramethyl-O-(N-succinimide) urea tetrafluoroborate in N, N-dimethylformamide and mixing; adding a polyethyleneimine solution, performing an amide reaction, separating, and obtaining the electrochemiluminescent compound. The electrochemiluminescent compound (Ir-PEI) of the present invention can improve the water solubility of the iridium-containing complex, can also be used as a coreactant unit in the molecule to promote the generation of ECL signals, and can be used as an ECL active material to construct and prepare an iridium ECL reagent.

The invention discloses a CO2 phase change absorbent based on N-formylmorpholine as well as a preparation method and application thereof, and belongs to the technical field of gas separation. The CO2 phase change absorbent based on N-formylmorpholine is prepared from the following components in percentage by mass: 30 to 40 percent of hydroxyethyl ethylenediamine, 30 to 40 percent of N-formylmorpholine and 27 to 37 percent of water, or 35% of compound amine composed of hydroxyethyl ethylenediamine and N-methylethylamine, 40% of N-formylmorpholine and 25% of water are contained. The preparation method of the CO2 phase change absorbent comprises the following steps: preparing the components in proportion, and uniformly mixing to obtain the CO2 phase change absorbent. The CO2 phase change absorbent is suitable for carbon capture of mixed gas with CO2 partial pressure of 10-20 kPa. The CO2 phase change absorbent can effectively reduce the volatility of the phase change absorbent and the CO2 enrichment phase viscosity, and has a good industrial application prospect.

The present invention provides a method for preparing the active pharmaceutical ingredient of fenfluramine. Aspects of the present invention include (a) hydrolyzing a 2-(3-(trifluoromethyl)phenyl)acetonitrile composition to produce a 2-(3-(trifluoromethyl)phenyl)acetic acid composition; (b) reacting the 2-(3-(trifluoromethyl)phenyl)acetic acid composition with acetic anhydride and a catalyst to prepare a 1-(3-(trifluoromethyl)phenyl)propan-2-one composition; and (c) reducing and aminating the 1-(3-(trifluoromethyl)phenyl)propan-2-one composition with a borohydride reducing agent and ethylamine to produce a fenfluramine composition. The present invention also provides a composition and a pharmaceutical ingredient comprising a pharmaceutically acceptable salt of fenfluramine prepared according to the method and having less than a total of 0.2% by weight of trifluoromethyl regioisomers.

The application belongs to the technical field of organic synthesis, and discloses a preparation method of N-ethyl-2-(N-methyl pyrrolyl) pyrrole, which comprises the following steps: dissolving 1-furfuryl pyrrole, ethylamine and ethanol in water, adding hydrochloric acid into the water, heating and reacting, the reaction temperature is 150-180 DEG C, and the reaction time is 15-35 h; and the target product is obtained. The 1-furfuryl pyrrole is prepared by condensation reaction of 2-furfurylamine and 2,5-dimethoxy tetrahydrofuran, and then the target product N-ethyl-2-(N-methyl pyrrolyl) pyrrole is prepared by reaction of the 1-furfuryl pyrrole and ethylamine, and the raw materials are relatively cheap and have high industrial value.

The invention belongs to the technical field of medicine synthesis, and particularly relates to a synthesis method of upatinib and an intermediate Up-3 thereof. The preparation method comprises the following steps: dissolving a compound Up-1 and a compound Up-2 in a solvent A, adding alkali 1, and reacting to obtain an intermediate Up-3; dissolving the intermediate Up-3 in a solvent B, adding an acid a, removing Boc protection and closing a ring to obtain an intermediate Up-6, and reacting under the action of an acid b to obtain a compound Up-14; the preparation method comprises the following steps: dissolving carbonyl diimidazole, trifluoroethylamine hydrochloride and alkali 2 in a solvent C, stirring, mixing with a compound Up-14 solution, reacting to obtain a compound Up-13, adding an alkali 3 solution, and removing Tos protecting groups to obtain upatinib. According to the method disclosed by the invention, the upatinib crude product is simply synthesized by taking Up-3 as a starting material through a two-pot method for the first time, the time of the whole process is saved, the total yield is relatively high, the purity of the obtained product is also relatively high, and the method is suitable for large-scale production.

The invention belongs to the technical field of pharmaceutical analysis, and particularly relates to a method for determining a residual solvent in LXH-1211 by adopting headspace gas chromatography. Preparing a reference solution and a test solution of the LXH-1211, respectively carrying out headspace equilibrium on the blank solution, the reference solution and the test solution, injecting the solutions into a gas chromatograph in a headspace sample injection manner, recording a chromatogram, and calculating the content of the residual solvent in the test solution by peak area according to an external standard method; wherein the residual solvent is one or more of methanol, ethanol, dichloromethane, dioxane, N, N-diisopropylethylamine or N, N-dimethylformamide. The method is high in sensitivity, good in repeatability and high in accuracy, and can be used for simultaneously detecting the contents of various residual solvents in the LXH-1211, so that the quality of the LXH-1211 is ensured, and the safety of clinical medication is improved.

The invention discloses a preparation method and application of a compound with a cold sensing regulation effect, which comprises the following steps: dissolving tryptophan in methanol, adding concentrated sulfuric acid, esterifying the acid to protect carboxyl so as to obtain tryptophan methyl ester, dissolving the obtained tryptophan methyl ester and aromatic carboxylic acid substances in N, N-dimethylformamide, and reacting to obtain the compound with the cold sensing regulation effect. The method comprises the following steps: catalyzing 2-(7-azabenzotriazole)-N, N, N ', N'-tetramethylurea hexafluorophosphate and N, N-diisopropylethylamine, dissolving a catalyzed product in ethanol (98%), adding into a NaOH solution, stirring, carrying out rotary evaporation treatment, slowly dropwise adding a 0.5 mol / L hydrochloric acid solution, adjusting the pH value of a reaction system to 3-4, and finally obtaining the tryptophan derivative compound with the yield of 70%. The invention provides a potential medicine for improving the working ability and cold injury in the cold environment for people living and working in the cold environment, and is developed into a medicine for effectively improving neuropathic pain diseases in the cold environment.

