Stereotactic radiotherapy plan evaluation method, device, equipment and storage medium

Abstract

The invention discloses a stereotactic radiotherapy plan evaluation method, device and equipment and a storage medium, and relates to the technical field of radiotherapy plan evaluation, and the method comprises the steps: obtaining the file data of a stereotactic radiotherapy plan; according to the file data, determining the division times and the division dose of the stereotactic radiotherapy plan; calculating according to the segmented dose to obtain dose basic parameters, target region parameters and organ-at-risk parameters of each time of division; and determining an evaluation result of the stereotactic radiotherapy plan according to the dose basic parameters, the target region parameters and the organ-at-risk parameters. Through full-automatic auxiliary structure generation, data extraction and dosimetry index calculation, evaluation of key parameters such as target area coverage and organ-endangering protection can be rapidly completed, manual intervention and personal errors are greatly reduced, and evaluation efficiency is remarkably improved.

Description

Technical Field

[0001] The present application relates to the technical field of radiotherapy plan evaluation, and particularly to a method, device, equipment and storage medium for stereotactic radiotherapy plan evaluation. Background Art

[0002] Clinically, the main plan evaluation method still adopts the manual evaluation method. Many evaluation parameters need to generate corresponding structures manually to obtain the evaluation results, which is time-consuming, laborious and error-prone. The existing automatic plan evaluation methods are mainly for conventional radiotherapy, or mainly focus on the evaluation of the target area, and cannot be applied to the multi-parameter evaluation of stereotactic radiotherapy. Summary of the Invention

[0003] The main purpose of the embodiments of the present application is to propose a method, device, equipment and storage medium for stereotactic radiotherapy plan evaluation, so as to evaluate the parameters of the target area and organs at risk in the stereotactic radiotherapy plan according to different fractionation numbers.

[0004] To achieve the above object, on the one hand, an embodiment of the present application proposes a method for stereotactic radiotherapy plan evaluation, the method comprising the following steps:

[0005] Obtain the file data of the stereotactic radiotherapy plan;

[0006] Determine the fractionation number and the fractionated dose of the stereotactic radiotherapy plan according to the file data;

[0007] Calculate the dose basic parameters, target area parameters and organ at risk parameters for each fractionation number according to the fractionated dose;

[0008] Determine the evaluation result of the stereotactic radiotherapy plan according to the dose basic parameters, the target area parameters and the organ at risk parameters.

[0009] In some embodiments, calculating the dose basic parameters for each fractionation number according to the fractionated dose comprises the following steps:

[0010] Calculate the biological equivalent dose and the equivalent dose for each fractionation number as the dose basic parameters;

[0011] The calculation formula of the biological equivalent dose is:

[0012]

[0013] where BED is the biological equivalent dose, n is the fractionation number, d is the fractionated dose, and α / β is the characteristic dose of the tissue;

[0014] The calculation formula of the equivalent dose is:

[0015]

[0016] Among them, EQD2 is the equivalent dose;

[0017] The method further includes the following steps:

[0018] Extract the treatment course, plan name, plan technique, total planned dose, the fractionated dose, the number of fractions, dose matrix size, monitor units, and plan designer as the basic plan information.

[0019] In some embodiments, calculating the target region parameters for each of the number of fractions according to the fractionated dose includes the following steps:

[0020] Extract the target volume and the dose coverage range of the fractionated dose from the file data, and generate D2cm and the 105% dose line structure outside the target region as auxiliary structures for evaluation;

[0021] Perform piecewise linear interpolation according to the requirements of RTOG0813 to determine the target region gradient index corresponding to the target volume;

[0022] Calculate the gradient index, high-dose spillage value, and medium-dose spillage value; among them, the target volume, the dose coverage range, the target region conformity, the gradient index, the high-dose spillage value, and the medium-dose spillage value are used as the target region parameters.

[0023] In some embodiments, calculating the organ-at-risk parameters for each of the number of fractions according to the fractionated dose includes the following steps:

[0024] Extract the organ-at-risk structure data from the file data;

[0025] Calculate the relevant doses of each organ-at-risk according to the organ-at-risk structure data and the number of fractions, and the relevant doses include the dose of the lung and the maximum dose of the spinal cord.

[0026] In some embodiments, determining the evaluation result of the stereotactic radiotherapy plan according to the dose basic parameters, the target region parameters, and the organ-at-risk parameters includes the following steps:

[0027] Compare the dose basic parameters, the target region parameters, and the organ-at-risk parameters with the corresponding standard values to determine the evaluation result of the stereotactic radiotherapy plan.

[0028] In some embodiments, the method further includes at least one of the following steps:

[0029] Dynamically update the display fields in the terminal interface; among them, the display fields include patient information, dosimetric indicators, and the evaluation result;

[0030] Alternatively, generate an evaluation report for the stereotactic radiotherapy plan; wherein, the evaluation report includes the total dose, the fractionated dose, the evaluation results of the target volume parameters, and the evaluation results of the organ at risk parameters;

[0031] Alternatively, export the evaluation results of the stereotactic radiotherapy plan in PDF format, CSV format, or Excel format;

[0032] Alternatively, generate a visual dose volume histogram based on the evaluation results of the stereotactic radiotherapy plan.

