66 results about "Phenethylamines" patented technology

The invention discloses a composite membrane with adsorption separation and catalytic degradation functions as well as a preparation method and application of the composite membrane. The composite membrane is supported by a porous base membrane, a polyamide separation layer formed by reaction of a 3, 4-dihydroxyphenylethylamine and 2, 3-diaminophenol comonomer and acyl chloride is constructed on the surface of the porous base membrane through interfacial polymerization, and FeCo-g-C3N4 nanosheets are anchored in situ; the membrane can efficiently activate peroxymonosulfate (PMS) to generate free radicals under the nearly neutral condition, efficient interception and catalytic degradation of organic pollutants (such as antibiotics) are synchronously achieved, and heavy metal ions (such as Pb < 2 + > and Cd < 2 + >) are adsorbed through a functional monomer structure; the invention provides an interfacial polymerization preparation method of the membrane. The composite membrane breaks through the limitation of'only interception but not degradation 'of a traditional membrane, realizes integration of'separation-adsorption-degradation', can remarkably reduce the volume of concentrated water and reduce the toxicity of the concentrated water, and is suitable for advanced treatment of wastewater containing composite pollutants in the industries of pharmacy, printing and dyeing and the like.

The application discloses a clay stabilizer and a preparation method thereof, and belongs to the technical field of oil field additives, and comprises the following steps: dissolving a first monomer and 2,3-epoxypropyl trimethyl ammonium chloride in a solvent, or respectively dissolving the first monomer and 2,3-epoxypropyl trimethyl ammonium chloride in a solvent to configure a solution, then dropping the 2,3-epoxypropyl trimethyl ammonium chloride solution into the first monomer solution; then, reaction is carried out to obtain a reaction liquid; after the reaction is completed, the reaction liquid is separated and purified to obtain the clay stabilizer; the first monomer is an aromatic monobasic amine, the aromatic monobasic amine is one of aniline, p-aminotoluene and phenethylamine, the number of active hydrogens on an amine group in the first monomer is n, and the molar ratio of the first monomer to the 2,3-epoxypropyl trimethyl ammonium chloride is 1:0.9n-1.1n. The clay stabilizer has good shale inhibition effect, and the preparation method is simple and easy to popularize.

The invention belongs to the technical field of medical polymer materials, and particularly relates to a preparation method of a surgical anti-adhesion hydrogel material. The material is prepared from 2, 3-diformylbenzoic acid modified gelatin, 3, 4-dihydroxyphenylethylamine, sodium hyaluronate, sodium tripolyphosphate, hydrogen peroxide, ascorbic acid and a phosphate buffer solution. Modified gelatin powder is obtained through a grafting reaction of 2, 3-diformylbenzoic acid and gelatin, then the modified gelatin powder, 3, 4-dihydroxyphenylethylamine and an auxiliary agent are prepared into a main gel solution, hydrogen peroxide and ascorbic acid are added before use, and the main gel solution is quickly crosslinked into gel under the body temperature condition. The obtained hydrogel can be stably combined with the tissue surface, the degradation process is matched with tissue repair, and the hydrogel has a free radical scavenging effect. Animal experiments show that the material can effectively reduce abnormal adhesion between postoperative tissues and has a good clinical application prospect.

The present invention relates to compounds according to formula (I), which are prodrugs of the psychoactive compound phenethylamine or its derivatives. The prodrugs provided herein exhibit improved pharmacokinetic properties during uptake as compared to phenethylamine (or the respective phenethylamine derivative), as well as reduced side effects resulting from the metabolites thus formed. Due to the affinity of the active phenethylamine compound, inter alia, for the 5-HT2a-receptor, these prodrugs are particularly advantageous for use in therapy, e.g., in the treatment of depression, posttraumatic stress disorder (PTSD), Alzheimer's disease or dementia.

