49 results about "Ethyl formate" patented technology

The invention relates to the technical field of microorganisms, in particular to an ethyl carbamate degrading bacterium and application thereof.The ethyl carbamate degrading bacterium is pichia kudriavzevii K44 and is preserved in the China Center for Type Culture Collection on April 25, 2025, the preservation date is April 25, 2025, and the biological preservation number is CCTCC NO: M 2025887. The ethyl carbamate degrading bacterium can obviously degrade ethyl carbamate in a yellow rice wine fermentation system, and a scientific basis is provided for safe production and quality improvement of traditional fermented food.

The invention relates to the technical field of fibers, and discloses an easily biodegradable polyester-nylon composite fiber and a preparation process thereof.The preparation method comprises the steps that 2-(2-acrylamido ethyl formate) benzoic acid is subjected to graft modification to obtain modified polylactic acid, and the modified polylactic acid, polyethylene glycol terephthalate PET and nylon 66 resin are subjected to blending melt spinning to obtain the polyester-nylon composite fiber. The modified polylactic acid improves the compatibility between the PET and the nylon 66 resin, so that the polyester-nylon composite fiber has higher mechanical properties, and the tensile strength and the elongation at break are obviously improved. The polylactic acid has better biodegradability, and the introduced ester group also has biodegradability, so that the biological decomposition rate of the fiber is improved. The modified polylactic acid contains a large amount of hydrophilic carboxyl and amido bonds, so that the moisture regain of the composite fiber is improved, and the modified polylactic acid can be better applied to hydrophilic moisture absorption fiber textiles.

The invention discloses an analysis method for determining multiple components of white spirit by high performance liquid chromatography-tandem mass spectrometry, and relates to the technical field of white spirit analysis and detection, and the analysis method comprises the following steps: firstly, preparing an ethyl carbamate precursor substance standard stock solution and a mixed standard intermediate solution, and diluting the mixed standard intermediate solution step by step to obtain a mixed standard working solution; then determining chromatographic and mass spectrometry conditions, wherein BEH Ami chromatographic column is adopted as the chromatographic condition, and 0.1% formic acid water-acetonitrile is adopted as a mobile phase for gradient elution; a mass spectrum condition adopts a multi-reaction monitoring mode under an electrospray positive ion mode; drawing a quantitative calibration curve; finally, preparing a to-be-detected sample for content determination. According to the analysis method for determining the multiple components of the Baijiu through the high performance liquid chromatography-tandem mass spectrometry, through chromatographic condition optimization and mass spectrometry parameter innovation, the detection efficiency is improved, peak area data of urea, citrulline and arginine can be synchronously obtained through single sample injection, the analysis time is short, and quantification is accurate.

The invention discloses quick heat-conducting precoated sand and a preparation process thereof, and relates to the technical field of precoated sand, the quick heat-conducting precoated sand comprises the following raw materials by weight: 100-105 parts of crude sand, 6-8 parts of a modified resin prepolymer, 2-4 parts of modified POE, 3.5-4.5 parts of a lubricant, and 3-5 parts of nano silicon nitride. The modified POE has a relatively strong high-temperature toughening effect on the modified resin prepolymer, can also form chemical crosslinking with the modified resin prepolymer, and has relatively strong compatibility with other raw materials in the precoated sand. The modified resin prepolymer is obtained by heating and ring-opening polymerization of a benzoxazine monomer obtained by reaction of 5-nitrosalicylaldehyde, 2, 4-bis (trifluoromethyl)-5-pyrimidinyl ethyl formate, paraformaldehyde, furfuryl amine and the like, the curing temperature of the modified resin prepolymer is reduced, the thermal stability is improved, and improvement of the high temperature resistance of the precoated sand is facilitated.

This invention discloses a method for preparing sodium houttuynia cordata, comprising the following steps: adding sodium methoxide and toluene to a reaction vessel, heating, then slowly adding nonanone and ethyl formate, and after the addition is complete, reacting with a gradient cooling process, and post-processing to obtain an aqueous phase containing intermediate I; adding the aqueous phase containing intermediate I and toluene to the reaction vessel, stirring, cooling, and rapidly introducing liquid sulfur dioxide, continuously stirring and reacting at 0-10°C for 5-15 minutes, cooling, and filtering to obtain crude sodium houttuynia cordata. The preparation method of this invention directly introduces liquid sulfur dioxide during the sulfonation reaction, greatly shortening the process time, while achieving high product yield and purity, and requiring less sulfur dioxide. Furthermore, in the post-processing of sodium houttuynia cordata, adding toluene to the reaction solution beforehand can effectively transfer the generated impurities to the toluene; recrystallization using a 50 v / v% ethanol aqueous solution removes water-soluble and oil-soluble impurities while further reducing the risk of fire and explosion during centrifuge operation.

