The invention relates to a preparation method of 3-(2-methylindolyl-3-)pyrryl-2,5-dione, which comprises the following steps: (1) adding 2-methylindole, maleimide and Lewis acid in a mol ratio of 1.0:(1.0-1.5):(0.2-1.0) into reaction solvent, and reacting under reflux at room temperature to 100 DEG C for 5-24 hours, thereby obtaining a yellow white solution; and (2) evaporating to remove the solvent, adding water, stirring, carrying out vacuum filtration, and recrystallizing the obtained solid with ethanol to obtain the 3-(2-methylindolyl-3-)pyrryl-2,5-dione. In the process of preparing the 3-(2-methylindolyl-3-)pyrryl-2,5-dione, by using boron trifluoride and other Lewis acid as a catalyst, the reaction time is shortened, and the treatment of three wastes is lowered. The method has the advantages of higher yield, accessible raw materials, low cost, simple reaction operation and short reaction route, can easily implement industrial production, and has wide favorable application prospects.