[0033] In some embodiments, the method further includes at least one of the following steps:

[0034] Query the relative amounts of other dosimetric parameters for any target volume or organ at risk; wherein, the other dosimetric parameters include the maximum dose, the minimum dose, the average dose, the dose corresponding to a fixed volume, and the volume corresponding to a fixed dose;

[0035] Alternatively, query the absolute amounts of the other dosimetric parameters for any target volume or organ at risk.

[0036] To achieve the above object, another aspect of the embodiments of the present application provides a stereotactic radiotherapy plan evaluation device, the device includes:

[0037] A data acquisition unit, configured to acquire file data of a stereotactic radiotherapy plan;

[0038] A fractionation parameter determination unit, configured to determine the number of fractions and the fractionated dose of the stereotactic radiotherapy plan according to the file data;

[0039] An index calculation unit, configured to calculate the dose basic parameters, target volume parameters, and organ at risk parameters for each of the number of fractions according to the fractionated dose;

[0040] A plan evaluation unit, configured to determine the evaluation results of the stereotactic radiotherapy plan according to the dose basic parameters, the target volume parameters, and the organ at risk parameters.

[0041] To achieve the above object, another aspect of the embodiments of the present application provides an electronic device, the electronic device includes a memory and a processor, the memory stores a computer program, and when the processor executes the computer program, the above method is implemented.

[0042] To achieve the above object, another aspect of the embodiments of the present application provides a computer-readable storage medium, the computer-readable storage medium stores a computer program, and when the computer program is executed by a processor, the above method is implemented.

[0043] The embodiments of the present application at least include the following beneficial effects:

[0044] The present application can obtain the file data of a stereotactic radiotherapy plan; determine the number of fractions and the fractionated dose of the stereotactic radiotherapy plan according to the file data; calculate the dose basic parameters, target parameters, and organ-at-risk parameters for each fraction based on the fractionated dose; and determine the evaluation result of the stereotactic radiotherapy plan according to the dose basic parameters, target parameters, and organ-at-risk parameters. Through fully automated auxiliary structure generation, data extraction, and dosimetric index calculation, the present application can quickly complete the evaluation of key parameters such as target coverage and organ-at-risk protection, greatly reducing manual intervention and human error, and significantly improving the evaluation efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0045] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the following will briefly introduce the drawings required for the description of the embodiments. Obviously, the drawings in the following description are only some embodiments of the present application. For those of ordinary skill in the art, other drawings can be obtained based on these drawings without creative efforts.

[0046] Figure 1 It is a flowchart showing the process of a method for evaluating a stereotactic radiotherapy plan provided by an embodiment of the present application;

[0047] Figure 2 It is an example flowchart of a method for evaluating a stereotactic radiotherapy plan provided by an embodiment of the present application;

[0048] Figure 3 It is an example diagram of a custom query provided by an embodiment of the present application;

[0049] Figure 4 It is an example flowchart of another method for evaluating a stereotactic radiotherapy plan provided by an embodiment of the present application;

[0050] Figure 5 It is an example diagram of a plan evaluation form provided by an embodiment of the present application;

[0051] Figure 6 It is a schematic structural diagram of a device for evaluating a stereotactic radiotherapy plan provided by an embodiment of the present application;

[0052] Figure 7 It is a schematic hardware structure diagram of an electronic device provided by an embodiment of the present application. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0053] In order to make the objectives, technical solutions, and advantages of this application more clearly understood, the following further elaborates on this application in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely used to explain this application and are not intended to limit this application. When the following description involves the accompanying drawings, unless otherwise indicated, the same numbers in different drawings represent the same or similar elements. The implementation manners described in the following exemplary embodiments do not represent all implementation manners consistent with the embodiments of this application. They are merely examples of devices and methods that are consistent with some aspects of the embodiments of this application as detailed in the appended claims.

[0054] It can be understood that the terms "first", "second", etc. used in this application may be used herein to describe various concepts, but unless otherwise specified, these concepts are not limited by these terms. These terms are only used to distinguish one concept from another. For example, without departing from the scope of the embodiments of this application, the first information may also be referred to as the second information. Similarly, the second information may also be referred to as the first information. Depending on the context, the words "if", "when" as used herein may be interpreted as "when...", "while...", or "in response to determining".

[0055] The terms "at least one", "multiple", "each", "any one", etc. used in this application, "at least one" includes one, two, or more than two, "multiple" includes two or more than two, "each" refers to each one in the corresponding multiple, and "any one" refers to any one in the multiple.

[0056] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by those skilled in the technical field to which this application belongs. The terms used herein are only for the purpose of describing the embodiments of this application and are not intended to limit this application.

