63 results about "Drug extraction" patented technology

The utility model discloses a multi-station perfluorohexanone quantitative filling system which comprises a filling operation table, a filling station area, a nitrogen drying device and a medicament extraction assembly. The utility model further discloses a multi-station perfluorohexanone quantitative filling method. The multi-station perfluorohexanone quantitative filling method comprises the following steps that S1, an inspection stage before filling is conducted; s2, a nitrogen replacement stage; s3, a medicament filling stage; s4, a nitrogen filling stage; and S5, a filling completion stage. According to the device, the filling process can be automatically completed through PLC control; a connector of the filling steel cylinder is a quick-release connector, and after filling is completed, the filling steel cylinder can be quickly replaced for next filling; according to the device, the water content in the perfluorohexanone filling process is controlled in two aspects, the overall function is complete, and the practicability is high.

The invention discloses a medicine extraction system and method based on a molecular biological technology and chromatographic equipment, and belongs to the technical field of pharmaceutical separation and purification. The medicine extraction system based on the molecular biological technology comprises a medicine extraction module, the medicine extraction module comprises a chromatographic column, a constant flow pump, a sample injector and a collector, the output end of the constant flow pump is connected with an inlet of the chromatographic column, the sample injector is connected with the chromatographic column through a valve, and the collector receives eluent output by the chromatographic column; the operation module is used for acquiring physical and chemical data of the target product, determining first operation data of the chromatographic equipment according to the physical and chemical data, and generating a first matching vector according to the physical and chemical data and the first operation data; predicting a prediction extraction result of the target product according to the first matching vector and a preset clustering recognition space; and the control module is used for controlling the constant flow pump according to the first operation data and the prediction extraction result, and the production efficiency is improved by reducing the test verification work.

The invention discloses a pretreatment method and application of a mirabegron resin compound, and relates to the pretreatment method of the mirabegron resin compound, which comprises the following steps: extracting the mirabegron resin compound by an extraction solvent to obtain a sample to be detected for detection; wherein the extraction solvent comprises an aprotic solvent, an ionized solvent and a counter-ion solvent. According to the method, a multi-factor synergistic strategy is adopted, the extraction time of mirabegron in the mirabegron resin compound is remarkably shortened, the medicine extraction efficiency is remarkably improved, the extraction method is high in recovery rate, meanwhile, comprehensive optimization of quality is ensured, a foundation is laid for accurate determination of the medicine content, the consistency of the medicine effect is ensured, and the method is suitable for large-scale popularization and application. The requirements of links such as drug research and development, production and quality control are met.

The invention provides a preparation method of a dogwood extract and application of the dogwood extract in bone strengthening products, and belongs to the technical field of medicine extraction. The method comprises the following steps: (1) crushing a dogwood raw material, and immediately spraying an acid solution; (2) sequentially extracting the pretreated material by adopting an ethanol water solution containing citric acid and L-ascorbic acid as a first-phase extraction solvent and a phosphate buffer solution containing a compound enzyme preparation as a second-phase extraction solvent; (3) combining the extracting solutions, sequentially separating through an ultrafiltration membrane and at least two stages of nanofiltration membranes to obtain active fractions with different molecular weight intervals, and recombining the active fractions according to a preset proportion to obtain a refined solution; and (4) drying the refined liquid to obtain the dogwood extract. The preparation method provided by the invention has the advantages of high extraction rate of target active ingredients (especially aglycone), synergistic retention of multiple active ingredients, strong process controllability, suitability for large-scale production and the like.

This application discloses a sustained-release formula and medicated pillow for the prevention and treatment of allergic rhinitis, including a pillow base with two symmetrically arranged sustained-release mechanisms and a drive mechanism in the bottom mounting compartment. The sustained-release mechanism consists of multiple sustained-release components, each containing a sustained-release tube and a drug storage tube, connected by a U-shaped connecting pipe and a one-way valve; the drug storage tube is inserted into a pierced tube with a filter screen, which balances air pressure and prevents contamination. The drive mechanism drives a sliding valve to reciprocate via a worm gear system, achieving quantitative drug extraction and precise sustained-release; the atomization design of the sustained-release port improves drug absorption efficiency, and the guide holes in the mounting compartment and the ventilation grooves on the pillow surface form a uniform diffusion channel. This solution solves the problems of cumbersome drug replacement, uncontrollable volatilization, and easy deterioration associated with traditional medicated pillows, offering advantages such as precise controlled release, convenient maintenance, and multiple safety protections. It allows for individualized drug administration based on drug characteristics and patient rhythms, significantly improving the effectiveness of sleep aid therapy and the user experience.