The invention discloses Leishan fish sauce sour essence as well as a preparation method and application thereof. The leishan fish sauce acid essence is prepared from ethyl acetate, absolute ethyl alcohol, ethyl isovalerate, ethyl hexanoate, isoamyl alcohol, furfuryl alcohol, ethyl lactate, ethyl caprylate, acetic acid, diethyl succinate, methyl salicylate, ethyl benzoate, ethyl laurate, hexanoic acid, phenethyl alcohol, 4-methyl guaiacol, ethyl myristate, ethyl palmitate, ethyl oleate, capsicum oleoresin, ethyl phenylacetate and ginger oil. And lactic acid, glycerol triacetate, ocimene, ethyl isovalerate, ethyl butyrate, anethole and phenylacetaldehyde. The Leishan fish sauce sour essence disclosed by the invention is soft and harmonious in overall fragrance, natural and vivid, still has stable flavor characteristics at high temperature, can make up the problem of flavor deficiency in sour soup products, realizes accurate reproduction and controllable release of composite fragrance, improves the standardization level of products, and effectively improves the preference degree of consumers.

The application discloses a kind of pyrimidine-substituted 1,2,4-triazole derivatives, it is characterized in that, with the structure expressed in general formula I or II:Wherein, R1 is hydrogen, methyl, ethyl, methoxy, ethoxy, thiomethyl, chlorine, fluorine, bromine, iodine, cyano, amine group, morpholine, triazole, pyrazole, trifluoromethyl, difluoromethyl, ethyl formate;R2 is hydrogen, methyl, ethyl, methoxy, chlorine, fluorine, bromine, iodine, cyano, amine group, trifluoromethyl, ethyl formate;R3 is hydrogen, methyl, ethyl, methoxy, ethoxy, thiomethyl, chlorine, fluorine, bromine, cyano, amine group, morpholine, triazole, pyrazole, trifluoromethyl, difluoromethyl.The compound of the application shows excellent activity against plant pathogens, such as rice sheath blight fungus, cucumber botrytis, blueberry botrytis, strawberry botrytis, tobacco botrytis, and sclerotinia sclerotiorum.

The invention relates to a plant-source attractant for peach tree pests and application of the plant-source attractant. The plant-source attractant is selected from any one or more of beta-phellandrene, 3-methylene-6-(tert-amyl) cyclohexane-1-ene, 1-isopropyl-4-methylene cyclohexane, 4-methylene cyclohexane-1-ethyl formate, 4-oxoisophorone and 3-carene, and the plant-source attractant is selected from any one or more of beta-phellandrene, 3-methylene-6-(tert-amyl) cyclohexane-1-ene, 1-isopropyl-4-methylene cyclohexane, 4-methylene cyclohexane-1-ethyl formate, 4-oxoisophorone and 3-carene. The compound can be used for preparing a preparation for attracting peach tree pests outdoors. Compared with the prior art, the peach tree pest plant source attractant can trap and kill female adults in external environments such as a field, and the prevention and control effect is greatly improved.

The invention relates to a tobacco flavor with glutinous rice fragrance and tea fragrance flavor and application of the tobacco flavor. The tobacco flavor is prepared from the following components: glutinous rice fragrance tea leaf essential oil, 2-carene, 2-propionyl-3, 4, 5, 6-tetrahydropyridine, 2-acetyl-3, 4, 5, 6-tetrahydropyridine, geraniol, 2-propionyl-1, 4, 5, 6-tetrahydropyridine, piperidine-2-ethyl formate and linalool. The sticky rice fragrance tea leaf essential oil and seven specific spice components are creatively combined to form the mixed spice, compared with single sticky rice fragrance tea leaf essential oil serving as spice, all the components in the mixed spice are matched and synergistic, sticky rice fragrance and tea fragrance are provided when cigarettes are smoked, the fragrance coordination of the cigarettes is obviously improved, and the flavor of the cigarettes is improved. The smoke characteristic of the cigarette is improved; after the spice is used for slow release treatment, the stability of glutinous rice fragrance and tea fragrance flavor can be maintained when cigarettes are smoked, and the flavor of the spice cannot be changed due to the change of the original proportion of the components in the slow release process, so that the sensory quality of tobacco products is comprehensively improved.

