Preparation method and detection method for edaravone dimer and tautomer thereof

Abstract

The invention belongs to the pharmaceutical field, and specifically relates to a preparation method and a detection method for edaravone dimers and tautomers thereof. The preparation method is characterized in that edaravone is dissolved in a solvent; a catalyst is added; the mixture is heated and filtered to obtain an insoluble substance; the substance is washed and dried to obtain a product. The detection method adopts a high performance liquid chromatography method. The preparation method of the invention has convenient operation and easily available initial raw materials, and the detection method is applicable to the detection of edaravone dimers in edaravone raw materials and preparation samples.

Description

technical field

[0001] The present invention relates to an Edaravone dimer 3,3'-dimethyl-1,1'-diphenyl-1H,1'H-[4,4'-dipyrazole]-5,5 'Diol or its tautomer 3,3'-dimethyl-1,1'-diphenyl-1H,1'H-[4,4'-dipyrazole]-5,5'( Preparation method of 4H, 4'H)-diketone, and detection method thereof. Background technique

[0002] Edaravone is developed by Japan's Mitsubishi Tokyo Pharmaceutical Co., Ltd., a kind of brain protectant (free radical scavenger) listed in Japan in June 2001. Its indication is acute cerebral infarction, and it is mainly used to improve acute cerebral infarction. Neurological symptoms, activities of daily living and functional impairment.

[0003] Clinical studies of edaravone suggest that N-acetylaspartic acid (NAA) is a marker of specific surviving nerve cells, and its content decreases sharply in the early stage of cerebral infarction. The administration of edaravone to patients in the acute stage of cerebral infarction can inhibit the reduction of local cerebr...

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