Traditional Chinese medicine granule for treating postpartum lochiorrhea and lesser-abdominal pain and preparation method thereof

Abstract

The invention provides a traditional Chinese medicine granule for treating postpartum lochiorrhea and lesser-abdominal pain and a preparation method thereof, and belongs to the field of medicine. The granule and the preparation method overcome the defects that according to an existing preparation method, the volatile oil extraction rate is low, the utilization rate is low, losses of effective components of medicine materials are large, particle appearance is not good, and dissolubility is poor. The preparation method includes the steps that seven decoction pieces of angelica sinensis, rhizome chuanxiong, peach kernels, honey-fried licorice roots, ginger charcoal, dried leonurus and safflower are obtained according to the formula of new granule for postpartm troubles (the fifth volume of drug standard traditional Chinese medicine prescription preparation of Ministry of Health of the People's Republic of China), the materials are smashed into coarse powder to extract volatile oil through a microwave method, a mixed volatile oil cyclodextrin clathrate compound is prepared through a colloid milling method, residues are decocted twice with water, decocted liquid of the first time and decocted liquid of the second time are combined and filtered, filter liquid is refrigerated, supernate is sucked to be subjected to centrifugation twice through a tubular centrifugal machine, then supernate is decompressed and concentrated to be clear ointment with the relative density being 1.05-1.30 (60 DEG C), the clear ointment is added into the cyclodextrin clathrate compound and evenly mixed into suspension, the suspension is sprayed, granulated, screened and subpackaged, and the granule is obtained. The invention further discloses application of novel particles for postpartm troubles in the aspect of treatment of climacteric syndromes.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine pharmacy, and in particular relates to traditional Chinese medicine granules for treating postpartum lochia and abdominal pain and a preparation method thereof. Background technique [0002] Shenghua Decoction first appeared in the postpartum chapter of "Fu Qingzhu Gynecology", and it is Fu's main prescription for treating postpartum syndromes. Fu believes that "you should take Shenghua decoction frequently for all syndromes of postpartum emergency, and add or subtract according to the syndrome." , how can it catch the blood that is about to die, and help the critical disease? Shenghua decoction plus Sanleng, curcuma, cinnamon, etc. must be used to attack and tonify, and the clots will disappear on their own"; "only Shenghua decoction is the holy medicine for blood clots". The above points out that Shenghua decoction can treat postpartum syndromes. All diseases start from the decline o...

AI Technical Summary

Problems solved by technology

The traditional process of Xinshenghua Granules is to use steam distillation to extract volatile oil and water to extract and concentrate the traditional Chinese medicine preparation directly. The traditional Chinese medicine preparations made directly after water extraction and concentration also have shortcomings: especially in hot and rainy seasons, moisture absorption and hardening are prone to occur in the particles, resulting in prolonged disintegration time and reduced drug efficacy, which is easy to cause in the current preparation process. Softening, melting, and even discoloration of materials, difficulty in drying, long drying time, high hygroscopicity, poor fluidity, uneven powder color, large dosage of excipients, etc., which affect the product qua

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