The invention discloses a stock pest fumigant and application thereof, the main active components of the fumigant are ethyl formate and mushroom alcohol, and the two components are mixed according to a specific proportion to be used for preventing and controlling stock pests such as callosobruchus maculatus, callosobruchus chinensis, rice weevil and maize weevil. Experiments prove that the blending formula of the fumigant has a remarkable synergistic effect, the defect that the mushroom alcohol is easily adsorbed by a medium is overcome while the single use concentration and the combustion risk of the ethyl formate are reduced; the efficient, safe and economical fumigation prevention and control on the storage object pests such as callosobruchus maculatus, callosobruchus chinensis, rice weevil, corn weevil and tribolium cavaleriei in the storage process of grains and agricultural products are realized. The invention provides a new solution for green prevention and control of stored insect pests.

The application belongs to the technical field of medicine synthesis, and particularly relates to a preparation method of an intermediate 4-methyl-2-piperidinecarboxylic acid ethyl ester of argatroban. The application takes SM-1 as a starting material, realizes single bromination of an alpha position of a carbonyl group of the SM-1, and prepares a target compound through a rearrangement reaction. Compared with the prior art, the application can effectively avoid the use of a toxic cyanide in the prior art, can avoid a catalytic hydrogenation reaction, is safe in operation, can effectively reduce production cost, and is suitable for industrialized scale production.

This invention relates to the field of organic synthesis technology, specifically a method for synthesizing 2-chloro-4-(1H-pyrazol-3-yl)benzonitrile and its application, comprising the following steps: S1. Compound 1a is added to a first organic solvent under inert gas protection and reacted with vinyl isobutyl ether under the conditions of a catalyst and potassium carbonate to obtain a system containing compound 2a; S2. The pH of the system containing compound 2a obtained in step S1 is adjusted to 2-3, and after reaction, compound 1 is obtained through post-treatment; S3. Compound 1 is added to a second organic solvent, and ethyl formate and sodium ethoxide are added to react and obtain a system containing compound 4a; S4. Acetic acid is added to the system containing compound 4a obtained in step S3 for neutralization, and under inert gas protection, hydrazine hydrate is added dropwise to react and the product is obtained through post-treatment. The synthesis method provided by this invention uses readily available raw materials, has a simple processing procedure, does not require column chromatography, simplifies the operation, and facilitates industrial-scale production.

The application discloses a synthesis method of 3-difluoromethyl-1-methylpyrazole-4-methyl ethyl formate. The synthesis method is to synthesize 3-difluoromethyl-1-methylpyrazole-4-methyl ethyl formate by taking 5-difluoromethyl-1-methylpyrazole-4-methyl ethyl formate and dimethyl carbonate as raw materials and under the action of a porous organic polymer catalyst with solidified Lewis acid. The porous organic polymer catalyst with solidified Lewis acid comprises a porous organic polymer, and the porous organic polymer is solidified with Lewis acid. In the synthesis method, under the action of the porous organic polymer catalyst with solidified Lewis acid, not only a high reaction conversion rate can be obtained at normal temperature, but also a large number of side reactions caused by high temperature can be effectively avoided, thereby the impurity content can be obviously reduced, and the synthesis method has the advantages of simple operation, good catalyst activity, mild reaction condition, few side reactions, fast reaction rate, high yield and the like, is suitable for industrial application, and has a good market prospect.

The application provides a synthesis process of an ocinaplon intermediate. S1, petroleum ether, methanol and ethyl formate are mixed to obtain a mixed system, ortho-phenyltoluene and sodium methoxide are added, and reaction is carried out to obtain intermediate 1; S2, intermediate 1 is added into methanol, a palladium-carbon catalyst is added, hydrogen is introduced, and reaction is carried out to obtain intermediate 2; S3, phosphoric acid and a supported catalyst are added into intermediate 2, and reaction is carried out to obtain iminodibenzyl. The problem of low iminodibenzyl yield in the prior art is solved.

