38 results about "Organ protection" patented technology

The invention discloses an automatic examination method and system for radiotherapy records based on a multi-modal pre-training model, and a storage medium, and belongs to the field of medical artificial intelligence and radiooncology quality control. The method comprises the following steps: acquiring and standardizing multi-modal data of the whole process of radiotherapy; extracting and fusing image, text and dose features through an improved vision-language model and an enhanced ClinicalBERT (ClinicalBERT); retrieving related clinical evidences from the radiotherapy knowledge base based on a retrieval enhancement generation framework; inputting the fusion features and the retrieval evidence into a locally deployed multi-modal model to generate a structured review report; and executing six functional modules of target coverage evaluation, organ protection analysis, DVH interpretation, quality scoring, guide compliance inspection and anomaly detection based on a report, outputting a grading decision result, and supporting full-link audit tracing. According to the invention, automatic and standardized examination of radiotherapy records is realized, the examination efficiency and consistency are improved, and the labor burden and subjective difference are reduced.

The invention relates to the technical field of clinical decision support and medical data intelligent analysis, in particular to a critical patient individualized liquid resuscitation decision support system, which is characterized in that a data acquisition unit acquires pulse pressure variation waveform and multi-dimensional physiological data of each stroke volume; a volume benefit analysis channel of the dynamic decision-making unit segments a respiratory cycle, extracts pulse pressure fluctuation characteristics, outputs a per-stroke volume increase probability value through a machine learning classifier, an organ injury early warning channel calculates a blood lactic acid and creatinine clearance rate change rate, and generates an acute kidney injury risk sign in combination with inferior vena cava image verification; the execution control unit sends an infusion control or limit instruction according to the combined state; and the feedback optimization unit adjusts the weight of the model according to the actual value of blood lactic acid removal, and recalculates the probability value, so that individualized precise resuscitation, balance capacity benefit and organ protection are realized, and the treatment safety and effectiveness are improved.

The invention discloses a radiotherapy plan automatic optimization method and device based on a large language model and RAG, and the device comprises an initial plan generation module which is used for generating an initial scheme based on a fixed weight; the data construction module is used for establishing a clinical knowledge base and completing semantic segmentation and vector indexing; the retrieval module is used for matching the query vector with a knowledge base, and obtaining a weighted knowledge set through similarity screening and reordering; the enhancement prompt generation module is used for generating an enhancement prompt; the large language model evaluation module is used for evaluating a scheme and outputting a weight adjustment suggestion; the iterative optimization module is used for updating parameters and generating a new scheme until convergence; and the comprehensive evaluation module analyzes the candidate schemes and outputs an optimal radiotherapy plan. According to the method, the large language model and the RAG are combined, clinical knowledge dynamic introduction and weight adaptive optimization are realized, manual intervention is reduced, target coverage and endangered organ protection are both considered, and radiotherapy plan intelligence and clinical value are improved.

The invention discloses a traditional Chinese medicine composition for treating sepsis as well as a preparation method and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from 1-15 parts of sulfur, 3-25 parts of calamitas urinae hominis, 1-20 parts of wine-treated rhubarb, 10-30 parts of fructus cannabis, 10-50 parts of radix bupleuri, 5-30 parts of scutellaria baicalensis, 5-25 parts of folium isatidis, 5-25 parts of peach kernels, 5-30 parts of salvia miltiorrhiza, 5-30 parts of angelica sinensis, 5-30 parts of sophora flower charcoal, 5-25 parts of fructus gardeniae praeparatus and 5-60 parts of wine-treated fructus corni. According to the invention, through a combined mode of'monarch drug targeted oral administration and synergistic decoction of minister, assistant and guide drugs', the whole-course intervention of'upstream inhibition, midstream blocking and downstream regulation 'on sepsis immune disorder can be realized, meanwhile, the functions of warming yang, dispelling cold, cooling blood and detoxifying are taken into account, and the pro-inflammatory / anti-inflammatory balance is successfully recovered to a physiological state; the action mode is superior to that of a traditional single anti-inflammatory strategy and a traditional Chinese medicine application mode of whole-prescription decoction. In a standard animal model, the traditional Chinese medicine composition definitely shows the dose-dependent extremely remarkable effects of anti-inflammation, immunoregulation, multi-organ protection and overall condition improvement, the curative effect of a high-dose group of the traditional Chinese medicine composition is equivalent to that of a classic potent medicine, and the traditional Chinese medicine composition has more advantages in the aspects of recovering immune homeostasis, warming yang and strengthening the body resistance.