The invention relates to the technical field of traditional Chinese medicine extraction equipment, and discloses a medicinal material extraction workshop clean automatic feeding device which comprises a rotary medicinal material conveying mechanism. According to the clean automatic feeding device for the medicinal material extraction workshop, a screw raw material conveying principle is utilized, medicinal materials can be ground into fine particles firstly in the feeding process, then the fine particles are quantitatively discharged downwards, and therefore the effective extraction degree of the medicinal materials in the medicinal material extraction process is improved; the device has the functions of instantly opening medicinal material feeding and closing medicinal materials, so that the capability of controlling the feeding amount of the medicinal materials is improved.

The invention discloses an L-carnitine-based ionic liquid aqueous two-phase system as well as a preparation method and application thereof, and belongs to the technical field of aqueous two-phase system separation. The prepared L-carnitine-based ionic liquid aqueous two-phase system is a novel ionic liquid aqueous two-phase system which is more efficient when active substances are extracted (extraction and separation can be achieved by stirring for 30 min and centrifuging for 5-8 min at the speed of 6000-8000 rpm), the extraction rate of vanillin, eugenol, p-hydroxybenzaldehyde, syringaldehyde and vanillic acid reaches 85.37% or above, and the L-carnitine-based ionic liquid aqueous two-phase system is a novel ionic liquid aqueous two-phase system. The method can be applied to the fields of organic compound extraction, medicine extraction, environmental protection and the like, and has a great development prospect.

The medicine extraction equipment comprises a control box and a smashing box installed on the control box, the smashing box comprises a feeding port in the top and a discharging port in one side, the discharging port extends into an extraction box through a connecting pipe, a main discharging pipe is arranged at the bottom of the extraction box, and the main discharging pipe is connected with the control box. An inverted U-shaped siphon is arranged on one side of the extraction box, one end of the siphon extends towards the inner bottom of the extraction box, the other end of the siphon penetrates through the extraction box and extends vertically and downwards, a heating tank is further arranged on the side, away from the control box, of the extraction box, and the top of the heating tank is communicated with a steam conveying pipe; the steam conveying pipe is connected with one end of the condenser, and the other end of the condenser extends into the extraction box through a pipeline; the medicine extraction equipment and the extraction process are stable in structure, easy and convenient to operate, capable of avoiding manual intervention and impurity pollution in the extraction process, capable of improving medicine active ingredients and suitable for application and popularization.

The invention discloses a herbal medicine extraction and concentration device, and relates to the technical field of herbal medicine extraction and concentration, the herbal medicine extraction and concentration device comprises a tank body and a feeding pipe, the feeding pipe is fixedly communicated with the top of the tank body, the top end of the tank body is provided with a tank cover, the tank cover is rotatably connected with a turntable, the top surface of the turntable is fixedly connected with a belt wheel, and the top surface of the tank cover is fixedly connected with a servo motor I; a belt is in transmission connection between an output shaft of the first servo motor and the belt wheel, a top supporting plate is fixedly connected to the top face of the tank cover, and a second servo motor is fixedly connected to the side, close to the belt wheel, of the top supporting plate. Impurities in an extracting solution are filtered and separated in real time through a filter disc, the impurities are prevented from entering a concentration link, extraction and concentration are carried out at the first time after filtering and next to an extraction and concentration step, crystals or precipitates are prevented from being generated again in a solution waiting period, and the impurities are prevented from changing physical properties of the solution; insoluble impurities are prevented from being attached to the heating surface to form a heat insulation layer.

The invention discloses a phoebe zhennan water-soluble extract as well as an extraction method and application thereof, and belongs to the technical field of medicine extraction. The method comprises the following steps: S1, crushing a phoebe zhennan raw material, adding 6 times of water, extracting twice, 1 hour each time, and combining filtrates; s2, concentrating the filtrate obtained in the step S1 under reduced pressure until the volume is 1: 1, standing at low temperature, and taking supernate; and S3, centrifuging the supernate obtained in S2, discarding the precipitate, concentrating under reduced pressure, and drying at low temperature to obtain the phoebe zhennan water-soluble extract. The invention discloses a phoebe zhennan water-soluble extract and an extraction method and application thereof. The phoebe zhennan water-soluble extract has efficient broad-spectrum antiviral activity and can effectively inhibit respiratory virus activity.

