178 results about "Ethylamines" patented technology

The invention discloses a method for preparing calcium hydroxide slurry with high specific surface area and high pore volume, which comprises the following steps: S1, adding an alcohol reagent into water to obtain a solution A; s2, adding an inorganic salt solution into the solution A, and uniformly mixing to obtain a solution B; s3, a reagent X is added into the solution B, ultrasonic mixing is performed to obtain a solution C, and the reagent X is a mixture of phenol or triethanolamine, ethidene diamine and ethylamine; and S4, adding calcium oxide powder into the solution C, continuously stirring, and reacting to obtain calcium hydroxide slurry. The invention provides a method for preparing calcium hydroxide slurry with high specific surface area and high pore volume, the calcium hydroxide slurry prepared by the method can form calcium hydroxide with high specific surface area and high pore volume when in use, and the method aims to solve the problems of low specific surface area and low pore volume of the existing calcium hydroxide. Therefore, the problem of desulfurization performance inactivation caused by blockage of calcium hydroxide (desulfurizer) pores by generated CaSO3 and CaSO4 in the desulfurization process is avoided.

The invention discloses a triazine desulfurizer and a preparation method thereof, and belongs to the technical field of gas purification. The triazine desulfurizer is mainly prepared from the following raw materials in percentage by weight: 20 to 50 weight percent of triazine derivative, 10 to 15 weight percent of sterically hindered amine, 3 to 7 weight percent of stabilizer, 1 to 3 weight percent of synergist, 0.5 to 1.5 weight percent of penetrant, 0.5 to 1.5 weight percent of inhibitor, 1 to 2 weight percent of additive and the balance of water, the preparation method of the triazine derivative comprises the following steps: adding 2-(diphenylphosphino) ethylamine into a toluene solvent, adding a paraformaldehyde aqueous solution in batches under a stirring condition, and reacting for 2-8 hours to obtain the triazine derivative. According to the triazine desulfurizer and the preparation method thereof provided by the invention, the triazine derivative and the sterically hindered amine are taken as a host, and the stabilizer, the synergist, the penetrant, the inhibitor and the assistant are compounded, so that the scaling trend of the triazine desulfurizer in an oil and gas well can be slowed down, the dissolution rate of hydrogen sulfide and the mass transfer rate in a solution are increased, and the desulfurization reaction is promoted; the desulfurization effect and the desulfurization rate are improved, and meanwhile, a very good scale inhibition effect is also achieved.

The invention discloses a preparation process of berberine hydrochloride, and belongs to the technical field of berberine production. The invention relates to a berberine hydrochloride preparation process, which comprises: S1, mixing a ferric sulfate-aluminum sulfate composite salt, sodium chloride, zinc chloride and anhydrous formic acid, pre-activating, adding N-2, 3-dimethoxybenzyl homopiperony lamine hydrochloride, dropwise adding a glyoxal mixed solution, and carrying out a reflux reaction. And S2, cooling the reaction liquid until a solid is separated out, filtering, adding a filter cake and diatomite into purified water, stirring, adjusting alkali, heating, and continuously stirring for 0.5-1 hour. Cooling and filtering, and reserving filtrate; s3, adjusting the acidity of the filtrate, cooling and growing crystals; and filtering, rinsing a filter cake, and carrying out vacuum drying on the filter cake to obtain berberine hydrochloride. The berberine hydrochloride prepared by the method is high in yield and purity, and the preparation process is safe, short in flow and friendly to human bodies and environment.

The application discloses a preparation method of enciferstat bulk drug and belongs to the field of drug synthesis. 9,10-dimethoxy-2-(2,4,6-trimethylphenylimino)-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-one (SM) is used as a raw material, and the raw material is reacted with cyclohexylamine under alkaline conditions, and the reaction is washed with water, dried, and concentrated to obtain an intermediate I; the intermediate I is reacted with urea under pressurized heating conditions to prepare an enciferstat drug molecule, the two-step yield is more than 67%, and the purity is more than 99%, the method has a simple operation process, the product is easy to purify, the yield is high, the product purity is high, and a new method for preparing enciferstat bulk drug is provided.