A family of bioactive compounds identified in self-resolving inflammatory exudates is disclosed. The compounds give UV chromophores characteristic of a conjugated triene double bond system coupled to an auxochrome allylic to the triene. Further elucidation of the compounds reveals that they have a resolvin backbone conjugated to a peptide or amino acid moiety via an auxochrome. In some embodiments the auxochrome is sulfur. However, the auxochrome may be NH, CH2 or O. The compounds have potent bioactivity, in vitro, and, in vivo, including promoting resolution of infection, stimulating macrophage phagocytosis of bacteria; protecting tissues from neutrophil mediated damage, promoting tissue repair and regeneration and preventing or limiting second organ reflow / reperfusion damage.

The invention belongs to the field of traditional Chinese medicine compositions, and particularly relates to a sobering and hangover alleviating traditional Chinese medicine composition which comprises a component A and a component B, wherein the component A comprises a component a, a component b, a component c and a component d; the component B comprises a component e, a component f, a component g and a component h; in the component A, the component a is radix puerariae and an extract thereof; the component b is rhizoma polygonati and an extract thereof; the component c is poria cocos and an extract thereof; the component d is lily and an extract thereof; in the component B, the component e is radix ophiopogonis and an extract thereof; the component f is fructus lycii and an extract thereof; the component g is konjak and an extract thereof; the component h is orange peel and an extract thereof. The eight medicines are combined and can realize synergism, and excellent sobering and hangover alleviating effects can be obtained. The traditional Chinese medicine composition disclosed by the invention can have better sobering and hangover alleviating functions on the basis of the combined action of multiple mechanisms of metabolism acceleration, organ protection and system conditioning, and the components in the traditional Chinese medicine composition all belong to safe raw materials with homology of medicine and food.

The application provides application of Trapidil in preparation of a drug for preventing and / or treating doxorubicin-induced organ toxicity, and belongs to the technical field of biological medicines.The application discloses that Trapidil plays an organ protection role by activating a cAMP / PKA / CREB signal axis and driving two parallel downstream effect channels: on the one hand, up-regulating an NRF2-GPX3 positive feedback loop to inhibit doxorubicin-induced myocardial cell pyroptosis and glomerular podocyte pyroptosis; and on the other hand, activating an NRF2 / HO-1 channel to inhibit myocardial cell apoptosis and glomerular podocyte apoptosis.In-vivo and in-vitro experiments prove that Trapidil can improve doxorubicin-induced cardiac dysfunction and kidney function damage, reduce histopathological damage, reduce the level of oxidative stress, inhibit the pyroptosis and apoptosis of myocardial cells and glomerular podocytes, and does not affect the antitumor effect of doxorubicin.The application provides a new drug strategy for doxorubicin chemotherapy-induced multi-organ toxicity.

A supporting cylinder is in a transverse cylindrical shape, sealing discs are coaxially, hermetically and rotatably connected to the front and rear parts of the supporting cylinder, sliding grooves penetrate through the middles of the two sealing discs correspondingly, and sealing plates are vertically, hermetically and slidably connected to the two sliding grooves correspondingly; vertical organ protection covers are fixed to the upper ends and the lower ends of the two sealing plates correspondingly, can be compressed up and down correspondingly and are in sealed sliding connection with the sliding grooves. By controlling the auxiliary electric push rod and the main electric push rod, the supporting roller can be located on the lower portion or the right lower portion of the inner cavity of the supporting barrel, namely, the structural characteristic that the upper gap between the supporting roller and the supporting barrel is large and the lower gap between the supporting roller and the supporting barrel is small is formed, and then traditional Chinese medicinal materials can be squeezed and extracted through cooperation of a scraper and a filter screen; and by further enhancing the structural characteristics, the traditional Chinese medicinal materials can be squeezed more fully without repeated squeezing and extraction, and the working efficiency is improved.

