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Medicine-release system of compound Rifampicin

A rifampicin and preparation technology, applied in the field of anti-tuberculosis drugs, can solve the problem that rifampicin is difficult to achieve

Inactive Publication Date: 2003-08-27
SICHUAN LONG MARCH PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

3. The bioavailability of rifampicin must be considered
Moreover, the current capsule filling machine has only four workers at most, and can only fill three kinds of materials in one capsule (the other station is used to put the capsule), so it is difficult to realize the accurate filling dose of rifampicin.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] A quadruple compound rifampicin capsule, in which rifampicin is an enteric-coated small tablet, ethambutol hydrochloride is an ordinary small tablet, isoniazid and pyrazinamide are made into granules together, and the granules are dissolved in the stomach to ensure the dosage Coating and then filling the capsule. By the way, the granules can be completely coated without gastric coating. (1) The prescription and preparation process of rifampicin enteric-coated tablets:

[0049] (1) The prescription and process of rifampicin tablets (tablets):

[0050] (A) Prescription:

[0051] Rifampicin 75.0g

[0052] Low-substituted hydroxypropyl cellulose 20.0g

[0053] Starch 10.0g

[0054] Sodium lauryl sulfate 6.5g

[0055] 10% starch slurry appropriate amount

[0056] Magnesium stearate

[0057] Make 1000 pieces (B) Preparation process:

[0058] The above-mentioned raw materials and auxiliary materials are passed through a 200-mesh sieve, accurately weighed according to the prescribe...

Embodiment 2

[0087] A compound rifampicin pellet capsule, each of the quadruple members is separately made into pellets and then coated after testing, wherein the rifampicin enteric coating and the other members are gastric coating. The final products of this example are Silian capsules, Sanlian capsules and Lianglian capsules. (1) Preparation of rifampicin enteric-coated pellets Preparation of rifampicin pills:

[0088] ①The formulation of rifampicin pills: 1 part of rifampicin, 0.0867 parts of pill core, 0.2 parts of microcrystalline cellulose, 0.1333 parts of sodium lauryl sulfate, 0.0667 parts of CMS-Na, 1% PVP (Ethanol:water=1:1) appropriate amount. (Or written as: Rifampicin 150g, pellet core 13g, microcrystalline cellulose 30g, sodium lauryl sulfate 20g, CMS-Na 10g, 1% PVP (ethanol: water = 1:1) appropriate amount.)

[0089] ②The preparation process of rifampicin pills:

[0090] A. Weigh the above-mentioned raw materials and auxiliary materials according to the proportion, sieving and m...

Embodiment 3

[0127] A compound rifampicin pellet capsule, each of the quadruple members is separately made into pellets and then coated after testing, wherein the isoniazid enteric coating, and the other members are gastric coating. The final products of this example are Silian capsules, Sanlian capsules and Lianglian capsules. In this example, except that the isoniazid pellets were enteric coated with the same process as the rifampicin enteric pellets in Example 2, the rifampicin pellets were coated with the same process as the isoniazid gastric pellets in Example 2. The gastric coating is performed, and the rest of the content is completely the same as that of Example 2. Due to space limitations, it will not be repeated here. Of course, due to the exchange of coating materials between isoniazid and rifampicin pills, the content of the drug in the pellets will be slightly changed, and this will also cause a small change in the filling amount of the pellets in the capsule. These small changes ...

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PUM

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Abstract

The present invention relates to a compound rifampin preparation, in particular, it relates to a medicine-releasing system of compound rifampin. Said system comprises rifampin and isoniazid, and further selectively can include pyrazinamide or pyrazinamide and etambol, which is characterized by that the isoniazid, pyrazinamide and etambol are gastric soluble, and the rifampin is enteric soluble orisoniazid is enteric soluble, and others are gastric soluble. Said preparation can be made into capsule, granules, tablet, multi-layer table and suspension preparation. Said invention also provides its preparation method.

Description

Invention field [0001] This application is actually a continuation application. The title of the invention previously applied for is the prescription composition of a compound rifampicin preparation. It was filed on April 15, 2002. The application number is 02116616.1, the content of which is incorporated herein by reference. [0002] The present invention relates to an anti-tuberculosis drug, in particular to a compound rifampicin preparation. A more accurate expression in modern pharmacy is a drug release system of a compound rifampicin preparation, its composition and a preparation method. technical background [0003] Tuberculosis is a chronic infectious disease that seriously endangers people's health. Since the mid- to late 1980s, the global epidemic has deteriorated sharply and formed a new peak. According to the latest estimate in the World Health Organization (WHO) Communiqué (2001), 8 million new tuberculosis patients worldwide occur each year. At least 2 million tuberc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K9/36A61K9/48A61K31/496A61K31/4965A61P31/06
Inventor 高华鲁同红
Owner SICHUAN LONG MARCH PHARMA CO LTD
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