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151 results about "Hot flash" patented technology
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A feeling of warmth, sometimes associated with flushing that spreads over the body and sometimes followed by perspiration.
Portable cooling system
InactiveUS20050262871A1Immediate cooling reliefDomestic cooling apparatusLighting and heating apparatusInsulation layerAbsorbent Pads
A personal portable cooling device for facilitating relief from hot environments or conditions, such as those caused by menopausal “hot flashes”, the cooling device having a waterproof plastic pouch with a sealable access port, internal insulation layer to resist heat transfer, waterproof inner liner to resist leakage, fastening device for selectively closing the access port, sealed bladder filled with a freezable agent that provides a cooling medium and absorbent pad to absorb moisture from the bladder.
Owner:BAILEY WESTON VALERIE
Methods of treating cutaneous flushing using selective alpha-2-adrenergic receptor agonists
InactiveUS20050020600A1Effective treatmentTreatment safetyBiocidePharmaceutical delivery mechanismQuinoxalineVasomotor instability
The present invention relates to a method of treating, reducing, inhibiting, preventing and / or reversing cutaneous facial flushing caused by abnormal, endogenously-induced vasomotor instability associated with, but not limited to acne rosacea, menopause-associated hot flashes, hot flashes resulting from orchiectomy or ingestion of substances capable of inducing a cutaneous facial flushing reaction (e.g.: alcohol, chocolate, spices) by topical dermatological application of an effective dose of a composition comprising at least one α2 adrenergic receptor agonist (such as a (2-imidazolin-2-ylamino) quinoxaline derivative such as brimonidine tartrate)and a suitable carrier.
Owner:GALDERMA LAB LP
Cooling device and method
InactiveUS20070193278A1Quick changeSurgeryMachines using electric/magnetic effectsThermoelectric coolingSkin surface
A device for providing cooling to a body is disclosed. The device operates in response to a measured change in temperature of the body's skin surface over a predetermined period of time or manually in response to a perceived or anticipated change in body temperature by the user. The device includes a controller, a temperature sensor, a power source, a thermoelectric cooler, and a heat absorbing reservoir containing a phase change material. The thermoelectric cooler has a heat absorbing surface engageable with the body to be cooled and a heat rejecting surface engaged with the heat absorbing reservoir. The controller is operatively connected to the temperature sensor, the power source, and the thermoelectric cooler and activates the cooler when the temperature sensor provides signals indicative of a predetermined rate of temperature change or in manual mode by user. A method of treating hot flashes with the device is also disclosed.
Owner:POLACEK DENISE +2
Pharmaceutical compositions
ActiveUS8268806B2Achieve beneficial effectAvoid their undesirable side effectOrganic active ingredientsMuscular disorderEstrogenic EffectsInsulin resistance
Owner:MYRIEL PHARM LLC
Scopolamine to Reduce or Eliminate Hot Flashes, Night Sweats, and Insomnia
InactiveUS20070010550A1Reduction in severity and frequencyAvoid problemsBiocideAnimal repellantsGynecologyHot flashes/flushes
Compositions and methods of treating or preventing hot flashes, night sweats, and / or insomnia in a subject that involve scopolamine are disclosed. For example, methods of treating hot flashes, night sweats, and / or insomnia in a subject that involve transdermal delivery of scopolamine are set forth herein.
Owner:BOARD OF RGT THE UNIV OF TEXAS SYST
Methods for reducing the side effects associated with mirtzapine treatment
InactiveUS20060122127A1Eliminate side effectsBiocideCarbohydrate active ingredientsDiseaseNorepinephrine reuptake inhibitor
Compositions, and methods of use thereof, are provided for the prevention or treatment of side effects associated with the use of drugs that act as 5HT2 / 5HT3 serotonin receptor antagonists and alpha-2 adrenergic receptor antagonists (5HT2 / 5HT3 antagonist / alpha-2 antagonist). The method involves using dopamine-releasing compounds, such as amantadine, anticonvulsants, such as zonisamide, or dopamine / norepinephrine reuptake inhibitors, such as bupropion, in combination with 5HT2 / 5HT3 antagonist / alpha-2 antagonists, such as mirtazapine, to reduce the excessive daytime drowsiness and / or weight gain associated with 5HT2 / 5HT3 antagonist / alpha-2 antagonist use for the treatment of disorders, such as, depression, schizophrenia, anxiety disorders, sleep-related breathing disorders, insomnia, migraine headache, chronic tension-type headache, hot flashes, lower back pain, neuropathic pain and functional somatic syndromes. Formulations of dopamine-releasing compounds or anticonvulsants with 5HT2 / 5HT3 antagonist / alpha-2 antagonists are provided. In particular embodiments, combination therapy with mirtazapine and zonisamide provides relief from chronic low back pain, while reducing or avoiding side effects associated with monotherapy with mirtazapine or zonisamide.
