38 results about "Cornus officinalis fruit extract" patented technology

The invention discloses an essence liquid containing tuber melanosporum extract and a preparation method thereof. The essence liquid comprises a component A, a component B and water. The component A comprises butanediol, diglycerin, sodium polyacrylate, xanthan gum, modified potato starch, betaine and disodium ethylenediaminetetraacetate. The component B comprises mulberry leaf extract, tuber melanosporum extract, a lactobacillus / soybean milk fermentation product filtrate, purslane extract, bifida ferment lysate filtrate, grapefruit seed extract, bifida ferment lysate, Aloe vera leaf polysaccharide, beta-glucan, 1, 2-pentanediol, 1, 2-hexanediol, p-hydroxyacetophenone, cladosiphon novae-caledoniae extract, hydrolyzed rice bran extract, a rice fermentation product filtrate, soluble proteoglycan, aloe extract, licorice root extract, radix angelicae sinensis, salvia miltiorrhiza flower / leaf / root extract, cornus officinalis fruit extract, wolfberry root extract, tremella polysaccharide, hyaluronic acid, and the balance of deionized water.

The invention discloses a method for preparing cornus officinalis extract, an application in cigarettes and the cigarette. The method for preparing the cornus officinalis extract comprises the following steps: preparing the cornus officinalis; using the ultrasonic wave to extract collaborated with microwaves; extracting the liquid and concentrating; centrifuging and separating; separating by column chromatography; and concentrating to obtain the cornus officinalis extract. The cornus officinalis extract prepared by the invention is applied to the cigarettes, the use is convenient, the quality and level of the cigarette are improved, the smoke is rich and sweet, and the palate aftertaste is improved. The method combines the advantages of the ultrasonic wave with the homogenization of the microwave vibration, so the stress of each point in the sample medium is the same, the range of the target extract is large, the combination force of the target object and the sample substrate is reduced, the process that the target object enters the liquid from the solid phase is accelerated, and the sample process quantity is large. The cornus officinalis extract is obtained after extracting and refining by column chromatography with gentle conditions, which provides a new perfume material for natural tobaccos.

The invention discloses a method for preparing a whitening cosmetic containing a dogwood extract, including: a first step of extracting extracts of dogwood, bupleurum and rose by ethanol; a second step of heating C18 alcohol, inositol hexaphosphate, glycerol, and stearic acid for melting, adding tert-Butylhydroquinone for dissolving to get an oil phase; a third step of adding borax, glycerol monostearate and purified water into Chinese herb extracts to get a water phase; and a fourth step of adding the oil phase into the water phase for emulsification, and adding essence to get the cosmetic with the effect of whitening and removing freckles. The cosmetic can improve skin metabolism, promote blood circulation, increase skin nutrition, effectively remove free radicals, eliminate pigmentation, fade skin wrinkles and pigmentation, and make skin to be delicate, smooth, white and flexible.

The invention relates to a traditional Chinese medicine composite peptide composition having the function of improving gastrointestinal tract functions and a preparation method of the traditional Chinese medicine composite peptide composition. The traditional Chinese medicine composite peptide composition comprises the following components in parts by weight: 5-13 parts of a lophatherum herb extract, 4-10 parts of a radix rehmanniae preparata extract, 4-10 parts of an Asiatic cornelian cherry fruit extract, 6-14 parts of radix angelicae sinensis microcapsules, 6-14 parts of coix seed microcapsules, 8-16 parts of casein peptide, 10-20 parts of wheat oligopeptide, 8-12 parts of xylooligosaccharide, and 1-13 parts of inulin. The components of the traditional Chinese medicine composite peptide composition are in compatibility, so that the effects of mutual promotion and synergistic interaction can be achieved, and the traditional Chinese medicine composite peptide composition has good effect of improving gastrointestinal tract functions. Radix angelicae sinensis and coix seeds are subjected to supercritical CO2 extraction, then the radix angelicae sinensis and the coix seeds after the supercritical CO2 extraction are entrapped to be made into microcapsules, and traditional Chinese medicines of lophatherum herbs, radix rehmanniae preparata, Asiatic cornelian cherry fruits and the like are subjected to pretreatment, extraction concentration and spray drying so as to be made into extracts, so that main functional components of the medicines are reserved to the maximum extent, the eating amount is notably reduced, besides, the biological availability of the medicines is greatly improved, the medicine effect is notably improved, and the purpose of improving the gastrointestinal tract functions is realized really.

