631 results about "Ethylamines" patented technology

The invention relates to the technical field of coatings, and provides an antifouling coating as well as a preparation method and application thereof. The antifouling paint comprises a component A and a component B, wherein the component A comprises fluorosilicone modified acrylic resin, fluorinated paraffin, modified nano attapulgite, a wetting agent, a defoaming agent and a dispersing agent; a modifying agent of the modified nano attapulgite is 2-imidazole-1-ethylamine and 2-(3, 4-cyclohexyl oxide) ethyl triethoxy silane, and a modifying agent of the modified nano attapulgite is 2-imidazole-1-ethylamine and 2-(3, 4-cyclohexyl oxide) ethyl triethoxy silane; and the component B comprises a curing agent and a diluent. The nano attapulgite is modified, so that the dispersity of the nano attapulgite in the coating and the compatibility of the nano attapulgite with resin are improved, the nano attapulgite can be subjected to cross-linking reaction with other network structures to form a more compact cross-linked network, and the mechanical strength and the wear resistance of the coating are further improved.

The invention discloses an acetonitrile hydrogenation catalyst and a preparation method and application thereof. The acetonitrile hydrogenation catalyst is a transition metal modified Pt supported catalyst. A transition metal precursor adopted in the transition metal improvement is an oxide containing transition metal elements; the transition metal element is selected from at least one of titanium, vanadium, manganese, iron, cobalt, nickel and copper; the acetonitrile hydrogenation catalyst also comprises a carrier; the carrier is selected from at least one of gamma-Al2O3, SiO2, an MOR molecular sieve and a ZSM-5 molecular sieve. The catalyst can effectively catalyze acetonitrile hydrogenation to prepare ethylamine under mild reaction conditions. The supported catalyst provided by the invention has excellent reaction performance such as high acetonitrile conversion rate in acetonitrile hydrogenation reaction, the reaction condition is mild, the operation is simple, and the catalyst is easy to prepare and can be recycled.

The invention discloses a lithium battery negative electrode binder of modified carboxymethyl cellulose lithium, and belongs to the technical field of lithium ion batteries, and the modified carboxymethyl cellulose lithium is prepared by grafting carboxymethyl cellulose with an acrylic monomer and a sulfonic monomer, acidifying, lithiating, cross-linking with cystine, and carrying out surface modification with 2-(3, 4-dihydroxyphenyl) ethylamine. The preparation method comprises the following steps: grafting an acrylic monomer and a sulfonic monomer copolymerization long chain on a main chain of carboxymethyl cellulose, introducing additional carboxyl and sulfonic groups, and introducing cystine with a disulfide bond as a cross-linking agent and 2-(3, 4-dihydroxyphenyl) ethylamine with a catechol group as a tackifier to prepare modified carboxymethyl cellulose lithium; the lithium content of the obtained modified lithium carboxymethyl cellulose is higher than that of common lithium carboxymethyl cellulose, the adhesive property is enhanced, the toughness is improved, and the cycle performance is enhanced.

The invention discloses a method for preparing calcium hydroxide slurry with high specific surface area and high pore volume, which comprises the following steps: S1, adding an alcohol reagent into water to obtain a solution A; s2, adding an inorganic salt solution into the solution A, and uniformly mixing to obtain a solution B; s3, a reagent X is added into the solution B, ultrasonic mixing is performed to obtain a solution C, and the reagent X is a mixture of phenol or triethanolamine, ethidene diamine and ethylamine; and S4, adding calcium oxide powder into the solution C, continuously stirring, and reacting to obtain calcium hydroxide slurry. The invention provides a method for preparing calcium hydroxide slurry with high specific surface area and high pore volume, the calcium hydroxide slurry prepared by the method can form calcium hydroxide with high specific surface area and high pore volume when in use, and the method aims to solve the problems of low specific surface area and low pore volume of the existing calcium hydroxide. Therefore, the problem of desulfurization performance inactivation caused by blockage of calcium hydroxide (desulfurizer) pores by generated CaSO3 and CaSO4 in the desulfurization process is avoided.