Owner:CYPRESS BIOSCI
Estrogen receptor modulators
The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to estrogen functioning including: bone loss, bone fractures, osteoporosis, cartilage degeneration, endometriosis, uterine fibroid disease, hot flashes, increased levels of LDL cholesterol, cardiovascular disease, impairment of cognitive functioning, cerebral degenerative disorders, restenosis, gynecomastia, vascular smooth muscle cell proliferation, obesity, incontinence, and cancer, in particular of the breast, uterus and prostate.
Owner:MERCK SHARP & DOHME CORP
Articles having enhanced reversible thermal properties and enhanced moisture wicking properties to control hot flashes
InactiveUS20080233368A1Improve breathabilityIncrease flexibilityLayered productsFibre treatmentPliabilityHot flash
A coated article for providing a phased response to rapid temperature changes, comprises a substrate and a coating disposed on a portion of the substrate. The coating comprises a polymeric material, a first temperature regulating material having a transition temperature between 22° C. and 50° C. and disposed within a first plurality of microcapsules, and a second temperature regulating material having a transition temperature between 25° C. and 45° C. and disposed within a second plurality of microcapsules. The first temperature regulating material and the second temperature regulating material are dispersed in the polymeric material. The coating includes a plurality of regions of discontinuity formed by the coating that create exposed portions of the substrate to provide improved flexibility and air permeability to the coated article and wherein the coating provides a buffered response to rapid temperature changes.
Owner:OUTLAST TECH LLC
Selective estrogen receptor modulators
InactiveUS7157604B2Urea derivatives preparationBiocideHormone Receptor ModulatorsPercent Diameter Stenosis
The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to estrogen functioning including: bone loss, bone fractures, osteoporosis, cartilage degeneration, endometriosis, uterine fibroid disease, hot flashes, increased levels of LDL cholesterol, cardiovascular disease, impairment of cognitive functioning, cerebral degenerative disorders, restenosis, gynecomastia, vascular smooth muscle cell proliferation, obesity, incontinence, and cancer, in particular of the breast, uterus and prostate.
Owner:MERCK & CO INC
Benzopyranone compounds, compositions thereof, and methods of treatment therewith
Benzopyranone compounds having the following structure: wherein R1, X, Y and n are as defined here, are disclosed. The compounds of formula (I), wherein R1 is H, can be prepared by demethylation of the corresponding phenolic methyl ether. The compounds are useful for treating a bone-resorbing disease, cancer, arthritis or an estrogen-related condition such as breast cancer, osteoporosis, endometriosis, cardiovascular disease, hypercholesterolemia, prostatic hypertrophy, prostatic carcinomas, obesity, hot flashes, skin effects, mood swings, memory loss, and adverse reproductive effects associated with exposure to environmental chemicals or natural hormonal imbalances.
Owner:SIGNAL PHARMA LLC +1
Antipyretic compositions and methods
InactiveUS20060100263A1Prevent hyperthermiaReducing elevated body temperatureBiocideNervous disorderSurgical removalFebrile seizure
Methods and compositions containing bicifadine are provided for the treatment and prevention of hyperthermia in mammalian subjects. The methods and compositions may be used to prevent or treat fever, pyresis, menopausal hot flashes; peri menopausal hot flashes, postmenopausal hot flashes, hot flashes caused by anti-estrogen therapy, hot flashes secondary to surgical removal of estrogen producing tissue, hot flashes caused by radiation therapy, malignant hyperthermia, serotonin syndrome, heat stroke, febrile seizures, and neuroleptic malignant syndrome, among other conditions. Additional compositions and methods are provided employing bicifadine to treat pyresis and simultaneously elicit an analgesic response in mammalian subjects. Yet additional compositions and methods are provided which employ bicifadine in combination with a second antipyretic agent, a second analgesic agent, or a different therapeutic agent to yield more effective antipyretic treatment tools, and / or dual activity therapeutic methods and formulations useful to prevent or reduce hyperthermia and one or more additional symptoms (e.g., pain, or depression) in mammalian subjects.