The invention relates to the technical field of eye masks, in particular to eye-brightening and glowing stay-up eye mask essence and a preparation method thereof. The eye-brightening and glowing stay-up eye mask essence is prepared from the following raw materials of deionized water, a component A, a component B, a component C, a component D and a component E, wherein the component A comprises 1,3-propylene glycol, allantoin, trehalose, acetyl chitosamine, sclerotium gum, and disodium EDTA, the component B comprises butylene glycol and hydrolyzed sodium hyaluronate, the component C comprises nicotinamide and magnesium ascorbyl phosphate, the component D comprises olea europaea fruit oil and a solubilizer, and the component E comprises a palmitoyl hexapeptide compound conditioner, an acetyltetrapeptide compound conditioner, a carnosine compound conditioner, a gentiana lutea root extract conditioner, a cornus officinalis fruit extract conditioner, a saccharomyces lysate extract conditioner, a herba centellae conditioner, a chlorella extract conditioner, a glycerol caprylate compound humectant, and an ethylhexylglycerin compound humectant. The eye mask essence is prepared in gradientstirring and temperature decreasing modes, full and even mixing of raw materials is promoted, biological activity of the raw materials is also ensured, and aging of periorbital skin can be effectively relieved.

The invention discloses a dogwood kernel extract which is prepared by the following steps of: 1) grinding the dry dogwood kernel into powder of 20-100 meshes; performing percolation extraction of the powder by use of petroleum ether; performing percolation extraction by use of acetone; collecting the acetone percolate; and recycling the acetone solvent to obtain the total extract; 2) adding water to disperse the total extract, and loading to a macroporous resin adsorption column, wherein the amount of resin is 8-12 times the volume of the total extract, the diameter-height ratio is 1:(5-10), and the adsorption flow rate is 0.1-0.5BV / h; and 3) after the loading, eluting with 12-20BV of 10% methanol aqueous solution, wherein the flow rate is 1-3BV / h; and collecting the eluent and recycling the solvent to obtain the blood pressure reducing extract. The test proves that the dogwood kernel extract disclosed by the invention has a blood pressure reducing function, and can be used as the active substance of blood pressure reducing medicines, foods or healthcare products.

The invention provides a dendrobe anti-oxidation preparation which is prepared from the following components in part by mass: 150-220 parts of dendrobe powder, 80-120 parts of notoginseng powder, 15-25 parts of radix astragali extract, 3-6 parts of cornus officinalis extract and 2-5 parts of salvia miltiorrhiza extract. Shown by the result of an animal test, the dendrobe anti-oxidation preparation can obviously reduce the level of a lipid per-oxidation (LPO) in blood and brain tissues of a rat and the lipofuscin content in the brain tissue, and improve the activity of super-oxide dismutase (SOD) in the blood and the brain tissue, and has no influence on the weight of the rat, therefore, the dendrobe anti-oxidation preparation has better anti-oxidation effect and the health-care effect of removing radicals, and has no toxic or side effects.

