The invention provides an internet and mobile communication network based medical logistic information processing system and method. In the system, drug electronic supervision codes and recording information of corresponding drugs are stored in a drug electronic supervision database, and identification marks are adhered to all drug package boxes, so that the drugs can be supervised according to the identification marks in production, sales, transportation, storage, use, after-service and other logistic links of the drugs. By adopting the internet technology, the mobile communication technology and the identification mark technology, the system and the method perform real-time tracking management on production, sales and use of drugs, realizes seamless transition of all links of a medical supply chain, and perform full-process tracking of source, storage, transportation, sales, use and other links of the medical supplies.