347 results about "Quinoxaline" patented technology

The present invention discloses a series of fluorine-substituted heterocyclic compounds, specifically, compounds represented by formula (XII) and pharmaceutically acceptable salts thereof. 【Chemical 1】 JPEG2025516367000403.jpg44170

The invention discloses a PARP1 selective protein degradation agent and an application of the PARP1 selective protein degradation agent in tumor resistance. The degradation agent has the following structural formula. Wherein the 3-ethyl-7-((4-(pyridine-3-yl) piperazine-1-yl) methyl) quinoxaline-2 (1H)-ketone part is a PARP1 target protein ligand, and L is a connecting unit; and B is an E3 ubiquitin ligase ligand. The PARP1 selective protein degradation agent prepared by the preparation method disclosed by the invention can be used for effectively degrading PARP1 protein, inhibiting cell proliferation and inducing tumor cell apoptosis. Meanwhile, when the compound is combined with chemotherapeutic drugs, the effect of enhancing the chemotherapeutic effect is achieved, almost no physiological toxicity exists, and the compound is expected to provide an ideal way for improving treatment of various diseases caused by PARP1 excessive activation. # imgabs0 #

The invention provides a light conversion adhesive film for sunlight wavelength conversion and application thereof, the light conversion adhesive film comprises an organic compound # imgabs0 # and a substrate transparent to visible light, the definition of each group in the organic compound is described in the specification, and the mass fraction of the organic compound in the light conversion adhesive film is 0.01%-5%. The light conversion adhesive film can be used for a solar cell so as to enhance the efficiency and the stability of the cell.

The invention discloses a hole transport material, a preparation method thereof and a perovskite solar cell, and belongs to the technical field of photovoltaic solar materials. The molecular structural formula of the compound is shown as a formula (I) or a formula (II). According to the invention, a quinoxaline part is used as an electron acceptor for extended conjugate modification, a plurality of single donors such as triphenylamine electron donating groups, dihydroacenaphthene, binaphthyloxy and the like are introduced, the hole transport material with a multi-donor structure is constructed, and the hole transport material adjusts the distribution of HOMO-LUMO, increases charge transfer channels, improves the separation and transport capabilities of charges, and improves the hole transport efficiency. Therefore, the mobility of current carriers is improved. A tert-butyl unit is further introduced to the periphery of the triphenylamine group, the hydrophobic property of tert-butyl reduces the interface energy barrier between the hole transport layer and the perovskite precursor solution, directional growth and defect passivation of perovskite crystals are promoted, and the crystallization quality of the perovskite thin film and the device performance are improved.

The invention discloses a star-shaped tripolymer type non-fullerene acceptor material as well as preparation and application thereof. The star-shaped tripolymer type non-fullerene acceptor material has a structure as shown in the following formula: # imgabs0 #. According to the invention, a star-shaped trimer type oligomer material connected with a quinoxaline development center with a derivative site in the middle is adopted, so that the defect that the PCE of the current oligomer type acceptor material is influenced due to oligomerization based on a halogen substitution site of tail-end isatin is overcome; compared with a traditional small molecule material (oligomer type acceptor material), the material has higher open-circuit voltage (Voc), the photoelectric conversion efficiency is excellent, the illumination stability is good, and when the material is applied to a solar cell, the photoelectric conversion efficiency and stability of the cell can be remarkably improved.

The invention provides a phenazine-quinoxaline organic electrode material, and belongs to the technical field of aqueous zinc ion battery electrode materials, and the phenazine-quinoxaline organic electrode material is synthesized from 2, 3-diaminophenazine and 2, 5-dihydroxy-1, 4-benzophenone through a dehydration condensation reaction. The organic electrode material can be used for manufacturing a positive electrode of an aqueous zinc ion battery, and shows relatively high reversible specific capacity, relatively long cycle life, relatively good rate capability and relatively good wide temperature range performance. The invention also provides an application of the phenazine-quinoxaline organic electrode material in preparation of an aqueous zinc ion battery.