Owner:DOV PHARMA
Use of amino acids for treatment of various conditions
InactiveUS20060094785A1Effective treatmentImprove toleranceOrganic active ingredientsBiocidePhysiologyAlloisoleucine
A method of treating a patient for a condition characterized by symptoms that can be alleviated by interfering with or supplementing the activity of endogenous ligands on the a2S subunit of a voltage gated calcium channel, said method comprising: administering to a patient experiencing the condition an amount of one or more of L-norleucine, L-isoleucine, L-alloisoleucine, L-methionine, Lleucine, 2-cyclohexylglycine, 2-phenylglycine, 2-amino-2-norbornane carboxylic acid, 1-aminocyclohexane carboxylic acid, 2-aminoheptanoic acid, 2-aminocaprylic acid, and 2-aminononanoic acid under conditions effective to treat the condition, wherein when the condition is a hot flash or a symptom of hormonal variation, the compound is not L-leucine.
Owner:UNIVERSITY OF ROCHESTER
Treatment of hot flashes, impulse control disorders and personality change due to a general medical condition
Selective norepinephrine reuptake inhibitors are useful for the prevention or treatment of hot flashes, vasomotor symptoms, impulse control disorders or personality change due to a general medical condition.
Owner:ELI LILLY & CO
Skin cooling composition
InactiveUS20090110656A1Cosmetic preparationsHydroxy compound active ingredientsSkin coolingPhysical exhaustion
A cooling composition for application to the skin of a mammal, such as a human. The base of the composition is an interpenetrating polymer network, which may contain a thermo-responsive polymer. Having a Critical Temperature above an average core body temperature, the material may undergo a phase change as the creature becomes too warm, such as when a person experiences a hot flash, a fever, exposure to very warm environments, physical exertion, and the like. The phase change results in a cooling and / or cooling sensation of the skin. Additives may be included in the cooling composition such as evaporative cooling components, neurosensory cooling components, and additional phase change components.
Owner:KIMBERLY-CLARK WORLDWIDE INC
Estrogen receptor modulators
The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to estrogen functioning including: bone loss, bone fractures, osteoporosis, cartilage degeneration, endometriosis, uterine fibroid disease, hot flashes, increased levels of LDL cholesterol, cardiovascular disease, impairment of cognitive functioning, cerebral degenerative disorders, restenosis, gynecomastia, vascular smooth muscle cell proliferation, obesity, incontinence, and cancer, in particular of the breast, uterus and prostate.
Owner:MERCK & CO INC
Pharmaceutical compositions
ActiveUS20090054383A1Achieve beneficial effectPrevent adverse side effectsBiocideOrganic active ingredientsDiseaseEstrogenic Effects
Novel methods for treating or reducing the likelihood of acquiring symptoms or diseases due to the menopause, in postmenopausal women, particularly osteoporosis, vaginal atrophy and dryness, hypogonadism, diminished libido, skin atrophy, connective tissue disease, urinary incontinence, breast, endometrial, ovarian and uterine cancers, hot flashes, loss of muscle mass, insulin resistance, fatigue, loss of energy, aging, physical symptoms of menopause, in susceptible warm-blooded animals including humans involving administration of a sex steroid precursor are disclosed. Said method comprising novel ways of administering and dosing dehydroepiandrosterone (DHEA) in order to take advantage of positive androgenic effects in the vaginal layers lamina propia and / or the layer muscularis, without undesirably causing systemic estrogenic effects in order to avoid the risk of breast and uterine cancer. Pharmaceutical compositions for delivery of active ingredient(s) useful to the invention are also disclosed.
Owner:MYRIEL PHARM LLC
Estrogen receptor modulators
The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to estrogen functioning including: bone loss, bone fractures, osteoporosis, cartilage degeneration, endometriosis, uterine fibroid disease, hot flashes, increased levels of LDL cholesterol, cardiovascular disease, impairment of cognitive functioning, cerebral degenerative disorders, restinosis, gynacomastia, vascular smooth muscle cell proliferation, obesity, incontinence, and cancer, in particular of the breast, uterus and prostate.
Owner:MERCK SHARP & DOHME LLC
Methods of treating hot flashes with formulations for transdermal or transmucosal application
ActiveUS20080025920A1Undesirable effectEfficient productionOrganic active ingredientsAerosol deliveryOestradiol levelLong chain fatty acid
The present invention relates generally to methods for treating hot flashes by administering formulations for transdermal or transmucosal administration of estrogen. The formulations of the invention are effective at treating hot flashes at surprisingly low daily doses, preferably the lowest effective dose of estrogen to treat hot flashes, e.g., about 0.45 to about 0.6 mg of estrogen per day. The amount of estrogen which is administered produces an estimated nominal daily estrogen dose in a subject undergoing treatment of from about 10 to about 15 micrograms, and a serum estradiol level of between about 25 pg / ml to about 50 pg / ml. The preferred formulations are substantially free of malodorous, and irritation causing long-chain fatty alcohols, long-chain fatty acids, and long-chain fatty esters.