The invention relates to a monomolecular micelle aqueous solution as well as a preparation method and application thereof, and belongs to the technical field of biomedicine. The monomolecular micelle aqueous solution is formed by assembling an amphiphilic polyether ester multi-block copolymer in an aqueous phase. The preparation method comprises the following steps: dissolving an amphipathic multi-block copolymer in a good solvent, slowly adding deionized water into the amphipathic multi-block copolymer, or slowly dropwise adding the amphipathic multi-block copolymer into a large amount of deionized water, self-assembling to form a monomolecular micelle, and removing the good solvent in water through dialysis to obtain a monomolecular micelle aqueous solution. And the amphiphilic polyether ester multi-block copolymer has good biocompatibility and degradability. The prepared monomolecular micelle has excellent stability and cannot be dissociated along with the dilution of the polymer concentration, and the problem that the current common micelle is dissociated along with the dilution of the polymer concentration is solved. The prepared monomolecular micelle has a good solubilizing effect on water-insoluble drugs, and can be used in the fields of drug extraction, drug delivery, controllable release and the like.

The application discloses a kind of based on HPLC Jian'erle granule multi-component fingerprint construction and active evaluation method, belong to the technical field of drug analysis.The application is based on ultra-high performance liquid chromatography technology, by optimizing drug extraction and chromatographic detection method, provide the fingerprint construction method of analysis Jian'erle granule drug quality;The method comprises the steps of ultrasonic dissolution Jian'erle granule, with 0.1% phosphoric acid and acetonitrile as mobile phase for liquid chromatography detection.According to the construction method provided by the application, a fingerprint consisting of 12 characteristic peaks is obtained, of which 10 characteristic peaks are identified to compounds.The results of the methodological experiment show that the construction method provided by the application has a similarity of >0.999 between 10 batches of Jian'erle granules, and has outstanding specificity, precision, repeatability and stability.The application provides a new strategy for efficient quality detection and quality control of Jian'erle granules, and has a broad application prospect.

The extraction device comprises a grinding groove, a top cover is arranged above the grinding groove, the top cover is fixed through a buckle assembly, a feeding port is formed in the surface of the top cover, a grinding assembly is arranged on the inner side of the grinding groove, and an extraction box is arranged below the grinding assembly. When a user uses the device, through the arrangement of a corresponding structure, the whole device can complete extraction work, the device is smaller and more exquisite and convenient to carry, the top cover and the extraction box can be taken down, the inner side can be conveniently cleaned, meanwhile, the extraction box can contain extraction liquid through a liquid inlet, and the extraction efficiency is improved. And the whole extraction process is cleaner.

The invention provides an extraction method of an asiaticoside compound, and relates to the technical field of medicine extraction. The method comprises the following steps: mixing a crude centella asiatica product with a first solvent (ethanol or methanol) for extraction, concentrating an extracting solution to be dry, dissolving an obtained first concentrate with a second solvent (n-amyl alcohol or isoamyl alcohol saturated aqueous solution), mixing with a third solvent (water saturated n-amyl alcohol or isoamyl alcohol) for extraction, collecting an organic layer, and concentrating to be dry, so as to obtain the centella asiatica extract. And dissolving the obtained second concentrate with a fourth solvent (methanol or ethanol), mixing the dissolved second concentrate with a fifth solvent (dichloromethane or acetonitrile), and carrying out precipitation to obtain a precipitate which is an asiaticoside compound product. Compared with a column chromatography method, the method for extracting the asiaticoside compound by adopting a solvent method has the advantages of simplicity in operation, large sample treatment capacity, easiness in solvent recovery and application and the like, is suitable for industrial production, and can be used for extracting the asiaticoside compound with high content (not less than 70wt%) from a crude product of centella asiatica.

The utility model discloses a medicine fumigation treatment instrument, which relates to the technical field of medical instruments and comprises a medicine storage barrel, and an atomizer is arranged at the top of the medicine storage barrel. An atomization conveying pipe is arranged at the top of the atomization machine; a fumigation barrel is arranged on the other side of the atomization conveying pipe; a sealing cover part is arranged at the top of the fumigation barrel, a protection box is arranged on the side, close to the atomization conveying pipe, in the fumigation barrel, and a steaming chair is arranged on the other side in the fumigation barrel; a neck protection sealing part is arranged in the sealing cover part; a medicine extraction part is arranged on the other side of the steaming chair; a cooling box is arranged at the bottom of the medicine extraction part; and a liquid medicine collecting barrel is arranged in the cooling box. By means of the structure, the medicine fumigation device can prevent medicine steam from overflowing and polluting the surrounding environment in the medicine fumigation process, the medicine steam can be rapidly pumped out, cooled, liquefied and collected, and the cleaning work difficulty is lowered.

