101 results about "Quinoxaline" patented technology

The application belongs to the field of compound synthesis and particularly relates to a photocatalytic preparation method of quinoxaline-2,3-dione compounds, which comprises the following steps: preparing a raw material solution containing quinoxaline-2-ketone, mercaptan, a photocatalyst and acetonitrile, and performing a photocatalytic reaction under light to obtain a quinoxaline-2,3-dione compound product; the mercaptan is C1-C4 alkyl mercaptan, and the -SH is connected to a primary carbon or a secondary carbon. The application adopts a photocatalytic method to perform hydroxylation on the C3 position of quinoxaline-2-ketone, and further controls the combination of the mercaptan and acetonitrile solvent to improve the photocatalytic reaction effect of C3 hydroxylation.

The application discloses a preparation method of a diphenylmethyl quinoxaline ketone derivative, and belongs to the technical field of biological medicines. The structure of the diphenylmethyl quinoxaline ketone derivative is shown in the specification. The application adopts a cross dehydrogenative coupling strategy, realizes quinoxaline ketone 3-alkylation through direct activation of an alkane and accompanying hydrogen atom transfer, and has the advantages of mild reaction conditions, cheap and easily available reagents, and higher efficiency and environmental friendliness. The diphenylmethyl quinoxaline ketone derivative has high-efficiency and broad-spectrum antifungal activity, shows inhibitory effects on a plurality of common plant pathogenic fungi, and can be developed into a product for treating plant fungal infections.

The invention belongs to the technical field of organic solar cell materials, and relates to a benzodithiophene polymer donor with a simple and stable structure and a preparation method and application thereof. The invention discloses a benzodithiophene polymer donor PBTQ-X (F / Cl / 2F) with a simple and stable structure, and discloses a preparation method of the benzodithiophene polymer donor PBTQ-X (F / Cl / 2F), and the preparation method comprises the following steps: under the action of a Stille coupling catalyst, carrying out two-stage polymerization on benzodithiophene containing bis (trimethyltin) and a quinoxaline derivative containing a dibromothiophene pi bridge, carrying out two-stage heating reflux reaction, and carrying out post-treatment to obtain the benzodithiophene polymer donor PBTQ-X (F / Cl / 2F). Adding an end-capping reagent for end capping; and finally, settling after passing through methanol, thereby obtaining the product. The benzodithiophene polymer donor with a simple and stable structure can be applied to an active layer of an organic solar cell device, and shows relatively good photovoltaic performance and long-term stability.

This invention discloses a polysubstituted indole[1,2-a]quinoxaline compound, its preparation method, and its applications. The structural formula of the polysubstituted indole[1,2-a]quinoxaline compound of this invention is or , where R 1 Selected from -H or -F, R 2 The compounds are selected from phenyl, 4-methylphenyl, 4-methoxyphenyl, or 4-fluorophenyl. The polysubstituted indole[1,2-a]quinoxaline compounds of this invention have novel structures and significant antitumor activity, making them suitable for the synthesis of anticancer drugs. Furthermore, their preparation methods offer advantages such as readily available and inexpensive catalysts, broad substrate applicability, good functional group tolerance, simple operation, mild reaction conditions, and high step economy, making them suitable for large-scale industrial production and application.

The invention discloses a near-infrared two-region aggregation-induced emission I-type photosensitizer as well as preparation and application thereof. The chemical structural general formula of the near-infrared two-region aggregation-induced emission I-type photosensitizer is shown in the specification, wherein X is independently selected from one of O, S and Se, R1 is independently selected from one of straight-chain alkyl groups with the carbon atom number of 1-20, R2 is independently selected from one of-F,-CN,-CF3,-OCH3,-C4H9 and-CH3, and R3 is independently selected from one of-H,-Br,-I and-TPA. A D-pi-A-pi-D type near-infrared two-region aggregation-induced emission I type photosensitizer is designed and synthesized, and 4, 4 '-dimethoxydiphenylamine is used as a distortion donor unit, ortho-substituted hexylthiophene is used as a pi-bridge, and acenaphthene alkene thiadiazolo quinoxaline and other derivatives are used as central acceptor units. The near-infrared two-region aggregation-induced emission type I photosensitizer has good fluorescence and active oxygen generation and photothermal conversion capabilities, and can be used for cancer multi-mode diagnosis and treatment integrated research.

A combination for use in treating cancer is provided. The combination comprises a therapeutically effective amount of an inhibitor of nuclear import protein Karyopherin Beta 1 (Kpnβ1) such as the substituted pyrrolo[2,3-b]quinoxalines of Formula I and a therapeutically effective amount of an inhibitor of nuclear export protein Chromosome Maintenance 1 (Crm1) such as the hydrazide- containing compounds of Formula II. The combination therapy provides an enhanced anti-cancer therapeutic effect compared to the effect of each of the nuclear transport inhibitors administered alone.