The invention relates to plant fermentation broth and a preparation method and application thereof, and belongs to the technical field of fermented beverages. The plant fermentation broth comprises the following raw materials in parts by weight: 60-80 parts of purified water, 5-10 parts of carrot juice, 1-5 parts of dried rehmannia root extract, 1-5 parts of rhizoma dioscoreae extract, 1-5 parts of fructus corni extract, 1-3 parts of rhizoma alismatis extract, 1-3 parts of poria extract, 1-3 parts of moutan bark extract, 0.1-1 part of cassia twig extract, 0.1-1 part of processed radix aconiticarmichaeli extract, 1-5 parts of walnut juice, 1-5 parts of passion fruit juice, 2-3 parts of L-arabinose, 2-3 parts of honey, 1-5 parts of resistant dextrin, 1-2 parts of xylitol and 0.1-0.3 part ofedible essence. The raw materials firstly undergo aerobic fermentation and then undergo anaerobic fermentation to obtain the plant fermentation broth. According to the preparation method, traditionalChinese medicines are fermented with probiotics, so that the utilization rate of the medicinal materials is increased, the medicinal effect is improved, and the taste of the product is better.

The invention relates to application of a dogwood extract, and belongs to the technical field of application of Chinese herbal medicines in inhibition of marine pathogenic bacteria. The application refers to application of the dogwood extract in preparation of drugs for inhibiting marine pathogenic bacteria. The marine pathogenic bacteria are vibrio harveyi and vibrio parahaemolyticus. According to the invention, the dogwood alcohol extract with the best antibacterial effect is extracted, separated, detected and analyzed, wherein it is determined that the effective component for inhibiting the marine pathogenic bacteria in the dogwood is a phenolic acid compound.

The invention discloses a health care oral liquid which is made from the following raw materials according to the weight proportion: plant extract to balsam pear lyophilized powder to edible auxiliary material of 1:(0.05-0.1):(0.3-1.0), wherein the edible auxiliary material is selected from stevioside and distilled water; and the plant extract is a mixture of a siberian solomonseal rhizome extract, a fructus corni extract and a tea flower extract. The health care oral liquid is convenient to carry and take, safe and reliable in dietary therapy, good in mouthfeel, remarkable in efficacy, low in price and high in quality.

The invention provides a preparation for enhancing immunity and a preparation method thereof. The preparation consists of the following components in parts by mass: 10-15 parts of dendrobium candidum powder, 4-10 parts of notoginseng powder, 1-1.5 parts of astragalus root extract, 0.2-0.5 part of fructus corni extract, 0.1-0.4 part of red sage root extract, and 98-105 parts of honey. The preparation method comprises the steps of uniformly mixing the dendrobium candidum powder, the notoginseng powder, the astragalus root extract, the fructus corni extract and the red sage root extract, then adding the honey, and uniformly stirring to obtain the preparation for enhancing the immunity. The preparation is suitable for persons with low immunity, can enhance the immunity of human bodies, and has the advantages of quick and obvious effect, high safety, low cost, simplicity and convenience in operation and the like.

The invention discloses an anhydrous skin activating and brightening mask for stay-up people and a preparation method thereof. The anhydrous skin activating and brightening mask comprises rose centifolia aqueous solution, glycerin, butanediol, Carbomer, hydrolyzed sclerotium gum, allantoin, ethylenediamine tetraacetic acid disodium, sodium hyaluronate, betaine, sodium hydroxide, collagen, dipeptide-1, nicotinamide, camellia extract, oat glucan, licorice root extract, Angelica sinensis root extract, salviae miltiorrhizae root extract, cornus officinalis fruit extract, boxthorn root extract, tremella polysaccharides, opuntia streptacantha extract, menthyl lactate, p-hydroxy phenyl ethyl ketone and octanohydroxamic acid. The preparation method includes: preprocessing the raw materials into aphase A, a phase B, a phase C, a phase D, a phase E, a phase F and a phase G, stirring and heating the phase A, adding the phase B, homogenizing, stirring and performing heat preservation, adding thephase C, evenly stirring, sequentially adding the preprocessed phase D, phase E, phase F and phase G, and evenly stirring to obtain the anhydrous skin activating and brightening mask. The anhydrous skin activating and brightening mask is good in skincare effect.

