1139 results about "Ethylamines" patented technology

An in situ method for forming a HfO₂ high-k dielectric layer in a batch wafer processing system. The method comprises first loading a plurality of wafers into a process chamber, and then pre-treating the plurality of wafers in the process chamber with a first oxidizer. After pre-treating the wafers, and without removing the wafers from the process chamber, the method then comprises depositing HfO₂ on the plurality of wafers by atomic layer deposition, which comprises a plurality of deposition cycles, each cycle comprising alternating exposure of the plurality of wafers in the process chamber to a second oxidizer and a hafnium precursor. The hafnium precursor is selected from hafnium tert-butoxide (HTB) or hafnium tetra-diethylamide (TDEAH).

The manufacture method of a kind of zirconia fibre cotton relates to the field of resistance of fire fibre material. We compose van-style acetamide acetone zirconium polymer according to chloridze zirconia, acetamide acetone and three-ethylamine. We use methanol as the dilute impregnant, we mix round them to let hloridize zirconia, acetamide acetone and three-ethylamine react at 40-20 deg.C, and we can receive poly-acetamide acetone zirconium van-substance. Four-hydrogen furan filtrate and remove the outgrowth hydrochloric three-ethylamine. The offspring dissolve in the filature liquid made of methanol. After centrifugal swing, we can receive van-substance fibre. After we do special hear treatment, the zirconia fibre cotton we receive has the characteristic of good filature ability, high content of zirconium, equality andclarity and jarles capability. It can be used as industrial stove, roomage fusion stove, atomic energy reactor and the high temperature heat insulation material used in aviation and military. The material of the invention cost low, the method is easy, the impregnant can be recycled, the preparation of fibre cost low.

The invention discloses a magnetic PAFs solid-phase extracting agent. A preparation method of the magnetic PAFs solid-phase extracting agent includes allowing 3-aminopropyl triethoxy silylation ferroferric oxide to have a temperature-programmed reaction with piperazine and cyanuric chloride in the presence of N, N-diisopropylethylamine to obtain the magnetic PAFs solid-phase extracting agent. The magnetic PAFs solid-phase extracting agent and the preparation method thereof have the advantages that the prepared magnetic PAFs solid-phase extracting agent is good in dispersity and stable in core-shell structure; the preparation method is simple, low in cost, widely applicable, capable of achieving repeated material recycling, and the like; a covalent organic framework bonded to the ferroferric oxide can provide various action sites such as an inclusion interaction site, a hydrogen-bond interaction site, a pi-pi interaction site and an anion exchange site, so that the covalent organic framework has specific recognition and retention acting force on polar substances such as phenols and carboxylic acids.

The invention relates to an ester type fire-resistant hydraulic fluid. The hydraulic fluid comprises the following raw materials by weight percent: 95-99% of base oil, 1.0-5.0% of diphenol propane, 0.005% of dimethylsilicone fluid or dimethylsilicone grease, 0.05% of tricresyl phosphate, 0.1% of benzotriazole, 100 parts per million (PPM) demulsifying agent T1001 or LZ5957 and 0.2-0.3% of triazole derivative, thiadiazole derivative, N-salicylidene ethylamine, N, N'-bis(salicylidene)ethylenediamine, N, N'-bis(salicylidene)propylene diamine or ethylenediamine tetraacetic acid. A preparation method of the ester type fire-resistant hydraulic fluid comprises the following steps of sufficiently and evenly stirring various materials at room temperature according to a formula, and then filtering. The ester type fire-resistant hydraulic fluid has the beneficial effects that the high temperature use performance of the product is greatly improved, the service life of a hydraulic system and the oil changing period of oils are prolonged, and the ester type fire-resistant hydraulic fluid has a good flame-retardant effect and is safe to use. The preparation method has the advantages that operation is convenient, technology and equipment are simple, energy consumption is low, cost is low, and the like.