This invention belongs to the field of two-dimensional material preparation technology, and provides an MXene material and its preparation method. The preparation method of the MXene material includes: mixing a MAX phase precursor to be etched with an organic halide reagent and a morphology modifier, performing a solvothermal etching reaction, and after the reaction, washing and drying the resulting product to obtain the MXene material; wherein the organic halide reagent is triethylamine trihydrofluoride, triethylamine hydrochloride, or dichloroethylamine hydrochloride, and the morphology modifier is ethylene glycol, dimethyl sulfoxide, or cyclohexane. The method of this invention can effectively control the microstructure and pore structure of the MXene material.

The invention discloses a CO2 phase change absorbent based on N-formylmorpholine as well as a preparation method and application thereof, and belongs to the technical field of gas separation. The CO2 phase change absorbent based on N-formylmorpholine is prepared from the following components in percentage by mass: 30 to 40 percent of hydroxyethyl ethylenediamine, 30 to 40 percent of N-formylmorpholine and 27 to 37 percent of water, or 35% of compound amine composed of hydroxyethyl ethylenediamine and N-methylethylamine, 40% of N-formylmorpholine and 25% of water are contained. The preparation method of the CO2 phase change absorbent comprises the following steps: preparing the components in proportion, and uniformly mixing to obtain the CO2 phase change absorbent. The CO2 phase change absorbent is suitable for carbon capture of mixed gas with CO2 partial pressure of 10-20 kPa. The CO2 phase change absorbent can effectively reduce the volatility of the phase change absorbent and the CO2 enrichment phase viscosity, and has a good industrial application prospect.

The application belongs to the technical field of organic synthesis, and discloses a preparation method of N-ethyl-2-(N-methyl pyrrolyl) pyrrole, which comprises the following steps: dissolving 1-furfuryl pyrrole, ethylamine and ethanol in water, adding hydrochloric acid into the water, heating and reacting, the reaction temperature is 150-180 DEG C, and the reaction time is 15-35 h; and the target product is obtained. The 1-furfuryl pyrrole is prepared by condensation reaction of 2-furfurylamine and 2,5-dimethoxy tetrahydrofuran, and then the target product N-ethyl-2-(N-methyl pyrrolyl) pyrrole is prepared by reaction of the 1-furfuryl pyrrole and ethylamine, and the raw materials are relatively cheap and have high industrial value.

The invention belongs to the technical field of medicine synthesis, and particularly relates to a synthesis method of upatinib and an intermediate Up-3 thereof. The preparation method comprises the following steps: dissolving a compound Up-1 and a compound Up-2 in a solvent A, adding alkali 1, and reacting to obtain an intermediate Up-3; dissolving the intermediate Up-3 in a solvent B, adding an acid a, removing Boc protection and closing a ring to obtain an intermediate Up-6, and reacting under the action of an acid b to obtain a compound Up-14; the preparation method comprises the following steps: dissolving carbonyl diimidazole, trifluoroethylamine hydrochloride and alkali 2 in a solvent C, stirring, mixing with a compound Up-14 solution, reacting to obtain a compound Up-13, adding an alkali 3 solution, and removing Tos protecting groups to obtain upatinib. According to the method disclosed by the invention, the upatinib crude product is simply synthesized by taking Up-3 as a starting material through a two-pot method for the first time, the time of the whole process is saved, the total yield is relatively high, the purity of the obtained product is also relatively high, and the method is suitable for large-scale production.

The invention discloses a preparation method and application of a compound with a cold sensing regulation effect, which comprises the following steps: dissolving tryptophan in methanol, adding concentrated sulfuric acid, esterifying the acid to protect carboxyl so as to obtain tryptophan methyl ester, dissolving the obtained tryptophan methyl ester and aromatic carboxylic acid substances in N, N-dimethylformamide, and reacting to obtain the compound with the cold sensing regulation effect. The method comprises the following steps: catalyzing 2-(7-azabenzotriazole)-N, N, N ', N'-tetramethylurea hexafluorophosphate and N, N-diisopropylethylamine, dissolving a catalyzed product in ethanol (98%), adding into a NaOH solution, stirring, carrying out rotary evaporation treatment, slowly dropwise adding a 0.5 mol / L hydrochloric acid solution, adjusting the pH value of a reaction system to 3-4, and finally obtaining the tryptophan derivative compound with the yield of 70%. The invention provides a potential medicine for improving the working ability and cold injury in the cold environment for people living and working in the cold environment, and is developed into a medicine for effectively improving neuropathic pain diseases in the cold environment.