The invention relates to a quinoxalinone derivative targeting poly ADP ribose polymerase and an androgen receptor as well as a preparation method and application of the quinoxalinone derivative. The structural formula of the quinoxalinone derivative is as follows: # imgabs0 #, R1 is one of hydrogen, methoxyl, methyl and halogen, the substituent position of R1 is at least one of 5, 6, 7 and 8 sites of a quinoxalinone ring, and X is a carbon atom or a nitrogen atom. The quinoxalinone derivative provided by the invention can be used as an active photosensitizer, a PARP inhibitor and an androgen receptor antagonist and can induce cell synthesis and death, and the process can improve the oxidation state and oxygen concentration in cells and improve the hypoxic microenvironment in tumors, so that the photodynamic therapy effect is further enhanced, namely, the effect of the quinoxalinone derivative is improved. The PDT therapy and the PARP inhibitor have a synergistic effect.

The invention discloses an all-organic aqueous zinc ion battery positive electrode material and a preparation method and application thereof, and belongs to the technical field of new energy materials and batteries, the positive electrode material is an azacyclo organic matter 5, 5, 12, 12 '-tetrahydro-2, 2'-biquinoxaline [2, 3-b] quinoxaline, and the negative electrode material is an imine and carbonyl organic matter. The nitrogen heterocyclic organic positive electrode loses electrons and is oxidized in the charging process, and the imine and carbonyl organic negative electrodes obtain electrons and are reduced, so that stable charging and discharging cycles can be carried out. According to the all-organic water-based zinc ion battery positive electrode material as well as the preparation method and the application thereof, the organic positive electrode with an adjustable structure and rich elements, the relatively stable imine and carbonyl organic negative electrodes and the environment-friendly and safe water-based electrolyte are adopted, and stable charging and discharging of an all-organic water-based zinc ion battery can be realized.

The invention provides a preparation method of a brominated benzhydryl quinoxaline ketone compound, which comprises the following step: under the condition of illumination, carrying out coupling reaction on 1-methylquinoxaline ketone and brominated diphenylmethane to obtain the brominated benzhydryl quinoxaline ketone compound. The preparation method of the brominated benzhydryl quinoxaline ketone compound provided by the invention is mild in reaction condition and simple and efficient in step.

The invention relates to 3-quinoxalinyl imidazoline thioketone derivatives, a synthesis method and application technical contents. The structural general formula of the derivative is formula 1 or formula 2. The invention provides a preparation method of the derivative. The invention proves that the developed 3-quinoxalinyl imidazoline thioketone derivative has an anti-myocardial hypertrophy effect and can be applied to preparation, research and development of anti-myocardial hypertrophy drugs.

The invention discloses a quinoxalinone boride with efficient bi-state luminescence and preparation and application thereof.The material mainly takes a quinoxalinone-BF2 structure as a core, the luminescent material has the advantages that synthesis steps are simple, the preparation method is convenient, the luminescent property is excellent, the efficient bi-state photoluminescence property of a solution state and a solid state is achieved, and the luminescent material is suitable for large-scale production. The biotoxicity is low, the biocompatibility is high, and the long-time cell imaging function is realized. And the probe can become a novel biological probe molecular platform.

The invention relates to a fused ring compound, a pharmaceutical composition containing the fused ring compound, a preparation method of the fused ring compound and application of the fused ring compound. Specifically, the invention relates to an imidazo [1, 5-a] quinoxaline derivative as shown in a formula I. The imidazo [1, 5-a] quinoxaline derivative has a good inhibition effect on tumor cells and has good pharmacokinetics and other properties. # imgabs0 #

An organometallic complex having an emission peak in a long wavelength region (a visible region having a wavelength of 700 nm or greater or a near-infrared region) is provided. The organometallic complex has a structure represented by General Formula (G1), in which a ligand having a quinoxaline skeleton is coordinated to a central metal, and an electron-withdrawing group (e.g., fluorine, a cyano group, a trifluoromethyl group, a trifluoromethylsulfonyl group, or a pentafluorosulfanyl group) is included as a substituent at at least one substitutable position of the benzene ring of the quinoxaline skeleton of the ligand.

