The invention discloses an anhydrous skin activating and brightening mask for stay-up people and a preparation method thereof. The anhydrous skin activating and brightening mask comprises rose centifolia aqueous solution, glycerin, butanediol, Carbomer, hydrolyzed sclerotium gum, allantoin, ethylenediamine tetraacetic acid disodium, sodium hyaluronate, betaine, sodium hydroxide, collagen, dipeptide-1, nicotinamide, camellia extract, oat glucan, licorice root extract, Angelica sinensis root extract, salviae miltiorrhizae root extract, cornus officinalis fruit extract, boxthorn root extract, tremella polysaccharides, opuntia streptacantha extract, menthyl lactate, p-hydroxy phenyl ethyl ketone and octanohydroxamic acid. The preparation method includes: preprocessing the raw materials into aphase A, a phase B, a phase C, a phase D, a phase E, a phase F and a phase G, stirring and heating the phase A, adding the phase B, homogenizing, stirring and performing heat preservation, adding thephase C, evenly stirring, sequentially adding the preprocessed phase D, phase E, phase F and phase G, and evenly stirring to obtain the anhydrous skin activating and brightening mask. The anhydrous skin activating and brightening mask is good in skincare effect.