The invention discloses a thin-layer chromatography identification method and application of radix cynanchi auriculati traditional Chinese medicine formula granules and radix cynanchi auriculati traditional Chinese medicine formula granules as well as a preparation method of the radix cynanchi auriculati traditional Chinese medicine formula granules and the radix cynanchi auriculati traditional Chinese medicine formula granules, and relates to the technical field of detection methods. The method comprises the following steps: dripping a test solution on a silica gel G thin-layer plate, and developing and inspecting under thin-layer chromatography conditions; thin-layer chromatography conditions are as follows: n-hexane-ethyl formate-formic acid is used as a developing solvent; the volume ratio of the normal hexane to the ethyl formate to the formic acid is 20: 15: 1; the spreading temperature is 4-26 DEG C, and the spreading humidity is 30% rh to 60% rh; compared with a thin-layer chromatogram of the radix cynanchi auriculati traditional Chinese medicine formula granules, the radix cynanchi auriculati charcoal traditional Chinese medicine formula granules have fluorescent spots at the specific shift value of 0.421-0.458. The method can be used for rapidly and effectively identifying the radix cynanchi bungei traditional Chinese medicine formula granules or radix cynanchi bungei charcoal traditional Chinese medicine formula granules which lose the form of the decoction pieces, is simple and convenient to operate, high in precision and sensitivity and good in stability, and has a good application prospect.

This invention belongs to the field of drug synthesis technology, specifically relating to a method for synthesizing an intermediate of osimertinib. The invention uses 1-methyl-3-acetylindole as a starting material and reacts it with ethyl formate to obtain an intermediate. This intermediate, without purification, is directly cyclized with 1-(4-((2-(dimethylamino)ethyl)(methyl)amino)-2-methoxy-5-nitrophenyl)guanidine to prepare N... 1 -(2-(dimethylamino)ethyl)-5-methoxy-N 1 -methyl-N 4 -(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)-2-nitrobenzene-1,4-diamine. This synthetic route has mild reaction conditions, simple post-processing, and high yield, making it suitable for industrial production.

The application discloses a high-efficiency cyclization micro-reaction device for pyrazolidine ethyl formate, and relates to the technical field of reaction devices.The device comprises a bottom plate, a stirring unit, an acid-base unit, a heat exchange unit, a heat conduction unit and a heat preservation unit.The top of the bottom plate is provided with a reaction cylinder.The stirring unit is arranged on the top of the reaction cylinder.The acid-base unit is arranged on the top of the stirring unit.The heat exchange unit is arranged on one side of the reaction cylinder, and is used for recycling the temperature of the solution in the reaction cylinder.The heat conduction unit is arranged on one side of the heat exchange unit, and is used for accelerating the heat exchange speed between the solution in the reaction cylinder and the heat exchange unit.The heat preservation unit is used for storing the solution in the reaction cylinder, and can further reuse the temperature of the solution in the reaction cylinder.The device can transfer the heat of the solution in the reaction cylinder which has reacted to the raw material for the next reaction in the heat exchange box, realizes the recycling of the heat in the reaction cylinder, and saves electric energy.

The invention discloses a preparation method of N1, N2-dimethylbenzene-1, 2-diamine, and belongs to the technical field of preparation of medical intermediates. O-phenylenediamine is used as a raw material and reacts with ethyl formate, then dimethyl sulfate is adopted for a nitrogen-methylation reaction, finally formyl is removed under the action of acid, and N1, N2-dimethylbenzene-1, 2-diamine is obtained. According to the method, all the raw materials can be conveniently purchased on the market, the process of each step of reaction is simple and convenient, no expensive catalyst is used, the yield is high, and industrial production is easy.