The utility model discloses a ferrosilicon nitriding alloy furnace, which relates to the technical field of auxiliary equipment for casting and comprises a furnace body with two furnace doors on one side. A plurality of mounting sub-cavity plates are arranged, and the plurality of mounting sub-cavity plates are fixedly connected into the furnace body at equal intervals; and the multiple cavity adjusting plates are arranged, each cavity adjusting plate is slidably connected to the corresponding installation cavity dividing plate, the two ends of each cavity adjusting plate are fixedly connected with organ protective covers, and one end of each organ protective cover is fixedly connected into the furnace body. According to the ferrosilicon nitriding alloy furnace, use of the cavity adjusting plate is controlled through the position adjusting mechanism, the space in the furnace body can be adjusted, the whole furnace can adapt to different use requirements, the situation that the internal space is too large, resources are wasted is avoided, the use efficiency is improved, the position of the bearing plate is controlled through the telescopic mechanism, treated metal is conveniently adjusted, and the use effect is guaranteed; in addition, the automatic feeding and discharging device is simple in structure and easy and convenient to use.

The present invention provides a material or method that can serve as an alternative to a related-art digestive fluid leak preventative material and method of preventing a leak of a digestive fluid. The digestive fluid leak preventative material of the present invention includes a self-assembling peptide gel, has an adhesion persistence ratio with respect to a collagen sheet of at least 40%, and has a decomposition ratio of 35% or less in pancreatic juice treatment at 37°C for 7 days.

The invention belongs to the technical field of biotechnology and medicine, and particularly relates to application of an Anapc11 gene / protein to screening of drugs for treating hyperuricemia-related multi-organ dysfunction. According to the invention, the Anapc11 gene is used as a molecular target or a drug action target, and is used for screening or preparing drugs for treating multi-organ dysfunction (including liver injury, testis dysfunction, intestinal barrier destruction and the like) caused by hyperuricemia. The invention provides a new application of the cell cycle promoting complex subunit E3 ubiquitin ligase Anapc11 gene, provides a new molecular target for treating hyperuricemia related multi-organ dysfunction, and breaks through the limitation that the existing uric acid reducing medicine is only limited to a metabolic link; a new direction and a good application prospect are provided for developing innovative medicines with organ protection effects.

The application discloses a plant extraction compound for reducing blood pressure, a preparation method and application thereof. The compound is composed of high-purity silybin extract and a specific fusion polypeptide through molecular self-assembly. The sequence of the fusion polypeptide is shown in sequence SEQ ID NO:1, which innovatively integrates cell membrane penetration function, angiotensin II receptor 1 antagonism function and hydrophobic drug binding function. The core of the application is that through polypeptide-mediated active targeting, silybin is accurately delivered to the diseased blood vessel area, and the double synergistic mechanism of upstream ACE inhibition and downstream receptor blocking of the renin-angiotensin-aldosterone system is realized. In-vivo pharmacodynamic experiments prove that compared with single components, the compound can produce more significant and persistent antihypertensive effect, and can effectively reverse myocardial hypertrophy and fibrosis caused by hypertension, and show excellent synergistic therapeutic effect and target organ protection ability.

The utility model belongs to the technical field of numerical control machine tools, and relates to a numerical control machine tool linear shaft heat dissipation protection mechanism which comprises an organ protection cover and an axial flow fan. The organ protective cover is composed of an organ type sleeve and T-shaped end sleeves arranged at the two ends of the organ type sleeve, and the organ type sleeve is of a flexible telescopic structure. An air inlet joint and an air outlet joint are respectively arranged on the two T-shaped end sleeves; the air inlet connector is communicated with an air outlet of the axial flow fan through an air supply pipe. The heat dissipation protection mechanism is used for shielding and protecting a lead screw of a linear shaft of a numerical control machine tool, scrap iron, cooling liquid and tool accidental accidents are prevented from damaging the lead screw, air is conveyed to an annular space between the organ protection cover and the lead screw through the air supply pipe and the air inlet connector by means of the axial flow fan, and the air flows out of the air outlet connector and can take away heat generated by the lead screw; and heat dissipation and cooling can be conducted on the lead screw, thermal elongation errors caused by temperature rise of the lead screw due to motion friction can be reduced, and the position precision and the machining precision of a workpiece on the workbench are ensured.