The invention belongs to the technical field of medicinal chemistry, and particularly relates to a quinoxaline compound as well as a preparation method and application thereof. Specifically, the quinoxaline compound provided by the invention is screened by adopting virtual screening and pharmacophore modes, is novel in structure, has relatively good inhibitory activity on MELK, and solves the problem of insufficient development of an existing MELK inhibitor that the activity is not ideal enough, the chemical structure is not diversified enough and the like.

This invention provides a method for preparing 4,1-disubstituted pyrrolo[1,2-a]quinoxaline-1-yl ketone derivatives, belonging to the field of organic synthesis technology. This invention uses 2-(1H-pyrrolo-1-yl)aniline compounds and α-carbonyl acids as reactants, employing only ammonium persulfate as an oxidant. Under metal-free catalysis, a one-pot tandem reaction is carried out to simultaneously complete the cyclization of the pyrrolo[1,2-a]quinoxaline nucleus and the C-1 acylation modification. The substituents at the 4- and 1-positions of the product can be flexibly controlled by changing the α-carbonyl acid with different structures. This method requires no pre-modified substrate, eliminates the need for metal catalysts, avoids the risk of metal residue, and features simplified steps and high functional group compatibility, providing a new green and low-cost route for the synthesis of polysubstituted pyrrolo[1,2-a]quinoxaline ketone derivatives.

The application discloses a synthesis method of C3-substituted quinoxaline ketone derivatives and application thereof. A series of C3-substituted quinoxaline ketone derivatives with both terpene and quinoxaline ketone biological activity skeletons are obtained by using N-alkoxy phthalimide and quinoxaline ketone as starting substrates, under the catalysis of a photocatalyst and visible light irradiation, and at a temperature of 55-65 DEG C for 10-15 h. The application has the advantages of stable and easy-to-prepare raw materials, mild reaction conditions, simple experimental operation, good chemical selectivity and functional group tolerance, and is a green chemical synthesis method with good application prospect. The activity experiment results show that the synthesized C3-substituted quinoxaline ketone derivatives have good inhibiting effect on the growth of plant pathogenic fungi.

The present invention addresses the problem of providing a light-emitting element having excellent luminous efficiency and a highly durable lifespan.　This compound is represented by general formula (1). (In general formula (1), L is a substituted or unsubstituted arylene group or a substituted or unsubstituted heteroarylene group. However, when these groups are substituted, the substituent groups are alkyl groups or alkoxy groups. n is an integer of 2-5. In addition, at least one of the n Ls has a structure represented by general formula (2). A is a substituted or unsubstituted pyrimidyl group, a substituted or unsubstituted triazinyl group, a substituted or unsubstituted quinoxalinyl group, or a substituted or unsubstituted quinazolinyl group. However, when these groups have substituents, the substituents do not form a ring structure. B is a hydrogen atom, a substituted or unsubstituted aryl group, or a substituted or unsubstituted heteroaryl group.) (In general formula (2), R1-R4 are each independently a hydrogen atom, an alkyl or an alkoxy group, and R1-R4 do not bond to each other to form a ring. * represents a bonding position with an adjacent substituent.)

The invention relates to quinoxaline derivatives as anti-cancer drugs. Specifically, the invention relates to azaquinolone compounds of formula (I) and their use in medicine.

The invention relates to a quinoxaline derivative containing trimethyl and n-propyl as well as a preparation method and application of the quinoxaline derivative, and the derivative is 1, 6, 7-trimethyl-3-propyl quinoxaline-2 (1H)-ketone and is particularly suitable for inhibiting fusarium oxysporum. The derivative is prepared by an organic synthesis method which comprises the step of carrying out cyclization reaction on N-protected o-phenylenediamine and a carbonyl compound in the presence of trifluoroacetic acid. Experiments show that the compound has a remarkable antibacterial effect on fusarium oxysporum, and the minimum inhibitory concentration is 0.50 mg / mL. The derivatives can destroy the cell membrane structure of fusarium oxysporum and cause leakage of RNA, protein and reducing sugar in cells, so that the growth of thalli is inhibited. The invention provides a theoretical basis and an experimental basis for developing a novel efficient and low-toxicity bacteriostatic agent.

The present application provides an organic material composition and its application, the organic material composition includes the fused heterocyclic compound containing quinoline structure and hole transport type compound, the fused heterocyclic compound containing quinoline structure has the structure as shown in formula (1), the hole transport type compound has the structure as shown in formula (2).The composition of the present application makes the organic electroluminescent device have lower driving voltage (3.85 V or less), higher current efficiency (25 Cd / A or more) and longer life (267 h or more).