The application discloses a green process for synthesizing 4-methyl-2H-pyrane-2,6(3H)-dione, which comprises the following steps: (a) hydrolyzing 4,6-dimethyl-2-oxo-2H-pyrane-5-ethyl formate with liquid alkali to obtain a hydrolysis mixture, and performing negative pressure distillation on the hydrolysis mixture to recover an ethanol aqueous solution; (b) neutralizing the product of the negative pressure distillation to 7.0-7.5, centrifuging to obtain a filtrate and a residue, drying the residue to obtain anhydrous sodium salt, and performing three-stage extraction on the filtrate to obtain an aqueous phase and an organic phase; (c) performing cooling crystallization on the aqueous phase, centrifuging to obtain a precipitate and a first centrifugal filtrate, wherein the first centrifugal filtrate is used for preparing liquid alkali; performing concentration crystallization on the organic phase, recovering an extraction agent, cooling to crystallize when the concentration crystallization is performed to the point that crystals are precipitated, and centrifuging to obtain 3-methyl pentene diacid solid and a second centrifugal filtrate, wherein the second centrifugal filtrate is used for concentration crystallization; and (d) performing ring formation on the 3-methyl pentene diacid by dehydration reaction with a dehydrating agent, wherein the dehydrating agent is acetic anhydride or acetyl chloride. In this way, the discharge amount of pollutants is greatly reduced.

The invention discloses a preparation method and application of a formamide-containing silane passivator, and belongs to the field of passivated perovskite. The preparation method of the silane passivator comprises the following steps: sequentially adding 1, 3-bis (3-aminopropyl) tetramethyldisiloxane and ethyl formate into a system, and heating to react in a nitrogen atmosphere; and carrying out reduced pressure distillation until no fraction is distilled out, so as to obtain the formamide-containing silane passivator. The silane passivator is stable in chemical property, and the synthesis method is simple. After perovskite is passivated by the passivator, a C = O double bond in formamide and uncoordinated lead ions (Pb < 2 + >) can form a hydrogen bond, so that a crystal structure is perfected; the imino group (-NH-) and halogen ions form a hydrogen bond, and halogen ion migration is reduced, so that perovskite defects are passivated, non-radiative recombination is inhibited, and the optical property and stability of the perovskite material are effectively improved.

The invention discloses a synthesis method of a hydroximic acid analogue intermediate, and belongs to the field of medicine synthesis. The preparation method comprises the following steps: by taking 3-(2-acetamido-2-oxoethyl)-1, 2, 4-thiadiazole-5-yl amino ethyl formate (III) as a starting material, carrying out five-step reaction of alcoholysis, oxidation, oximation, protective group connection and hydrolysis, so as to obtain (Z)-2-(5-amino-1, 2, 4-thiadiazole-3-yl)-2-triphenylmethoxy imino acetic acid (II). The method provided by the invention has the characteristics of cheap and easily available raw materials, mild and safe reaction conditions, simple and convenient post-treatment and the like, thereby having great production value and social and economic benefits.

The present invention provides a method and catalyst for preparing ethyl formate by carbonylation of ethanol with carbon dioxide. The catalyst is copper-doped strontium titanate (SrTiCuO 3‑x The catalyst, loaded with copper at a copper loading of 0.0-3.50 wt%, exists in the form of nanoparticles with an average particle size of 2-20 nm. Under 300W xenon lamp illumination, with carbon dioxide as the carbonyl source, the HCOOC2H5 generation rate can reach up to 320 μmol / g / h, with good reproducibility.

The invention relates to a method for detecting a residual solvent formic acid in an opinapone intermediate product. The detection method comprises the following steps: performing pre-column derivatization on formic acid, and detecting by using gas chromatography of a flame ionization detector. According to the detection method, the problem that the formic acid content of the olpinapone intermediate product is difficult to detect by ion chromatography or liquid chromatography due to extremely poor solubility of the olpinapone intermediate product in a conventional solvent can be solved, and the situation that formic acid is easily degraded from the olpinapone intermediate product under a gas-phase high-temperature condition can be prevented through structural modification. Wherein the substance for preventing formic acid from being degraded from the intermediate product of the opiapone not only can be used as a catalyst to catalyze the formic acid to react faster and more completely, but also can ensure that the formic acid is completely converted into ethyl formate. While the detection efficiency is improved, the true and reliable quality of an olpiapone intermediate product is also ensured. The method can be used for quantitatively detecting formic acid higher than 0.02% in the intermediate product of opinapone, and has the advantages of high sensitivity, strong practicability and simple and fast detection process.