The invention belongs to the technical field of organic photoelectric materials, and particularly relates to preparation and application of an indolo-indole quinoxaline phenazine MR-TADF blue light material. The material has a rigid large-plane skeleton and is modified by a plurality of chemical sites, and efficient and narrow-spectrum blue light emission of the material can be realized by simply regulating and controlling a peripheral hooking group. The blue-light-doped electroluminescent device prepared by the method has the advantages that the blue-light-doped electroluminescent device prepared by the aid of the method has the advantages that the blue-light-doped electroluminescent device prepared by the aid of the method is high in light emitting efficiency, the thermal decomposition temperature can reach 426.1 DEG C, the blue-light-doped electroluminescent device is excellent in thermal stability, the maximum photoluminescence emission peak in methylbenzene solution is 458 nm, the half-peak width of the blue-light-doped electroluminescent device is 40 nm, the fluorescence quantum efficiency of the blue-light-doped electroluminescent device is 78.2%, the maximum emission peak of the obtained blue-light-doped electroluminescent device is 468 nm, color coordinates of the blue-light-doped electroluminescent device are (0.15 and 0.25), and the corresponding maximum external quantum efficiency The MR-TADF blue light-emitting material with an innovative structure and multiple expandability has an attractive application prospect. # imgabs0 #

The present invention provides a fluorine-containing electrochromic polymer, a preparation method thereof and an application thereof. The fluorine-containing electrochromic polymer has a structure shown in Formula I. In the present invention, by introducing fluorine atoms into the electrochromic polymer and through the interaction between the fluorine atoms and a single alkoxy group with a specific structure on the quinoxaline group, the prepared fluorine-containing electrochromic polymer has excellent properties, and thus the prepared electrochromic device has a lower starting voltage, a lower contrast attenuation rate, a faster response speed and a higher coloring efficiency.

The application belongs to the field of compound synthesis and particularly relates to a photocatalytic preparation method of quinoxaline-2,3-dione compounds, which comprises the following steps: preparing a raw material solution containing quinoxaline-2-ketone, mercaptan, a photocatalyst and acetonitrile, and performing a photocatalytic reaction under light to obtain a quinoxaline-2,3-dione compound product; the mercaptan is C1-C4 alkyl mercaptan, and the -SH is connected to a primary carbon or a secondary carbon. The application adopts a photocatalytic method to perform hydroxylation on the C3 position of quinoxaline-2-ketone, and further controls the combination of the mercaptan and acetonitrile solvent to improve the photocatalytic reaction effect of C3 hydroxylation.

The present invention discloses an efficient C-H arylation reaction between quinoxalinone compounds and aryltriazenes induced by ionic liquids. Specifically, it relates to a method for the electrochemical synthesis of 3-arylquinoxalinone compounds, using aryltriazenes as stable arylation reagents and ionic liquids as promoters and electrolytes. Under mild, metal-free, and oxidant-free conditions, the method can synthesize a variety of 3-arylquinoxalinone compounds and arylated quinoxaline compounds in moderate to excellent yields. This scheme has the remarkable characteristics of simple operation, excellent functional group tolerance, high selectivity, strong product derivatization, and suitability for gram-scale continuous flow chemical synthesis.

The disclosure relates to analogs of quinoxaline / quinoline cytotoxic agents, termed"Nupomycins" herein, linker-payloads, and protein-drug conjugates thereof, pharmaceutical compositions comprising same, and methods of treating disease therewith.

The application discloses a preparation method of a diphenylmethyl quinoxaline ketone derivative, and belongs to the technical field of biological medicines. The structure of the diphenylmethyl quinoxaline ketone derivative is shown in the specification. The application adopts a cross dehydrogenative coupling strategy, realizes quinoxaline ketone 3-alkylation through direct activation of an alkane and accompanying hydrogen atom transfer, and has the advantages of mild reaction conditions, cheap and easily available reagents, and higher efficiency and environmental friendliness. The diphenylmethyl quinoxaline ketone derivative has high-efficiency and broad-spectrum antifungal activity, shows inhibitory effects on a plurality of common plant pathogenic fungi, and can be developed into a product for treating plant fungal infections.