The invention relates to a preparation method for synthesizing an apremilast intermediate. The preparation method comprises the following steps of: carrying out condensation reaction on 3-ethoxyl-4-methoxyl-benzoate and dimethyl sulfone under an alkaline condition to generate 2-(3-ethoxy-4-methoxyphenyl)-1-methylsulfonyl acetone; reacting the compound II and chiral amine in the presence of an acidic catalyst to obtain 1-N-substituted amino-1-(3-ethoxyl-4-methoxyl) phenyl-2-methylsulfonyl ethylene (III), and directly hydrogenating the obtained compound III in the presence of a hydrogenation catalyst without separating the compound III to obtain a product (S)-1-(3-ethoxyl-4-methoxyl) phenyl-2-methanesulfonyl ethylamine (I), namely the apremilast intermediate, wherein the apremilast intermediate can be further prepared into N-acetyl L-leucinate. The invention also provides a preparation method of apremilast. The preparation method disclosed by the invention has the advantages of simple process flow, safety, environmental friendliness and low cost and is favorable to clean industrialized production.

The invention relates to a method of maleate formation of a silodosin intermediate indoline compound 1 - (3 - (4 - fluoro benzoyl) hydroxypropyl) -5 - ((2R) -2 - (2 - (2 - (2,2,2 - trifluoroethoxyl) phenoxy) ethylamine) propyl) indoline -7 - cyano (compound (1)), i.e., a crude product of the compound (1) forms a salt with maleic acid in a mixed solvent of a good solvent and a poor solvent. The maleate of the compound can be stably obtained by the method, and the method has the advantages of good impurity removal effect, stable process, high yield, simpleness in operation and the like.

The invention relates to a method for synthesizing theanine, which comprises the following steps: aminating L-N-acyl glutamic acid-gamma-ester in 70-percent ethylamine aqueous solution to obtain L-N-acyltheanine; hydrolyzing the L-N-acyltheanine by adopting L-aminoacylase to remove the acyl group of the L-N-acyltheanine; and performing separation in ethanol aqueous solution to obtain high-quality L-theanine. The method combines the advantages of industrialized acyl hydrolyzation by the L-aminoacylase, uses cheap acyl group as a protective group, and uses the L-aminoacylase to hydrolyze the acyl group after reaction with the ethylamine aqueous solution to obtain the L-theanine. The method has the characteristics of low raw material price, low production cost, high selectivity, high reaction speed and high yield. The used raw materials and reagents are suitable for industrial production, the operation process is simple, and the product quality can be ensured.

The invention discloses a method for synthesizing L-theanine through an enzyme process, and belongs to the biotechnical field. The method is characterized in that a gamma-glutamyltranspeptidase gene is obtained through chemical synthesis, a gene engineering bacterium over-expressing gamma-glutamyltranspeptidase is constructed by treating Escherichia coli as a host bacterium, glutamine and ethylamine hydrochloride having different concentrations are acted by a recombinase, and theanine is efficiently produced at a temperature of 37-50DEG C under a pH value of 9.5-10.5. The enzyme source preparation process has the advantages of simplicity, low cost, and large enzyme amount, and the theanine production method has the advantages of simplicity, high conversion rate, high output, short time and the like, and is in favor of the industrialized amplification production.

The invention provides a selective Sigma 1 or Dopamine D3 receptor agonist or a 5HT2c receptor ligand for use in the treatment of symptoms of anxiety and/or depression associated with an affective disorder and/or symptoms associated with cognitive impairment disorder. Particularly useful are diphenhydramine derivatives of Formula (I) and particularly (2-[(4-butylsulfanylphenyl)-phenyl-methyl]sulfanyl-N,N-dimethyl-ethanamin) (Captodiamine).

The invention solves a new method of preparation of Carvedilol for pharmaceutical use. In the synthesis of Carvedilol a reaction of 4-(oxirane-2-ylmethoxy)-9H-arbazole (II) with 2-(2-methoxyphenoxy)ethylamine salts (IV) in the presence of a base, in an alcohol having the number of carbons C2 to C5 as a solvent, at an elevated temperature, is used. After processing of the crude reaction mixture crude Carvedilol is obtained, which is purified by crystallization from ethylacetate with an addition of activated carbon and the final substance is formulated by crystallization from ethylacetate.

The present invention discloses a novel process for preparation of carvedilol by using eco friendly solvents to obtain the said carvedilol in high purity. The said process comprises, reacting 4-hydroxy carbazole of formula (IV) with epichlorhydrin in presence of an organic solvent and a base at temperatures between 10° C.-30° C.; further reacting the resultant 4-(2,3-epoxypropoxy)- carbazole of formula (II) with a salt of 2-(2-methoxyphenoxy)ethylamine of formula (III), preferably hydrochloride salt in presence of a base and a hydroxylic solvent at temperatures between 30° C.-90° C.