The subject matter of the invention is an oral composition comprising a Gymnema sylvestre liquid extract characterised in that the Drug Extract Ratio (DER, the ratio of the amount of plant material to the amount of the obtained extract) is from 1:3 to 1:5, wherein the composition is in the form of an aerosol and is sprayed with an atomizer. The invention also relates to the use of the composition according to the invention for the topical blocking of taste receptors.

To efficiently inspect each medicine of a plurality of medicine packages.SOLUTION: A medicine inspection system includes an image acquisition unit configured to acquire a medicine package image obtained by photographing each of a plurality of medicine packages in which a medicine is packaged based on a prescription, an inspection unit configured to inspect whether or not the medicine of each of the plurality of medicine packages conforms to the prescription based on the medicine package image of each of the plurality of medicine packages, an output unit configured to output an inspection result of the inspection unit, and a medicine extraction display unit configured to extract and display a medicine package image containing a designated medicine from the medicine package images of the plurality of medicine packages.SELECTED DRAWING: Figure 1

The utility model belongs to the technical field of medicine extraction equipment, and particularly relates to a medicine extraction device for microbiological detection of traditional Chinese medicine decoction pieces, which comprises a sampling tube body I and a sampling tube body II, the sampling tube body I and the sampling tube body II are buckled to form a containing cavity for containing microorganisms, and a piston block is connected to the inner wall of the containing cavity through a piston. A sampling pipe is inserted into the lower ends of the sampling pipe body I and the sampling pipe body II in a penetrating manner, a pull rod is fixedly connected to the center of the surface of the upper end of a piston block, and an anti-separation mechanism is connected between the sampling pipe body I and the sampling pipe body II. A dismounting assembly is connected among the sampling pipe body I, the sampling pipe body II and the sampling pipe; according to the utility model, by designing the dismounting assembly, the operation convenience and the dismounting efficiency are obviously improved; according to the dismounting and mounting assembly, the sampling pipe and the sampling pipe body are quickly mounted and dismounted through adsorption connection of a magnetic attraction block and an iron ring piece, additional tools or complex operation steps are not needed, and the operation time is greatly saved.

The utility model discloses a medicine extraction device with a built-in shunting structure, and relates to the technical field of medicine extraction devices. The steam distillation device comprises a steam distillation structure which comprises a cylinder body, a movable cylinder embedded with the cylinder body, a heating assembly positioned in the cylinder body, hydraulic rods I fixedly arranged at two ends of the cylinder body, and a supporting net positioned in the upper end of the cylinder body; and; the flow dividing structure comprises a conveying pipe located on one side of the barrel, a collecting barrel connected to the outer wall of the conveying pipe in a sleeving mode, a barrel-shaped filter screen installed on the inner wall of the conveying pipe in an embedded mode and located in the collecting barrel, a liquid discharging pipe installed in the lower end of the collecting barrel in a penetrating mode, and a hose installed in the conveying pipe in a penetrating mode. According to the utility model, by arranging the shunting structure, the problem that subsequent secondary separation is required and is relatively complicated due to the fact that part of chippings and particles flow along with distilled steam during component extraction under a steam distillation device is solved.

The application provides a kind of intelligent recommendation herbal extraction method and equipment, belong to intelligent recommendation technical field, its method includes: when user triggers extraction device, the facial image and scalp image of user are collected and image processing and identification are carried out, obtain the facial representation information and scalp representation information of user;Receive the questionnaire information related to health that user inputs in the interactive interface of extraction device, and carry out information analysis, obtain the present basic information;Preliminary estimate the present health condition of user, and extract several health strengthening indexes from the present health condition;Determine the conditioning direction of user in dependence on all health strengthening indexes, and the conditioning effect of traditional Chinese medicine herb and the various extraction methods of traditional Chinese medicine herb existing in extraction device are intelligently matched, output recommended mode for user to select.It is convenient for the required extraction drug to meet the actual needs of user's pathology, to maximize the efficiency of drug extraction and subsequent effective use of drug.

