The invention discloses health-care medicinal granules capable of relieving mental pressure and resisting depression. The medicinal granules mainly comprises the following nutritional ingredients: Inca Inchi oil, Inca Inchi polypeptide, plantain powder, soybean polypeptide, L-theanine, passionflower, kendir, licorice root, kudzu root, schisandra fruit extract, deep sea fish oil, tryptophan, tyrosine, folic acid and the like. The method comprises the following steps: carrying out cold pressing and enzymolysis, evenly mixing according to parts by weight, adding emulsifier glycerol monostearate,homogenizing and carrying out spray drying. The nutritional medicinal granules disclosed by the invention have good mouthfeel, and has favorable action on improving depressed people with irritability, great mood fluctuations, obvious energy reduction, causeless continuous fatigue, insomnia, early sleep, hypersomnia, and concentration difficulty or plummet. Compared with products which can only relieve pressure and resist depression or western medicines with side effect, the nutritional medicinal granules have obvious advantages, are a novel health-care solid beverage, and have wide market development and application prospects.