[0057] Before elaborating in detail on the embodiments of this application, first, some related technologies involved in the embodiments of this application are described as follows:

[0058] The automatic evaluation of radiotherapy plans is a research direction. In recent years, there have been some related research reports. Related technology 1 designed a software for automatically generating and comparing dose-volume histograms (DVHs) based on AutoHotKey and the Eclipse scripting application programming interface (ESAPI); Related technology 2 developed a radiotherapy plan DVH evaluation software based on ESAPI; Related technology 3 developed the Plan-Checker Tool through ESAPI for automatically verifying the items in the pre-treatment plan checklist. The above related technologies have all achieved certain clinical results, but they mainly focus on the evaluation of conventional radiotherapy plans, and the evaluation parameters are relatively single. Stereotactic Body Radiation Therapy (SBRT) has fewer fractions, higher single-dose, and larger biological equivalent dose, so the plan evaluation of SBRT is very different from that of conventional radiotherapy. The relevant guidelines put forward specific requirements for target conformity, medium and high-dose spillage, and dose fall-off. In addition, the requirements for the dose received by organs at risk are also more stringent. In the currently commercially available treatment planning system (TPS), when evaluating a plan, it is impossible to directly obtain indicators such as dose spillage and dose fall-off. Usually, a series of complicated operations such as manual isodose contour creation, Boolean operations, numerical calculations, and layer-by-layer viewing of the spillage dose are required, which not only has low efficiency but is also extremely prone to human operation errors. In response to this, researchers such as related technology 4 achieved the automatic evaluation of relevant target indicators according to the requirements of the stereotactic radiotherapy plan for NSCLC in the Radiation Therapy Oncology Group (RTOG) report No. 0915. However, this study did not evaluate the organs at risk and did not conduct corresponding evaluations for different numbers of fractions. In addition, for stereotactic radiotherapy plans with different numbers of fractions, the restrictive requirements for the dose evaluation parameters of the relevant organs at risk are different. Currently, the main method used clinically is manual evaluation, which is inefficient. Therefore, there is an urgent need for an automatic evaluation scheme for stereotactic radiotherapy plans to automatically evaluate the dosimetric index parameters of the target area and organs at risk according to different total treatment fractions and improve the evaluation efficiency.

[0059] The embodiments of the present application provide a method, device, equipment and storage medium for evaluating a stereotactic radiotherapy plan. The technical solution of the present application includes: obtaining the file data of the stereotactic radiotherapy plan; determining the number of fractions and the fractionated dose of the stereotactic radiotherapy plan according to the file data; calculating the dose basic parameters, target parameters and organ at risk parameters for each fraction number according to the fractionated dose; and determining the evaluation result of the stereotactic radiotherapy plan according to the dose basic parameters, target parameters and organ at risk parameters. Through fully automated auxiliary structure generation, data extraction and dosimetric index calculation, the present application can quickly complete the evaluation of key parameters such as target coverage and organ at risk protection, greatly reducing manual intervention and human error, and significantly improving the evaluation efficiency.

[0060] The embodiments of the present application provide a method, device, equipment and storage medium for evaluating a stereotactic radiotherapy plan, which relates to the technical field of radiotherapy plan evaluation. The method, device, equipment and storage medium for evaluating a stereotactic radiotherapy plan provided by the embodiments of the present application can be applied to a terminal, or to a server, or can also be software running on a terminal or a server. In some embodiments, the terminal can be a smart phone, a tablet computer, a notebook computer, a desktop computer, a smart speaker, a smart watch, a vehicle-mounted terminal, etc., but is not limited thereto; the server side can be configured as an independent physical server, or can be configured as a server cluster or a distributed system composed of multiple physical servers, or can also be configured as a cloud server providing basic cloud computing services such as cloud services, cloud databases, cloud computing, cloud functions, cloud storage, network services, cloud communications, middleware services, domain name services, security services, CDN, and big data and artificial intelligence platforms. The server can also be a node server in a blockchain network; the software can be an application for implementing the knowledge extraction method, etc., but is not limited to the above forms.

[0061] The present application can be used in many general or special computer system environments or configurations. For example: personal computers, server computers, handheld or portable devices, tablet devices, multi-processor systems, microprocessor-based systems, set-top boxes, programmable consumer electronic devices, network PCs, minicomputers, mainframe computers, distributed computing environments including any of the above systems or devices, and so on. The present application can be described in the general context of computer-executable instructions executed by a computer, such as program modules. Generally, program modules include routines, programs, objects, components, data structures, etc. that perform specific tasks or implement specific abstract data types. The present application can also be practiced in a distributed computing environment where tasks are performed by remote processing devices connected through a communication network. In a distributed computing environment, program modules can be located in local and remote computer storage media including storage devices.

[0062] Refer to Figure 1, an embodiment of the present application provides a method for evaluating a stereotactic radiotherapy plan, which may include but is not limited to S100 to S130, specifically as follows:

[0063] S100: Obtain the file data of the stereotactic radiotherapy plan.

[0064] Specifically, the file data includes all data of the stereotactic radiotherapy plan, such as the planning process, various dose parameters, etc.

[0065] S110: Determine the number of fractions and the fractionated dose of the stereotactic radiotherapy plan according to the file data.