The invention discloses a moisturizing mask capable of timely brightening skin. The moisturizing mask comprises the following raw materials in percentage by weight: 3%-5% (another name is Luminescine) of a verbascum thapsus extract, citric acid, sodium benzoate and potassium sorbate, 5%-10% of 1, 3-propylene glycol, 3%-7% of a PEG / PPG-17 / 6 copolymer, 0.05%-0.2% of sodium hyaluronate, 0.05%-0.2% of an ammonium acryloyldimethyl taurate and VP copolymer, 0.05%-0.3% of sclerotium rolfssii, 1%-5% of trehalose, 0.3%-1% of arginine ferulate and 1-methyl hydantoin-2-imide and dogwood extract, 1%-8% of butanediol, 0.5% of p-hydroxyacetophenone, 0.4% of 1, 2-hexanediol, 0.5%-5% of polyphosphorylcholine ethylene glycol acrylate, 0.1%-5% of a green alga extract, 0.2%-4% of oat beta-glucan, 0.5%-2% of a peony root extract and the balance water. The moisturizing mask provided by the invention is safe in quality, and can automatically absorb and release light sources according to ambient light conditions to adjust the brightness and glossiness of the skin without influencing the basic functions of moisturizing and the like, so that damage of hormone masks to the skin is avoided, and the time period of a conventional whitening and moisturizing masks is shortened.

The invention discloses drink tea with a blood sugar reduction healthcare effect and a making process of the drink tea and relates to the technical field of tea type drinks. The healthcare tea disclosed by the invention comprises 5-35% of an astragalus root extract, 5-35% of a kelp extract, 5-35% of a dogwood fruit extract, 5-35% of a fragrant solomonseal rhizome extract, 5-35% of a rhizoma polygonati extract, 5-35% of a mulberry leaf extract, 5-35% of a discolor cinquefoil herb extract, 5-35% of a kudzu-vine root extract, 5-35% of a tea leaf extract and 5-35% of a herba dendrodii officinalisextract. The making process disclosed by the invention comprises the following steps: weighing the components according to proportions, uniformly mixing the components, and performing sub-packaging, so as to obtain the drink tea. The tea made by the invention is good in taste, natural in source of used raw materials, free of chemical additives and applicable to long-term drinking and has effects of treating and preventing diabetes; and diabetes can be treated and prevented through the blood sugar reduction tea made by the invention, and effects of good quality and low price can be achieved.

The invention relates to a method for simultaneously preparing high-purity morroniside and high-purity loganin from dogwood extract. The method comprises the following steps: performing macroporous adsorption resin enrichment and normal phase silica gel preliminary separation on the dogwood extract, then performing treatment by a medium-pressure reverse phase silica gel chromatographic column, performing gradient elution by taking ethanol and water as a mobile phase, mixing the same components, and performing concentration under reduced pressure to respectively obtain a morroniside crude product of which the purity is greater than or equal to 90% and a loganin crude product of which the purity is greater than or equal to 90%; and respectively performing purification with a Sephadex LH-20 gel column, performing elution by adopting a chloroform and methanol mixed solvent, mixing the same components, and performing evaporation to dryness under reduced pressure to obtain the high-purity morroniside and the high-purity loganin. The method is simple and easy in operation and mild in conditions and is suitable for simultaneously preparing and producing morroniside of which the purity is greater than or equal to 98% and loganin of which the purity is greater than or equal to 98% in a large scale from the dogwood extract.

The invention provides an anti-wrinkle composition and an anti-wrinkle cream. The anti-wrinkle composition is prepared from rhizoma polygonati extract, fructus corni extract and kumquat extract according to the weight ratio of (5 to 7) to (3 to 6) to 1. The anti-wrinkle composition comprises the rhizoma polygonati extract, the cornus officinalis extract and the kumquat extract, and can block a voltage-dependent Nav1.4 channel on a cell membrane in muscle, so that release of ions is influenced, the action target is clear, and the effect is also clear; and due to the use of the rhizoma polygonati extract and the cornus officinalis extract, the absorption of the kumquat extract is promoted. The compounds in the extracts are small in molecular weight and easy to penetrate through the skin, theeffect of remarkably relaxing excessively single muscle tension can be achieved, and generated wrinkles can also be relieved and improved.