The invention belongs to the technical field of organic solar cell materials, and relates to a benzodithiophene polymer donor with a simple and stable structure and a preparation method and application thereof. The invention discloses a benzodithiophene polymer donor PBTQ-X (F / Cl / 2F) with a simple and stable structure, and discloses a preparation method of the benzodithiophene polymer donor PBTQ-X (F / Cl / 2F), and the preparation method comprises the following steps: under the action of a Stille coupling catalyst, carrying out two-stage polymerization on benzodithiophene containing bis (trimethyltin) and a quinoxaline derivative containing a dibromothiophene pi bridge, carrying out two-stage heating reflux reaction, and carrying out post-treatment to obtain the benzodithiophene polymer donor PBTQ-X (F / Cl / 2F). Adding an end-capping reagent for end capping; and finally, settling after passing through methanol, thereby obtaining the product. The benzodithiophene polymer donor with a simple and stable structure can be applied to an active layer of an organic solar cell device, and shows relatively good photovoltaic performance and long-term stability.

The present invention relates to a nitrogen-containing fused ring compound and its application in an organic electroluminescent device. The structure of the nitrogen-containing fused ring compound is shown in Formula I. In Formula I, X and Y are the same or different and are each independently oxygen or sulfur; Z is oxygen, sulfur or N-R, where R is an alkyl group or an aryl group; R 1 、R 2 、R 3 and R 4 are the same or different and are each independently H, an alkyl group, an aryl group or a heteroaryl group, and R 1 、R 2 、R 3 and R 4 one or more of them are heteroaryl groups having a nitrogen heterocycle, and the nitrogen-containing heterocycle is selected from one or more of a pyrimidine ring, a quinoxaline ring, a quinazoline ring and a triazine ring. When L 3 and L 4 do not exist, R 3 and R 4 are not H; L 1 、L 2 、L 3 and L 4 are the same or different and are each independently selected from non-existence, arylene and heteroarylene. When the compound of the present invention is applied to an organic electroluminescent device, it has a lower driving voltage and a higher device luminous efficiency.

This invention discloses a polysubstituted indole[1,2-a]quinoxaline compound, its preparation method, and its applications. The structural formula of the polysubstituted indole[1,2-a]quinoxaline compound of this invention is or , where R 1 Selected from -H or -F, R 2 The compounds are selected from phenyl, 4-methylphenyl, 4-methoxyphenyl, or 4-fluorophenyl. The polysubstituted indole[1,2-a]quinoxaline compounds of this invention have novel structures and significant antitumor activity, making them suitable for the synthesis of anticancer drugs. Furthermore, their preparation methods offer advantages such as readily available and inexpensive catalysts, broad substrate applicability, good functional group tolerance, simple operation, mild reaction conditions, and high step economy, making them suitable for large-scale industrial production and application.

The present invention relates to novel heteroaryl-substituted (aza)quinoxaline derivatives of the general formula (I), in which the structural elements A1, A2, A3, A4, R1, R2, R3, R4 and R5 have the meaning given in the description, to formulations and compositions comprising such compounds and for their use in the control of animal pests including arthropods and insects in plant protection and to their use for control of ectoparasites on animals.

The invention discloses a near-infrared two-region aggregation-induced emission I-type photosensitizer as well as preparation and application thereof. The chemical structural general formula of the near-infrared two-region aggregation-induced emission I-type photosensitizer is shown in the specification, wherein X is independently selected from one of O, S and Se, R1 is independently selected from one of straight-chain alkyl groups with the carbon atom number of 1-20, R2 is independently selected from one of-F,-CN,-CF3,-OCH3,-C4H9 and-CH3, and R3 is independently selected from one of-H,-Br,-I and-TPA. A D-pi-A-pi-D type near-infrared two-region aggregation-induced emission I type photosensitizer is designed and synthesized, and 4, 4 '-dimethoxydiphenylamine is used as a distortion donor unit, ortho-substituted hexylthiophene is used as a pi-bridge, and acenaphthene alkene thiadiazolo quinoxaline and other derivatives are used as central acceptor units. The near-infrared two-region aggregation-induced emission type I photosensitizer has good fluorescence and active oxygen generation and photothermal conversion capabilities, and can be used for cancer multi-mode diagnosis and treatment integrated research.

