Method for preparing DL-threonine chelated copper serving as feed additive

A feed additive and chelated copper technology, which is applied in the field of preparation of feed additive DL-threonine chelated copper, can solve the problems of uncomfortable reaction route, low equipment investment and high production cost, and achieves high biological titer and equipment. The effect of low investment and short response route

Inactive Publication Date: 2010-09-22
INST OF SUBTROPICAL AGRI CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this method can obtain the threonine copper product of certain performance, yet this method has used expensive threonine and copper sulfate (price is higher than copper carbonate 2-3 time

Method used

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  • Method for preparing DL-threonine chelated copper serving as feed additive

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] a. Preparation of glycine chelated copper

[0036]Take 100 grams of glycine, add 0.7 liters of water, heat and dissolve at 60°C, add 80 grams of basic copper carbonate, keep warm at 60°C for 1 hour, filter while hot to remove unreacted basic copper carbonate, and the filtrate crystallizes at 0°C, filter Dry at 60°C to obtain 119.2 g of glycine chelated copper.

[0037] b. Preparation of DL-threonine chelated copper

[0038] Take the glycine chelated copper obtained in step a, add 500 ml of methanol, stir to dissolve, cool to 5° C., add 200 ml of acetaldehyde, add 180 ml of 5% sodium hydroxide methanol solution, and keep the reaction at 60° C. for 1 hour. Filter while hot to remove insoluble matter, add 15 ml of glacial acetic acid to the filtrate, cool overnight, filter, and dry at 60°C to obtain 163.4 g of DL-threonine chelated copper, with a yield of 82%.

Embodiment 2

[0040] a. Preparation of glycine chelated copper

[0041] Take 110 grams of glycine, add 0.8 liters of water, heat and dissolve at 65°C, add 90 grams of basic copper carbonate, keep warm at 65°C for 1.5 hours, filter while hot to remove unreacted basic copper carbonate, the filtrate crystallizes at 1°C, filter , and dried at 60° C. to obtain 127.2 grams of glycine chelated copper.

[0042] b. Preparation of DL-threonine chelated copper

[0043] Glycine chelated copper obtained in step a, add 550 ml of methanol, stir to dissolve, cool to 6°C, add 240 ml of acetaldehyde, add 200 ml of 5% sodium hydroxide methanol solution, and heat at 70°C for 1 hour. Filter while hot to remove insoluble matter, add 20 ml of glacial acetic acid to the filtrate, cool overnight, filter, and dry at 60°C to obtain 177.5 g of DL-threonine chelated copper, with a yield of 81%.

Embodiment 3

[0045] a. Preparation of glycine chelated copper

[0046] Take 120 grams of glycine, add 0.85 liters of water, heat and dissolve at 70°C, add 100 grams of basic copper carbonate, keep warm at 70°C for 2 hours, filter while hot to remove unreacted basic copper carbonate, and the filtrate crystallizes at 2°C, filter Dry at 70°C to obtain 144.8 grams of glycine chelated copper.

[0047] b. Preparation of DL-threonine chelated copper

[0048] The glycine chelated copper obtained in step a was added with 700 ml of methanol, stirred and dissolved, cooled to 7° C., 260 ml of acetaldehyde was added, and 220 ml of 5% sodium hydroxide methanol solution was added, and the reaction was kept at 75° C. for 1 hour. Filter while hot to remove insoluble matter, add 25 ml of glacial acetic acid to the filtrate, cool overnight, filter, and dry at 65°C to obtain 191.3 grams of DL-threonine chelated copper, with a yield of 80%

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Abstract

The invention discloses a method for preparing DL-threonine chelated copper serving as a feed additive. The invention adopts a technical scheme of taking aminoacetic acid as raw material, allowing aminoacetic acid to react with basic copper carbonate to form glycine chelated copper and allowing glycine chelated copper to react with acetaldehyde to form DL-threonine chelated copper. Compared with the conventional method for preparing threonine chelated copper, the method of the invention has the following outstanding advantages that: 1) as threonine and threonine chelated copper are prepared from aminoacetic acid, the method is readily available in raw material, needs no threonine and is low in cost; 2) as the feed additive amino-acid chelated copper does not need separation, and DL-threonine copper is directly utilized, so over 50 percent of cost is reduced; and 3) the preparation of the DL-threonine chelated copper is performed at normal temperature under normal pressure and is short in reaction route, little in equipment investment and convenient for industrial production.

Description

technical field [0001] The invention relates to an amino acid and a method for preparing amino acid chelated copper, in particular to a preparation method for a feed additive DL-threonine chelated copper. Background technique [0002] Threonine is an essential amino acid, mainly used in medicine, chemical reagents, food fortifiers, feed additives, etc. In particular, the amount of feed additives is increasing rapidly. It is often added to the feed of immature piglets and poultry. It is the second limiting amino acid in pig feed and the third limiting amino acid in poultry feed. Threonine is the fourth essential amino acid additive for poultry feed after methionine, lysine and tryptophan. It can obviously promote the growth and development of poultry and livestock, strengthen fattening, milking and egg production. The lack of threonine can lead to reduced animal feed intake, reduced feed utilization, growth retardation, immune function suppression and other symptoms. Adding...

Claims

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Application Information

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IPC IPC(8): C07C229/76C07C229/22C07C227/16A23K1/16
Inventor 印遇龙吴信
Owner INST OF SUBTROPICAL AGRI CHINESE ACAD OF SCI
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