The invention discloses a methylamine-free perovskite thin film with high thermal stability and a preparation method of the methylamine-free perovskite thin film. The perovskite thin film is prepared from an FAPbI3 perovskite precursor solution doped with 2-(methylsulfonyl) ethylamine hydrochloride. A proper amount of 2-(methylsulfonyl) ethylamine hydrochloride is added into the perovskite precursor solution, the compact and uniform FAPbI3 perovskite thin film with photovoltaic activity is obtained under the condition that methylamine ions are not introduced, the thin film has excellent thermal stability, the service life of a perovskite solar cell can be prolonged, and the service life of the perovskite solar cell is prolonged. And the positive significance is realized on the commercialized application of the perovskite battery.

According to the invention, a novel ternary acidic deep eutectic solvent (DES) is prepared, ethylamine hydrochloride (EH) is used as a hydrogen bond acceptor (HBD), and DL-malic acid (MA) and polyethylene glycol-400 (PEG-400) are used as hydrogen bond donors (HBA). The DES solvent has good performance on wood fiber biomass refining pretreatment, and three major components of lignocellulose can be efficiently separated. The ternary acidic DES disclosed by the invention is easy to synthesize, good in stability and simple in use method, and an ideal separation effect can be achieved when high biomass solid content is treated, that is, most cellulose is reserved in a solid form, and most hemicellulose and lignin are converted into a liquid form through dissolution or partial degradation to be separated; and separating the lignin component from the hemicellulose by anti-solvent precipitation. The prepared DES can be recycled after being filtered and subjected to rotary evaporation, still has a separation effect equivalent to that of an original solvent after being recycled for six times, and has good industrial application prospect and value.

This invention discloses a highly selective method for preparing triethylenetetramine. The method uses 2-chloroethylamine hydrochloride and ethylenediamine as raw materials, reacting them in an aqueous solution. An aqueous solution of ethylenediamine with a concentration of 1-100 wt% is added dropwise to an aqueous solution of 2-chloroethylamine hydrochloride with a concentration of 1-100 wt%. The dropping rate of the ethylenediamine solution is 5% to 100% of its own mass per hour. The reaction temperature is 30-200 °C (oil bath temperature), and the reaction time is 2-20 hours (including the dropping time). The molar ratio of 2-chloroethylamine hydrochloride to ethylenediamine is 2:1 to 40:1. This invention is the first to propose a direct synthesis of triethylenetetramine from the bulk chemicals 2-chloroethylamine hydrochloride and ethylenediamine. Compared with the previously reported dichloroethane amination method and the nucleophilic substitution method between dichloroethane and ethylenediamine, this method offers milder reaction conditions, simpler operation, and higher selectivity, making it suitable for industrial production.

The invention belongs to the technical field of organic ultrathin nanomaterials, and particularly relates to a photoresponse type polymer ultrathin nanosheet as well as a preparation method and application thereof. The preparation method comprises the following steps: (1) adding dicyclohexylcarbodiimide, N-hydroxysuccinimide, N, N-diisopropylethylamine and 4-carboxyl phenylboronic acid pinacol ester into a solvent, and reacting to obtain an intermediate product; (2) carrying out heating reaction on the intermediate product, triethylene glycol and a catalyst to obtain a phenylboronic acid pinacol ester derivative; (3) adding 4, 4-dibromo azobenzene, a phenylboronic acid pinacol ester derivative, a palladium catalyst and potassium carbonate into a solvent for reaction to obtain an amphiphilic alternating copolymer; and (4) dispersing the amphiphilic alternating copolymer in a solvent for self-assembly to obtain the amphiphilic alternating copolymer. According to the invention, a photoresponse group azobenzene structure is introduced into a polymer main chain, so that the ultrathin organic material is endowed with a unique photoresponse characteristic; the method is simple and easy to implement, good in repeatability and high in stability.