Owner:ANTARES PHARMA IPL
Compositions comprising 5-alpha reductase inhibitors and SERMs and methods of use thereof
InactiveUS20060019989A1Reduce development riskSuppress and inhibit and reduce riskBiocideMetabolism disorder5 Alpha-Reductase InhibitorGynecomastia
This invention provides for combinations of 5 alpha reductase inhibitors and SERMs. These combinations are useful in: 1) preventing prostate carcinogenesis in a subject; 2) preventing the recurrence of, suppressing, inhibiting or reducing the incidence of prostate carcinogenesis in a subject; 3) treating a subject with prostate cancer; 4) suppressing, inhibiting or reducing the incidence of prostate cancer in a subject; 5) treating a subject with pre-malignant lesions of prostate cancer; 6) suppressing, inhibiting or reducing the incidence of pre-malignant lesions of prostate cancer in a subject; 7) reducing the incidence, inhibiting, suppressing, preventing and / or treating androgen-deprivation induced conditions in men suffering from prostate cancer, such as androgen-deprivation induced osteoporosis, bone fractures, loss of bone mineral density (BMD), hot flashes and / or gynecomastia; and 8) treating polycystic ovarian syndrome and reducing the incidence, inhibiting, suppressing, preventing and / or treating diabetes, cardiovascular disease, breast cancer and endometrial cancer in women suffering from polycystic ovarian syndrome.
Owner:GTX INCORPORATED
Heteroatom containing tetracyclic derivatives as selective estrogen receptor modulators
The present invention is directed to novel heteroatom containing tetracyclic derivatives, pharmaceutical compositions containing them, their use in the treatment and / or prevention of disorders mediated by one or more estrogen receptors and processes for their preparation. The compounds of the invention are useful in the treatment and / or prevention of disorders associated with the depletion of estrogen such as hot flashes, vaginal dryness, osteopenia and osteoporosis; hormone sensitive cancers and hyperplasia of the breast, endometrium, cervix and prostate; endometriosis, uterine fibroids, osteoarthritis and as contraceptive agents, alone or in combination with a progestogen or progestogen antagonist.
Owner:KANOJIA RAMESH M +4
Substituted aryloxypropylamines with serotoninergic and/or norepinephrinergic activity
Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts and prodrugs thereof, for the treatment and / or management of psychotropic disorders, anxiety disorder, generalized anxiety disorder, depression, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, hot flashes, senile dementia, migraine, hepatopulmonary syndrome, chronic pain, nociceptive pain, neuropathic pain, painful diabetic retinopathy, bipolar depression, obstructive sleep apnea, psychiatric disorders, premenstrual dysphoric disorder, social phobia, social anxiety disorder, urinary incontinence, anorexia, bulimia nervosa, obesity, ischemia, head injury, calcium overload in brain cells, drug dependence, and / or premature ejaculation are described.
Owner:AUSPEX PHARMA INC
Apparatus and method for applying cooling substances to pressure points in the human body
InactiveUS20050240251A1Effectively combat effectImprove thermal conductivityTherapeutic coolingTherapeutic heatingHuman bodyHot flashes/flushes
A mechanism and method is presented for applying a cool object to various pressure points of the body to relieve the effects of hot flashes. In particular, the present invention involves cooling small internal sacks in a freezer, removing them when a hot flash occurs, placing the sacks in larger external pouches and then attaching the pouches to either a bracelet or watch around the wrist or a necklace such that the cool pouches can provide relief to the pressure points on the inside of the wrist, ankles or the back of the neck. Application of the cold pouches to these pressure points provides relief from the effects of hot flashes.
Owner:SMITH DEBORAH A
Treatment of vasomotor symptoms with selective estrogen receptor modulators
ActiveUS8933130B2Reduce and eliminate symptomBiocideAmide active ingredientsVasomotor symptomMedicine
The present invention is directed toward methods for treating vasomotor symptoms, (e.g., hot flashes and night sweats) in a patient in need thereof comprising administering a SERM as described herein.