The present disclosure relates to a membrane prepared from a blend comprising i) a polysulfone, polyether sulf one or polyarylethersulfone and ii) polyvinylpyrrolidone, characterized in that the membrane is coated with polydopamine and chon-droitin. Optionally the coating further comprises heparin. The disclosure further relates to a process for producing the coated membrane, a method of increasing the selectivity of a membrane, and to a filtration / diffusion device comprising the membrane which can be used, for example, in hemodialysis applications.

The present invention discloses an imidazole derivative, a preparation method thereof, and an application, belonging to the field of organic chemistry. The preparation method of the imidazole derivative of the present invention includes: adding compound 2a and dimethyl sulfate into an organic solvent, heating and reacting to obtain compound 3a; wherein, compound 2a is prepared by adding compound 1a, TrtCl, and a base reagent into a solvent, controlling the temperature at 0-10 °C, mixing evenly and reacting. The present invention also further prepares 2-(1-methylimidazol-5-yl)ethylamine (4a) by using the imidazole derivative. The present invention selects dimethyl sulfate as a methylation reagent and cooperates with a specific protecting group design to achieve the efficient preparation of 2-(1-methylimidazol-5-yl)ethylamine, with a total yield of 82.4%.

The invention relates to a green preparation method of fluopyram intermediate 3-chloro-5-(trifluoromethyl)-2-ethylaminopyridine, which comprises the following steps: step 1, Ullmann reaction: coupling 3-chloro-2-methyl-5-trifluoromethylpyridine (C1) and N-bromomethyl phthalimide (C2) in the presence of a copper catalyst and potassium tert-butoxide to generate an intermediate (C3); and step 2, hydrolysis reaction: hydrolyzing the intermediate (C3) in the presence of hydrazine sulfate and an alkaline condition to generate the fluopyram intermediate 3-chloro-5-(trifluoromethyl)-2-ethylamino pyridine. The method has the advantages of short synthesis steps, easily available raw materials, no use of high-toxicity cyanogen compounds, low catalyst cost, difficult poisoning, recycling, simple post-treatment process, and less waste liquid generation, greatly reduces the production cost, improves the production safety, reduces the waste liquid discharge amount, and accords with the idea of green synthesis.

The utility model discloses a perovskite solar cell and an electric device, and the perovskite solar cell comprises a conductive substrate, a first carrier transmission layer, a first passivation layer, a perovskite layer, a second passivation layer, and a second carrier transmission layer which are stacked in sequence. Each of the first passivation layer and the second passivation layer independently comprises one or more of a 2-phenylethylamine hydrochloride layer, a 4-trifluoromethyl-aniline hydrochloride layer, a 2-thiophene ethylamine hydrochloride layer, an ethylamine hydrochloride layer and an n-butylamine hydrochloride layer. According to the perovskite solar cell structure provided by the utility model, through arranging the passivation layers on the two sides of the perovskite layer and limiting the selection of the passivation layers, the quality of front and back interfaces of the perovskite absorption layer can be simultaneously improved, the interface defects are reduced, the non-radiative recombination is inhibited, and the transmission of carriers on the interface is improved; and the performance of the perovskite solar cell, such as open-circuit voltage, filling factor and cell efficiency, can be further improved.

The invention relates to a nitrogen-containing heterocyclic compound as well as a preparation method and application thereof, belongs to the technical field of heterocyclic compound synthesis, and solves the problems of low reaction efficiency and high energy consumption caused by the fact that an existing method for synthesizing an indole maleimide derivative needs to be carried out step by step. The preparation method comprises the following steps: step 1, adding indoleacetamide and a nucleophilic reagent into a mixed solution, and reacting; 2, performing post-treatment to obtain a nitrogen-containing heterocyclic compound; the mixed solution comprises alkali, an additive and an organic solvent; the alkali comprises one of triethylamine (Et3N), N, N-diisopropylethylamine, pyridine and 1, 8-diazabicyclo [5.4. 0] undec-7-ene, and the alkali comprises one of 1, 8-diazabicyclo [5.4. 0] undec-7-ene.

