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Traditional Chinese medicine granule for treating postpartum lochiorrhea and lesser-abdominal pain and preparation method thereof

A technology of traditional Chinese medicine granules and postpartum lochia, which is applied in the direction of pharmaceutical formulas, non-central analgesics, medical preparations containing active ingredients, etc. It can solve the problems of reducing drug efficacy, difficulty in drying, and long drying time, etc., and achieves simplification The effect of production process, improvement of product quality, and short extraction time

Inactive Publication Date: 2016-03-02
JIANGSU TIANZHAO PHARMA
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional process of Xinshenghua Granules is to use steam distillation to extract volatile oil and water to extract and concentrate the traditional Chinese medicine preparation directly. The traditional Chinese medicine preparations made directly after water extraction and concentration also have shortcomings: especially in hot and rainy seasons, moisture absorption and hardening are prone to occur in the particles, resulting in prolonged disintegration time and reduced drug efficacy, which is easy to cause in the current preparation process. Softening, melting, and even discoloration of materials, difficulty in drying, long drying time, high hygroscopicity, poor fluidity, uneven powder color, large dosage of excipients, etc., which affect the product quality of Xinhua Granules
At the same time, the main medicinal material base in the preparation - the volatile oil components extracted by steam distillation, without pre-treatment, will also reduce the efficacy due to volatilization, and the quality is not easy to be effectively controlled
In order to improve the above problems, cyclodextrin is used to clathrate the volatile oil, and cyclodextrin is used as an excipient in the granules, and the granules are prepared by spray granulation technology, which overcomes the difficulties of traditional drying, high hygroscopicity, poor fluidity, and drying. Long drying time, uneven powder color, etc., to obtain particles with good fluidity, low water content, uniform size and excellent solubility in a short period of time

Method used

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  • Traditional Chinese medicine granule for treating postpartum lochiorrhea and lesser-abdominal pain and preparation method thereof
  • Traditional Chinese medicine granule for treating postpartum lochiorrhea and lesser-abdominal pain and preparation method thereof
  • Traditional Chinese medicine granule for treating postpartum lochiorrhea and lesser-abdominal pain and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0056] 240g of angelica, 90g of chuanxiong, 24g of peach kernel, 15g of roasted licorice, 15g of ginger charcoal, 300g of dried motherwort, and 15g of safflower are weighed as raw materials of Chinese medicinal materials. Prepare according to the following steps: take angelica, chuanxiong, peach kernel, roasted licorice, ginger charcoal, dried motherwort, and safflower 7 decoction pieces, grind them into coarse powder, and use microwave method to extract volatile oil: add appropriate amount of water to the coarse powder of medicinal materials and soak for 12 hours. In the continuous microwave reactor, add several glass beads, connect the volatile oil measuring device and the reflux condenser, and prepare the mixed volatile oil cyclodextrin inclusion compound by the colloid milling method for the extracted volatile oil, wherein the mixed volatile oil: cyclodextrin (1:4, v / m), cyclodextrin: water (1:10, m / v), use a colloid mill at 40-55°C for 40 minutes, refrigerate the grinding ...

Embodiment 2

[0058] 240g of angelica, 90g of chuanxiong, 24g of peach kernel, 15g of roasted licorice, 15g of ginger charcoal, 300g of dried motherwort, and 15g of safflower are weighed as raw materials of Chinese medicinal materials. Prepare according to the following steps: take angelica, chuanxiong, peach kernel, roasted licorice, ginger charcoal, dried motherwort, and safflower 7 decoction pieces, grind them into coarse powder, and use microwave method to extract volatile oil: add appropriate amount of water to the coarse powder of medicinal materials and soak for 12 hours. In the continuous microwave reactor, add several glass beads, connect the volatile oil measuring device and the reflux condenser, and prepare the mixed volatile oil cyclodextrin inclusion compound by the colloid milling method for the extracted volatile oil, wherein the mixed volatile oil: cyclodextrin (1:5, v / m), cyclodextrin: water (1:12, m / v), use a colloid mill for inclusion at 45°C for 50 minutes, refrigerate th...

Embodiment 3

[0060] 240g of angelica, 90g of chuanxiong, 24g of peach kernel, 15g of roasted licorice, 15g of ginger charcoal, 300g of dried motherwort, and 15g of safflower are weighed as raw materials of Chinese medicinal materials. Prepare according to the following steps: take angelica, chuanxiong, peach kernel, roasted licorice, ginger charcoal, dried motherwort, and safflower 7 decoction pieces, grind them into coarse powder, and use microwave method to extract volatile oil: add appropriate amount of water to the coarse powder of medicinal materials and soak for 12 hours. In the continuous microwave reactor, add several glass beads, connect the volatile oil measuring device and the reflux condenser, and prepare the mixed volatile oil cyclodextrin inclusion compound by colloid milling method for the extracted volatile oil, wherein the mixed volatile oil: cyclodextrin (1:8, v / m), cyclodextrin: water (1:15, m / v), use a colloid mill at 55°C for 80 minutes, refrigerate the grinding liquid ...

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Abstract

The invention provides a traditional Chinese medicine granule for treating postpartum lochiorrhea and lesser-abdominal pain and a preparation method thereof, and belongs to the field of medicine. The granule and the preparation method overcome the defects that according to an existing preparation method, the volatile oil extraction rate is low, the utilization rate is low, losses of effective components of medicine materials are large, particle appearance is not good, and dissolubility is poor. The preparation method includes the steps that seven decoction pieces of angelica sinensis, rhizome chuanxiong, peach kernels, honey-fried licorice roots, ginger charcoal, dried leonurus and safflower are obtained according to the formula of new granule for postpartm troubles (the fifth volume of drug standard traditional Chinese medicine prescription preparation of Ministry of Health of the People's Republic of China), the materials are smashed into coarse powder to extract volatile oil through a microwave method, a mixed volatile oil cyclodextrin clathrate compound is prepared through a colloid milling method, residues are decocted twice with water, decocted liquid of the first time and decocted liquid of the second time are combined and filtered, filter liquid is refrigerated, supernate is sucked to be subjected to centrifugation twice through a tubular centrifugal machine, then supernate is decompressed and concentrated to be clear ointment with the relative density being 1.05-1.30 (60 DEG C), the clear ointment is added into the cyclodextrin clathrate compound and evenly mixed into suspension, the suspension is sprayed, granulated, screened and subpackaged, and the granule is obtained. The invention further discloses application of novel particles for postpartm troubles in the aspect of treatment of climacteric syndromes.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine pharmacy, and in particular relates to traditional Chinese medicine granules for treating postpartum lochia and abdominal pain and a preparation method thereof. Background technique [0002] Shenghua Decoction first appeared in the postpartum chapter of "Fu Qingzhu Gynecology", and it is Fu's main prescription for treating postpartum syndromes. Fu believes that "you should take Shenghua decoction frequently for all syndromes of postpartum emergency, and add or subtract according to the syndrome." , how can it catch the blood that is about to die, and help the critical disease? Shenghua decoction plus Sanleng, curcuma, cinnamon, etc. must be used to attack and tonify, and the clots will disappear on their own"; "only Shenghua decoction is the holy medicine for blood clots". The above points out that Shenghua decoction can treat postpartum syndromes. All diseases start from the decline o...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61K9/16A61K47/40A61P15/00A61P29/00A61P15/12
Inventor 孙大正沈玉红吴彩玲席保玲黄胜良
Owner JIANGSU TIANZHAO PHARMA
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