[0066] Specifically, the number of fractions is the number of radiotherapy sessions of the stereotactic radiotherapy plan, and the fractionated dose is the radioactive dose of each radiotherapy session.

[0067] S120: Calculate the dose basic parameters, target parameters, and organ-at-risk parameters for each of the number of fractions according to the fractionated dose.

[0068] Further, S120 may include S121 to S123:

[0069] S121: Calculate the dose basic parameters for each of the number of fractions according to the fractionated dose.

[0070] Specifically, S121 may include the following steps:

[0071] Calculate the biologically equivalent dose and the equivalent dose for each of the number of fractions as the dose basic parameters;

[0072] The calculation formula for the biologically equivalent dose is:

[0073]

[0074] where BED is the biologically equivalent dose, n is the number of fractions, d is the fractionated dose, and α / β is the characteristic dose of the tissue;

[0075] The calculation formula for the equivalent dose is:

[0076]

[0077] where EQD2 is the equivalent dose;

[0078] The method further includes the following steps:

[0079] Extract the course of treatment, plan name, plan technique, total planned dose, the fractionated dose, the number of fractions, dose matrix size, monitor units, and plan designer as the basic plan information.

[0080] S122: Calculate the target area parameters for each fraction number according to the divided dose.

[0081] Specifically, S122 may include the following steps:

[0082] Extract the target area volume and the dose coverage range of the divided dose from the file data, and generate D2cm and the 105% dose line structure outside the target area as auxiliary structures for evaluation;

[0083] Perform piecewise linear interpolation according to the requirements of RTOG0813 to determine the target area gradient index (R50%) corresponding to the target area volume;

[0084] Calculate the gradient index, high-dose spillage value, and medium-dose spillage value; wherein, the target area volume, the dose coverage range, the target area conformity, the gradient index, the high-dose spillage value, and the medium-dose spillage value are used as the target area parameters.

[0085] S123: Calculate the organ-at-risk parameters for each fraction number according to the divided dose.

[0086] Specifically, S123 may include the following steps:

[0087] Extract the organ-at-risk structure data from the file data;

[0088] Calculate the relevant doses of each organ-at-risk according to the organ-at-risk structure data and the fraction number, and the relevant doses include the dose of the lung and the maximum dose of the spinal cord.

[0089] S130: Determine the evaluation result of the stereotactic radiotherapy plan according to the dose basic parameters, the target area parameters, and the organ-at-risk parameters.

[0090] Further, S130 may include S131:

[0091] S131: Compare the dose basic parameters, the target area parameters, and the organ-at-risk parameters with the corresponding standard values to determine the evaluation result of the stereotactic radiotherapy plan.

[0092] It can be understood that each parameter calculated in the embodiments of the present application corresponds to its own standard value. If each parameter meets the requirements of the standard value, it can be determined that the evaluation result of the stereotactic radiotherapy plan passes the evaluation.

[0093] Next, the solution of the embodiments of the present application will be introduced and described in detail with specific application examples.

[0094] Refer to Figure 2 , this embodiment provides an example flowchart of a method for evaluating a stereotactic radiotherapy plan.

[0095] Specifically, this embodiment may include the following steps:

[0096] 1. Software initialization.

[0097] 1.1 Load the user interface (MainControl.xaml) and initialize the evaluation window.

[0098] 1.2 Set window display parameters, such as size and position.

[0099] 1.3 Check whether the necessary planning data is available.

[0100] 2. Data loading.

[0101] 2.1 Load data from the radiotherapy planning system:

[0102] Prioritize loading PlanSetup (single plan).

[0103] If multiple plan summations (PlanSum) exist, then PlanSum is loaded.

[0104] 2.2 Verify whether the loaded plan data is complete and confirm whether key parameters exist (such as dose matrix, target area data).

[0105] Error handling: When the plan data is empty, an error message will be displayed and the program will exit.

[0106] 3. Plan basic data extraction.

[0107] 3.1 Extract the planned total dose, single fraction dose and number of fractions.

[0108] 3.2 Obtain the planned dose matrix resolution for subsequent dose-volume analysis.

[0109] 3.3 Obtain the planning technique type (IMRT / VMAT).

[0110] 3.4 Obtain plan name, dose calculation matrix and other information.

[0111] 3.5 Calculate the biological equivalent dose (BED) and equivalent dose (EQD2).

[0112] 3.6 Extract key dosimetric parameters for each fractionation plan.

[0113] BED calculation:

[0114]

[0115] EQD2 calculation:

[0116]

[0117] 4. Target volume evaluation.

[0118] 4.1 Extract the target volume and dose coverage range.

[0119] 4.2 Calculate indicators such as the conformity index (CI), gradient index (GI), high-dose spillage value, medium-dose spillage value, and target volume dose coverage of the target volume. The limit of GI is interpolated linearly in segments according to the requirements of RTOG0813, and the corresponding limit is obtained through the target volume.

[0120] 4.3 Compare the calculation results with the standard values to determine whether the plan passes or not.

[0121] 5. Organ-at-risk evaluation.

[0122] 5.1 Extract the structural data of OAR (Organ at Risk).