The invention discloses a molecularly imprinted membrane of a new psychoactive substance and a preparation method and application of the molecularly imprinted membrane, the molecularly imprinted membrane comprises a membrane substrate and an adsorption material layer arranged on the membrane substrate, and the material of the adsorption material layer comprises 3, 3 ', 4', 4 '-tetramethyl-3, 3', 4 '-tetramethyl-3, 3'-tetramethyl-3, 3 '-tetramethyl-3, 3'- The molecularly imprinted polymer is prepared by using 2, 4-methylenedioxyphenylethylamine as an alternative template and using a bulk polymerization method. The novel molecularly imprinted membrane prepared by combining a molecularly imprinted technology and a separation technology is used as a membrane extraction material, and integrates the advantages of a membrane extraction technology and an imprinting technology, so that the problems that a membrane material is easy to pollute and low in selectivity are solved, and the novel molecularly imprinted membrane is suitable for being used as a membrane extraction material. The method shows the capability of accurately identifying a target analyte in the membrane separation process, has the advantages of high efficiency, stability, repeatability and the like, and provides a new technical means and potential application for identifying and detecting common forbidden drugs in a water body.

The present invention is directed to novel chemical compositions of matter, and in particular novel MDMA class of compounds having substituted methylenedioxyphenethylamine and substituted amphetamine, having a metabolically labile thioether group.

The invention relates to a body temperature-triggered adhesion degradable polyurethane patch as well as a preparation method and application thereof.The method comprises the steps that diisocyanate, semi-crystalline polyester diol, a carboxyl-containing chain extender and 3, 4, 5-trihydroxyphenylethylamine hydrochloride are taken as raw materials, and body temperature-triggered adhesion degradable polyurethane is synthesized through a condensation polymerization reaction; the degradable polyurethane is prepared into the degradable polyurethane adhesive patch capable of being triggered to be adhered by body temperature through a solution casting method. A polyester segment of the patch keeps high crystallinity at room temperature, a rigid physical cross-linked network is formed, molecular chain slippage and migration of catechol groups in 3, 4, 5-trihydroxyphenylethylamine hydrochloride are inhibited, and the patch does not show adhesion performance. At the body temperature, the crystalline region of the polyester segment is partially fused, the molecular chain segment obtains the movement ability to drive the suspended catechol group to migrate to the surface, the molecular thermal movement at the body temperature is intensified, the original hydrogen bond of the catechol is dissociated, and the catechol and the tissue surface form a hydrogen bond to realize adhesion. And stable and controllable degradation can be realized.

Disclosed herein are salts and solid forms of MDMA, (R)-MDMA, (S)-MDMA, MDE, S-MDE, R-MDE, MDAI, MBDB, S-MBDB, R-MBDB, MEAI, and 5,6-Dimethoxy-2-aminoindane, including salts, solid forms of the compound and salts thereof, as well as polymorphs of solid forms. The solid forms disclosed herein may have improved properties, such as improved physical, chemical, and / or pharmacokinetic properties. Also disclosed are methods for making the salts and solid forms and methods for administering the same. The disclosed salt and solid forms of MDMA, (R)-MDMA, (S)-MDMA, MDE, S-MDE, R-MDE, MDAI, MBDB, S-MBDB, R-MBDB, MEAI, and 5,6-Dimethoxy-2-aminoindane may be useful for treating neurological disease and / or a psychiatric disorder in a subject.

The invention discloses a growth method of an organic-inorganic hybrid two-dimensional phenylethylamine lead bromide perovskite single crystal, relates to a growth method of a phenylethylamine lead bromide perovskite single crystal, and aims to solve the technical problems of long growth period and small thickness of the existing two-dimensional phenylethylamine lead bromide single crystal. The method comprises the following steps: 1, obtaining seed crystals; 2, thermodynamically regulating and controlling the solution supersaturation degree by a constant-temperature water bath device; 3, seed crystal growth is dynamically regulated and controlled through a seed crystal rotating-gradient cooling method under the solution rotating condition, the phenylethylamine lead bromide perovskite single crystal is obtained, the length and width of the phenylethylamine lead bromide perovskite single crystal are larger than 2 cm, the thickness of the phenylethylamine lead bromide perovskite single crystal is larger than 2 mm, fast neutron detection and high-energy nuclear particle screening can be met, and the phenylethylamine lead bromide perovskite single crystal is applied to the field of nuclear radiation detectors.

The present invention aims to provide a carbon dioxide absorbent that can efficiently absorb, fix, and simply separate and recover carbon dioxide in the air. The present invention relates to an atmospheric carbon dioxide absorbent consisting of an amine selected from the group consisting of m-xylylene diamine, benzylamine, phenethylamine, p-methoxybenzylamine, and p-trifluoromethylbenzylamine, and water, and having the amine content of 1 to 50 wt % with respect to the total amount. The present invention also relates to a method for generating carbon dioxide which uses the aforementioned carbon dioxide absorbent and is simple and superior in energy efficiency.