The invention discloses a PPARγ receptor agonist and its preparation method and application. The first receptor agonist is ursolic acid extracted from Cornus officinalis. Specifically, it is implemented according to the following steps: preparing the cornus officinalis extract; step 2: separating and purifying the cornus officinalis extract obtained in step 1 to obtain a receptor agonist. The present invention discloses a novel natural PPARγ receptor agonist. At a concentration of 3 μM, the relative average intensity of firefly luciferase activity and Renilla luciferase activity of the compound is the same as that of the full agonist of PPARγ receptor Rosiglitazone, the results of this study provide a lead compound for the development of new natural antidiabetic drugs.

The invention provides repairing essence extracted from plants and a preparation method of the repairing essence. The invention relates to a repairing essence extracted from plants, which comprises the following components by weight: 5-10% of witch hazel extract; glycerol accounting for 2-5%; 1, 3-propylene glycol accounting for 2 to 5 percent; propylene glycol with a ratio of 2-5%; a trimethyl pentanediol / adipic acid / glycerol cross-linked polymer accounting for 2-5%; 2-5% of a portulaca oleracea extract; a dogwood extract with a ratio of 0.8-2%; a Chinese herbaceous peony extract accounting for 0.5-2%; a Chinese prickly ash peel extract accounting for 0.2-2%; a fructus forsythiae extract accounting for 0.2-2%; apple stem cells accounting for 0.1-3%; the proportion of the sclerotium gum is 0.1 to 0.5 percent; small molecular sodium hyaluronate, which accounts for 0.05 to 0.3%; eDTA (Ethylene Diamine Tetraacetic Acid)-2Na, which accounts for 0.05 On the basis of the components, the balance is water. The invention relates to a preparation method of repairing essence extracted from plants. The preparation method comprises the following steps: (1) preparing components according to a weight ratio; (2) preparing a basic solution; and (3) obtaining the finished product repairing essence. The facial cleanser is rich in various plant extract components, and is suitable for various skin types.

The invention discloses a functional beverage capable of continuously relieving weariness. The functional beverage consists of the following components in parts by weight of 0.1-0.5 part of an asiaticcornelian cherry fruit extract, 0.05-0.2 part of a herba epimedii extract, 0.07-0.15 part of a ginseng extract, 1-2 parts of taurine, 0.05-0.2 part of a glossy ganoderma extract, 0.15-0.3 part of a herba rhodiolae extract, 0.1-0.4 part of a natural flavoring agent, 4-6 parts of cane sugar invert sugar and the balance of water. The functional beverage has the effects of quickly and effectively relieving weariness and supplementing energy, and has the effects of conditioning and improving the problem of weariness caused by different reasons. The cane sugar invert sugar is added, so that the blood sugar peak time can be prolonged, energy supply time is greatly prolonged, and long-time blood sugar peak can promote functional components in the beverage to exert functions well.

The invention discloses a PPAR gamma receptor stimulant as well as a preparation method and application thereof. One receptor stimulant is ursolic acid extracted from asiatic cornelian cherry fruit. The preparation method specifically comprises the following steps: step 1, preparing an asiatic cornelian cherry fruit extract; and step 2, separating and purifying the asiatic cornelian cherry fruit extract obtained in the step 1 to obtain the receptor stimulant. The invention provides a novel natural PPAR gamma receptor stimulant, and the relative average intensity of the firefly luciferase activity and the internal control renilla luciferase activity of the compound is equivalent to that of the full stimulant rosiglitazone of the PPAR gamma receptor under the concentration of 3 microns; theresearch result provides a lead compound for research and development of novel natural antidiabetic drugs.