[0123] 5.2 Calculate the corresponding key dosimetric indicators to be evaluated according to the number of fractions of SBRT, such as:

[0124] V20Gy and V5Gy of the lung;

[0125] The maximum dose (Dmax) of the spinal cord.

[0126] 5.3 Compare with the corresponding standard values (such as RTOG, NCCN, TG101 reports, etc.) according to the number of fractions of SBRT and mark whether it passes.

[0127] 6. Custom input parameter query.

[0128] Refer to Figure 3 , in this embodiment, other dosimetric parameters of any target volume or OAR can be customarily input for query: including the maximum dose, minimum dose, average dose, dose corresponding to a fixed volume, and volume corresponding to a fixed dose. Relative and absolute quantity parameter queries can be performed.

[0129] 7. Result visualization.

[0130] 7.1 Dynamically update the display fields in the interface, including patient information, dosimetric indicators, and evaluation results.

[0131] 7.2 The icon color of the organ-at-risk (OAR) is displayed by reading the actual color of the TPS.

[0132] 7.3 Use color to mark whether it passes or not:

[0133] Green: Passed;

[0134] Red: Failed.

[0135] 8. Evaluation report generation.

[0136] 8.1 Integrate the evaluation results, including:

[0137] Total dose, fractionated dose;

[0138] Target volume evaluation results;

[0139] OAR protection index.

[0140] 8.2 Generate a report file (such as PDF) and save it.

[0141] 8.3 Printing module: Can directly print the current interface.

[0142] 9. Extended functions (can be added).

[0143] 9.1 Export the evaluation results to CSV / Excel format.

[0144] 9.2 Visualize the DVH (Dose-Volume Histogram).

[0145] This embodiment may include steps such as data loading, dose calculation, target volume evaluation, OAR evaluation, result visualization, and report generation, and complete the rapid and accurate evaluation of radiotherapy plans in an automated manner, significantly improving the efficiency and evaluation quality of stereotactic radiotherapy plans.

[0146] In summary, this embodiment includes the following technical solutions:

[0147] 1. Automated evaluation process: Provide a fully automated evaluation method to automatically extract the data of the target volume and organs at risk from the radiotherapy plan file, avoiding manual intervention and improving efficiency and accuracy.

[0148] The data extraction module can automatically parse the plan file and identify the dose distribution and geometric information of the target volume and organs at risk.

[0149] Automatically identify the plan type (such as PlanSetup or PlanSum) and dynamically adapt the evaluation criteria.

[0150] 2. Automated calculation of dosimetric indices: Implement the automatic calculation of key dosimetric parameters, including but not limited to:

[0151] Biologically equivalent dose (BED);

[0152] Equivalent dose (EQD2);

[0153] Target volume conformity index (CI);

[0154] Gradient index (GI);

[0155] Dose limits for organs at risk (such as V20Gy, Dmax, etc.).

[0156] Automatically calculate indicators such as BED, EQD2, CI, and GI based on formulas, and compare the results with the recommended values in international guidelines (such as RTOG or NCCN). Through the piecewise linear interpolation algorithm, automatically obtain the corresponding GI requirements according to the size of the target area.

[0157] Quickly evaluate the dose limits of organs at risk using the dose matrix and DVH data.

[0158] 3. Dynamic threshold evaluation and pass / fail determination: Judge the plan quality based on dynamic thresholds (such as fractionated dose, target volume), and support color coding (red / green) and grading (pass / fail).

[0159] Dynamically adjust the evaluation criteria according to the target area dose distribution and organ at risk protection indicators (such as the threshold for lung V20Gy).

[0160] Provide intuitive color markings (green for passed, red for failed).

[0161] 4. Graphic and text combined display of evaluation results: Intuitively display the evaluation results through tables and visual charts (such as DVH curves, bar charts) to improve the user experience.

[0162] Output a detailed evaluation report, including dosimetric parameters, pass / fail determination, and optimization suggestions.

[0163] Support generating the evaluation report as a PDF or other format file.

[0164] 5. Modular and extensible design: Design a modular software structure that allows for flexible expansion of new evaluation indicators (such as the dose fall-off value outside the target area) and support for new treatment modalities (such as Hypofractionation).

[0165] Modular design, including a data extraction module, a calculation module, an evaluation module, and a report generation module.

[0166] Support users to customize evaluation criteria and add new dosimetric indicators.

[0167] 6. Compatibility with existing radiotherapy systems: Through interaction with the API interface of the TPS (such as Varian Eclipse) system, achieve efficient data extraction and processing.

[0168] Provide a seamless interface with the radiotherapy planning system (TPS), and support automatically loading data from the plan file.

[0169] Ensure that the evaluation system can be compatible with multiple radiotherapy plan file types (such as PlanSetup and PlanSum).

[0170] 7. Optimization for Specific Treatment Types (such as SBRT): Optimize the evaluation method according to the characteristics of SBRT (high single - dose, few fractions, high biological dose), and pay special attention to the target - area dose uniformity and the protection of organs at risk.