The invention discloses a preparation method of a composite flocculant based on efficient water treatment, belongs to the technical field of flocculant processing, and aims to solve the technical problem that the flocculation performance and the settling performance of a flocculant need to be further improved in the prior art. The preparation method specifically comprises the following steps: putting acrylamide, diallyldimethylammonium chloride, 2-hydroxypropyl methacrylate and deionized water into a reaction kettle, and uniformly mixing to obtain a mixed monomer; according to the preparation method, citric acid monohydrate and iron nitrate nonahydrate react under a mild acidic condition to form a Fe < 3 + >-citric acid complex, and then 2-hydroxyethylamine is introduced to further participate in complexing to obtain a citric acid complexing solution, so that not only is the flocculation performance of the composite flocculant improved, but also the settling performance of the composite flocculant is improved.

The invention provides application of a CsZAT6 gene or protein in regulation and control of theanine synthesis, and belongs to the technical field of molecular breeding. According to the application of the CsZAT6 gene or the encoding protein of the CsZAT6 gene in regulation and control of theanine synthesis, specifically, the synthesis of theanine is reduced by negatively regulating and controlling the expression level of the CsZAT6 gene, or the synthesis of theanine is promoted by positively regulating and controlling the expression level of the CsZAT6 gene. The CsZAT6 gene is a potential target gene for synthesizing the theanine. Experimental results show that the CsZAT6 gene can respond to IAA treatment, and the content of ethylamine and theanine is regulated and controlled in a tea tree body by regulating and controlling a CsAlaDC promoter.

The invention provides a cross-linking and curing environment-friendly polyurethane waterproof coating and a preparation method thereof, and the cross-linking and curing environment-friendly polyurethane waterproof coating comprises the following raw materials by weight: 15-30 parts of a polyhydroxy compound; 6 to 15 parts of pentaerythritol polyether; 1-5 parts of an anionic surfactant; 1 to 5 parts of nano silicon dioxide aerogel; 1-8 parts of wollastonite powder; 25 to 45 parts of fly ash floating beads; 10 to 25 parts of diisocyanate; 0.5 to 3 parts of chlorinated paraffin; and 0.5 to 3 parts of N, N-dimethyl-2-hydroxyethylamine. The cross-linking curing environment-friendly polyurethane waterproof coating provided by the invention solves the environment-friendly problem of the traditional polyurethane waterproof coating, realizes solvent-free curing, meets the environment-friendly requirement, improves the comprehensive properties such as elasticity and durability of a coating film, and provides a safer and more effective solution for waterproof construction.

The invention discloses a method for enriching a sulfydryl-containing peptide fragment based on covalent binding, in the method, a chemical reagent, namely 2-(2-pyridyl disulfide) ethylamine, capable of reacting with sulfydryl is used, the reagent comprises two functional reactive groups, specifically, amino and pyridyl disulfide, the amino can react with carboxyl magnetic beads, and the sulfydryl-containing peptide fragment can react with carboxyl magnetic beads. A novel pyridine disulfide-based magnetic bead material, namely the pyridine disulfide-based agar magnetic bead, is formed. According to the method, pyridine disulfide can directly react with the sulfydryl peptide fragment to form a covalent bond, so that the enrichment of the sulfydryl peptide fragment is realized, the sulfydryl peptide fragment can be eluted by adding a reducing agent such as DTT, and the method has the characteristics of low cost, good selectivity and the like.

The invention provides a high-chirality one-dimensional perovskite single crystal and a preparation method thereof, and the preparation method comprises the following steps: 1, using lead oxide, hydriodic acid, hypophosphorous acid and (R)-1-(1-naphthyl) ethylamine to prepare a white precipitate in a glass bottle; 2, heating the glass bottle, and continuously stirring the liquid containing the white precipitate by using magnetons; and 3, cooling the glass bottle to obtain the single crystal. According to the preparation method of the high-chirality one-dimensional perovskite single crystal, provided by the invention, a material (R)-1-(1-naphthyl) ethylamine with ultrahigh chirality is selected as positive ions of perovskite, so that the grown perovskite single crystal also has ultrahigh chirality; the pure one-dimensional chiral perovskite single crystal which is yellow is obtained by adjusting the ratio of lead oxide to (R)-1-(1-naphthyl) ethylamine; and the obtained single crystal has a flat surface, the size can be as long as 6mm, and the application field of the single crystal is widened.