Disclosed are novel fused mescaline derivative compounds, notably substituted ethylamine fused heterocyclic mescaline derivatives, including substituted ethylamine fused dioxolane mescaline derivatives, and pharmaceutical and recreational drug formulations containing the same. Methods of making and using these compounds are also disclosed.

The application relates to a method for visible light catalytic synthesis of organic compounds based on low-toxicity ZnSe@ZnS core-shell quantum dots. ZnSe@ZnS quantum dots are used as a sensitizer, the surface of the quantum dots is chelated with 4-benzoylbenzoic acid (BP), N,N-diisopropylethylamine (DIPEA) molecules are added to the solution as an electron sacrificial reagent and a substrate organic molecule to construct a quantum dot sensitized electron reduction system. The photocatalytic reduction product can be obtained under 405nm visible light excitation. In the system, the electron transfer and transmission process is studied through a transient absorption spectrum.

The invention relates to the field of monoethylamine preparation processes, and discloses a monoethylamine production method, which comprises: under the action of an ammonolysis catalyst, uniformly mixing and preheating diethylamine, hydrogen and ammonia gas, allowing diethylamine to pass through an ammonolysis reactor and a deamination tower, carrying out monoethylamine refining, diethylamine refining and triethylamine refining, and preparing monoethylamine, the ammonolysis catalyst comprises a carrier as well as an active component and an auxiliary agent which are loaded on the carrier, and is characterized in that the carrier is aluminum oxide modified by a titanium silicalite molecular sieve, the content of the aluminum oxide exceeds 68wt% of the total mass of the carrier, the active component comprises nickel, the auxiliary agent comprises iridium, and the content of the titanium silicalite molecular sieve is more than 68wt% of the total mass of the carrier. On the basis of the total weight of the ammonolysis catalyst, the content of the nickel element is 15-30 wt%, and the content of the iridium element is 0.2-2 wt%. By adopting the method disclosed by the invention, monoethylamine can be directly produced by taking diethylamine as a raw material.

The application provides a synthesis method of active piperidone alkaloid, and the active piperidone alkaloid is Dysidone A. The raw material piperidine is used as a substrate, and the substrate is reacted with p-methoxy benzyl chloride under the condition of N,N-diisopropylethylamine, so that the secondary amine is protected, and the side reaction of sodium hydride and hydrogen on the secondary amine is avoided. Then, the secondary amine is oxidized under the condition of iodine and iodobenzenediacetic acid. Next, the secondary amine is reacted with triethyl phosphine acetic acid ester to obtain an alpha, beta unsaturated ester. Then, the p-methoxy benzyl protection is removed by using ammonium cerium nitrate in a mild and efficient manner. Finally, the ester is reduced into an alcohol by using diisobutylaluminum hydride. The piperidone alkaloid or the like is obtained through five reaction steps. The synthesis process is simple, the raw material is cheap and easy to obtain, the cost is low, the reaction condition is relatively mild, the purity is high, and the method has good economic and social benefits.

