8 results about "Drug standards" patented technology

The invention provides a stable alprostadil injection and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations. The stable alprostadil injection comprises the following components: alprostadil, oil for injection, a compound emulsifier, an osmotic pressure regulator and water for injection. According to the invention, a certain amount of soybean phosphatidylinositol is used as an auxiliary emulsifier, and the auxiliary emulsifier and high-purity egg yolk lecithin (for injection) form a composite emulsifier, so that the chemical stability of the product can be remarkably improved, the product can tolerate an over-killing method, the product has a high SAL (Sterile Assurance Language), and the product can be stored for 24 months at a conventional cold chain temperature (2-8 DEG C), and the product quality still meets the national drug standard.

The invention discloses an indobufen intermediate compound as well as a preparation method and application thereof. The structure of the indobufen intermediate compound is shown as a formula (I). The synthesis method of the compound comprises the following steps: reacting a compound 4 with a compound 5 to obtain a compound 6, reacting a compound 7 with a compound 8 to obtain a compound 9, and further reacting the compound 6 with the compound 9 to obtain the compound shown in the formula (I). The compound can be used for qualitative and quantitative analysis of impurities in the production process of indobufen, is beneficial to promoting improvement of standard quality of indobufen drugs, and further guarantees medication safety of indobufen. Meanwhile, research on the compound shown in the formula (I) shows that the compound has good effects in the aspects of analgesia, fever abatement and inflammation diminishing. Formula (I).

The invention discloses an intelligent supervision system and method based on cyclocarya paliurus and poria cocos pharmaceutical composition production, and relates to the technical field of traditional Chinese medicine analysis. The intelligent supervision system based on cyclocarya paliurus and poria cocos pharmaceutical composition production comprises a formula proportion control module, an ingredient standardization module and an auxiliary material additive detection module. According to the invention, proportioning and shunting treatment is carried out on the to-be-produced batch of medicines through the formula proportion control index, then standardized shunting treatment is carried out on the to-be-produced batch of medicines through the medicine standardization evaluation index, and finally auxiliary material shunting treatment is carried out on the to-be-produced batch of medicines through the auxiliary material adding accuracy index. The effect of improving the processing supervision accuracy of the cyclocarya paliurus and poria cocos pharmaceutical composition is achieved, and the problem of inaccurate processing supervision of the cyclocarya paliurus and poria cocos pharmaceutical composition in the prior art is solved.

The invention discloses a drug identification and curative effect analysis method based on a large model and multi-round treatment data. Comprising the following steps: firstly, giving multiple rounds of doctor seeing records and a disease diagnosis and treatment knowledge base of a patient, and carrying out preprocessing and candidate medicine extraction on text contents to obtain an initial medicine set which is being taken by the patient; thirdly, identifying the drug state to remove invalid drugs, and outputting a drug standard category in combination with disease diagnosis and treatment knowledge base information and large model reasoning ability; if the current doctor-seeing information is lost, automatically backtracking historical doctor-seeing records; through semantic verification and fact check, an accurate and credible recognition result is generated; and finally, according to an identification result, automatically constructing a real world research queue so as to carry out drug curative effect analysis. The method has high accuracy and high clinical adaptability, and large model illusion is avoided. The method is suitable for scenes of chronic disease management, clinical auxiliary decision making, intelligent health follow-up visit, curative effect analysis and the like.

The embodiment of the invention provides an early warning monitoring method and device for a drug standard substance. The method comprises the following steps: acquiring the demand quantity of a target drug standard substance within a preset duration from the current time; determining an early warning period of the target drug standard substance according to the development period of the target drug standard substance; processing the demand quantity by adopting a weighted velocity method to obtain the daily average demand quantity of the target drug standard substance, the daily average demand quantity being used for representing the daily demand quantity of the target drug standard substance; and performing early warning monitoring on the target drug standard substance according to the daily average demand quantity, the stock quantity of the target drug standard substance and the early warning period. According to the embodiment of the invention, the dynamic 100% supply of the whole variety of the drug standard substance can be effectively realized.

The invention relates to the field of medicine synthesis, in particular to a synthesis method of tropisetron. Compared with the traditional method, the synthesis method of tropisetron provided by the invention has the advantages that the synthesis route is more efficient, rapid, environment-friendly and mild, and the selectivity is higher. On the basis of the effect of the Pd monatomic catalyst, the Pd monatomic catalyst has good selectivity on indole serving as an N-H substrate, tropisetron with a substituent group being N-H can be synthesized, and the problem that in the prior art, an N-CH3 substituted tropisetron analogue can only be synthesized by taking 1-methylindole serving as an N-CH3 substrate as a raw material is solved. The yield of the synthesized tropisetron is close to 98%, the purity of the product can reach the medication standard of Chinese pharmacopoeia through a simple purification process, and large-scale industrial production is facilitated. The coordination structure of the Pd monatomic catalyst is optimized, the positive valence state of Pd is kept, a C-H bond at the 3-position of indole can be directly activated, I2 and K2CO3 do not need to be additionally added, and no waste residues are generated after the reaction.

The invention provides a method for rapidly screening and confirming 120 anti-infective drugs in cosmetics, which comprises the following steps: preparing a mixed solution of standard substances of 120 anti-infective drugs and a to-be-detected sample solution, adopting a real-time direct analysis ion source to complete the ionization process of a target compound, and adopting a high-resolution mass spectrum to determine the content of 120 anti-infective drugs. And based on a positive ion and negative ion first-level full scanning-data dependence second-level scanning mode, collecting data and processing the data. The invention provides a detection method for rapidly screening 120 anti-infective drugs in cosmetics by real-time direct analysis ion source-high resolution mass spectrometry, the real-time direct analysis ion source-high resolution mass spectrometry is adopted, and compared with a traditional chromatographic separation technology, complex sample pretreatment and time-consuming chromatographic analysis are not needed, and the detection method has the advantages that the detection method is simple and convenient, and the detection cost is low. The method reduces the usage amount of chemical reagents, shortens the test period, avoids the interference of sample matrixes, and can be used for rapid screening of various cosmetic matrixes.

The present invention provides a pharmaceutical composition comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and an auxiliary agent comprising one or more fillers, binders, flow promoters, disintegrants, and lubricants, wherein the pharmaceutical composition is prepared for formulation processes, has excellent formulation properties, stability and dissolution, and meets pharmaceutical standards. TIFF2026516804000057.tif46170