This invention discloses a processing method for promoting the dissolution of effective substances in buffalo horn, belonging to the field of drug extraction technology, including the following steps: S1, crushing raw buffalo horn into particles of 3-5 mm to obtain buffalo horn granules; S2, adding the buffalo horn granules to distilled water for hydrolysis for 30-60 minutes to obtain buffalo horn hydrolysate; the hydrolysis temperature is 130-230℃ and the pressure is 2-20 MPa; S3, filtering the hydrolysate and directly collecting the filtrate, or evaporating the filtrate to dryness to obtain the processed buffalo horn product. This invention uses microwave hydrolysis, which can hydrolyze the insoluble substances in buffalo horn in a short time. The average buffalo horn extract content of the processed buffalo horn product reaches 18.57%, which is nearly six times higher than the extract content of long-term decoction, greatly increasing the extract content of buffalo horn. Therefore, microwave hydrolysis of buffalo horn dissolves the sample more completely than decoction, and can significantly increase the water-soluble extract content of buffalo horn.

This invention discloses a preparation method and application of a gel plaster, belonging to the field of traditional Chinese medicine plaster preparation technology. The preparation steps are as follows: S1, drug extraction: ultrapure water is measured at a material-to-liquid ratio of 1:10, and the decoction is separated three times. The three decoctions are combined, concentrated, and stored in a refrigerator for later use; S2, matrix preparation: phase A, phase B, and phase C are accurately prepared according to the prescription; the above contents are mixed evenly and coated onto non-woven fabric, and dried in an oven to obtain the matrix; the gel plaster is used in the treatment of insomnia. This invention optimizes the preparation process of the heart-nourishing and calming plaster, using the traditional decoction method to extract the drug. While ensuring the effective components of the drug, the drug is made into a gel plaster that is easier to wash, has a moderate consistency, is non-greasy, and has better biocompatibility. The transdermal absorption rate of this plaster determines the drug's ability to act on the body and its efficacy. By examining the transdermal rate of the heart-nourishing and calming gel plaster, the drug's permeability is ensured.

The invention belongs to the technical field of natural medicine extraction, and particularly relates to a method for extracting total flavonoids from scabrous doellingeria rhizome and root stems, which comprises the following steps: S1, cleaning fresh scabrous doellingeria rhizome and root stems, drying to constant weight, crushing and sieving; s2, soaking scabrous doellingeria rhizome powder in an ethanol solution for 30 minutes; performing reflux extraction in a water bath kettle, cooling to room temperature, and filtering to obtain a flavone crude extract; s3, adding petroleum ether into the crude flavone extracting solution, and extracting with an extracting agent to obtain an extracting solution; and S4, concentrating and drying the obtained extract liquor to obtain the scabrous doellingeria rhizome and root total flavonoids. The extraction method disclosed by the invention is simple and efficient in process and high in total flavone extraction yield, and can provide powerful support for development of main active ingredients of scabrous doellingeria rhizome and root medicinal materials. In addition, experiments find that the scabrous doellingeria rhizome total flavonoids have a relatively strong inhibition effect on escherichia coli and also have an inhibition effect on staphylococcus aureus.

The invention discloses medicine pumping equipment, a control method and device thereof and a storage medium, the medicine pumping equipment comprises an instruction reading module, a driving module and a bubble detection module, and the method comprises the steps that a medicine configuration instruction is obtained through the instruction reading module; controlling a driving module to drive a medicine extraction device to execute medicine extraction operation according to the medicine configuration instruction; in the process that the medicine extraction equipment executes the medicine extraction operation, the gas suction amount of the medicine extraction equipment is monitored through the bubble detection module, and after the gas suction amount is larger than the sucked gas safety threshold value, the medicine extraction equipment is controlled to stop the medicine extraction operation. Therefore, starting and stopping of medicine extraction operation are accurately controlled based on the medicine configuration instruction and the gas suction amount of the medicine extraction equipment, manual medicine extraction operation is replaced with automatic mechanical operation, and therefore clinical work efficiency is improved, occupational exposure risks are reduced, and safety of medical staff is ensured.

The application belongs to the technical field of medicine extraction and medicine detection, and discloses a detection method of related substances in palonosetron-containing fat emulsion injection. Methanol is used as a main demulsifier, and a sodium dihydrogen phosphate buffer salt solution with a suitable ionic strength is used for assistance, so that full demulsification is realized under the premise of not introducing a third organic phase; a water bath evaporation and redissolution method is used to enrich target components in the solution after demulsification, so that good chromatographic behavior and complete recovery of the target components are ensured, and the detection sensitivity is effectively improved. The palonosetron and related impurities have good separation degree, the method is simple to operate, accurate to measure, and strong in specificity, and is suitable for the determination of palonosetron related substances in rolapitant palonosetron fat emulsion.