The presently claimed invention relates to an alkaline composition for cleaning a substrate comprising i) copper or copper alloy and ii) cobalt or cobalt alloy, the composition comprising: a) at least one pH adjustor selected from diglycolamine, 4,4-diethoxy-N,N-dimethyl-1-butanamine, 3-dimethylaminopropan-1-ol, dimethylaminoethoxyethanol, N,N-dimethylisopropanolamine, ethylethanolamine, N-methyldiethanolamine, 2-(2-(methylamino)ethoxy)ethanol, 3-(methylamino)propane-1,2-diol, 2-[2-[2-(2-methoxy- ethoxy)ethoxy]ethoxy]ethylamine, 2-[2-(2-aminoethoxy)-ethoxy]-ethanol, N-butyldiethanolamine, diisopropanolamine, N-methyldiisopropanolamine, monoethanolamine, 3-dimethylamino-1,2-propandiol, 2- amino-1-butanol, 2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethanol, prolinol, 1-methyl-2-pyrrolidinemethanol, 1-methyl-2-pyrrolidinemethanol, 1-methyl-3-pyrrolidinol, 2-amino-2-methyl-1-propanol, N,N-dimethylethanolamine, butylethanolamine, diethylethanolamine, 3-methoxypropylamine, 4-(2-hydroxyethyl)morpholine, 4-(dimethylamino)cyclohexanol, 2-amino-2-methyl-1, 3-propanediol, or diisopropylamine; b) at least one complexing agent selected from C2 to C12 hydrocarbon having at least two sulfonic acid or carboxylic acid groups; c) at least one polymeric dispersing agent having a weight average molecular weight ≥ 1000 g / mol; and d) a solvent comprising water.

The invention relates to an N-terminal acetylation and C-terminal ethylamine dual-modified LMN-NKA polypeptide derivative or a pharmaceutically acceptable salt and a preparation method thereof. The chemical name of the LMN-NKA polypeptide derivative is N-acetyl-L-aspartic acid-L-lysine-L-phenylalanine-L-valine-glycine-N-methyl-L-leucine-L-n-leucine-ethylamine, and the structural general formula of the LMN-NKA polypeptide derivative is Ac-Asp-Lys-Phe-Val-Gly-NMe-Leu-Nle-NHCH2 CH3, and the structural general formula of the LMN-NKA polypeptide derivative is shown in the description. According to the dual-modification strategy, the binding activity of the NK2 receptor can be specifically reserved, the enzymolysis stability is high, the transmembrane efficiency is high, the lipid solubility is high, and the physicochemical property is stable. The LMN-NKA polypeptide derivative or the pharmaceutically acceptable salt thereof disclosed by the invention is particularly suitable for preparing a medicine for treating diseases related to an NK2 receptor.

This invention belongs to the field of chemical catalyst preparation technology, and discloses a catalyst for the disproportionation of diethylamine to triethylamine. The catalyst includes a support, and MgO, ZnO, and rare earth oxides supported on the support. The content of each component, based on 100% mass, is as follows: support 80-85%, MgO 5-10%, ZnO 5-10%, and rare earth metal oxides 2-5%. When used for the disproportionation of diethylamine to triethylamine, the catalyst exhibits high diethylamine conversion and high selectivity for the triethylamine product. After separation, unreacted diethylamine can be recycled, while monoethylamine is collected separately or recycled back to the diethylamine synthesis unit, significantly reducing overall costs.

The invention belongs to the technical field of electrolysis, and discloses a method for preparing p-hydroxyanisole through electrolytic oxidation of anisole. The method comprises the following steps: S1, adding anisole, an acylation reagent, an organic alkali proton trapping agent and an alkaline amine group-containing solvent into a single-chamber electrolytic bath together, starting electrification, carrying out electrolysis, and obtaining a product liquid containing p-methoxytrifluoroacetic acid phenyl ester in the single-chamber electrolytic bath after electrolysis is finished; the organic base proton trapping agent is at least one of N, N-diisopropylethylamine, tributylamine and tripropylamine; and S2, adding a saturated sodium bicarbonate aqueous solution into the product liquid containing p-methoxytrifluoroacetic acid phenyl ester in the step S1 to hydrolyze p-methoxytrifluoroacetic acid phenyl ester, and extracting to obtain p-hydroxyanisole. The selectivity of para-position and ortho-position products of methoxyl on anisole is regulated and controlled, so that the selectivity of p-hydroxyanisole prepared by the method is higher.