The embodiment of the utility model provides a machine tool which comprises a base, a stand column arranged on the base and a cross beam arranged on the stand column and further comprises an outer protection structure, an organ protection piece, a connecting piece and a guide groove, the outer protection structure fixedly covers the periphery of the stand column and the periphery of the cross beam, and the organ protection piece is arranged on the front side face of the cross beam; a first gap is formed between the side portion of the organ protection piece and the outer protection structure, a second gap is formed between the bottom of the organ protection piece and the cross beam, the organ protection piece is fixedly connected with the outer protection structure through the connecting piece, the connecting piece covers the first gap, and the second gap is formed between the bottom of the organ protection piece and the cross beam. The guide groove is formed in the lower side face of the cross beam and covers the second gap, and the organ protection piece is in sliding fit with the guide groove. According to the machine tool, adaptive protection can be achieved along with adjustment of the height of the cross beam.

This application discloses a method, system, device, and medium for perfusion control of ex vivo organs, relating to the field of ex vivo organ protection and intelligent control technology. The method includes: constructing an extended state vector based on hemodynamic state variables within multiple consecutive control cycles; using a prediction model to determine a predicted output vector based on the extended state vector and a set perfusion flow control sequence; using an optimization function to determine a perfusion flow control sequence based on the predicted output vector, a reference vector, and the set perfusion flow control sequence; perfusing the ex vivo organ based on the perfusion flow control sequence; obtaining the actual value of the cycle-equivalent perfusion pressure after perfusion; updating the prediction model based on the actual value and predicted value of the cycle-equivalent perfusion pressure; and returning to the step of using the prediction model to determine the predicted output vector based on the extended state vector and the set perfusion flow control sequence. This application enables closed-loop control of ex vivo organ perfusion.

Systems and methods for providing medial compression for abdominal open wounds for negative pressure procedures using wound filling materials and organ protection layers are described. The wound filler may pull the abdominal wall toward the midline when under negative pressure. The wound filler can provide medial tension and reduce the risk of long-term rectus abdominis separation or abdominal separation. The organ protection layer may also be modified to facilitate medial compression and promote fluid.

The utility model relates to the technical field of dust covers, in particular to a telescopic dust cover for a fork arm of an AGV forklift, the telescopic dust cover is applied to a fork arm mechanism of the AGV forklift, the fork arm mechanism comprises a fork arm bottom cover, a fork arm body and a fork arm top cover, and the fork arm bottom cover and the fork arm top cover are connected through the fork arm body; the dustproof cover comprises a protection assembly, the protection assembly is arranged between the fork arm bottom cover and the fork arm top cover, the protection assembly comprises an organ protection cover, and the organ protection cover is detachably connected with the outer portion of the fork arm body. According to the telescopic dust cover for the fork arm of the AGV forklift provided by the utility model, the organ protective cover in the protective assembly can be sleeved and protected outside the lead screw in the fork arm body when the fork arm mechanism is unfolded for use, so that the phenomenon that the later use of the device is influenced by blockage of the lead screw due to the fact that impurities such as external dust fall outside the lead screw in the use process can be avoided; therefore, the fork arm mechanism can be used more smoothly in the later period.

The utility model relates to the field of electronic organs, in particular to an electronic organ convenient to fold and store, which comprises an electronic organ main body, sliding grooves I are formed in two side surfaces of the electronic organ main body, a connecting column is slidably connected to the inner wall of each sliding groove I, and a limiting head is fixedly connected to one end, far away from the electronic organ main body, of each connecting column. According to the electronic organ protection device, through the arrangement of the first sliding groove, the connecting columns, the protection cover, the connecting grooves and other components, when the electronic organ protection device is used, the protection cover is firstly moved downwards, then the connection columns move to drive the protection cover to move to the rear portion of the electronic organ along the first sliding groove, and then the electronic organ protection device is used for protecting the electronic organ. The protection cover is rotated to the position above the electronic organ by rotating the protection cover, the position of the protection cover is fixed by fixing the rotating cover, the protection cover surrounds the outer side of the electronic organ, and the effect that the device can store and fold the electronic organ according to requirements is achieved.