[0171] Optimize the algorithm to adapt to the high single - dose characteristics of SBRT, calculate and evaluate the indicators matching international guidelines.

[0172] Provide target - area dose - uniformity analysis (such as HI calculation) and organ - at - risk protection evaluation (such as spinal cord Dmax) dedicated to SBRT.

[0173] This embodiment provides an automatic evaluation method for lung cancer SBRT plans, which has significant efficiency, accuracy, and ease of use. Through fully automated auxiliary - structure generation, data extraction, and dosimetric - index calculation, this embodiment can quickly complete the evaluation of key parameters such as target - area coverage and organ - at - risk protection, greatly reducing manual intervention and human error, and significantly improving the evaluation efficiency. In addition, dynamic - threshold comparison and result marking (such as color coding and grading) based on international guidelines make the evaluation process more accurate and intuitive. Moreover, this embodiment can automatically select corresponding evaluation requirements according to different fractionation numbers of SBRT. Finally, custom parameters can be arbitrarily input to obtain other dosimetric indicators.

[0174] This embodiment adopts a modular design, supports the addition of new evaluation indicators and the adaptation of different treatment modes (such as Hypofractionation), and has good scalability. At the same time, the evaluation results are presented in a combination of text and graphics, providing detailed optimization suggestions and exportable reports, which greatly facilitate the use of clinicians and physicists, and provide reliable guarantee for the evaluation of SBRT.

[0175] As another more specific implementation manner, Figure 4 is a specific example flowchart of this embodiment.

[0176] Exemplarily, Figure 5 is the plan evaluation form of this embodiment. The evaluated parameters can include: basic information, target - area - related parameters, and organ - at - risk - related parameters. The basic information includes: patient basic information (name, ID), plan basic information (course of treatment, plan, technology, EQD2, BED, MU, calculation grid, plan designer). The target - area parameters include: CI, HI, GI, D2cm, V105% - VPTV, PTV V100%, PTV D99%, GTV Dmin, PTV volume. The organs at risk mainly include the evaluation parameters of the spinal cord, esophagus, heart, chest wall, left and right lungs, and ribs, and different evaluation criteria are automatically used for evaluation according to different total fractionation numbers in reports such as AAPM TG 101.

[0177] Reference Figure 6 The embodiment of the present application further provides a stereotactic radiotherapy plan evaluation device, which can implement the above-mentioned stereotactic radiotherapy plan evaluation method. The device includes:

[0178] A data acquisition unit for acquiring file data of a stereotactic radiotherapy plan;

[0179] A segmentation parameter determination unit for determining the number of fractions and the segmentation dose of the stereotactic radiotherapy plan according to the file data;

[0180] An index calculation unit for calculating dose basic parameters, target area parameters, and organ at risk parameters for each fraction according to the segmentation dose;

[0181] A plan evaluation unit for determining an evaluation result of the stereotactic radiotherapy plan according to the dose basic parameters, the target area parameters, and the organ at risk parameters.

[0182] It can be understood that the content in the above method embodiment is applicable to the device embodiment of the present application. The functions specifically implemented by the device embodiment of the present application are the same as those in the above method embodiment, and the beneficial effects achieved are also the same as those in the above method embodiment.

[0183] The embodiment of the present application further provides an electronic device. The electronic device includes a memory and a processor. The memory stores a computer program, and when the processor executes the computer program, it implements the above-mentioned stereotactic radiotherapy plan evaluation method. The electronic device can be any intelligent terminal including a tablet computer, an in-vehicle computer, etc.

[0184] It can be understood that the content in the above method embodiment is applicable to the device embodiment of the present application. The functions specifically implemented by the device embodiment of the present application are the same as those in the above method embodiment, and the beneficial effects achieved are also the same as those in the above method embodiment.

[0185] Please refer to Figure 7 , Figure 7 which schematically shows the hardware structure of an electronic device in another embodiment. The electronic device includes:

[0186] A processor 701, which can be implemented in a general-purpose CPU (Central Processing Unit), a microprocessor, an application-specific integrated circuit (ASIC), or one or more integrated circuits, etc., and is used to execute relevant programs to implement the technical solution provided by the embodiment of the present application;

[0187] The memory 702 can be implemented in the form of a read-only memory (ROM), a static storage device, a dynamic storage device, or a random access memory (RAM), etc. The memory 702 can store an operating system and other application programs. When implementing the technical solutions provided in the embodiments of this specification through software or firmware, the relevant program codes are stored in the memory 702 and are called by the processor 701 to execute a stereotactic radiotherapy plan evaluation method according to an embodiment of the present application;

[0188] The input / output interface 703 is used to implement information input and output;

[0189] The communication interface 704 is used to implement communication and interaction between this device and other devices. Communication can be achieved through wired means (such as USB, network cable, etc.) or wireless means (such as mobile network, WIFI, Bluetooth, etc.);

[0190] The bus 705 transmits information between various components of the device (such as the processor 701, the memory 702, the input / output interface 703, and the communication interface 704);

[0191] Among them, the processor 701, the memory 702, the input / output interface 703, and the communication interface 704 are communicatively connected to each other inside the device through the bus 705.