The invention relates to the technical field of production of monoethylamine and acetonitrile by using ethylenediamine and refining and separation thereof, and discloses a method for co-production of monoethylamine and acetonitrile, which comprises the following steps: (S1) in the presence of a catalyst, diethylamine, hydrogen and ammonia gas are uniformly mixed and preheated, and then are subjected to an ammonolysis reactor reaction and gas-liquid separation, and a crude product obtained after gas-liquid separation passes through a monoethylamine refining tower to obtain a monoethylamine product; separating into a monoethylamine product at the top of the tower and a tower kettle product containing diethylamine and acetonitrile at the bottom of the tower; the catalyst comprises aluminum oxide modified by an SAPO-34 molecular sieve, Ni, Co, Pr and / or Nd, the content of Ni and Co is 15-40 wt%, and the molar ratio of Ni to Co is 1-8.5; (S2) separating a tower kettle product containing diethylamine and acetonitrile, which is led out by the monoethylamine refining tower, into a solvent-containing material flow at the tower top and an acetonitrile product at the tower kettle through an acetonitrile refining tower; according to the method, monoethylamine and acetonitrile products are produced at the same time through diethylamine ammonolysis reaction and rectification separation.

The present description relates to a method for treating a patient having a mood disorder, comprising administering to a subject in need a pharmaceutical composition comprising a base compound consisting substantially of N-ethyl-2-(5-fluoro-1H-indol-3-yl)-N-methylethan-1-amine or a pharmaceutically acceptable salt thereof in a specified dosage regimen.

The invention discloses an electroplating disqualified cadmium layer stripping solution, a preparation method and a use method, and the electroplating disqualified cadmium layer stripping solution comprises 6-8 parts of sodium phytate, 1-3 parts of sodium nitrilotriacetate, 2-4 parts of borate, 5-10 parts of sodium bromate, 1-2 parts of sodium alkyl naphthalene sulfonate, 1-2 parts of glucoside, 5-8 parts of sodium nitrate, 3-5 parts of ammonia water, 2-4 parts of triol ethylamine, 4-6 parts of 1-hydroxyethylidene-1, 1-diphosphonic acid and 8-12 parts of ammonium persulfate. The total amount of the purified water is 100 parts, and the total amount of the purified water is 100 parts. The pH value of the deplating agent solution is alkaline, the problem of hydrogen evolution of a hydrogen sensitive material is solved, the risk of hydrogen embrittlement is avoided, and hydrogen removal is not needed after steel and iron materials are deplated; cadmium ion heavy metal pollution and sewage treatment difficulty exist, the stripped cadmium ions automatically generate precipitates, recycling is facilitated, and the sewage treatment difficulty is reduced; the metal deplating liquid is convenient to use and simple to operate, only unqualified products need to be put into the deplating liquid in a room-temperature environment, after a certain time, after a plating layer is completely removed, the unqualified products are washed with water, and a metal base material is not damaged.

The application discloses a kind of ultrafast metal-free and solvent-free preparation method for preparing symmetric and asymmetric disulfide, which comprises the following steps: at room temperature, raw material R-SH, R'-SH and oxidant and base are added to reaction bottle, shake rapidly for 10-30 seconds, and R-S-S-R' is prepared after the reaction product is purified;Wherein R in R-SH is aliphatic or aromatic group, R' in R'-SH is aliphatic or aromatic group;R in R-SH and R' in R'-SH are same or different;The aromatic group has substituent or no substituent, and the aliphatic is straight chain or has branch;The oxidant is chloroform, and the base is N, N-diisopropylethylamine (DIPEA).The method is simple in operation, high in yield (60-99%), ultrafast in reaction kinetics, greatly improves production efficiency, wide in applicability, avoids the use of organic reaction solvent, raw material is cheap and easy to obtain, and does not contain residual metal and other sticky contaminants from reagent and ligand, provides a safer and more effective method for the synthesis and production of symmetric and asymmetric disulfide-containing compounds.