The invention provides a proton intensity modulated therapy radiation field direction automatic planning method, system and device based on deep learning and multi-objective optimization, and a storage medium, and the method comprises the steps: inputting a patient medical image, a tumor target region, an endangered organ structure and a treatment plan radiation field direction into a pre-trained 3DU-Net model, and obtaining a three-dimensional radiation field direction probability distribution diagram; performing Fibonacci spherical sampling to generate a candidate radiation field direction, calculating a path length score and an organ-at-risk avoidance score in each direction, and dynamically weighting and balancing the two scores; a proton range error and a patient positioning error are introduced to simulate dose distribution, target area coverage and organ-endangering dose change under the error are evaluated, and a robustness score is calculated; performing collision detection on the treatment rack, and rejecting directions which are not reachable or have collision risks; and selecting a direction to encrypt and sample near the direction, and optimizing a final radiation field direction according to comprehensive scoring results. According to the method, the radiation field direction can be automatically optimized, target dose coverage and organ-endangering protection are improved, and the robustness of a treatment plan to errors is enhanced.

This utility model discloses a novel long-distance bellows cover guide rail, including a main mounting assembly, a main support assembly disposed on the rear side of the main mounting assembly, an upper guide assembly disposed on the main support assembly, and a lower guide assembly disposed on the main mounting assembly. A protective assembly is connected to the upper guide assembly and the lower guide assembly via a wear-resistant component. The beneficial effects of this utility model are that the guide rail of this technical solution has an ingenious structural design, strong practicality, and stable operation. Using this guide rail effectively ensures the stability and smoothness of the protective cover's movement, while avoiding the use of machine tool guide rails and effectively preventing wear on machine tool guide rails.

The present application belongs to the field of biotechnology and medical technology, and particularly relates to Anapc11 gene / protein for screening drugs for treating hyperuricemia related multi-organ dysfunction. The present application uses Anapc11 gene as a molecular target or a drug action target for screening or preparing drugs for treating multi-organ dysfunction caused by hyperuricemia (including liver injury, testicular dysfunction and intestinal barrier damage). The present application provides a new use of cell cycle promoting complex subunit E3 ubiquitin ligase Anapc11 gene, provides a new molecular target for treating hyperuricemia related multi-organ dysfunction, breaks the limitation of existing uric acid lowering drugs only in the metabolic link, and provides a new direction and good application prospect for developing innovative drugs with organ protection effect.

The present invention relates to a nucleic acid molecule or a composition comprising said molecule for use as an anti-inflammatory and / or anticoagulant and / or organ protective drug. The present invention also relates to the use of said nucleic acid molecule or said composition for the manufacture of a medicament for the prevention, treatment, regression, cure and / or delay of a disease or condition in which inflammation and / or coagulation and / or organ impairment or failure occurs in an individual. Finally, the present invention further relates to a method for alleviating one or more symptoms and / or parameters and / or improving a disease or condition in which inflammation and / or coagulation and / or organ impairment or failure occurs in an individual, the method comprising administering to said individual said nucleic acid molecule or said composition.

The utility model discloses a bale plucker which comprises a bottom plate and an outer wall body arranged at the top end of the bottom. A rotating assembly is arranged in the middle of the top end of the bottom plate, an outer frame is mounted at the rotating end of the rotating assembly, a moving assembly is connected to the end, away from the rotating assembly, of the outer frame, and the moving assembly is slidably mounted on the outer contour of the outer wall body; a mounting frame is mounted in the outer frame, a cotton grabbing assembly is arranged in the mounting frame, a dust suction hood is arranged above the mounting frame, a sealing assembly is detachably mounted between the mounting frame and the dust suction hood and comprises a protection frame, and a first groove is formed in the top end of the mounting frame. By means of the sealing assembly composed of the protection frame and the organ protection cover, dust generated by the cotton grabbing assembly in the installation frame can enter the dust collection cover through the sealing assembly, and the dust is prevented from leaking out through a gap between the installation frame and the dust collection cover.

The present disclosure relates to compositions and methods of modulating B lymphocyte activity, and organ protection after acute injury. In particular, PEG-Pirfenidone has increased half-life, improved bioavailability and is equipotent in modulating B cell activity and is particularly useful as protective agents from acute organ damage and disease caused by dysregulation of B cell activity.

