4 results about "Drug standards" patented technology

The invention discloses an indobufen intermediate compound as well as a preparation method and application thereof. The structure of the indobufen intermediate compound is shown as a formula (I). The synthesis method of the compound comprises the following steps: reacting a compound 4 with a compound 5 to obtain a compound 6, reacting a compound 7 with a compound 8 to obtain a compound 9, and further reacting the compound 6 with the compound 9 to obtain the compound shown in the formula (I). The compound can be used for qualitative and quantitative analysis of impurities in the production process of indobufen, is beneficial to promoting improvement of standard quality of indobufen drugs, and further guarantees medication safety of indobufen. Meanwhile, research on the compound shown in the formula (I) shows that the compound has good effects in the aspects of analgesia, fever abatement and inflammation diminishing. Formula (I).

The invention discloses a drug identification and curative effect analysis method based on a large model and multi-round treatment data. Comprising the following steps: firstly, giving multiple rounds of doctor seeing records and a disease diagnosis and treatment knowledge base of a patient, and carrying out preprocessing and candidate medicine extraction on text contents to obtain an initial medicine set which is being taken by the patient; thirdly, identifying the drug state to remove invalid drugs, and outputting a drug standard category in combination with disease diagnosis and treatment knowledge base information and large model reasoning ability; if the current doctor-seeing information is lost, automatically backtracking historical doctor-seeing records; through semantic verification and fact check, an accurate and credible recognition result is generated; and finally, according to an identification result, automatically constructing a real world research queue so as to carry out drug curative effect analysis. The method has high accuracy and high clinical adaptability, and large model illusion is avoided. The method is suitable for scenes of chronic disease management, clinical auxiliary decision making, intelligent health follow-up visit, curative effect analysis and the like.

The embodiment of the invention provides an early warning monitoring method and device for a drug standard substance. The method comprises the following steps: acquiring the demand quantity of a target drug standard substance within a preset duration from the current time; determining an early warning period of the target drug standard substance according to the development period of the target drug standard substance; processing the demand quantity by adopting a weighted velocity method to obtain the daily average demand quantity of the target drug standard substance, the daily average demand quantity being used for representing the daily demand quantity of the target drug standard substance; and performing early warning monitoring on the target drug standard substance according to the daily average demand quantity, the stock quantity of the target drug standard substance and the early warning period. According to the embodiment of the invention, the dynamic 100% supply of the whole variety of the drug standard substance can be effectively realized.

The present invention provides a pharmaceutical composition comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and an auxiliary agent comprising one or more fillers, binders, flow promoters, disintegrants, and lubricants, wherein the pharmaceutical composition is prepared for formulation processes, has excellent formulation properties, stability and dissolution, and meets pharmaceutical standards. TIFF2026516804000057.tif46170