The invention relates to a traditional Chinese medicine composite peptide composition having the function of improving gastrointestinal tract functions and a preparation method of the traditional Chinese medicine composite peptide composition. The traditional Chinese medicine composite peptide composition comprises the following components in parts by weight: 5-13 parts of a lophatherum herb extract, 4-10 parts of a radix rehmanniae preparata extract, 4-10 parts of an Asiatic cornelian cherry fruit extract, 6-14 parts of radix angelicae sinensis microcapsules, 6-14 parts of coix seed microcapsules, 8-16 parts of casein peptide, 10-20 parts of wheat oligopeptide, 8-12 parts of xylooligosaccharide, and 1-13 parts of inulin. The components of the traditional Chinese medicine composite peptide composition are in compatibility, so that the effects of mutual promotion and synergistic interaction can be achieved, and the traditional Chinese medicine composite peptide composition has good effect of improving gastrointestinal tract functions. Radix angelicae sinensis and coix seeds are subjected to supercritical CO2 extraction, then the radix angelicae sinensis and the coix seeds after the supercritical CO2 extraction are entrapped to be made into microcapsules, and traditional Chinese medicines of lophatherum herbs, radix rehmanniae preparata, Asiatic cornelian cherry fruits and the like are subjected to pretreatment, extraction concentration and spray drying so as to be made into extracts, so that main functional components of the medicines are reserved to the maximum extent, the eating amount is notably reduced, besides, the biological availability of the medicines is greatly improved, the medicine effect is notably improved, and the purpose of improving the gastrointestinal tract functions is realized really.

The invention discloses a composition for teenager eye health care. The composition is composed of the following raw materials in parts by weight: 20-30 parts of raspberry or raspberry extract, 20-30parts of semen cassiae or semen cassiae extract, 20-30 parts of bilberry or bilberry extract, 10-20 parts of fructus corni or fructus corni extract, 20-30 parts of honeysuckle or honeysuckle extract,5-10 parts of papaya or papaya extract and 10-20 parts of honey. All the raw materials are medicinal and edible components, and the composition is natural and safe, can relieve visual fatigue, effectively improve the myopia susceptibility period, early myopia and myopia distant vision conditions of teenagers, eliminate symptoms such as blurred vision, eyeball distension, eye pain, photophobia, eyedryness and eyeball soreness caused by visual fatigue, and has the effects of clearing away heat and toxic materials, nourishing the liver and improving eyesight.

The invention discloses a Panax notoginseng compound composition. The composition and weight parts of the Panax notoginseng compound composition are 15-25 parts of Panax notoginseng extract, 8-12 parts of Cornus officinalis extract, and 8-12 parts of Schisandra chinensis extract; The compound composition of Panax notoginseng in proportion has a protective effect on the acute liver injury of mice caused by carbon tetrachloride, can effectively reduce the content of ALT and AST in the serum of mice, and the liver-protecting effect is better than that of the single extract; The preparation method is simple, the operation steps are controllable, and the content of active ingredients is high, which can be used in the preparation of medicines for treating and preventing various liver diseases.

The invention provides an application of a plant extract in preparing a medicine of a naval 1.4 inhibitor. The plant extract comprises a polygonatum sibiricum extract, a cornus officinalis extract anda kumquat extract. The plant extract disclosed by the invention comprises the polygonatum sibiricum extract, the cornus officinalis extract and the kumquat extract, and the plant extract can block avoltage dependent Nav1.4 channel on a cell membrane in muscle, so that the release of ions is influenced, the action target is clear, and the effect is also clear. The compounds in the extracts are small in molecular weight and easy to penetrate through the skin, and the effect of remarkably relaxing excessively single muscular tension can be achieved.

The invention relates to an anti-aging life-prolonging pill, which can stimulate human stem cells, improve the activity of cells, delay cell death, remove redundant free radical components in the body, strengthen the heart, tonify the liver and the kidney, and is a medical and edible health-care product with an anti-aging effect. Life prolonging is a general willingness of people, many health care products are prepared from traditional Chinese medicines and western medicines in the past, but few health care products are applied to the cell technology for resisting aging and prolonging life, and the traditional Chinese medicines and the western medicines are combined to stimulate human stem cells and play a role in delaying aging. The composition comprises the following components: 0.1%-1% of vitamin A, 0.1%-1% of vitamin D, 35%-45% of an astragalus extract, 34%-44% of a dogwood extract and 15%-25% of honey. The traditional Chinese medicine and the western medicine are combined and cooperate with each other, so that human stem cells can be stimulated, the activity of the cells is improved, free radicals in the body can be removed, the heart is strengthened, the liver and the kidney are tonified, immunity is enhanced, cancer is prevented, diseases are resisted and senescence is delayed.

