18 results about "Hot flashes/flushes" patented technology

The present invention relates to an oral extract composition comprising Shatavari (Asparagus racemosus Willd.) and Fenugreek (Trigonella foenum-graecum L.) extract composition, and its process of preparation. Also relates to the oral extract composition formulation comprising with synergistic combinations of the Shatavari (Asparagus racemosus Willd.) and Fenugreek (Trigonella foenum-graecum L.) in suitable doses and at least one nutraceutically and / or pharmaceutically accepted excipient for, improvement, and maintenance of women health more preferably in improving of hot flashes, night sweats, poor sleep, anxiety, sexual dysfunction, mood changes, Genitourinary symptoms in overall improving the quality of life, serum estradiol, progesterone, follicle stimulating hormone (FSH), and cortisol during the period of menopause (perimenopause and menopause). The oral extract composition formulation comprising with synergistic combinations of the Shatavari (Asparagus racemosus Willd.) and Fenugreek (Trigonella foenum-graecum L.) in suitable doses and at least one nutraceutically and / or pharmaceutically accepted excipient is used for improving Brain-derived neurotrophic factor (BDNF) levels in women during the period of menopause. The present invention, further related to the extraction process of Shatavari (Asparagus racemosus Willd.) and Fenugreek (Trigonella foenum-graecum L.), also provides the process for the preparation of formulation composition. This invention further relates to the extraction process from Shatavari (Asparagus racemosus Willd.) and Fenugreek (Trigonella foenum-graecum L.) either as individual herbs or co-extraction of the two herbs or mixing the extracts at various stages of the individual extracts.

The invention discloses an artificial intelligence female climacteric medical data auxiliary processing method and system, and relates to the technical field of medical data auxiliary processing. The monitoring module is set, the monitoring module is a wearable intelligent device, physical sign information data and environment information data of a target patient are obtained based on the monitoring module, and feature information items and environment information items are obtained; the acquisition module is used for acquiring questionnaire score information of a target patient to obtain questionnaire information items; by setting the monitoring module of the wearable intelligent device, the typical hot tide phenomenon of female climacteric is accurately captured, body surface temperature and current change data are obtained through a micro heat-sensitive sensor and a micro current sensor, accurate feature information items are obtained through strict threshold judgment, meanwhile, environment information data such as noise and illumination can be obtained, and the intelligent female climacteric monitoring system is suitable for being used for monitoring female climacteric climacteric conditions. Interference of environmental factors on female endocrine and climacteric symptoms is comprehensively considered.

The current invention is in the field of molecular biology / pharmacology and provides novel 3-oxabicyclo[3.3.1]nonene compounds and derivatives that modulate the effects of the classical estrogen receptors alpha and beta (ERalpha and ERbeta) with little to no biological or physiological effects on the G protein-coupled estrogen receptor GPER (also known as GPR30). These compounds may function as agonists and / or antagonists of one or more of the disclosed classical estrogen receptors. Diseases that are mediated through one or more of these receptors include cancer (including but not limited to breast (particularly endocrine or anti-hormone resistant, and for the prevention / reduction of endocrine or anti-hormone resistance), reproductive and other hormone-dependent cancers, leukemia, colon cancer, prostate cancer), reproductive (genito-urological) including endometritis, prostatitis, polycystic ovarian syndrome, bladder control, hormone-related disorders, hearing disorders, cardiovascular conditions including hot flashes and profuse sweating, hypertension, stroke, obesity, osteoporosis, hematologic diseases, vascular diseases or conditions such as venous thrombosis, atherosclerosis, among numerous others and disorders of the central and peripheral nervous system, including depression, insomnia, anxiety, multiple sclerosis, neuropathy, neurodegenerative disorders (such as Parkinson's disease and Alzheimer's disease), as well as inflammatory bowel disease, Crohn's disease, coeliac (celiac) disease and related disorders of the intestine, among numerous others as described herein. A contraceptive indication to prevent or reduce the likelihood of pregnancy after intercourse is a further aspect of the present invention.

The invention relates to the technical field of traditional Chinese medicine preparation, in particular to a traditional Chinese medicine formula for treating climacteric syndrome and a preparation method thereof.The traditional Chinese medicine formula is formed by compatibility of tuber fleeceflower stem, polygala tenuifolia, rhizoma acori graminei and other raw materials according to a specific proportion, the preferable proportion is clear, the formula contains specific active ingredient groups, and the content of the active ingredient groups reaches the standard through HPLC determination. The composition is accurate in compatibility, can comprehensively condition and improve various climacteric symptoms such as hectic fever, night sweat, insomnia and the like, and is definite in active ingredients, reliable in curative effect, high in universality and high in safety. The preparation method comprises specific decoction steps, such as first decoction of the raw dens draconis, staged decoction and adoption of a gradient heating process, the drug effect is improved, meanwhile, the quality is guaranteed through strict quality control, the process is flexible, various dosage forms can be prepared, the traditional Chinese medicine formula is combined with the preparation method, and the traditional Chinese medicine composition has an efficient and safe treatment effect on the climacteric syndrome and is worthy of popularization and application. The clinical application value is obvious.