The invention provides a method for preparing a nitrogen, phosphorus and sulfur tri-doped hollow carbon nanocage material derived from a covalent triazine polymer. The method comprises the following steps: by taking zinc nitrate hexahydrate and 2-methylimidazole as reactants and methanol as a solvent, stirring at room temperature to synthesize ZIF-8; the preparation method comprises the following steps: by taking phosphonitrilic chloride trimer and bisphenol S as monomers and ZIF-8 as a template agent, carrying out polymerization under the induction of an N, N-diisopropylethylamine initiator so as to generate ZIF-8 (at) PZS; and performing high-temperature pyrolysis to synthesize the nitrogen, phosphorus and sulfur triple-doped hollow carbon nanocage material. The invention also discusses the application of the nitrogen, phosphorus and sulfur tri-doped hollow carbon nanocage material in an air electrode material of a zinc-air battery. Meanwhile, the conductivity and the oxygen reduction reaction electro-catalytic performance of the obtained carbon material are remarkably improved through the nitrogen, phosphorus and sulfur doped synergistic effect, the half-wave potential of the carbon material reaches up to 0.85 V vs. RHE, and the limiting current density can reach 5.19 mA cm. A zinc-air battery assembled by using the material as an air electrode shows high peak power density of 194 mW cm.

The invention provides a fluorine-containing polymer wetting reversal agent suitable for shale reservoir protection as well as a preparation method and application of the fluorine-containing polymer wetting reversal agent. The preparation method of the reverse wetting agent comprises the following steps: adding ethylamine, triethylamine and deionized water into a reaction flask, and adding perfluorooctanoyl chloride into the system for reaction; after the reaction is completed, potassium hydroxide and 2-chloroethanol are continuously added for reaction; and after the reaction is completed, obtaining the N-ethyl-N-hydroxyethyl perfluorooctanamide. Adding nanoparticles, a silane coupling agent and ammonia water into the dispersant solution, and carrying out a modification reaction to obtain a modified nanoparticle solution; and adjusting the pH value of the obtained modified nanoparticle solution to 5-9, adding N-ethyl-N-hydroxyethyl perfluorooctanamide, introducing nitrogen to remove oxygen, adding an initiator, and carrying out thermal initiation polymerization reaction to obtain the composite material. The wetting reversal agent disclosed by the invention has excellent wetting reversal performance and a certain filtration reduction effect, and provides innovative thinking for development of a high-performance water-based drilling fluid technology.

The invention discloses a high-conversion-rate transaminase mutant, a coding gene and application of the high-conversion-rate transaminase mutant, and belongs to the technical field of bioengineering. The transaminase mutant is obtained by amino acid mutation of a transaminase mutant M1 as shown in an amino acid sequence SEQ ID NO.3, and the mutation site is at least one of the 33rd site, the 88th site, the 90th site, the 157th site, the 177th site, the 391th site, the 392nd site and the 442nd site. Compared with the transaminase mutant M1, the transaminase mutant provided by the invention has higher enzyme activity, and can be used for preparing the transaminase mutant. According to the method, the (S)-1-(3-methoxyphenyl) ethylamine can be prepared by taking the 3-methoxyacetophenone as the substrate, the yield of the product is high, when the concentration of the substrate is increased, the conversion rate is still high, no by-product is generated, and the method has a very good industrial application prospect.

The invention discloses a triazine desulfurizer and a preparation method thereof, and belongs to the technical field of gas purification. The triazine desulfurizer is mainly prepared from the following raw materials in percentage by weight: 20 to 50 weight percent of triazine derivative, 10 to 15 weight percent of sterically hindered amine, 3 to 7 weight percent of stabilizer, 1 to 3 weight percent of synergist, 0.5 to 1.5 weight percent of penetrant, 0.5 to 1.5 weight percent of inhibitor, 1 to 2 weight percent of additive and the balance of water, the preparation method of the triazine derivative comprises the following steps: adding 2-(diphenylphosphino) ethylamine into a toluene solvent, adding a paraformaldehyde aqueous solution in batches under a stirring condition, and reacting for 2-8 hours to obtain the triazine derivative. According to the triazine desulfurizer and the preparation method thereof provided by the invention, the triazine derivative and the sterically hindered amine are taken as a host, and the stabilizer, the synergist, the penetrant, the inhibitor and the assistant are compounded, so that the scaling trend of the triazine desulfurizer in an oil and gas well can be slowed down, the dissolution rate of hydrogen sulfide and the mass transfer rate in a solution are increased, and the desulfurization reaction is promoted; the desulfurization effect and the desulfurization rate are improved, and meanwhile, a very good scale inhibition effect is also achieved.