The invention discloses a bright-ala-ruilin preparing method of solid-phase polypeptide, which comprises the following steps: adopting Wang resin or CTC resin as original material to connect amino with protective group to produce protective nonapeptide resin; removing Fmoc-protective group sequently; proceeding side-chain protective group synchronizingly and cutting peptide; connecting ethylamine through ethylamine-to-HOBT to produce crude product; proceeding separation and purifying through C18 (or C8) pillar to produce fine bright-ala-ruilin. The invention avoids the utility of poisonous agent, which improves the purifying, peptide connecting and obtaining rate.

The invention relates to an anti-fatigue cold mixed epoxy resin material, preparation method and application thereof, comprising component A and component B with mass ratio of 1:1-10:1, component A comprising fluid epoxy resin, active toughener, active diluents, coupling agent and defoamer; component B is any one of or a mixture of two or more than two of alicyclic amine or amino terminated polyether, cyanoethylamine, phenolic modified amine or hydroxyalkyl modified amine. Introduced epoxy terminated organosilicon block polyurethane prepolymer breaks the limitation that elongation at fracture of epoxy resin system based on “sea-island structure” is difficult to break through 100%. The invention is suitable for bridge deck pavement of long-span cable bearing bridge, waterproof bonding material or used for airport pavement, municipal viaduct, ramp and other occasions with high requirements for fatigue resistance of pavement material.

The invention aims at providing a preparation method of 2-(7-anisyl-1- naphthyl) ethylamine (II) which is an important midbody of agomelatine. The preparation method uses 2- (7-anisyl-1-naphthyl) acetamide (VII) as an initiative raw material, only needs one reaction step, has higher yield, abolishes high-voltage hydrogenation, has mild conditions and does not need special devices.

The invention relates to a method for preparing rivastigmine hydrogen and tartrate thereof, which comprises the following steps: taking metamethoxyacetophenone as an initial raw material, and obtaining 1-(3-methoxyphenyl)ethanol by the reduction; then performing the chlorination to obtain 1-(chloroethyl)-3-methoxyphenyl; then reacting the1-(chloroethyl)-3-methoxyphenyl with dimethylamine hydrochloride to obtain 1-(3-methoxyphenyl)-N, N-dimethylethanamine; demethylating the reaction product to obtain 3-[1-(dimethylamino)ethyl]phenol; then performing salt formation resolution with (s)-(+)-camphor-10-sulfonic acid, recrystallizing, and dissociating to obtain (s)-3-[1-(dimethylamino)ethyl]phenol; then taking ethylamine as a raw material to react with ethyl formate to obtain formylethylamine; then reacting the formylethylamine with phosphorus oxychloride to obtain an imine intermediate; reducing the imine intermediate by sodium borohydride to obtain ethyl methyl amine; then reacting the ethyl methyl amine with triphosgene to obtain N-methyl-N-ethylformyl chloride; and finally using (s)-3-[1-dimethylamino)ethyl]phenol to condensate with the N-methyl-N-ethylformyl chloride, and then performing salt formation with levotartaric acid to obtain the rivastigmine hydrogen tartrate. The method has the advantages of easily-obtained raw materials, simple and convenient operation, low cost, high yield and small pollution, and is a brandnew synthesis route at present.

The invention discloses a disinfectant health-care aromatic hand paper towel and a preparation method thereof. The hand paper towel comprises the following components: softwood sulfite pulp, bamboo-pulp paper fiber, straw pulp, a cationic starch solution, a wet strength agent, a powerful antibacterial agent, an aromatic agent and titanium dioxide, wherein the wet strength agent is polyethylene ethylamine resin, the powerful antibacterial agent is composed of pure-oxygen-based quaternary ammonium salt, Sophora flavescens, common cnidium fruit, honeysuckle, borneol, isatis root, ethanol and distilled water, and the aromatic agent is composed of chitosan, ethanol, essence extract, deionized water, glycerin and triphosphoric acid. The prepared disinfectant health-care aromatic hand paper towel in the invention has the characteristics of no toxicity, harmlessness, environmental protection, highly-efficient antibacterial property and emission of aroma, can efficiently avoid contact-type cross infection with bacteria in public places and is safer and more secure to use.