The application discloses a compound shown in formula I. The compound shown in formula I is a 3,5-dimethoxyaniline FGFR2 macrocycle inhibitor. The compound of the application can effectively inhibit the growth of various tumor cells and has FGFR2 inhibiting effect, and thus can be used for preparing an antitumor drug. The application further relates to the compound shown in formula I, a pharmaceutical composition containing the compound shown in formula I and the use of the compound in treating FGFR2-mediated related diseases and preparing a drug for treating FGFR2-mediated related diseases.

The patent application discloses an orange-red light thermal activation delayed fluorescence material and a preparation method and application thereof, and relates to the field of organic luminescent materials. The thermal activation delayed fluorescence orange-red light material is composed of an electron acceptor fragment and two same electron donor fragments (triphenylamine), the electron acceptor fragment is quinoxaline-6,7-dicyanide, and the electron donor fragment is triphenylamine. The material has the thermal activation delayed fluorescence characteristic, and the maximum external quantum efficiency of the prepared device is 23.2%.

The invention relates to quinoxaline derivatives as anti-cancer drugs. Specifically, the invention relates to azaquinolone compounds of formula (I) and their use in medicine.

To provide a new compound useful for treatment, prevention and / or diagnosis of seizure or the like in diseases accompanied by epileptic seizure or convulsive seizure (including multidrug-resistant seizure, intractable seizure, acute symptomatic seizure, febrile seizure and status epilepticus).SOLUTION: There are provided a compound represented by formula [I] and a salt thereof. Ring C is selected from pyridazine, pyrimidine, indole, pyrrolopyridine, indazole, pyrazolopyridine, imidazopyridine, imidazopyrazine, imidazopyridazine, triazolopyridine, pyrazolopyrimidine, imidazopyrimidine, triazolopyrimidine, isoquinoline, naphthyridine, quinazoline, quinoxaline, benzodioxole, oxazine, oxazepine, benzothiazole, and triazolopyridazine, with the proviso that pyrimidine-2, 4-dione and dihydropyrimidine-2, 4-dione are excluded.SELECTED DRAWING: None

This invention discloses a method for synthesizing chiral quinoxalones. Using a copper salt, a chiral ligand, and a base as a catalytic system, the target chiral quinoxalone compound is obtained by reaction in an organic solvent. This invention utilizes an economical and readily available copper catalyst, constructing C-N bonds through propargyl substitution and aminolysis of the ester group to synthesize chiral quinoxalones. This method has advantages such as good substrate universality, high yield, good enantioselectivity, and ease of industrial production. The synthesis method of this invention does not require the use of special and expensive catalysts, and the reaction conditions are simple, requiring no special reaction environment such as high-pressure hydrogen, with low requirements for reaction equipment, making it easy to scale up for industrial production.

The invention relates to a heterogeneous asymmetric synthesis method of a chiral benzoaromatic heterocyclic compound, which comprises the following steps: under the catalysis of a heterogeneous catalyst SL-n or SL / M-n, dissolving a reaction substrate in a solvent for reaction to obtain a target product, the invention develops the heterogeneous asymmetric synthesis method of the chiral benzo aromatic heterocyclic compound, the target product can be obtained only by simple distillation after the reaction is completed by using the heterogeneous catalyst, the product separation process is greatly simplified, the ICP-OES result shows that the catalyst is not subjected to metal leaching in the reaction process, and the method is suitable for industrial production. Good stability is shown. The method shows good selectivity and catalytic activity on asymmetric hydrogenation of a series of benzoxazinone and quinoxalinone compounds, and has great industrial application potential.

The application discloses a kind of heat-insulating fireproof materials and preparation method thereof, from top to bottom sequentially include first encapsulation layer, first fireproof support layer, first viscose layer, heat-insulating layer, second viscose layer, second fireproof support layer and second encapsulation layer;The first viscose layer, second viscose layer are independently made of the following raw materials respectively: amino-terminated hyperbranched polyimide, acrylic modified poly (ether ether ketone), 1,3-bis (oxymethylene methyl) -5- (2-propenyl) -1,3,5-triazine-2,4,6 (1H,3H,5H) -trione, 1,1,3,3-tetramethyl-1,3-divinyl disilazane, 3- (1,1-difluoro-2-propylene-1-yl) -2 (1H) -quinoxaline ketone, 2- (1-propylene-2-yl) benzo [d] oxazole, terpene resin, initiator, solvent.The material heat-insulating fireproof effect is remarkable, and mechanical mechanical property and high temperature resistance are sufficient.

The application discloses a kind of dihydroquinoxaline selective bromine domain recognition protein inhibitor and its preparation method and purposes. According to the application, the compound represented by the following general formula (I), its stereoisomer, prodrug, functional molecule of PROTAC technology, pharmaceutically acceptable salt or solvate is provided, and the substituent group is defined as described in the specification. According to the dihydroquinoxaline compound of the application, as BET inhibitor, relative to prior art, the selectivity of kinase is higher, can be used for the treatment of polycystic kidney, cancer and BET expression abnormality related disease, and has good safety.