The invention relates to a low greenhouse gas emission process for converting carbon dioxide to a commodity chemical, ethyl formate. Carbon dioxide is converted to an aqueous formic acid product using an electro-chemical process, wherein the concentration of formic acid is about 10 wt %. The aqueous formic acid is converted to ethyl formate by esterification of formic acid with bioethanol in a reactor. The product, ethyl formate, is separated from the reaction product and water rejected using an integral low-energy membrane separation system.

The invention provides a high-transparency sulfone polymer as well as a preparation method and application thereof, the sulfone polymer comprises ester impurities with the mass percent of m, m is more than 0 and less than 0.05%, and m is more than 0 and less than 0.05%. The ester impurities are selected from one or more of methyl acetate, methyl formate, methyl N-methylbutyrate, methyl N-ethylbutyrate, ethyl acetate, ethyl formate, ethyl N-methylbutyrate and ethyl N-ethylbutyrate. The sulfone polymer provided by the invention has higher transparency.

The application discloses a preparation method of N1,N2-dimethyl benzene-1,2-diamine and belongs to the technical field of medical intermediate preparation. The method comprises the following steps: taking o-phenylenediamine as a raw material, reacting with ethyl formate, then adopting dimethyl sulfate to perform a nitrogen-methylation reaction, and finally removing a formyl group under the action of an acid to obtain N1,N2-dimethyl benzene-1,2-diamine. In the method, all raw materials can be conveniently purchased on the market, the process of each reaction is simple, there is no expensive catalyst, the yield is high, and the industrialized production is easy.

The invention relates to a liquid soldering flux suitable for various welding processes and a preparation method of the liquid soldering flux. The liquid soldering flux comprises the following components in percentage by weight: 2.0 to 3.0 percent of film-forming agent, 1.0 to 2.0 percent of active agent, 0.1 to 0.5 percent of surfactant, 0.5 to 1.0 percent of corrosion inhibitor and the balance of solvent. According to the invention, a plurality of components such as a film forming substance with water resistance, solvent resistance and chemical resistance, an active agent with chelating property, a polyether modified polysiloxane surfactant with a twin structure, a 2-butoxyethyl benzoate solvent with high boiling point and splashing resistance and the like are compounded; the prepared liquid soldering flux is suitable for wave soldering, dip soldering, series soldering and the like and is halogen-free, low in residue, high in activity, high in reliability, few in splashing and residue and low in corrosion.

The invention belongs to the technical field of fracturing fluid chemical systems, and particularly relates to a self-generating foam acid system as well as a preparation method and an evaluation method thereof. The self-generating foam acid system provided by the invention consists of the following reagents in parts by mass: 15-50 wt% of a reagent I, 10-35 wt% of a reagent II, 3-10 wt% of a reagent III, 0.5-5 wt% of a reagent IV and the balance of water, wherein the reagent I is one or more of paraformaldehyde, methyl formate, ethyl formate, methyl acetate, ethyl lactate, chloracetyl and chloromethane; the reagent II is one or more of ammonium chloride and aluminum chloride; the reagent III is NaNO2; and IV is selected from the group consisting of NP-10 and / or FS-3100. The self-generating foam acid system does not generate an acid generation reaction in an environment with the temperature lower than 60 DEG C, corrosion to underground equipment and damage to a stratum are reduced, the limestone reaction rate can be delayed under the high-temperature condition, and the acting distance of acid liquor in the stratum is prolonged.

The invention provides an ethyl formate fumigation control device and method, and relates to the technical field of grain storage and pest prevention and control. Ethyl formate is injected into a mixing cavity barrel through a liquid inlet device, inert gas is conveyed to a gas outlet ring pipe through a variable frequency motor, the ethyl formate is rapidly atomized through a plurality of gas outlet holes in the gas outlet ring pipe, and the gas outlet holes are formed in the gas outlet ring pipe; meanwhile, gas in the granary is circulated through a circulating gas pipe, a gas outlet and a frequency conversion fan in the circulation unit to achieve rapid atomization and uniform diffusion of ethyl formate, gas does not need to be heated while the insect killing efficiency is improved, and the system energy consumption and the burning explosion risk are reduced; through the arrangement of the temperature sensor, the ethyl formate concentration sensor and the oxygen sensor on different height layers of the barrel body and the central control unit, environmental parameters of different positions in the barrel can be comprehensively and accurately reflected, the fumigation strategy is dynamically adjusted according to monitoring data, and automatic control and real-time monitoring of the fumigation process are achieved.