The application relates to the technical field of compound preparation, and discloses a synthesis method of fosfomycin intermediate levofosfoxacin salt, which comprises the following steps: taking propynol as raw material, performing esterification reaction, adding Pt / C, Cu (II) EDTA and hydrogen into the obtained reaction solution to prepare a cis-propenyl dichloro oxygen phosphorus solution, adjusting the pH of the reaction solution by using ammonia gas after hydrolysis, and performing salt reaction and epoxidation by using R- (+) -alpha-phenylethylamine to obtain the product after post-treatment. The propynol is not hydrolyzed after esterification, so that the impurity propadienyl phosphate is reduced; the later hydrogenation can obtain higher-purity cis-propenyl phosphate; the step of hydrolysis after esterification is reduced, a large amount of water does not need to be distilled and concentrated, and energy consumption is reduced; the reaction temperature and hydrogen pressure in the hydrogenation step are both low, and the reaction safety is high; R- (+) -alpha-phenylethylamine is used in the epoxidation stage, so that the splitting operation is not needed, and the process is simplified; the solvents can be recycled and reused, and the method is environment-friendly.

The invention discloses a DL-phenylethylamine resolution process, which belongs to the technical field of chemical engineering, and comprises the following steps: S1, resolution: heating D-glutamic acid and DL-phenylethylamine in a mixed solvent of methanol and water to react, then cooling to crystallize, filtering and drying to obtain a composite salt, S2, D-glutamic acid recovery: dissolving the composite salt obtained in the step 1 in water, and recovering the DL-glutamic acid to obtain the DL-phenylethylamine. And S3, dissociation: regulating the pH value of the mother liquor after the D-glutamic acid is recovered in the step 2 to 12 by using alkali, standing for layering, taking an upper oil layer, and distilling to obtain the S (-)-alpha-phenylethylamine. According to the present invention, the S-(-)-alpha-phenylethylamine is successfully efficiently prepared by using the D-glutamic acid as the resolving agent, the product yield is 81.8%, the optical rotation is-38.2 degrees, the optical purity is excellent, the resolving agent recovery rate is as high as 88.1%, the expensive catalyst or the complex equipment is not required, and the industrial implementation is easy.

The invention discloses a preparation method of high-F-value protein oligopeptide, and belongs to the technical field of special food processing. Alkaline protease, PepS enzyme and malic acid acidolysis are adopted to construct a three-stage synergistic reaction system, and meanwhile, beta-cyclodextrin, phenylethylamine and chitosan are introduced as composite adsorbents to synergistically enhance the selective adsorption capacity to a target product, so that the loss of branched chain amino acid (BCAA) in the separation and purification process is effectively prevented. The prepared protein oligopeptide has excellent nutritional indexes, the Fisher ratio of the protein oligopeptide is greater than 36, and the protein oligopeptide shows good protein quality and bioavailability. Besides, the final product is uniform in particle size distribution, active ingredients are completely reserved, and freeze drying and sieving process treatment are combined, so that the physical stability and storage performance of the product are greatly improved, the damage of a high-temperature link to the active ingredients is effectively avoided, and the nutritional value and physiological function characteristics of the protein oligopeptide are completely reserved.

The application belongs to the field of organic chemistry and particularly relates to a synthesis method of berberine hydrochloride. The method comprises the following steps: taking 3,4-dimethoxyphenethylamine hydrochloride and 3,4-methylenedioxybenzaldehyde as starting materials, sequentially undergoing oxidative cyclization, selective reduction and quaternary ammonium ring closure through three-step reactions, and finally directly obtaining the target product berberine hydrochloride through acid treatment. The technical scheme has the characteristics of high efficiency, simplicity, and high industrial cost ratio in the synthesis of berberine hydrochloride, the overall reaction is more green and safe, the reaction condition is more mild, the reaction process has high selectivity, and the berberine hydrochloride product with higher purity can be obtained.