The invention relates to the technical field of deep processing of agricultural products, and discloses a preparation method and application of Tibetan tea polysaccharide self-assembled nanoparticles, and the method comprises the following steps: firstly, carrying out crushing and hydrothermal extraction on a Tibetan tea raw material; then soybean lecithin is added under the condition of constant temperature to construct a composite system; the key step is as follows: a three-section staged gradient cooling process at 50 DEG C and 30-10 DEG C is adopted to induce the system to generate ordered self-assembly; and finally, centrifuging, ultra-filtering, purifying and freeze-drying to obtain a finished product. The nano-particles prepared by the method are of a uniform spherical structure, and the particle size is distributed between 100nm and 200nm. The whole process does not need a chemical cross-linking agent, is green and controllable, and effectively solves the problems of loose structure, poor stability and low bioavailability of the traditional Tibetan tea extract. The obtained nanoparticles have remarkable effects of resisting oxidation, reducing blood sugar and lipid and protecting organs, and are suitable for preparing functional foods and medicines for treating type II diabetes mellitus and fatty liver.

The invention discloses an adjustable bus duct expansion joint connecting device, and relates to the technical field of bus ducts, the adjustable bus duct expansion joint connecting device comprises a bus duct body, and the bus duct body is provided with an adjusting assembly, a suspension assembly and an expansion compensation assembly; the adjusting assembly comprises a first shell and a second shell, organ protection covers are symmetrically installed at the joint of the first shell and the second shell, a rotating shaft is installed between the first shell and the second shell, a nut is installed at the top end of the rotating shaft, and a limiting plate is installed at the bottom end of the rotating shaft. A plurality of conductive connecting sheets I are mounted on the inner sides of the shell I and the shell II, and extension grooves are formed in the conductive connecting sheets I; through the design of the adjusting assembly, when the bus duct is used, the flexibility of angle adjustment greatly improves the application range of the device, the device can be easily adapted to wall corner wiring needing right-angle steering or an open area extending linearly, shell assemblies of different specifications do not need to be replaced, and the equipment purchase and inventory cost is reduced.

The utility model discloses an online cut-off machine which comprises a base, a large lifting plate is arranged on the upper surface of the base, linear guide rails are symmetrically and fixedly connected to the upper surface of the large lifting plate, sliding blocks are slidably connected to the upper surfaces of the linear guide rails, a movable frame is fixedly connected to the upper ends of the sliding blocks, and a first driving mechanism is arranged on the lower surface of the movable frame. Lifting assemblies are symmetrically arranged at the two ends of the large lifting plate, organ protective covers are fixedly connected to the two ends of the large lifting plate, a bottom plate is arranged on the upper surface of the moving frame, one end of the bottom plate is rotationally connected with the inner side surface of the moving frame, a pushing mechanism is arranged at the other end of the bottom plate, and a supporting plate is fixedly connected to the upper surface of the bottom plate; the upper surface of the bottom plate is rotationally connected with a rotating shaft. The use flexibility of the cut-off machine is improved, meanwhile, a worker is prevented from disassembling and rotating the cutting die and the cutting die feeding port, therefore, the trouble and the workload of the worker are reduced, meanwhile, shutdown operation of the cut-off machine is avoided, and the production efficiency of the cut-off machine is improved.

A balloon catheter, comprising an elongate body having a proximal end and a proximal opening, a distal end and a distal opening, the proximal and distal openings defining an inner lumen therebetween, wherein the body defines an inner surface and an outer surface, a first internal channel positioned within the inner lumen and fluidly connected to at least one balloon positioned on the outer surface of the body at the distal end, wherein the balloon is configurable between an inflated state and a deflated state, and a second internal channel positioned within the inner lumen.

The application belongs to the technical field of veterinary antibacterial drugs, and provides application of LUT combined with FF in preparation of a drug for treating duck Riemerella anatipestifer infection. The application uses luteolin (LUT) in a sub-inhibitory concentration in combination with florfenicol (FF), which can significantly reduce the MIC value of florfeniol to duck Riemerella anatipestifer, greatly reduce the dosage of florfenicol, reduce the risk of drug residues and breeding costs, avoid the generation of drug resistance caused by the single use of florfenicol, and prolong the clinical service life of florfenicol; the bactericidal effect is enhanced, the application has significant anti-inflammatory and organ protection effects, high safety, is not prone to drug resistance, and has a wide application prospect.