[0192] An embodiment of the present application also provides a computer-readable storage medium. The computer-readable storage medium stores a computer program, and when the computer program is executed by a processor, it implements the above-mentioned stereotactic radiotherapy plan evaluation method.

[0193] It can be understood that the content in the above method embodiments is applicable to the embodiments of this storage medium. The functions specifically implemented by the embodiments of this storage medium are the same as those of the above method embodiments, and the beneficial effects achieved are also the same as those of the above method embodiments.

[0194] As a non-transitory computer-readable storage medium, the memory can be used to store non-transitory software programs and non-transitory computer-executable programs. In addition, the memory can include high-speed random access memory, and can also include non-transitory memory, such as at least one magnetic disk storage device, a flash memory device, or other non-transitory solid-state storage devices. In some embodiments, the memory optionally includes a memory remotely set relative to the processor, and these remote memories can be connected to the processor through a network. Examples of the above networks include, but are not limited to, the Internet, an enterprise intranet, a local area network, a mobile communication network, and combinations thereof.

[0195] The embodiments described in the embodiments of the present application are for more clearly illustrating the technical solutions of the embodiments of the present application, and do not constitute a limitation to the technical solutions provided by the embodiments of the present application. Those skilled in the art can know that with the evolution of technology and the emergence of new application scenarios, the technical solutions provided by the embodiments of the present application are also applicable to similar technical problems.

[0196] Those skilled in the art can understand that the technical solutions shown in the figures do not constitute a limitation to the embodiments of the present application, and may include more or fewer steps than shown in the figures, or combine certain steps, or different steps.

[0197] The device embodiments described above are merely illustrative. The units described as separate components may or may not be physically separated, that is, they may be located in one place, or may be distributed to multiple network units. Some or all of the modules can be selected according to actual needs to achieve the purpose of the solution of this embodiment.

[0198] Those of ordinary skill in the art can understand that all or some of the steps in the methods disclosed above, and the functional modules / units in the systems and devices, can be implemented as software, firmware, hardware, and their appropriate combinations.

[0199] The terms "first", "second", "third", "fourth", etc. (if any) in the specification of the present application and the above-mentioned drawings are used to distinguish similar objects, and do not have to be used to describe a specific order or sequence. It should be understood that the data used in this way can be interchanged under appropriate circumstances, so that the embodiments of the present application described here can be implemented in an order other than those illustrated or described here. In addition, the terms "including" and "having" and any variations thereof are intended to cover non-exclusive inclusion. For example, a process, method, system, product, or device that includes a series of steps or units does not have to be limited to those steps or units clearly listed, but may include other steps or units not clearly listed or inherent to these processes, methods, products, or devices.

[0200] It should be understood that in this application, "at least one (item)" means one or more, and "a plurality" means two or more. "And / or" is used to describe the association relationship of associated objects and indicates that there can be three relationships. For example, "A and / or B" can mean: only A exists, only B exists, and both A and B exist at the same time. Among them, A and B can be singular or plural. The character " / " generally represents an "or" relationship between the associated objects before and after. "At least one (one) of the following" or its similar expression refers to any combination of these items, including any combination of single items (ones) or plural items (ones). For example, at least one (one) of a, b, or c can mean: a, b, c, "a and b", "a and c", "b and c", or "a and b and c", where a, b, c can be single or multiple.

[0201] In several embodiments provided in this application, it should be understood that the disclosed devices and methods can be implemented in other ways. For example, the device embodiments described above are merely illustrative. For example, the above division of units is only a logical function division. In actual implementation, there can be other division methods. For example, multiple units or components can be combined or integrated into another system, or some features can be ignored or not executed. Another point is that the displayed or discussed coupling or direct coupling or communication connection between each other can be through some interfaces. The indirect coupling or communication connection of devices or units can be in electrical, mechanical or other forms.

[0202] The units described above as separate components may or may not be physically separated. The components displayed as units may or may not be physical units, that is, they can be located in one place or distributed to multiple network units. Some or all of the units can be selected according to actual needs to achieve the purpose of the solution of this embodiment.

[0203] In addition, each functional unit in various embodiments of this application can be integrated in a processing unit, or each unit can exist physically alone, or two or more units can be integrated in one unit. The above integrated units can be implemented in the form of hardware or in the form of software functional units.

[0204] When the integrated unit is implemented in the form of a software functional unit and sold or used as an independent product, it can be stored in a computer-readable storage medium. Based on such an understanding, the technical solution of this application, in essence, or the part that contributes to the prior art, or all or part of this technical solution, can be embodied in the form of a software product. This computer software product is stored in a storage medium and includes multiple instructions for causing a computer device (which may be a personal computer, a server, or a network device, etc.) to execute all or part of the steps of the methods in various embodiments of this application. The aforementioned storage medium includes: various media that can store programs, such as USB flash drives, mobile hard disks, read-only memory (ROM), random access memory (RAM), magnetic disks, or optical discs.