The application discloses a preparation method and application of a photocatalytic synthesis of nitrogen heteroaromatic compound, and the nitrogen heteroaromatic compound is obtained by mixing isonitrile compound, alkyl boronic acid reagent, photosensitizer, alkali reagent and solvent and then performing a reaction under irradiation of visible light. The synthesis method has the advantages of easy availability of raw materials, simple operation, mild reaction and wide applicability of substrates, and the obtained indole / pyrrolo[1,2-a]quinoxaline compound has fluorescence performance.

The present application relates to the field of organic synthesis, specifically a method for synthesizing C3 fluorine alkyl substituted quinoxaline ketone derivatives from olefin derivatives and quinoxaline ketone derivatives under photocatalysis by using [bis(fluoroalkyl acetoxy)iodo] benzene as different fluorine alkyl sources. [Bis(fluoroalkyl acetoxy)iodo] benzene is used as a fluorine alkylating agent to generate fluorine alkyl radicals under photocatalysis, then the radicals add to olefin derivatives to obtain alkyl radicals, the alkyl radicals then add to quinoxaline ketone, and finally, after oxidation and deprotonation, C3 fluorine alkyl substituted quinoxaline ketone derivatives are obtained. The present application uses simple and stable [bis(fluoroalkyl acetoxy)iodo] benzene as a fluorine alkyl source to prepare C3 different fluorine alkyl substituted quinoxaline ketone derivatives from quinoxaline ketone and olefin derivatives in a three-component reaction without the action of photocatalysts. The synthesis method is simple and easy to operate, and different fluorine alkyl group substituted quinoxaline ketone derivatives can be quickly obtained.

This invention discloses a class of fluorescent compounds containing indole-diones and indole-quinoxaline derivatives, their preparation methods, and uses, belonging to the field of fluorescent compound technology. This invention provides a novel class of fluorescent compounds containing indole-diones and indole-quinoxaline derivatives with structures shown in general formulas (I) and (II). These compounds exhibit low toxicity and long emission wavelengths, showing significant application potential in the field of bioimaging.

The invention provides a cyanation quinoxaline-based n-type polymer semiconductor material and a preparation method and application thereof, and the cyanation quinoxaline-based n-type polymer semiconductor material has a chemical structural general formula as follows: in the n-type polymer semiconductor material, quinoxaline is used as a matrix and has good solubility and a planar skeleton structure, and the structural formula is shown in the specification. The introduction of the cyano group significantly reduces the electricity shortage of the quinoxaline, so that the prepared n-type polymer semiconductor material has lower molecular front track energy level and more excellent photoelectric properties, thereby showing excellent application potential in the fields of organic field effect transistors, organic thermoelectricity or organic solar cells and the like.

The present invention relates to a process for preparing 9-Chloro-2,3-dimethyl-6-(N,N-dimethylaminoethylamino-2-oxoethyl)-6H-indolo-[2,3-b]quinoxaline, wherein said process is suitable for large scale synthesis.

To provide a rubber composition for a hose excellent in heat resistance, acid resistance and settling resistance, and various hoses obtained by using the same.SOLUTION: A rubber composition for a hose comprising the following components (A) to (C), wherein a content of the component (B) is from 1 to 3 parts by mass, and a content of the component (C) is from 0.05 to 0.4 parts by mass, per 100 parts by mass of the component (A): (A) an epichlorohydrin-ethylene oxide-allyl glycidyl ether copolymer rubber having an ethylene oxide content of 50 mol% or less and an allyl glycidyl ether content of 5 mol% or more; (B) At least one of a quinoxaline-based crosslinking agent and a triazine-based crosslinking agent. (C) Sulfur.SELECTED DRAWING: None

This invention relates to a photosensitizer with a D1-π-A-π-D2 type structure based on asymmetric end-capped donor units. This material is characterized by using 4-(5-(4-(9H-carbazole-9-yl)phenyl)) as donor units (D1) and 5-(4-(diphenylamino)phenyl) as donor units (D2), with isooctylthiophene as the connecting π-bridge, and phenazine as the central acceptor unit (A), specifically naphthiazo[1,2-b][1,2,5]thiadiazo[3,4-g]quinoxaline and [1,2,5]thiadiazo[3,4-i]dithienozo[2,3-a:3',2'-c]phenazine. The photophysical properties of this D1-π-A-π-D2 type photosensitizer were tested, and a novel photosensitizer with high photothermal conversion efficiency and high reactive oxygen species (ROS) yield was developed. The material involved in this invention has near-infrared II region imaging and photothermal in-situ imaging diagnostic functions, and is expected to be used as an organic photosensitizer material for integrated photothermal and photodynamic diagnosis and treatment.