The utility model discloses a rectifying tower sampling device for phenylethylamine production, which belongs to the technical field of distillation devices and comprises a distillation unit, a heating unit and a condensing unit, the distillation unit comprises a distillation tower and a heater arranged right below the distillation tower, the heating unit comprises a vertically mounted support plate, and the condensing unit is arranged on the support plate. The heating mechanism is arranged on one side of the supporting plate, an air spraying pipe is fixedly installed at the end, close to the guide pipe, of the heating mechanism, the fixing plate is arranged at a bent connector of the guide pipe, a connecting hole is formed in the outer wall of the fixing plate, and a sealing block is fixedly installed at the end, close to the guide pipe, of the fixing plate; and the condensation unit comprises a support frame fixedly connected with the bottom of the support plate. The device disclosed by the utility model has the advantages that gas can be further vaporized to a greater extent to move, the gas is prevented from being condensed into beads in the guide pipe, the heated gas is further contacted with the condensation unit, and collection and distillation are facilitated to a greater extent.

The invention discloses a modified bismuth oxybromide composite photocatalyst as well as a preparation method and application thereof, and belongs to the technical field of photocatalytic organic synthesis. The preparation method comprises the following steps: mixing Bi (NO3) 3, KBr and Cu (NO3) 2, adding chlorophyll, and stirring to obtain the modified bismuth oxybromide composite photocatalyst. The Cu-doped chlorophyll co-regulated nano bismuth oxybromide photocatalyst is synthesized, the Cu-doped chlorophyll co-regulated nano bismuth oxybromide photocatalyst is used for photocatalysis of bimolecular oxidative coupling of benzylamine and methylamphetamine, bimolecular coupling of methylamphetamine and benzylamine is carried out under 10W visible light for the first time, the conversion rate can reach 99.5%, the product is alpha-methyl-N-(benzylidene) phenylethylamine, and the product has a wide application prospect. The method realizes detoxification treatment of methylamphetamine, realizes efficient and green synthesis of an imine compound under a noble metal-free condition, and can efficiently photocatalyze oxidative coupling of methylamphetamine and chemically degrade pollutants in water.

This invention discloses a strain of Maggi-Megaki yeast with amine-reducing and flavor-enhancing capabilities and its applications, belonging to the field of microbial fermentation technology. This invention screened a strain of Maggi-Megaki yeast Y21 from fermented soybean paste, which has the ability to degrade biogenic amines. This strain can completely degrade tryptamine, phenylethylamine, putrescine, cadaverine, spermidine, and spermine; simultaneously, it also has a strong degradation effect on histamine and tyramine, with degradation rates reaching 69.58% and 65.32%, respectively. Using the Maggi-Megaki yeast Y21 described in this invention for inoculation and fermentation can significantly reduce the content of various biogenic amines in fermented soybean paste under low-to-medium salt conditions, especially showing outstanding removal effects on histamine, tyramine, phenylethylamine, and polyamine biogenic amines, increasing the total amount of volatile flavor compounds, and is suitable for the safe production of low-salt fermented foods.

The application provides a kind of chiral P, N, N ligand and its preparation method and application in asymmetric hydrogenation reaction. 2-diphenylphosphinyl phenethylamine is mixed with 6-phenylpyridine-2-formaldehyde, nitrogen is filled, methanol is added, the formed mixture is refluxed, after cooling, NaBH4 is added. Then, the mixture is refluxed again. Cooling, water is added, dichloromethane is extracted, anhydrous sodium sulfate is dried, after removing solvent, the desired chiral P, N, N ligand is obtained by column chromatography. The catalyst formed by the chiral ligand described in the application and Mn, Ir-, Ru- and other metal precursors has excellent catalytic activity and stereoselectivity in the catalytic asymmetric hydrogenation reaction of C=C, C=N and C=O double bond. The enantioselectivity is as high as 99% ee, and the TON is as high as 100000.

The invention relates to a preparation method of chiral beta-substituted phenylethylamine and a derivative thereof, which comprises the following step: by taking aziridine as a raw material, nickel salt as a catalyst and a chiral ligand as a ligand and a metal reducing agent, carrying out asymmetric cross electrophilic coupling reaction to prepare the chiral beta-substituted phenylethylamine. The chiral beta-substituted phenylethylamine and the derivative thereof are obtained in one step by adopting a nickel-catalyzed asymmetric electrophilic cross-coupling method, and the method has the advantages of high step economy, high reaction efficiency, less pollutant emission and the like.