Owner:RADIUS PHARMA INC
Selective estrogen receptor modulators for the treatment of vasomotor symptoms
Owner:ELI LILLY & CO
4-((4-(2-pyrrolidinylethoxy)phenyl)methyl)-3-(4-(trifluoromethyl)phenyl)-7-hydroxychromen-2one, pharmaceutically acceptable salts thereof and methods of use therewith
Benzopyranone compounds having the following structure: wherein R1, X, Y and n are as defined here, are disclosed. The compounds of formula (I), wherein R1 is H, can be prepared by demethylation of the corresponding phenolic methyl ether. The compounds are useful for treating a bone-resorbing disease, cancer, arthritis or an estrogen-related condition such as breast cancer, osteoporosis, endometriosis, cardiovascular disease, hypercholesterolemia, prostatic hypertrophy, prostatic carcinomas, obesity, hot flashes, skin effects, mood swings, memory loss, and adverse reproductive effects associated with exposure to environmental chemicals or natural hormonal imbalances.
Owner:MCKIE JEFFREY A +1
Method for Treating Hot Flashes Associated with Menopause During Sleep
InactiveUS20100204764A1Relieve symptomsTherapeutic coolingTherapeutic heatingMedicineHot flashes/flushes
A method and device for automatically detecting the onset of a hot flash while the subject is sleeping, and of cooling the subject using a cold fluid circulating through a vest or a mattress pad, before sweating and / or chills develop and awaken the subject. A temperature sensor is attached to the subject's skin, and is connected to a computer or microprocessor. The subject dons a vest that is connected to a coolant circulation system. Alternatively, the subject lies on a mattress pad that is connected to a coolant circulation system. During the night, if the subject's skin temperature rises more than a predetermined amount within a time period, or rises above a predetermined threshold temperature, the coolant circulation system is activated for a fixed period of time. The cooled vest or pad helps to draw heat away from the subject's skin and thus reduce the symptoms of the hot flash. After the circulation terminates, the system is reset to monitor the skin temperature once again. The cycle can be repeated any number of times during the night. Instead of a temperature sensor, a humidity sensor can also be used.
Owner:POLYTECHNIC INSTITUTE OF NEW YORK UNIVERSITY
Methods of treating hot flashes with formulations for transdermal or transmucosal application
ActiveUS8268346B2Efficient productionUndesirable effectOrganic active ingredientsAerosol deliveryLong chain fatty acidPhysiology
Owner:ANTARES PHARMA IPL
Furan-azo- [3,2-g] chromene compound and application thereof
ActiveCN101805349AEasy to prepareHigh yieldSenses disorderOrganic chemistryFuranHormone Receptor Modulators
The invention relates to a furan-azo-[3,2-g] chromene derivative and application thereof, belonging to the technical field of medicine. The furan-azo-[3,2-g] chromene derivative comprises stereoisomers and pharmaceutically applicable salts of a compound of the furan-azo-[3,2-g] chromene derivative and has a structural general formula shown in the specification of the invention. The furan-azo-[3,2-g] chromene derivative and pharmaceutically applicable acid addition salts of the compound can be used as an estrogen receptor regulator singly or by combining with traditional drugs to treat or prevent various diseases related to estrogen functions, such as bone loss, fracture, osteoporosis, hot flash, LDL (Low Density Lipoprotein) cholesterol level rise, angiocardiopathy, cognitive function impairment, brain-wasting diseases, anxiety, depression caused by estrogen shortage, inflammation, inflammatory bowel diseases, sexual dysfunction, hypertension, retinosis and cancer, especially breast cancer, ovarian cancer, osteosarcoma, endometrial cancer and prostatic cancer.
![Furan-azo- [3,2-g] chromene compound and application thereof](https://images-eureka.patsnap.com/patent_img/8316c59b-abe5-47b6-856d-fdeaf1018ef7/DSA00000085333600011.PNG "Furan-azo- [3,2-g] chromene compound and application thereof")
![Furan-azo- [3,2-g] chromene compound and application thereof](https://images-eureka.patsnap.com/patent_img/8316c59b-abe5-47b6-856d-fdeaf1018ef7/FSA00000085333700011.PNG "Furan-azo- [3,2-g] chromene compound and application thereof")
![Furan-azo- [3,2-g] chromene compound and application thereof](https://images-eureka.patsnap.com/patent_img/8316c59b-abe5-47b6-856d-fdeaf1018ef7/GSA00000085333800021.PNG "Furan-azo- [3,2-g] chromene compound and application thereof")
Owner:SHENYANG PHARMA UNIV
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