The application discloses a bird's nest compound product with the effect of improving female body health and a preparation method and application thereof. The preparation method comprises the following steps: mixing red ginseng, Gastrodia elata, ophiopogon, donkey-hide gelatin, eucommia and ganoderma lucidum with a solvent to form a mixed slurry; treating and extracting the mixed slurry by applying an electric field to prepare a compound liquid; and mixing the compound liquid with bird's nest to prepare the bird's nest compound product with the effect of improving female body health. The bird's nest is matched with the medicine-food homologous material, and on the basis of the theory of "suo zhuo jun chen", the bird's nest compound product capable of obviously improving menopausal syndrome is prepared, the hormone level is effectively adjusted, symptoms such as hot flashes, night sweats, sleep quality improvement, ovary and uterus repair promotion and the like are relieved, and the product is mild in action, high in safety, good in flavor and color.

The invention discloses a TCM syndrome differentiation system for early breast cancer during chemotherapy, including four syndrome types, namely: liver depression and yin deficiency syndrome, corresponding syndrome items are: irritability, thin white tongue coating, forgetfulness, chest and flank distension and pain, dry mouth, hot flashes, chest and abdominal pain, bone pain, abdominal distension, chest tightness; qi and yin deficiency syndrome, corresponding syndrome items are: deep pulse, thin white tongue coating, red tongue, hot flashes, forgetfulness, dry mouth, pale complexion, sore waist and knees, spontaneous sweating, ruddy complexion; spleen deficiency and blood deficiency syndrome, corresponding syndrome items are: pale tongue color, white and greasy tongue coating, pale complexion, dry mouth, poor appetite, thin pulse, fat tongue; qi stagnation and blood stasis syndrome, corresponding syndrome items are: ecchymosis on tongue, blue lips, varicose veins under tongue, stringy pulse, dark complexion, numbness of limbs, oral ulcers. The invention also discloses a construction method and application of the system. The invention provides a theoretical basis for the standardized TCM treatment of patients in the chemotherapy period of early breast cancer, and has broad application prospects.

The present invention is based on the realization and verification that inhibition of Luteinizing hormone (LH) and / or luteinizing hormone / choriogonadotropin receptor (LHCGR) is useful in the treatment, alleviation or prevention of different medical states related to perimenopause and menopause in women or hypogonadism in men. Thus, an aspect of the present invention relates to LH and / or LHCGR inhibitors for use in the treatment of postmenopausal osteoporosis in a female subject. Another aspect relates to LH and / or LHCGR inhibitors for use in the reduction of fat mass in a postmenopausal female subject. A further aspect relates to LH and / or LHCGR inhibitors for use in the treatment, hypergonadotropic hypogonadism in a male subject. In addition, another aspect relates to LH and / or LHCGR inhibitors for use in the treatment of symptoms of perimenopause and / or postmenopause such as hot flashes, night sweats, osteoporosis, weight gain, hypothyroidism, conversion of T4 to T3, and / or primary hyperparathyroidism.

Disclosed herein are compositions for treating, ameliorating, preventing, or reducing the symptoms associated with menopause and / or hot flashes. The compositions disclosed herein comprise a curcumin composition, a green tea extract composition, and a phycocyanin composition that act as neurokinin 3 receptor antagonists. Also described herein are methods utilizing the aforementioned compositions.

The present disclosure relates to compositions comprising an aqueous solution of at least about 70% by weight water in combination with selected fatty acid salts and optionally an alcohol and / or a cooling sensate, as well as methods of using the same to treat symptoms of hot flashes. The fatty acid salts form fiber-like crystalline particles that together form a self-supporting mesh structure with voids, the aqueous solution being contained in the voids. When the composition is compressed above a critical stress, the mesh allows for the entrapped aqueous solution to be expressed.

