The invention discloses a full-circumference spherical surface stereotactic radiotherapy device. The device comprises an X-band accelerator, a multi-leaf collimator, a treatment couch, an image system, an EPID, a fixed rack and a rotary rack, the rotary rack is arranged on the fixed rack in a rotatable mode, the treatment couch is fixed relative to the fixed rack, the image system is arranged on the rotary rack, the X-band accelerator is connected to the multi-leaf collimator, and the X-band accelerator is arranged on the rotary rack, so that the X-band accelerator forms spherical irradiationon a treatment center; and the EPID is arranged on the rotary rack, and the EPID is orthogonal to a beam of the X-band accelerator so as to receive residual beams. The full-circumference spherical surface stereotactic radiotherapy device can perform full-circumference spherical surface stereotactic radiotherapy on a patient.