The application discloses a preparation method of cherimoya leaf extract and belongs to the technical field of natural medicine extraction and preparation. The conventional preparation method of the cherimoya leaf extract in the prior art has limited bioavailability of the extract, and lacks a systematic method for effectively enriching specific active components of the extract and stably encapsulating the specific active components in a suitable delivery system. The preparation method provided by the application comprises the following steps: crushing dried cherimoya leaves, refluxing and extracting the dried cherimoya leaves with an ethanol aqueous solution, and concentrating the extract; adding ethyl acetate to the concentrated solution to perform extraction; mixing the obtained ethyl acetate extraction phase with a phospholipid aqueous dispersion liquid composed of phosphatidylcholine and phosphatidylethanolamine in a specific ratio; performing high-pressure homogenization treatment to obtain a nanoliposome suspension liquid; and finally performing spray drying to obtain an extract powder. The extract prepared by the method can be used for preparing a medicine for treating type 2 diabetes.

This invention discloses a drug extract for enhancing the efficacy of porcine reproductive and respiratory syndrome (PRRS) vaccines, its preparation method, and its application. The drug extract comprises aqueous extracts of Astragalus membranaceus and Curcuma zedoaria, wherein the optimal mass ratio of Astragalus membranaceus to Curcuma zedoaria is 4-5:1. The Astragalus membranaceus and Curcuma zedoaria extract of this invention enhances the efficacy of existing PRRSV vaccines, improves vaccine resistance to PRRSV, and effectively stimulates the body to produce sufficient neutralizing antibodies, thereby enhancing the overall immune effect of the vaccine, with significantly better results than using the vaccine alone.

The high-risk medicine containing box comprises an outer box body, a box cover and a plurality of inner box bodies, the inner box bodies are slidably installed in the outer box body, the box cover is arranged at an opening of the outer box body, one side of the box cover is hinged to the outer box body, and the other side of the box cover is connected with the outer box body through an electronic card swiping lock; one side of the inner box is connected with the outer box through a sliding mechanism, and the other side can extend out of the outer box. The multiple inner boxes are arranged and pulled out of the outer box through the sliding mechanisms, one kind of medicine is placed in each inner box, it can be guaranteed that all the medicine is prevented from being exposed to the outside, and the safety and accuracy of high-risk medicine extraction can also be guaranteed.

This invention provides a traditional Chinese medicine oral gel for relieving wind-cold, clearing the lungs, stopping cough, and soothing the throat, along with its preparation method. After combining the thick pastes, an impurity removal process is added, followed by refrigeration for at least 48 hours to remove some impurities and reduce the solid content. Then, by selecting 1.0%-2.5% xanthan gum as a matrix, and using 0.1%-0.2% Gannan orange flavoring and 0.2%-0.3% sucralose to form a complex flavoring system, and controlling the parameters during homogenization, this invention effectively solves the problems of poor gelation and instability in oral gel formulations. It also overcomes the bitter taste caused by the acidic and astringent odor of the drug extract and volatile oils. This invention features convenient administration, safety and effectiveness, good taste, and superior formulation stability, improving compliance for children and the elderly. The entire preparation method is simple and suitable for large-scale industrial production.

The invention provides anaerobic treatment equipment for drug extraction wastewater, and relates to the technical field of wastewater treatment, the anaerobic treatment equipment comprises a reactor, and a sludge bed is arranged in the reactor; a circulating part and a bottom plate are further arranged in the reactor, the circulating part is located in the sludge bed, the circulating part comprises a first conveying assembly and a second conveying assembly which are used for continuously conveying sludge, the sludge bed is located above the bottom plate, the bottom plate guides the sludge at the bottom to the first conveying assembly, and the first conveying assembly lifts the sludge at the bottom; the second conveying assembly is used for horizontally conveying the lifted sludge, the lifted sludge is gradually discharged into the reactor when being conveyed by the second conveying assembly, and the discharged sludge falls under the action of self weight, so that up-down circulation and horizontal circulation of the sludge in the reactor are realized; the sludge bed is prevented from being hardened due to continuous compaction to a certain extent, the internal porosity and permeability of the sludge bed are ensured, the wastewater is in full contact with sludge microorganisms, and the degradation effect of organic pollutants is ensured.