The utility model discloses a sealed sampling device for a phenylethylamine rectifying tower, which relates to the technical field of rectifying equipment and comprises a sampling tube and a sampling bottle, a bottle neck is arranged on the sampling bottle, a connecting cover is in threaded connection with the bottle neck, a threaded cylinder is fixedly arranged on the sampling tube, the connecting cover can be in threaded connection with the threaded cylinder, and a piston is slidably arranged in the sampling bottle. A connecting cover is arranged in the threaded cylinder, a through hole used for communicating the sampling tube with the sampling bottle is formed in the connecting cover, a plug capable of plugging the through hole is arranged in the connecting cover, and when the connecting cover is screwed into the threaded cylinder, the plug can move and open the through hole. Phenylethylamine is prevented from making contact with carbon dioxide in internal air when injected into the bottle body, and the connecting cover can be switched between the opening state and the closing state by matching the through hole in the connecting cover with the plug.

The application provides a MOF-polyimide composite fiber membrane and a preparation method and application thereof, and the preparation method comprises the following steps: mixing diamine, dianhydride, a solvent and an additive, and obtaining a polyamide acid mixed solution after reaction; wherein the additive at least comprises phenethylamine, pectin and citrate; an MOF solution is added into the polyamide acid mixed solution to obtain a mixed solution; and after the mixed solution is subjected to electrostatic spinning treatment and imidization treatment in sequence, a MOF-polyimide composite fiber membrane is obtained, and the MOF-polyimide composite fiber membrane with excellent gas separation performance can be efficiently and simply prepared.

This disclosure relates to phenethylamine compounds, and pharmaceutically acceptable salts, stereoisomers, tautomers, solvates, polymorphs, or prodrugs and pharmaceutical compositions thereof, and in some embodiments, to serotonin 5-HT2 receptor agonists and their use in the treatment of diseases related to the 5-HT2 receptor.

The application discloses a preparation method of an organic-inorganic hybrid perovskite quantum dot, and comprises the following steps: first, preparing a precursor solution I containing an A unit, wherein the A unit is selected from formamidinium, methylamine and phenethylamine; second, preparing a precursor solution II containing an X element, wherein the X element is selected from I, Br, Cl, SCN and CN; third, adding a compound containing a B metal element into the precursor solution I for mixing, wherein the B metal element is selected from lead, tin, manganese, indium and bismuth; and fourth, adding the precursor solution II for reaction. According to the application, a diffusion-controlled reaction system is constructed by selecting a metal cation source with low solubility in the reaction system, so that the reaction kinetics is significantly slowed down, the reaction window is prolonged, the reaction is kept in a size focusing stage, the problem that nucleation and growth are too fast to be controlled due to the ion characteristics of the perovskite quantum dot is effectively solved, and the organic-inorganic hybrid perovskite quantum dot with high single size dispersity and a near-hundred fluorescence quantum yield can be prepared in batches.

The application discloses a synthesis method of 4-(aminoalkyl) benzene sulfonic acid compound and relates to the technical field of organic synthesis. Benzylamine or phenethylamine is dissolved in a halogenated hydrocarbon solvent, the temperature is lowered to 0-5 DEG C, chlorosulfonic acid is added dropwise for sulfonation reaction, after dropwise addition is completed, the temperature is raised to 40-65 DEG C for reaction until the raw material is completely reacted, the temperature is lowered to 0-5 DEG C, then C1-C4 alcohol solvent containing trace moisture is added into the reaction system as a quenching agent for quenching, after quenching, the halogenated hydrocarbon solvent is recovered by distillation, the remaining substance is cooled, crystallized, filtered and dried, and 4-(aminoalkyl) benzene sulfonic acid is obtained. In the application, n-butanol containing trace moisture (0.5-8%) is used as a quenching agent, the reaction of chlorosulfonic acid and water is diluted and buffered by alcohol, the heat release is gentle, there is no risk of material shock, and the operation safety is far superior to traditional ice water quenching.

The application discloses a kind of high dispersion stability ultra-low structure carbon black material and its application.The material is prepared by the reaction of 3,4-dihydroxyphenethylamine, carbonyl coupling agent, N,N-dimethyl-1,3-propanediamine and 1,3-propane sulfolane to obtain a reactive low-melting micro-phase auxiliary agent, which is then dispersed in ethylene tar after compounding with urea and choline acetate, and is prepared by incomplete combustion, quenching, elution and homologous stabilization treatment. The application utilizes the micro-phase isolation effect of the composite micro-phase auxiliary agent during the formation of carbon black, reducing the branching degree of carbon black aggregates; and through post-treatment, a stable layer containing catechol / quinoxaline anchoring structure and sulfobetaine hydration structure is formed, improving the water-based dispersion stability of carbon black. The obtained carbon black material has the advantages of low structure, low metal residue, narrow particle size distribution and good anti-settling property, and can be used in water-based paint, water-based ink, water-based conductive paste and water-based polymer composite.