The invention discloses graphene-butadiene-acrylonitrile latex compound slurry and a preparation method and application thereof. The compound slurry comprises the following components in parts by weight: 100 parts of butadiene-acrylonitrile rubber and 0.025-5 parts of graphene. The compound slurry also comprises 4-6 parts of a ball-milled sulfur material. Based on the total weight of the ball-milled sulfur material, the ball-milled sulfur material comprises the following components in percentages by weight: 5-8% of sulfur, 22-28% of zinc oxide, 5-8% of an accelerant, 2-4% of an anti-ageing agent, 1.5-3% of ethylamine, 2-4% of a dispersant, 5-8% of casein and 40-55% of soft water. A pair of graphene-butadiene-acrylonitrile latex gloves prepared from the composite slurry is flexible in texture, comfortable to wear, high in tear strength, antibacterial, antistatic, small in stress at definite elongation and good in anti-ageing property, and fully exerts the advantages of graphene which is high in conductivity, high in strength, resistant to friction, high in bacteriostatic property, and the like.

The invention provides a preparation method of 1-(3-protecting propyl)-5-((2R)-2-(2-(2-(2,2,2-trifluoroethyoxyl)phenoxy)ethylamine)propyl)indoline-7-cyan and 1-(3-(4-flurobenzoyl)hydroxyl propyl)-5-((2R)-2-(2-(2-(2,2,2-trifluoroethyoxyl)phenoxy)ethylamine)propyl)indoline-7-cyan shown as in a specific compound structure (Ia) in the specification. The method is characterized in that water is used as a solvent and the yield is high. The 1-(3-(4-flurobenzoyl)hydroxyl propyl)-5-((2R)-2-(2-(2-(2,2,2-trifluoroethyoxyl)phenoxy)ethylamine)propyl)indoline-7-cyan shown as in the specific compound structure (Ia) can be used as an intermediate to be applied to the preparation of an indoline derivative. The method of the invention is simple in operation and high in yield.

The invention relates to a goserelin acetate solid-phase synthesis method, which comprises the following steps: HBTU/DIPEA is employed as a condensation system, Fmoc-Ser-OH, Fmoc-Trp-OH are successively coupled; a whole-protection lysate with corresponding voluminal amount according to 10 times of resin weight is added, a carrier 2-CTC Resin in an intermediate is removed, all side chain protective groups are reserved; the whole-protection lysate is adjusted to slight alkaline by using DIPEA(N,N-diisopropylethylaine), semicarbazide hydrochloride and PyBop(1H-benzotriazole-1-oxygen tripyrrole alkyl hexafluorophosphate) (used for a coupling agent of peptide) are added in the whole-protection lysate for reaction coupling, a goserelin peptide solution with the side chain protective group is obtained; the lysate with 20% of TFA/DCM is added in a freezing ether for settling to obtain the white solid crude peptide; the white solid crude peptide is dried under vacuum for solving by methyl alcohol, ammonium formate and Pa/c are added for a hydrogenation reaction to remove the side chain protective group in a peptide sequence. According to the invention, side reaction phenomena can be avoided, target peptide purity is increased, yield is high, operation is convenient and feasible, the intermediate can be tracked and controlled, and the whole process is benefit for enlarged production.

Disclosed herein is a process for preparation of carvedilol substantially free from its bis-impurity comprises the reaction of 4-(2,3-epoxypropoxy)carbazole and 2-(2-methoxyphenoxy)ethylamine in a polar aprotic solvent media; followed by isolation of carvediol from the reaction mass as an acid addition salt and subsequent conversion into pure carvedilol.

The invention discloses a kinetic resolution method, in particular a method for preparing chemical enzyme of (R)-1-(1-naphthyl) ethylamine by resolution, which using 1-(1-naphthyl) ethylamine as a raw material. In the method, kinetic resolution is performed by using 1-(1-naphthyl) ethylamine which is a racemic mixture as a raw material, phenylethyl acetate as an acyl donor and immobilized lipase from Candida Antarctica as a catalyst under the controlled operation conditions that: the temperature is 30 to 80 DEG C, the volume ratio of the raw material to a solvent is 1:(25-50), the mass ratio of the raw material to the catalyst is 1:(0.02-0.05), and the molar ratio of the raw material to the phenylethyl acetate is 1:(1.2-4.0). The method has the advantages of high catalytic efficiency and environment friendliness.