The utility model discloses a seat cushion with a heat dissipation function, which comprises a shell, a mounting rack is fixedly arranged in the shell, a honeycomb plate is fixedly arranged in the mounting rack, a heat-conducting fin is fixedly arranged on the front side of the honeycomb plate, the shell is made of net-shaped sponge, the heat-conducting fin is made of heat-conducting silicone grease, and the heat-conducting silicone grease is made of heat-conducting silicone grease. A cooling fin is fixedly arranged at the top of the heat conducting fin, a protection plate is fixedly arranged on the front side of the cooling fin, a cooling assembly is arranged in the mounting frame, a connecting plate is fixedly arranged in the mounting frame, and a connecting assembly is arranged in the connecting plate; the connecting plate is provided with a contact pad through a connecting assembly, a skirt edge is fixedly arranged on the surface of the contact pad, the seat cushion can avoid temperature accumulation of the buttocks of a user, so that the buttocks of the user are prevented from hot flashes, and the use comfort of the seat cushion is improved.

The present invention discloses a probiotic composition for improving menopausal symptoms and its application, which combines raw materials of both medicine and food with probiotics complementing each other, having a simple composition and synergistic effect, being rich in various essential nutrients and trace elements for the human body, and having the functions of strengthening the spleen and stomach, nourishing the liver and kidney, and calming the nerves, and can improve symptoms such as hot flashes and sweating, insomnia and dreaminess during menopause. The present invention can be used to improve menopausal syndrome, expanding the application field of probiotics.

Provided herein are methods for treating patients, including patients in need of analgesic treatment, as well as reducing the likelihood of abuse of opioids and opioid compounds (e.g., class II, class III and class IV analgesics) in the treated patient and reducing, eliminating and / or preventing hectic fever, hidrosis and / or pruritus side effects. The methods comprise administering to a patient once a day an immediate release composition comprising Cibopadol in form of Form A and / or free base.

A wearable device, such as a garment or containing garment portions, for managing and / or reducing the symptoms of a hot flash in a subject. The device comprises: a first set of components, each comprising a fabric comprising a cooling yarn; a second set of components, each comprising a quick-dry wicking fabric; and a third set of components, each comprising a phase change material fabric, wherein the first set of components are adapted to cover at least a neckline region and a peripheral region that extends adjacently around the armpit and the clavicle of the subject; the second set of components are adapted to cover at least the abdominal muscles and the lumbar regions of the subject; and the third set of components are adapted to cover at least the mammary and the dorsum regions of the subject.

This invention discloses an antibody targeting CGRP and its applications. The antibody or its antigen-binding portion comprises a heavy chain variable region and a light chain variable region. The heavy chain variable region comprises CDR-H1, CDR-H2, and CDR-H3, and the light chain variable region comprises CDR-L1, CDR-L2, and CDR-L3. This antibody can specifically bind to human and rat CGRP peptides and α / β subtype CGRP peptides with high affinity, blocking the binding of CGRP to its receptor CGRPR, reducing pain perception, and achieving the treatment of pain disorders such as migraines caused by CGRP. Furthermore, it can also relieve or treat hot flashes.

An exemplary system and method that can predict or estimate using machine learning based classification the onset of hot flash events or episodes that can be used to trigger the preemptive cooling intervention to prevent the experience of hot flash or to reduce the severity of the symptoms. The machine learning based classification can employ data from electrodermal activity (EDA) sensor measurements to generate a trigger for administration of active cooling via an active wearable device or garment prior to the subjective perception of hot flashes.

This invention belongs to the field of pharmaceutical technology, specifically relating to a composition for improving perimenopausal symptoms. It comprises the following components: 400-700 parts protein, 30-50 parts fat, 120-170 parts carbohydrates, 40-90 parts dietary fiber, 30-80 parts food-grade medicinal materials, 2-6 parts complex trace minerals, 50-95 parts complex macrominerals, 3-5 parts complex vitamins, and 5-10 parts blueberry powder. The protein is composed of whey protein, soy protein, and collagen peptides in a mass ratio of 7-12:6.1-8.5:1. By precisely controlling the ratio of soy protein and collagen peptides in the protein, this composition can significantly improve perimenopausal symptoms such as hot flashes, insomnia, osteoporosis, decreased estrogen levels, and uterine atrophy.

To provide a method for treating hot flash in a subject.SOLUTION: A method has administering a therapeutically effective amount of a transient receptor potential channel (TRP channel) blocker or pharmaceutically acceptable salt thereof. Preferably, the TRP channel blocker is a TRP channel subfamily V member 1 (TRPV1) blocker, or a pharmaceutical equivalent, analog, derivative, or salt thereof.SELECTED DRAWING: None

A device and method for treatment of hot flashes in perimenopausal and menopausal women. The device includes a cooling agent distributed over at least a portion of an area of the device, at least one liner positioned against and attached to at least one side of the cooling agent over at least the portion of the area of the device, and an adhesive. The adhesive is arranged on at least one side of the device so as to permit the device to be secured with respect to the anatomy of a user.