The invention discloses a methylamine-free perovskite thin film with high thermal stability and a preparation method of the methylamine-free perovskite thin film. The perovskite thin film is prepared from an FAPbI3 perovskite precursor solution doped with 2-(methylsulfonyl) ethylamine hydrochloride. A proper amount of 2-(methylsulfonyl) ethylamine hydrochloride is added into the perovskite precursor solution, the compact and uniform FAPbI3 perovskite thin film with photovoltaic activity is obtained under the condition that methylamine ions are not introduced, the thin film has excellent thermal stability, the service life of a perovskite solar cell can be prolonged, and the service life of the perovskite solar cell is prolonged. And the positive significance is realized on the commercialized application of the perovskite battery.

The invention provides a preparation method of N, N-diisopropylethylamine based on a liquid-phase compression synthesis process, which comprises the following steps: mixing ethanol with hydrobromic acid with specified concentration, and carrying out reactive distillation treatment in the presence of a phase transfer catalyst to generate bromoethane; p-bromoethane and diisopropylamine are subjected to a liquid phase addition and compression combination reaction, and a reaction mixture is obtained; and sequentially neutralizing, distilling, condensing and filtering the reaction mixture to obtain the N, N-diisopropylethylamine, so as to solve the problems that the existing preparation method of the N, N-diisopropylethylamine is high in energy consumption, high in operation risk, large in pollutant discharge amount, low in by-product resource utilization rate, low in cost and the like. The safety is poor; the energy efficiency is low; and by-products cannot be recycled.

According to the invention, a novel ternary acidic deep eutectic solvent (DES) is prepared, ethylamine hydrochloride (EH) is used as a hydrogen bond acceptor (HBD), and DL-malic acid (MA) and polyethylene glycol-400 (PEG-400) are used as hydrogen bond donors (HBA). The DES solvent has good performance on wood fiber biomass refining pretreatment, and three major components of lignocellulose can be efficiently separated. The ternary acidic DES disclosed by the invention is easy to synthesize, good in stability and simple in use method, and an ideal separation effect can be achieved when high biomass solid content is treated, that is, most cellulose is reserved in a solid form, and most hemicellulose and lignin are converted into a liquid form through dissolution or partial degradation to be separated; and separating the lignin component from the hemicellulose by anti-solvent precipitation. The prepared DES can be recycled after being filtered and subjected to rotary evaporation, still has a separation effect equivalent to that of an original solvent after being recycled for six times, and has good industrial application prospect and value.

The present invention belongs to the field of probe technology, and provides a trifunctional probe based on a photocrosslinking group, a preparation method thereof, and an application thereof. The method comprises the following steps: under a protective atmosphere, compound 1, compound 2, 1-hydroxybenzotriazole, dimethylformamide, carbodiimide, and N,N-diisopropylethylamine are mixed, and a condensation reaction is performed to obtain a trifunctional probe based on a photocrosslinking group. The probe provided by the present invention can be bonded with baicalein, TFAE, and scutellaria baicalensis medicated serum to form a corresponding probe, and compete with its original compound. Under excitation of different ultraviolet wavelengths, the probe can be cross-linked with small molecules and target proteins in traditional Chinese medicine, and accurately reflect the level of target protein labeling of the reactive group in the proteome through a "reporter group", and can also selectively enrich the labeled target protein, and achieve the identification of single compounds, compound combinations, and natural drug extract targets through subsequent experiments.

This invention discloses a highly selective method for preparing triethylenetetramine. The method uses 2-chloroethylamine hydrochloride and ethylenediamine as raw materials, reacting them in an aqueous solution. An aqueous solution of ethylenediamine with a concentration of 1-100 wt% is added dropwise to an aqueous solution of 2-chloroethylamine hydrochloride with a concentration of 1-100 wt%. The dropping rate of the ethylenediamine solution is 5% to 100% of its own mass per hour. The reaction temperature is 30-200 °C (oil bath temperature), and the reaction time is 2-20 hours (including the dropping time). The molar ratio of 2-chloroethylamine hydrochloride to ethylenediamine is 2:1 to 40:1. This invention is the first to propose a direct synthesis of triethylenetetramine from the bulk chemicals 2-chloroethylamine hydrochloride and ethylenediamine. Compared with the previously reported dichloroethane amination method and the nucleophilic substitution method between dichloroethane and ethylenediamine, this method offers milder reaction conditions, simpler operation, and higher selectivity, making it suitable for industrial production.

The invention discloses a method for synthesizing dipeptide Fmoc-Leu-Aib-OH, and belongs to the field of polypeptide synthesis, the specific preparation method comprises the following steps: under the action of organic alkali and an activating reagent, Fmoc-Leu-OH and H-Aib-OH react to obtain the dipeptide Fmoc-Leu-Aib-OH; the activating reagent comprises at least one of N, N, N ', N'-tetramethyl chloroformamidine hexafluorophosphate, 2-(7-azabenzotriazole)-N, N, N ', N'-tetramethyl urea hexafluorophosphate and benzotriazole-1-yl-oxytripyrrolidinyl phosphorus hexafluorophosphate, and the organic base comprises at least one of N-methylimidazole, N, N-diisopropylethylamine and pyridine. The dipeptide Fmoc-Leu-Aib-OH prepared by the preparation method disclosed by the invention is high in yield, high in purity and high in raw material conversion rate.