The invention discloses a preparation process of berberine hydrochloride, and belongs to the technical field of berberine production. The invention relates to a berberine hydrochloride preparation process, which comprises: S1, mixing a ferric sulfate-aluminum sulfate composite salt, sodium chloride, zinc chloride and anhydrous formic acid, pre-activating, adding N-2, 3-dimethoxybenzyl homopiperony lamine hydrochloride, dropwise adding a glyoxal mixed solution, and carrying out a reflux reaction. And S2, cooling the reaction liquid until a solid is separated out, filtering, adding a filter cake and diatomite into purified water, stirring, adjusting alkali, heating, and continuously stirring for 0.5-1 hour. Cooling and filtering, and reserving filtrate; s3, adjusting the acidity of the filtrate, cooling and growing crystals; and filtering, rinsing a filter cake, and carrying out vacuum drying on the filter cake to obtain berberine hydrochloride. The berberine hydrochloride prepared by the method is high in yield and purity, and the preparation process is safe, short in flow and friendly to human bodies and environment.

The invention relates to a preparation and synthesis method of an amino-substituted nitrogen-containing heterocyclic ring, which is carried out by using an ice bath auxiliary device, and is characterized by comprising the following steps: adding p-aminobenzaldehyde into a toluene solution of aminoacetaldehyde dimethyl acetal, heating to reflux to obtain (Z)-N-(4-acetamido-benzylidene)-2, 2-dimethoxyethylamine, and reacting for 2-4 hours to obtain the N-(4-acetamido-benzylidene)-2, 2-dimethoxyethylamine. And carrying out three steps to obtain the 6-aminoisoquinoline. Wherein the reaction liquid is poured into the crushed ice, an ice bath auxiliary device is used for implementing, and the ice bath auxiliary device comprises an ice crusher (1), a carrying table (2), a heating plate array (3) and a tray (4).

The invention discloses a triphenylamine supramolecular polymer capable of adjusting circularly polarized light as well as a preparation method and application thereof. The polymer is formed by co-assembling a triphenylamine donor and a naphthalene monoamide acceptor through intermolecular non-covalent acting force; the preparation method of the triphenylamine donor comprises the following steps: S1, adding methyl gallate and bromododecane into DMF (Dimethyl Formamide), and reacting to obtain a compound A; s2, adding the compound A and sodium hydroxide into ethanol to react to obtain a compound B; s3, adding the compound B, 1-(4-bromophenyl) ethylamine, 1-ethyl-(3-dimethylaminopropyl) carbodiimide and 4-dimethylaminopyridine into dichloromethane, and carrying out a reaction so as to obtain a compound C; s4, adding the compound C, Pd (PPh3) 2Cl2, CuI and trimethylsilylacetylene into triethylamine in an inert atmosphere, and reacting to obtain a compound D; and S5, adding the compound D, Pd (PPh3) 2Cl2, CuI and tris (4-iodophenyl) amine into triethylamine in an inert atmosphere, and reacting to obtain the triphenylamine donor. The invention develops a CPL material with a wide-range tunable characteristic.

The invention belongs to the technical field of chemical pharmacy, and particularly relates to a preparation method and application of an impurity of a beta2 adrenal receptor stimulant and M receptor antagonist bifunctional active compound. According to the impurity preparation method of the beta2 adrenal receptor stimulant and M receptor antagonist bifunctional active compound, acetylation of amino is successfully realized by using acetylation reagents such as acetyl chloride and alkali accelerators such as N, N-diisopropylethylamine, then debenzylation is performed through hydrogenation reaction, and the compound shown in the formula I is successfully prepared. Then, through liquid chromatography purification, a high-purity compound as shown in the formula I is obtained, and the raw material medicine as shown in JKN2304 can meet the requirements of reference substances in the research and development process; the technical problem that in the prior art, an impurity synthesis process of a beta 2 adrenal gland receptor agonist and M receptor antagonist bifunctional active compound is lacked is solved.