[0205] The preferred embodiments of the embodiments of this application have been described above with reference to the accompanying drawings, which does not limit the scope of rights of the embodiments of this application. Any modifications, equivalent replacements, and improvements made by those skilled in the art without departing from the scope and essence of the embodiments of this application shall be within the scope of rights of the embodiments of this application.

Claims

1. A method for evaluating a stereotactic radiotherapy plan, characterized in that: The method comprises the following steps: Obtain stereotactic radiotherapy planning file data; Determine the number of fractions and the fractionation dose of the stereotactic radiotherapy plan according to the file data; According to the fractionated dose calculation, basic dose parameters, target area parameters and risk organ parameters of each of the fractionated doses are obtained; An evaluation result of the stereotactic radiotherapy plan is determined according to the basic dose parameter, the target area parameter and the risk organ parameter.

2. A stereotactic radiotherapy plan evaluation method according to claim 1, characterized in that: The step of calculating the dose basic parameters of each of the divided doses according to the divided dose comprises the following steps: Calculate the biological equivalent dose and equivalent dose of each of the number of fractions as the basic dose parameters; The calculation formula of the bioequivalent dose is: Wherein, BED is the biological equivalent dose, n is the number of fractions, d is the fraction dose, and α / β is the characteristic dose of the tissue; The calculation formula of the equivalent dose is: Wherein, EQD2 is the equivalent dose; The method further comprises the following steps: The treatment course, plan name, plan technology, total planned dose, the fractionated dose, the number of fractions, dose matrix size, machine hop count, and plan designer are extracted as basic plan information.

3. A stereotactic radiotherapy plan evaluation method according to claim 1, characterized in that: The target area parameters of each of the divided times are obtained according to the divided dose calculation, including the following steps: Extracting the target volume and the dose coverage of the fractionated dose from the file data, and generating D2cm and a 105% dose line structure outside the target area as auxiliary structures for evaluation; Perform piecewise linear interpolation according to RTOG0813 requirements to determine the target gradient index corresponding to the target volume; The gradient index, the high dose overflow value and the medium dose overflow value are calculated; wherein the target volume, the dose coverage range, the target conformality, the gradient index, the high dose overflow value and the medium dose overflow value are used as the target parameters.

4. A stereotactic radiotherapy plan evaluation method according to claim 1, characterized in that: Calculating the risk organ parameters of each of the fractions according to the fractionated doses includes the following steps: extracting the organ-at-risk structure data from the file data; The relevant doses of each organ at risk are calculated according to the organ at risk structure data and the number of fractions, wherein the relevant doses include the dose of the lung and the maximum dose of the spinal cord.

5. A stereotactic radiotherapy plan evaluation method according to claim 1, characterized in that: Determining the evaluation result of the stereotactic radiotherapy plan according to the basic dose parameter, the target area parameter and the risk organ parameter comprises the following steps: The basic dose parameters, the target volume parameters and the risk organ parameters are compared with corresponding standard values ​​to determine the evaluation result of the stereotactic radiotherapy plan.

6. A stereotactic radiotherapy plan evaluation method according to claim 1, characterized in that: The method further comprises at least one of the following steps: Dynamically updating the display fields in the terminal interface; wherein the display fields include patient information, dosimetric indicators and the evaluation results; Alternatively, an evaluation report of the stereotactic radiotherapy plan is generated; wherein the evaluation report includes the total dose, the fractionated dose, the evaluation results of the target area parameters and the evaluation results of the risk organ parameters; Alternatively, exporting the evaluation results of the stereotactic radiotherapy plan in PDF format, CSV format or Excel format; Alternatively, a visualized dose volume histogram is generated according to the evaluation result of the stereotactic radiotherapy plan.

7. A stereotactic radiotherapy plan evaluation method according to any one of claims 1 to 6, characterized in that: The method further comprises at least one of the following steps: Querying the relative amount of other dosimetric parameters of any target area or organ at risk; wherein the other dosimetric parameters include maximum dose, minimum dose, average dose, dose corresponding to a fixed volume, and volume corresponding to a fixed dose; Alternatively, the absolute amount of the other dosimetric parameters of any target volume or organ at risk is queried.

8. A stereotactic radiotherapy plan evaluation device, characterized in that: The device comprises: A data acquisition unit, used for acquiring file data of stereotactic radiotherapy plan; A segmentation parameter determination unit, used for determining the number of fractions and the fractionation dose of the stereotactic radiotherapy plan according to the file data; An index calculation unit, used for calculating the basic dose parameters, target area parameters and risk organ parameters of each of the said fractionated doses according to the said fractionated dose; A plan evaluation unit is used to determine an evaluation result of the stereotactic radiotherapy plan according to the basic dose parameters, the target area parameters and the risk organ parameters.

9. An electronic device, characterized in that: The electronic device comprises a memory and a processor, the memory stores a computer program, and the processor implements the method according to any one of claims 1 to 7 when executing the computer program.

10. A computer-readable storage medium storing a computer program, characterized in that: When the computer program is executed by a processor, the method according to any one of claims 1 to 7 is implemented.

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