The invention provides a direct diphosphorylation reaction method and application of a quinoxaline compound, the quinoxaline compound is used as a raw material, diarylphosphine oxide, phosphate or phosphite ester and the like are used as a phosphorus source, an easily available solvent is added, and the diphosphorylation quinoxaline compound is directly synthesized in an oxygen-free environment without a catalyst. According to the invention, the nucleophilic diphosphorylation reaction of the quinoxaline compound can be realized under the mild condition without a catalyst, and a series of diphosphorylated quinoxaline compounds can be synthesized. The reaction method has the advantages of mild reaction conditions, few byproducts, easiness in separation and purification, environmental friendliness, simplicity and convenience in operation, wide application range, high yield (up to 98%) and the like, and gram-level reaction and derivatization reaction show potential application value of the reaction method.

A combination for use in treating cancer is provided. The combination comprises a therapeutically effective amount of an inhibitor of nuclear import protein Karyopherin Beta 1 (Kpnβ1) such as the substituted pyrrolo[2,3-b]quinoxalines of Formula I and a therapeutically effective amount of an inhibitor of nuclear export protein Chromosome Maintenance 1 (Crm1) such as the hydrazide- containing compounds of Formula II. The combination therapy provides an enhanced anti-cancer therapeutic effect compared to the effect of each of the nuclear transport inhibitors administered alone.

The application provides an organic negative electrode and a metal-air battery, the organic negative electrode comprises an organic matter with a low redox potential, the organic matter with the low redox potential comprises phenazine, diquinoxaline phenazine, a nitrogen heterocyclic ring, a carboxylate or an azo compound, the organic matter in the organic negative electrode is corrosion resistant and the redox potential can be adjusted, even reaching a negative reduction potential comparable to that of hydrogen, so that the phenomenon of hydrogen evolution corrosion cannot occur; a large number of functional groups and active sites in the organic matter can induce uniform deposition of metal ions, and there is no condition for dendrite growth and formation of a passivation layer, so that various problems caused by the above metal negative electrode can be completely avoided; the metal-air battery with the above organic negative electrode has the advantages of long cycle time, stable performance, safety, environmental protection and low cost, and has a wide application prospect in the field of large-scale energy storage.

The invention belongs to the technical field of medicinal chemistry, and particularly relates to a quinoxaline compound as well as a preparation method and application thereof. Specifically, the quinoxaline compound provided by the invention is screened by adopting virtual screening and pharmacophore modes, is novel in structure, has relatively good inhibitory activity on MELK, and solves the problem of insufficient development of an existing MELK inhibitor that the activity is not ideal enough, the chemical structure is not diversified enough and the like.

The invention provides a method for synthesizing a 3-alkylated quinoxaline-2 (1H)-ketone compound through visible light catalysis and application of the 3-alkylated quinoxaline-2 (1H)-ketone compound, and belongs to the technical field of catalytic synthesis. The method comprises the following steps: under visible light, a quinoxaline-2 (1H)-ketone derivative is excited by light to reach an excited state and then reacts with an alkylating reagent to obtain an alkyl carbon free radical; further, the quinoxaline-2 (1H)-ketone is attacked, so that the synthesis of the 3-alkylated quinoxaline-2 (1H)-ketone derivative is realized; according to the method, the quinoxaline-2 (1H)-ketone derivative is directly excited under the visible light condition, no extra photocatalyst is needed, the application of an equivalent oxidant is avoided due to the use of a catalytic amount of cobalt catalyst, and particularly, the method also has the advantages of simple reaction raw materials, high product yield and mild reaction conditions.

The application discloses a kind of all-organic aqueous zinc ion battery positive electrode materials and preparation method and application, belong to new energy materials and battery technical field, and positive electrode material is nitrogen heterocyclic organic 5,5,12,12'-tetrahydro-2,2'-bi quinoxaline [2,3-b] quinoxaline, negative electrode material is imine and carbonyl organic matter.Nitrogen heterocyclic organic positive electrode loses electron and is oxidized in charging process, and imine and carbonyl organic negative electrode obtains electron and is reduced, so stable charge-discharge cycle can be carried out.The application uses the above-mentioned one all-organic aqueous zinc ion battery positive electrode material and preparation method and application, using structure adjustable and element rich organic positive electrode, relatively stable imine and carbonyl organic negative electrode, environment-friendly and safe water-based electrolyte, can realize the stable charge-discharge of all-organic aqueous zinc ion battery.