The invention discloses a synthesis method of a mutagenic impurity alpha of trazodone hydrochloride, and belongs to the technical field of impurity synthesis, the operation steps of the synthesis method are as follows: S1, taking m-chloroaniline and bis (2-chloroethyl) amine hydrochloride as initial raw materials, adding the initial raw materials into a reaction flask, stirring for reaction, and keeping the temperature at 60-90 DEG C to obtain a faint yellow solid intermediate 1; s2, performing silica gel column chromatography purification on the crude product of the intermediate 1 by using a developing solvent with the volume ratio of dichloromethane to methanol being (20: 1)-(5: 1); s3, obtaining a white solid intermediate 1 from the intermediate 1 subjected to column chromatography; s4, adding the intermediate 1 and N-(2-bromoethyl)-2-chloroethylamine hydrochloride serving as raw materials into a reaction flask to obtain a yellow solid intermediate 2; and S5, obtaining a target product from the intermediate 2. The preparation method of the mutagenic impurity compound provided by the invention is simple to operate, mild in reaction condition, easy to obtain used reagents and low in synthesis cost, and meanwhile, the mutagenic impurity compound with high purity and high yield can be obtained.

The invention discloses a preparation method of cinacalcet hydrochloride. The preparation method comprises the following steps: 1) carrying out a reaction on 3-(3-trifluoromethylphenyl) propanol and phosphorus oxychloride; first post-treatment: extracting the product obtained in the step 1) by using an organic solvent, drying and concentrating to obtain 1-(3-chloropropyl)-3-trifluoromethyl benzene; (2) carrying out substitution reaction on the 1-(3-chloropropyl)-3-trifluoromethyl benzene obtained by the first post-treatment and (R)-1-(1-naphthyl) ethylamine; the product obtained in the second step is subjected to extraction, drying and concentration through an organic solvent and then subjected to a salt forming reaction with hydrochloric acid, and cinacalcet hydrochloride is obtained.According to the method, it is guaranteed that the product has the good yield and high purity, meanwhile, the impurity content, especially oxidation impurities, is remarkably reduced, and the appearance color and luster of cinacalcet hydrochloride are effectively improved.

The application discloses a synthesis method of 2,2-difluoroethylamine, which comprises the following steps: mixing a solvent, a copper-based catalyst and an ammonia source in a sealed container, wherein the ammonia source is gaseous, liquid or supercritical ammonia; heating the mixed system to 80-120 DEG C; adding 2,2-difluoro-1-chloroethane; keeping the reaction for a certain time; filtering the reaction liquid; and distilling the filtrate to obtain 2,2-difluoroethylamine. The reaction selectivity and reaction yield of the method are obviously improved compared with the prior art. The insoluble copper salt and organic ligand are adopted in the form of the catalyst, so that the catalyst recovery is simple and convenient, the ammonia excess ratio can be reduced in the reaction process, the energy consumption for ammonia recovery is greatly saved, the reaction yield is high, the amount of three wastes is small, and large-scale industrial production can be easily realized.

The invention provides a method for chiral resolution of (trans)-2,2-dichloro-3-(3-chloro-4-fluorophenyl)cyclopropane-1-carboxylic acid. The method comprises the steps of: (a) treating (trans)-2,2-dichloro-3-(3-chloro-4-fluorophenyl)cyclopropane-1-carboxylic acid with a chiral base selected from the list consisting of: quinine, R )-1-cyclohexylethan-1-amine, S )-1-cyclohexylethan-1-amine and L )-leucinamide, in an organic solvent to form a suspension, (b) separating the desired enantiomer and diastereomeric salt of the chiral base from the suspension, and (c) optionally, treating the separated diastereomeric salt with an acid to obtain the desired enantiomer of 2,2-dichloro-3-(3-chloro-4-fluorophenyl)cyclopropane-1-carboxylic acid.

The invention relates to the technical field of catalysts and ammonolysis reactions, and discloses a supported catalyst and a preparation method thereof, and a method for preparing monoethylamine and co-producing acetonitrile by using the supported catalyst, the supported catalyst comprises a carrier, an active component and an auxiliary agent, and the active component and the auxiliary agent are supported on the carrier. The carrier is alumina modified by an SAPO-34 molecular sieve, the active components are Ni and Co, the auxiliary agent is Pr and / or Nd, the total content of Ni and Co elements is 15-40wt% based on the total weight of the supported catalyst, the molar ratio of Ni to Co is 1-8.5, and the content of alumina in the carrier is 55-90wt% of the total weight of the carrier; according to the method, two products of high-purity monoethylamine and acetonitrile can be produced at the same time, and water is not produced in the reaction process.