The present invention relates to a composition for preventing or treating prostate disease containing, as active ingredients, extracts from Stauntonia hexaphylla and Cornus officinalis. In particular, the extracts from Stauntonia hexaphylla and Cornus officinalis are not cytotoxic and have an excellent effect in inhibiting the expression of androgen receptors, prostate specific antigens and prostate specific enzymes, and thus can be used as active ingredients of a composition for preventing or treating prostate disease.

The invention relates to a composition for resisting fatigue, enhancing immunity and treating rheumatism and a preparation method thereof. The composition is prepared from the following components in parts by mass: 19 to 35 parts of herba cistanche extract, 12 to 26 parts of fructus corni extract, 8 to 18 parts of radix angelicae pubescentis enzymolysis powder, 4 to 12 parts of cortex moutan enzymolysis powder, 14 to 28 parts of compound traditional Chinese medicine fermentation extract and 8 to 16 parts of compound traditional Chinese medicine extract. The traditional Chinese medicine composition has the effects of enhancing immunity, relieving physical fatigue and treating rheumatoid arthritis, the dose-effect relationship of all the components is fully mastered, the extract is prepared through a specific production and preparation technology, the medicine effect and the bioavailability of the medicinal materials are improved, and the preparation method is high in general applicability and suitable for industrial production. The method is suitable for producing and processing various dosage forms such as tablets, hard capsules, soft capsules, granules, oral liquid and the like, is easy to operate, stable in process, controllable in quality, high in production efficiency, high in economic added value and suitable for large-scale and industrial mass production.

The invention relates to a traditional Chinese medicine composition capable of shrinking and tightening vagina as well as a preparation method and application thereof, and belongs to the technical field of medicine and health. The traditional Chinese medicine composition for shrinking and tightening vagina is characterized by mainly comprising the following components in parts by weight: 1-10 parts of gallnut extract, 1-10 parts of pomegranate rind extract, 1-10 parts of lime fruit extract, 1-10 parts of dogwood extract, 1-10 parts of centella asiatica extract, 1-20 parts of propylene glycol and 1-20 parts of deionized water. The traditional Chinese medicine composition for shrinking and tightening the vagina provided by the invention is prepared from natural traditional Chinese medicines,is refined in coagulation and scientific in compatibility, and has a synergistic effect; the composition has the effects of improving vagina smooth muscle activity, increasing elasticity, repairing intima damage of the private part, resisting private part aging and fading black to pink skin, can take effect after being used for 5-7 days, and can reshape and tighten the private part and restore the private part to the original position; the traditional Chinese medicine composition has the advantages of safety, high efficiency, no side effect, no medicine residue, difficulty in generating medicine resistance, convenience in use and the like, and can be widely applied to private tightening products.

The invention relates to a method for preparing high-purity loganin from cornus officinalis extract. After the extract of Cornus officinalis was enriched by macroporous adsorption resin and preliminarily separated by normal phase silica gel, the sample containing loganin was passed through a medium-pressure reversed-phase silica gel chromatography column, and the mobile phase was ethanol and water for gradient elution, and the samples rich in loganin The eluent of glycoside was concentrated under reduced pressure to obtain crude loganin with a purity of ≥ 90%; finally, it was purified by Sephadex LH‑20 gel column chromatography, eluted with a mixed solvent of chloroform and methanol, and the eluent was evaporated under reduced pressure. Dry to obtain loganin with a purity of ≧98%. The method has remarkable separation effect, high speed and high efficiency, simple operation and mild conditions.