11 results about "Nitrone" patented technology

The invention discloses an application of nitrone compounds in preparation of related products for improving athletic ability. The nitrone compound disclosed by the invention has a structure shown in a general formula (I), and experimental results show that the nitrone compound disclosed by the invention can be used for increasing the exercise capability of nematodes of different age groups, including the body swing frequency and the pharyngeal pumping rate.

The application discloses application of a nitro compound in preparation of products prolonging life, and the nitro compound has the structure shown in the following general formula (I). The application takes Caenorhabditis elegans as an object, and studies influence of TBN on life and health indexes of the Caenorhabditis elegans. Experimental results show that the TBN prolongs the life of the Caenorhabditis elegans, significantly improves pharyngeal pumping rate and movement ability of the Caenorhabditis elegans, and significantly reduces lipofuscin accumulation degree of the Caenorhabditis elegans.

The invention relates to fluorine-containing isoxazolidine-5-ketone as well as a synthesis method and anti-tumor application thereof. According to the synthesis method, gem-difluorocycloacrylimide and nitrone are taken as substrates, Ni (ClO4) 2.6 H2O is taken as a catalyst, (+ / -)-2, 2 '-(propane-2, 2-diyl) bis (4-phenyl-4, 5-dihydrooxazole) is taken as a ligand (L) in an organic solvent, cycloaddition isomerization reaction is carried out at about 30 DEG C, and the fluorine-containing isoxazolidine-5-ketone compound is obtained. And the fluorine-containing isoxazolidine-5-ketone is obtained through preparation. The method is mild in reaction condition, capable of being well compatible with various functional groups and high in yield, and the product further has certain biological activity and can inhibit proliferation of cancer cells. The invention discloses the realization of the cycloisomerization reaction of the gem-difluorocyclopropene and the nitrone for the first time, provides a new idea for the synthesis of the fluorine-containing isoxazolidine-5-ketone and the derivative thereof, and has a good application prospect in the fields of medicines and synthesis.

The invention discloses application of a nitrone compound in preparation of a product for prolonging the service life, the nitrone compound has a structure as shown in the following general formula (I), caenorhabditis elegans is taken as an object, and the influence of TBN on the service life of the caenorhabditis elegans is researched; experimental results show that the TBN can significantly prolong the service life of caenorhabditis elegans.

The application discloses a preparation method of adamantane nitroketone derivatives and application of the adamantane nitroketone derivatives in ischemic stroke drugs. The adamantane nitroketone derivatives are combined by 2,3,5,6-tetramethylpyrazine and adamantane compounds through nitroketone. The compound not only has strong free radical scavenging capacity, but also integrates the nerve protection function of the adamantane compound.

The invention discloses a copper monatomic catalyst with stable N-heterocyclic carbene as well as a preparation method and application of the copper monatomic catalyst with stable N-heterocyclic carbene. According to the method, construction of a porous organic polymer carrier and anchoring of metal monatomic active sites are innovatively combined, and the copper monatomic catalyst with stable N-heterocyclic carbene is prepared through a one-pot mechanical grinding strategy. A triazine compound, a nitrogen-containing heterocyclic compound, a copper salt and alkali directly react under the assistance of no solvent or a trace amount of solvent, and the catalyst POP-n-NHC-CuX (n = I-IV, X = Cl, Br or I) is obtained through in-situ synchronous synthesis. In the obtained catalyst, copper atoms are stably anchored on a polymer skeleton in a coordination bond form through an NHC ligand to form atomic-scale dispersed active sites. The catalyst can efficiently catalyze the conversion reaction of CO2 and propargyl alcohol and derivatives thereof under mild conditions, is suitable for synthesizing various high value-added chemicals including alpha-alkylene cyclic carbonate, oxazolidinone and beta-oxypropyl carbamate, and shows excellent catalytic cycle stability and substrate universality.

There is provided a polymer system for producing a hydrogel. The system has two components. A first component comprising a first synthetic polymer and a gel former and a second component comprising a second synthetic polymer. The first synthetic polymer is functionalized with a first click chemistry group and the second synthetic polymer is functionalized with a second click chemistry group that reacts with the first click chemistry group to form a covalent link by click chemistry. One of the first click chemistry group or the second click chemistry group comprises a cycloalkene, a heterocycloalkene, a cycloalkyne or a heterocycloalkyne and the other comprises an azide, a tetrazine, a triazine, a pyridazine, an oxime, a nitrone or nitrile-oxide. The gel former has a gelation mechanism that is independent from the click chemistry.

This invention discloses a method for preparing hydroxylamine compounds by reducing nitroketone compounds without a metal catalyst. This method uses benzylsilane as a hydrogen source and toluene as a solvent, requiring no additional metal catalyst. The reduction product is obtained by stirring the reaction at 70–80°C under inert gas protection and a closed system. This invention employs a metal catalyst-free system for the reduction of nitroketone compounds, offering advantages such as low cost, mild reaction conditions, and high selectivity. It avoids the use of special equipment such as hydrogen and autoclaves, as well as excessive sodium borohydride reducing agents.

Disclosed herein are nitrones that are capable of forming 4-isoxazoline compounds by strain-promoted alkyne-nitrone cycloaddition (SPANC), which have improved stability. The 4-isoxazoline compounds do not disintegrate by rearrangement into two molecules. The nitrone compounds disclosed herein are suitable for preparing bioconjugates by SPANC reaction. Also disclosed herein are the thus obtained bioconjugates, as well as the application thereof in targeting cells and treating cancer.

Provided is use of a nitrone compound in the preparation of a product for preventing or treating side effects caused by anti-obesity drugs. Animal experiments have found that combined use of the nitrone compound with glucagon-like peptide-1 drugs does not affect the ability of the glucagon-like peptide-1 drugs to reduce the fat mass of mice, and can also resist / weaken the side effects caused by the glucagon-like peptide-1 drugs. Moreover, after the use of the glucagon-like peptide-1 drugs is stopped, the continuous administration of the nitrone compound can also delay the speed of body weight rebound after drug withdrawal, especially the speed of fat mass rebound. The nitrone compound can effectively prevent or treat the side effects caused by the glucagon-like peptide-1 drugs, and thus has important clinical significance.

The invention belongs to the technical field of medicines, and discloses a magnolol / honokiol nitrone derivative as well as a preparation method, a pharmaceutical composition and application thereof. Specifically, the invention discloses magnolol / honokiol nitrone derivatives as shown in a general formula I and a general formula II. The derivatives are prepared in an artificial synthesis mode, pharmaceutical compositions containing the derivatives and application of the derivatives in the anti-inflammatory aspect.