The invention discloses a high-strength energetic compound based on a polydopamine and thiourea polymer and a preparation method of the high-strength energetic compound, and the energetic compound is composed of energetic crystal 1, 3, 5-triamino-2, 4, 6-trinitrobenzene, the polydopamine and the thiourea polymer. The preparation method comprises the following steps: modifying an energetic crystal 1, 3, 5-triamino-2, 4, 6-trinitrobenzene through polydopamine in advance; the polythiourea is obtained through reaction of 2, 2 '-(ethylene dioxygen) diethylamine, carbon disulfide and trimethylolpropane tripolypropylene glycol ether, and the addition amount is 2.5 wt.%-10 wt.%; and mixing the two components by a kneading method, and drying to obtain the energetic compound. The obtained compound has the characteristics of strengthening and toughening, the Brazil mechanical strength reaches 14.76 MPa, and the fracture strain reaches 0.474%. By introducing polyphenol polydopamine and polythiourea to achieve a synergistic effect, the mechanical property of the explosive is greatly improved, and a technical support can be provided for the application of the explosive; meanwhile, the preparation method is simple, mild in reaction condition and easy for large-scale production.

The invention relates to a solid electrolyte of organic-inorganic hybrid halogen compound molecules, preparation thereof and an all-solid-state battery, and belongs to the technical field of energy storage batteries. The chemical general formula of the solid electrolyte is MaNb + eQcXdYa + bn + cq + dxZen or MaN2b + eQcXdYa + cq + dxZenObn, wherein M is selected from one of methylamine, ethylamine, propylamine, butylamine, aniline, benzylamine and phenylethylamine; n, Q and X are different metal elements; y is selected from halogen; z is a pseudohalide ion; the value range of a, b, c, d and e is 0 lt; a < = 3, 0lt; b < = 3, 0lt; c < = 1, 0lt; d < = 1, 0lt; e < = 6; and n, q and x are values of valences of the N element, the Q element and the X element respectively. The electrolyte material disclosed by the invention has high ionic conductivity, good flexibility and machinability and excellent air stability, and a battery formed by the solid electrolyte material has excellent electrochemical performance.

The invention discloses a gamma-glutamyl formamide synthetase mutant, which has higher theanine synthesis activity and can be used for improving the yield and conversion rate of theanine. The invention also discloses a theanine production chassis strain constructed by introducing genes such as tea tree alanine decarboxylase and the like, the strain can be used for endogenous synthesis of ethylamine, and the problems of safety, high cost and the like caused by exogenous addition of ethylamine in the theanine production process can be avoided. When the strain is used for expressing a high-activity gamma-glutamylformamide synthetase mutant, and is applied to fermentation production of theanine, the yield and conversion rate of theanine can be greatly improved, the safety is improved, the production cost is reduced, and the strain has important significance on large-scale production of theanine.

The present invention provides a detection kit for detecting 25-hydroxyvitamin D and a detection method thereof. Formulations of a dissociating agent and an antibody dry powder are known through screening and optimization, such that self-mixing and dissociation of a sample are realized without being affected by human factors and depending on any mixing equipment, ensuring a 25-hydroxyvitamin D antibody is fully reacted with a substance to be tested. In addition, an operating process of an immunochromatography assay is improved, such that dissociation of the sample and bonding of the 25-hydroxyvitamin D antibody and the substance to be tested are completed in one reaction tube and completely separated from a test strip; and the test strip is employed for sample injection and detection after completion of reaction, and a specific control line is arranged. This significantly improves the accuracy and sensitivity of portable detection of 25-hydroxyvitamin D with the immunochromatography assay, and the detection sensitivity of the 25-hydroxyvitamin D reaches 1 ng / mL.

