8 results about "Amantadine" patented technology

The utility model discloses an amantadine amination process reaction device, which belongs to the technical field of reaction equipment, and comprises a reaction kettle for amantadine amination reaction, the top end of a base is fixedly connected with a mounting frame, and the inner side of the mounting frame is rotatably connected with two driving shafts connected with the reaction kettle; the side surface of the mounting frame is provided with a fixed end of a stepping motor, the driving end of the stepping motor and the periphery of the driving shaft are both provided with gears, the two gears are in meshed connection, the side surface of the reaction kettle is provided with a heating assembly, and the side surface of the mounting frame is provided with a fixed end of a second hydraulic rod; and the driving end of the second hydraulic rod penetrates through the mounting frame and is fixedly connected with a limiting plate, the side face of the limiting plate is provided with the fixed end of a servo motor, and the driving end of the servo motor is fixedly connected with an L-shaped linkage plate. According to the amantadine amination process reaction device, the reaction kettle can be automatically cleaned, so that the cleaning operation of the device is more time-saving and labor-saving.

New use of 1-amino-3,5-dimethyladamantane hydrochloride in treating or preventing cognitive impairment, reducing microglia in the cortex and hippocampus, reducing neuron loss in the cortex and hippocampus, and ameliorating the mitochondrial dysfunction state. The cognitive impairment includes cognitive impairment in systemic lupus erythematosus, Parkinson's disease, lateral sclerosis, stroke, multiple sclerosis, rheumatoid arthritis, inflammatory bowel disease, attention deficit hyperactivity disorder, sepsis-related encephalopathy, or mild cognitive disorder. The present application also provides a corresponding drug and a treatment or prevention method.

Opiperidone for use as an adjuvant therapy of levodopa and a DOPA decarboxylase inhibitor (DDCI) formulation in the treatment of Parkinson's disease; the method is characterized in that a patient suffering from Parkinson's disease can be treated with levodopa and DDCI preparations without clinically diagnosed motor complications.

The invention belongs to the technical field of biomedical materials and biomedical engineering, and discloses self-repairing peach gum hydrogel based on reversible subject-object and boric acid ester bonds, a preparation method and application. The preparation method comprises the following steps: modifying boric acid and amantadine on purified peach gum to obtain boric acid-amantadine peach gum; modifying chitosan with carboxymethyl cyclodextrin to obtain beta cyclodextrin-chitosan; boric acid-amantadine peach gum and beta cyclodextrin-chitosan are mixed, and the self-repairing peach gum hydrogel is obtained through the mutual synergistic effect of a subject, a guest and boric acid ester. The hydrogel has multiple functions of excellent biocompatibility, self-repairing, hemostasis, antibiosis and the like, and can be applied to body surface skin wound repairing.

The invention belongs to the technical field of medicines, and relates to a benzyl alcohol derivative with anti-influenza virus and anti-inflammatory activity. According to the invention, on the basis of 2, 5-dihydroxybenzyl alcohol, 14 benzyl alcohol derivatives are synthesized by combining 2, 5-dihydroxybenzyl alcohol with cysteine, amantadine or sesquiterpene. All the derivatives show excellent anti-influenza virus activity and also have a relatively good anti-inflammatory effect at the same time. The compounds can inhibit virus replication by acting with influenza virus hemagglutinase or M2 ion channels, can also reduce excessive inflammatory response by activating a host Nrf2 / HO-1 signal axis, can inhibit virus replication driven by NF-kappa B, can reduce over-high expression of inflammatory factors such as host cells IL-6, IL-1beta and TNF-alpha, and can reduce inflammatory factor storm. The action mechanism not only reduces the generation of drug resistance, but also reduces pathological effects caused by oxidative damage and inflammatory factor storm, and lays a foundation for developing novel anti-influenza virus drugs.

The invention relates to the field of food detection, in particular to an analysis and detection method for antiviral drug residues in eggs, which comprises the following steps: S1, sample pretreatment: 1.1, sample preparation: shelling eggs, homogenizing, and storing at 4 DEG C; 1.2, extracting: weighing a homogenate sample, extracting twice by using 90% acetonitrile-1% formic acid solution, and merging supernate; 1.3, purifying and redissolving: purifying the supernate through an EMR-Lipid solid-phase extraction column, collecting eluent, blowing the eluent to be nearly dry at 40 DEG C by nitrogen, redissolving by using a formic acid-methanol solution, and filtering to obtain a matrix extracting solution; s2, preparing a standard solution; s3, instrument detection: performing chromatography-tandem mass spectrometry detection; s4, quantitative analysis: calculating the residual quantity of the eight antiviral drugs in the eggs according to the quantitative ion peak area by adopting a matrix matching standard curve external standard method. The precise detection of eight viruses, namely nevirapine, peramivir, famciclovir, rimantadine, amantadine, oseltamivir, imiquimod and memantine, is realized.

The utility model discloses an amantadine amination wastewater treatment system, which belongs to the field of wastewater treatment, and comprises a filter, a bipolar membrane electrodialyzer and a distiller, the two compartment structures are that first bipolar membranes and first anion exchange membranes are alternately arranged to form a first receiving chamber and a stock solution chamber, cation exchange layers of the first bipolar membranes face the first receiving chamber, a water outlet of the filter is communicated with a water inlet of the stock solution chamber, and a water outlet of the stock solution chamber is communicated with a water inlet of the distiller. According to the amantadine amination wastewater recycling device, the recycling treatment of the amantadine amination wastewater is realized, bromide ions and ammonia ions in the amantadine amination wastewater can be recycled, ammonia water and hydrogen bromide recycling liquid are obtained, the problem of adjusting the pH value of the wastewater is not needed, the consumption of water resources and time cost is reduced, the acid production efficiency is improved, and the economic benefit is increased.