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58results about How to "Decreased substances" patented technology

Injection-purpose medicine composition for improving stability of ligustrazine medicine injection formulation and preparation method of injection-purpose medicine composition

The invention discloses an injection-purpose medicine composition for improving stability of ligustrazine medicine injection formulation and a preparation method of the injection-purpose medicine composition. The injection-purpose medicine composition is prepared by the method comprising following steps: dissolving ligustrazine salt in water for injection, adjusting the pH value of the liquid medicine by adding citric acid and / or sodium citrate used as a pH regulator, wherein the dosage of the citric acid and / or sodium citrate ranges from (0.1mg to 200.0mg) / 100ml. In the invention, pH value of the injection liquid can be more stable, the content of ligustrazine degradation substance is greatly reduced compared with that of the prior art, the clarity of the ligustrazine injection liquid is improved under the condition of not using other cosolvents to increase the clinical application risk, particularly, the problems of small white spots, white blocks and solution turbidity are solved under the condition that the ligustrazine injection liquid is stored for a long time by adopting the prior art, and the medicine composition ensures that the inspection of visible foreign substances of the product is in accordance to the formulation of medicine quality standard, and is convenient for clinical medication and popularization.
Owner:SICHUAN SUNNYHOPE PHARM CO LTD

Container and one-way valve assembly for strong and dispensing substances, and related method

A device for storing and dispensing a substance includes a container having a body defining therein a storage chamber for receiving and storing the substance. The container includes a first passageway that is in fluid communication with the storage chamber of the body and defines a flow path therebetween. The container also includes a pierceable wall located on an opposite side of the first passageway relative to the storage chamber, and a first threaded connecting portion located at one end of the body for connecting another component thereto. The device also includes a one-way valve assembly that includes a valve body including a body base defining a second passageway and a piercing portion mounted within the valve body and engageable with the pierceable wall of the container. At least one of the piercing portion and the pierceable wall is movable relative to the other between a first position wherein the pierceable portion is not piercing the pierceable wall, and a second position wherein the pierceable portion is piercing the pierceable wall and the first passageway of the container is in fluid communication with the second passageway of the valve body for allowing the flow of substance from the storage chamber therethrough. The valve assembly includes a second threaded connecting portion that is threadedly connectable to the first threaded connecting portion of the container for fixedly securing the valve assembly to the container when the valve assembly and container are located in the second position. A manually-engageable and removable member is disposed intermediate the valve body and the container that prevents movement of at least one of the piercing portion and pierceable wall to the second position until the removable member is removed. The valve assembly includes a valve seat and at least one flow aperture extending through the valve body adjacent to the valve seat and in fluid communication with the second passageway for receiving the substance from the storage chamber there through.
Owner:MAEJ LLC ODONNELL & TESSITORE

Preparation method of injection medicine for improving stability of quercetin medicine injection preparation

The invention discloses an injection medicine composition for improving the stability of a quercetin medicine injection preparation, and a preparation method thereof. The injection medicine composition is an injection medicine composition mainly prepared by dissolving salt of quercetin into injection water and adding citric acid and/or sodium citrate as pH regulators to regulate the pH value of medicine liquid. The consumption of the citric acid and/or sodium citrate is 0.1mg to 200.0mg/100ml. The injection medicine composition has the advantages that the pH value of the injection liquid is more stable; the quercetin degradation substances are greatly reduced through being compared with that in the prior art; under the condition of not using other solutizers increasing the clinic application risks, the clarity of the quercetin injection liquid is improved; the problems of small white points, white blocks and solution turbidity of a product of the quercetin injection liquid in the prior art under the condition of long storage time are particularly solved; the visible foreign matter inspection of the product is enabled to conform to the specification of the medicine quality standard; the clinic medication and popularization are convenient.
Owner:CHENGDU YICHUANGSI BIOLOGICAL SCI & TECH

Injection pharmaceutical composition for improving stability of rhizoma dioscoreae nipponicae drug injection preparation

The invention discloses an injection pharmaceutical composition for improving stability of a rhizoma dioscoreae nipponicae drug injection preparation. The injection pharmaceutical composition is mainly prepared by dissolving an extracting solution of rhizoma dioscoreae nipponicae in water, and regulating pH value of medicine liquid with the addition of formic acid and/or sodium formate which serves as a pH regulator, wherein the dosage of the formic acid and/or the sodium formate is 1-3g/100ml. According to the injection pharmaceutical composition disclosed by the invention, the stability of the pH value of the injection (the injection pharmaceutical composition) is enhanced, the content of rhizoma dioscoreae nipponicae degradable substances is greatly reduced in comparison with the prior art, and the clarity of the rhizoma dioscoreae nipponicae injection is improved under the circumstance of avoiding the use of other cosolvents which can increase the risk of clinical application; especially, the problems of the prior art that small white spots, white plaques and solution turbidity easily occur in a finished rhizoma dioscoreae nipponicae injection product can be solved; the obvious foreign matter inspection of the product (the injection pharmaceutical composition) can conform to the specifications of drug quality standard; and the injection pharmaceutical composition is convenient for clinical medication and popularization.
Owner:成都佳迪璐莎生物科技有限公司
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