The invention relates to a tetramethylpyrazine substituted p-hydroxybenzyl alcohol analog derivative (LQC-F) having neuroprotection activity, and applications thereof, and provides a class of tetramethylpyrazine substituted p-hydroxybenzyl alcohol analog derivatives having a structure general formula 1, wherein the compound comprises a p-hydroxybenzyl alcohol analog mother nucleus and a substituent containing a tetramethylpyrazine structure, the structure general formula is represented by the formula 1, R1 is any one selected from -OH, -NH2, 3,5,6-trimethyltetramethylpyrazine-2-methyleneoxy, 3,5,6-trimethyltetramethylpyrazine-2-formyloxy and 3,5,6-trimethyltetramethylpyrazine-2-formamide, R2 is any one selected from -H and -OCH3, R3 is any one selected from -OH, 3,5,6-trimethyltetramethylpyrazine-2-methylene and 3,5,6-trimethyltetramethylpyrazine-2-formyl, at least one of R1-R3 is a substituent containing a tetramethylpyrazine structure, and n is 1 or 2. The invention further providesa preparation method of the derivative, and applications of the derivative in preparation of drugs for treatment of brain nerve injury and sequela thereof. The formula 1 is defined in the specification.