The invention belongs to the technical field of medicinal chemistry. The invention relates to a quinazoline compound, in particular to a hydroxyphenylethylamine quinazoline compound as well as a preparation method and application thereof. The hydroxyphenylethylamine quinazoline compound has excellent anti-tumor cell proliferation activity on cancers such as colonic adenocarcinoma and the like, has lower cytotoxicity, and has a wide prospect in the application of preparing anti-tumor drugs.

The present disclosure relates to compounds of Formula I that exhibit 5-HT2A receptor agonist activity and low 5HT2B receptor agonist activity or deemed 5HT2B receptor agonist inactivity. In at least some cases, such compounds show selectivity for the 5-HT2A receptor over the 5-HT2C receptor. As contemplated herein, phenethylamines may be used for the treatment of neuropsychiatric, neurodegenerative, neuroinflammatory and pain disorders including depression, drug (e.g. tobacco, opiate, and cocaine) addiction, alcoholism, post-traumatic stress disorder (PTSD), and neuropathic pain syndromes including cluster headaches and chemotherapy induced peripheral neuropathy.

The invention discloses a chemical enzyme synthesis method of chiral aporphine alkaloids, and relates to the field of biochemistry, the method comprises the following steps: taking a phenylethylamine compound and a phenylacetic acid compound as initial raw materials, and carrying out amide condensation and dehydration cyclization to form a compound IV; then reducing through imine reductase or an imine reductase mutant to form a V-type compound; then, a compound VI is formed through a methylation reaction of methyltransferase or Eschweiler-Clarke or methyl iodide, and the compound VI is formed through a methylation reaction of methyltransferase or Eschweiler-Clarke or methyl iodide; and finally, carrying out photocatalytic coupling to obtain the aporphine alkaloid. According to the preparation method disclosed by the invention, purification is not needed in the preparation reaction process from the IV-type compound to the VI-type compound, and the compound can be directly used for the last step of photocatalytic coupling; the optically pure (S)-VII aporphine alkaloid can be obtained; the method is mild in reaction condition, green, environment-friendly, simple in process, low in cost, capable of reaching gram-level scale and suitable for industrial production.

The invention relates to the technical field of chemical synthesis, in particular to a preparation method of N-(4-hydroxyphenethyl) tetracosanamide. The method comprises the following steps: carrying out condensation reaction on tetracosanic acid and p-hydroxyphenylethylamine under the action of an onium salt condensing agent to obtain a product, and purifying the product to obtain N-(4-hydroxyphenethyl) tetracosanamide; the temperature of the condensation reaction is 40-50 DEG C. The method has the advantages of mild reaction conditions, high selectivity and few byproducts; the product is high in yield and high in purity, and can meet the large-scale requirements in the fields of medicines, materials and the like; the melting purification is realized by utilizing the melting point difference between the target product and impurities, multiple column chromatography or recrystallization is omitted, and the process route is short; the method has the advantages of safety, economy and easiness in expanded production, and provides powerful support for industrial development of N-(4-hydroxyphenethyl) tetracosanamide.

The invention discloses multi-element modified epoxy resin for an MARK III type LNG ship containment system and a preparation method thereof. The multi-element modified epoxy resin comprises a component A. The component A comprises modified epoxy resin, a thixotropic synergist, a silane coupling agent, gas silicon, a dispersing agent, color paste and heavy calcium carbonate. The modified epoxy resin comprises a PU (polyurethane) prepolymer, 3, 4-dihydroxyphenylethylamine, N, N-dimethylformamide and E51 epoxy resin; the PU prepolymer is prepared from diphenylmethane diisocyanate and polytetrahydrofuran glycol through catalysis of dibutyltin dilaurate. Through combination of the PU prepolymer and the DOPA, the contradiction that high toughness and high bonding strength of traditional epoxy resin cannot be achieved at the same time is broken through, the toughness is improved, meanwhile, the mechanical strength of the material is guaranteed, and a final product has the comprehensive advantages of being low in shrinkage, high in strength, resistant to working conditions and the like and can be stably applied to a force bearing structure of an MARK III type LNG ship containment system; and safe operation of the system is ensured.