The invention discloses a preparation method of a near-infrared two-region fluorescently-labeled phospholipid molecule and a preparation method of a lipid nano-carrier of the phospholipid molecule, and relates to the field of preparation methods of cyanine dyes. The invention aims to solve the technical problems that the application of the organic cyanine dye in a living body is limited by the hydrophobicity of the organic cyanine dye and the fluorescence intensity is low due to the aggregation quenching effect of the organic cyanine dye. The method comprises the following steps: preparing a compound 2 from 1, 8-naphthalimide and iodohexane, and then preparing C6 from the compound 2, 2-chloro-3-(hydroxymethylene)-1-cyclohexene-1-formaldehyde and sodium acetate; then C6 and mercaptobenzoic acid are used for preparing C6-COOH; the preparation method comprises the following steps: preparing C6-Lipid from N, N-diisopropylethylamine, HBTU, C6-COOH and 4-(1, 2, 2-triphenylvinyl) aniline by virtue of a hydrothermal method; the preparation method comprises the following steps: preparing a lipid nano-carrier from C6-Lipid, DMPC (Dimethyl Pyrrolidone), DOPE (Dioctyl Olefin Polyethylene) and According to the phospholipid molecule and the lipid nano-carrier thereof prepared by the invention, effective imaging of fluorophores is realized, and aggregates such as J aggregation and the like are possibly generated, so that the fluorescence quantum yield is improved, and an efficient fluorescence imaging effect is achieved. The cyanine dye prepared by the invention is used for fluorescence imaging.

The invention belongs to the technical field of organic synthesis, and particularly relates to a preparation method of 5-bromopyridine-2-carboxylic acid methyl ester, which specifically comprises the following steps: 1) reacting 3-butyric acid-2-oxo-methyl ester with 2-bromoethylamine to synthesize 6-amino-5-bromo-3, 5-diene-2-ketone; (2) enabling the 6-amino-5-bromine-3, 5-diene-2-ketone prepared in the step (1) to react with glacial acetic acid, and synthesizing 5-bromine-2-methylpyridine; (3) reacting the 5-bromo-2-methylpyridine prepared in the step (2) with potassium permanganate to synthesize 5-bromopicolinic acid; 4) reacting the 5-bromopicolinic acid prepared in the step 3) with methanol and concentrated hydrochloric acid to synthesize the 5-bromopyridine-2-carboxylic acid methyl ester.The preparation method of the 5-bromopyridine-2-carboxylic acid methyl ester.The preparation method of the 5-bromopyridine-2-carboxylic acid methyl ester.The preparation method of the 5-bromopyridine-2-carboxylic acid methyl esterhas the advantages that the total reaction yield is high, the prepared 5-bromopyridine-2-carboxylic acid methyl esteris high in purity, reaction conditions are mild, cyanide does not need to participate in the reaction, and operation is easy.

The invention discloses a modified polypeptide as well as a preparation method and application thereof, the preparation method comprises the following steps: on the basis of solid-phase synthesis of RADA16, 1-hydroxybenzotriazole and benzotriazole-N, N, N ', N'-tetramethylurea hexafluorophosphate are adopted as condensing agents, N, N-diisopropylethylamine-containing N, N-diisopropylethylamine is added into the condensing agents, and a reaction is carried out for 2-4 hours to obtain the modified polypeptide. And adding amino-terminated or carboxyl-terminated polyethylene glycol or amino-containing chitosan oligosaccharide into N, N-dimethylformamide for condensation, cutting polypeptide from the resin after the reaction is completed, precipitating, washing, re-dissolving and freeze-drying to obtain the polypeptide. The polypeptide provided by the invention has the characteristic of forming hydrogel through self-assembly in a specific medium, and the gel forming time of the polypeptide is within 21-60 seconds and is obviously faster than that of RADA peptide (gel forming in 150 seconds) under the same condition; the polypeptide modified by the polyethylene glycol or the chitosan oligosaccharide can spontaneously form gel after being injected into the blood vessel so as to embolize the blood vessel, and the embolism is long in stabilization time and stable, and meets the actual clinical requirements.

The invention discloses a flue gas desulfurization composite synergist and a preparation method thereof, and relates to the technical field of flue gas desulfurization. The desulfurization composite synergist is prepared from the following raw materials in parts by weight: 5 to 10 parts of citric acid, 20 to 30 parts of binary acid, 15 to 20 parts of sodium formate, 15 to 20 parts of sodium salt, 12 to 18 parts of magnesium salt, 2 to 4 parts of surfactant, 2 to 4 parts of pH buffering agent and 5 to 10 parts of calcium oxide. The preparation method comprises the following steps: carrying out a ring-opening reaction on 3-(2-aminoethylamine) propyl methyl dimethoxy silane and glucolactone to obtain an intermediate 1, and then carrying out a two-step quaternization reaction to synthesize the novel surfactant. The prepared desulfurization composite synergist has a good desulfurization effect and is suitable for limestone-gypsum wet flue gas desulfurization.