280 results about "Biochemical Process" patented technology

A tissue cell growth-promoting solution produced by this invention comprising water containing at least 1 to 500 ppm of active oxygen, when applied to a wound, supplies active oxygen originating from outside the biobody to supplement the active oxygen produced by the biobody's own protective system cells such as neutrophils and macrophages which gather at the wound site, thus increasing the concentration of active oxygen at the site of the wound, mimicking a state in which a large quantity of such bio-signals is secreted by the biobody itself, to promote the reconstruction of tissues, the action corresponding to the last of the four main steps involved in wound healing biochemical processes of "blood vessel reaction", "blood vessel coagulation", "inflammation", "reconstruction of tissues" and which would otherwise have to rely on the natural healing power of the biobody itself.

The methods described herein enable the evaluation of compounds on subjects to assess their therapeutic efficacy or toxic effects. The target of analysis is the underlying biochemical process or processes (i.e., metabolic process) thought to be involved in disease pathogenesis. Molecular flux rates within the one or more biochemical processes serve as biomarkers and are quantitated and compared with the molecular flux rates (i.e., biomarker) from control subjects (i.e., subjects not exposed to the compounds). Any change in the biomarker in the subject relative to the biomarker in the control subject provides the necessary information to evaluate therapeutic efficacy of an administered drug or a toxic effect and to develop the compound further if desired. In one aspect of the invention, stable isotope-labeled substrate molecules are administered to a subject and the label is incorporated into targeted molecules in a manner that reveals molecular flux rates through one or more metabolic pathways of interest. By this method, a comparison between subjects and control subjects reveals the effects of the chemical entity or entities on the biomarkers. This, in turn, allows for the identification of potential therapeutic uses or toxicities of the compound. Combinations of compounds can also be systematically evaluated for complementary, synergistic, or antagonistic actions on the metabolic pathways of interest, using the methods of the present invention as a strategy for identifying and confirming novel therapeutic or toxic combinations of compounds.

A method and apparatus for delivering one or more fluids. Fluids may be delivered sequentially from a common vessel to a chemical, biological or biochemical process.

The invention relates to a comprehensive electroplating wastewater treatment method. The electroplating wastewater is divided into six brand-new classes, a chemical and biochemical combined process is adopted, a separate system drainage pipe network is adopted, the electroplating wastewater is divided into ink wastewater, complex wastewater, pretreatment wastewater, cyanogen-containing wastewater, chromium-containing wastewater and common electroplating wastewater, the six classes of wastewater respectively flows into respective underground adjusting tank through the pipe network, and is treated by respective process, and the effluent is discharged after reaching a standard. Because of the scientific water separating and stepwise pretreatment of a front-end chemical treatment part, different pollutants are respectively removed in different process sections according to characteristics, crossed enrichment and mutual reaction of the different pollutants are reduced to the greatest extent, and the pressure of microorganisms in the biochemical process is reduced. Treatment facilities for the six classes of wastewater are mutually connected and relatively dependent, and when inlet water quality fluctuates, a corresponding section is only required to be adjusted, the whole process is not influenced, the management is scientific and orderly, and operational risks are reduced.

The invention relates to a sewage disposal process monitoring and intelligent early-warning cloud system and a sewage disposal monitoring and early-warning method. The system comprises a sewage disposal process monitoring and intelligent early-warning cloud system body. The sewage disposal process monitoring and intelligent early-warning cloud system is characterized by comprising a distributed data collection terminal module and/or an on-spot photographing unit, and further comprising a process monitoring embedded data collection instrument and a cloud computing server, wherein the distributed data collection terminal module and the on-spot photographing unit are in communication with the process monitoring embedded data collection instrument separately, and the process monitoring embedded data collection instrument is in communication with the cloud computing server. The sewage disposal process monitoring and intelligent early-warning cloud system is simple in structure, all phases of a sewage disposal process can be monitored, multiple kinds of real-time data in a sewage biochemical process are provided for an operation unit, and with the assistance of the means of on-spot photographing, visual picture monitoring is conducted on a sewage disposal site, and the disposal effect of various biochemical disposal links is reflected in real time, which is beneficial to improving ofsewage biochemical disposal efficiency.

A system for modifying a model of a chemical reaction or biochemical process responsive to experimental results generated by an in situ experiment conducted on an experimental platform includes a simulation engine and an analysis environment. The simulation engine generates an expected result from a model of the chemical reaction or biochemical process. The analysis environment communicates with the simulation engine, gathers data from an experimental platform, and compares the expected result to data gathered from the platform.

The invention relates to a method for preparing seaweed biological long-acting fertilizer. Seaweed dregs from which seaweed gum, carrageenan and agar are extracted are taken as an active carrier so as to turn waste into treasure, and a plurality of seaweed bio-active substances contained in seaweed extract and chelated-type nutritive elements or nutrients easily absorbed by plants are all wrapped up to form a slow-release system so as to ensure slow long-term release of fertilizer efficiency and provide plants with demand for nutrition throughout a growing season. The method extracts nutrient components in seaweed adopting a low-temperature extraction process, thereby ensuring that active components of the seaweed are not destroyed and increase the content of the effective nutrient components of products. The method adopts a special biochemical process, adds a multifunctional fermentation strain which has synergy and is formed mainly by compounding fungi, yeast, actinomycetes and bacterial beneficial microorganisms which are not mutually antagonistic and cooperate during fermentation, and effectively extracts biological nutrient components of the seaweed through a large amount of powerful biochemical reaction during reproduction. The seaweed biological long-acting fertilizer belongs to non-toxic pollution-free purely-natural seaweed bio-organic fertilizer.

The invention relates to a command filtering backstepping control method based on an interference observer. An anti-interference non-linear controller is designed according to a multi-source interference non-linear system. The command filtering backstepping control method comprises the following steps of firstly building a non-linear mathematical model of a multi-source interference system; secondly designing equivalence interference in an estimation system of the non-linear system interference observer; then substituting equivalence interference estimated values obtained from the non-linear system interference observer into a command filtering backstepping controller, building the command filtering backstepping controller; and finally using a pole allocation method to design command filtering backstepping controller gain and non-linear interference observer gain for guaranteeing a closed loop composite error system to asymptotically be stable. The command filtering backstepping control method is strong in anti-interference capability, and can be applied to anti-interference control for systems such as aircrafts, mechanical arms, biochemical processes and ships.

This invention provides a biochemical organic fertilizer containing rich active humid acid, N, P and K necessary for plants combined with biobacteriums and its production method, in which, the technical target of the fertilizer is: NPK 4-14%, organic matters 30-50%, available active bacteriums 0.2-1.0x108/g, microelements 2-6%, active humid acid 10-20% and amino acid 2-5%. The production method includes: activation and biochemical process of organic materials, granulation, drying, cooling, screening, enveloping and measuring and packaging.

The invention provides a drink and a sauce having rich nutrients and multiple health-care functions, which are prepared by leaching fermented soybeans with added vinegar (wine, fruit juice, water or tear), deep processing and adding raw sugar and other auxiliaries containing rich nutrients and bioactivators. Soybeans undergo germination, fermentation and other extremely complex biochemical processes to form hundreds of nutrients and activators with the nutrients of the soybeans. A large number of Chinese and foreign documents prove that the substances have health care functions such as human body free radical clearing, arteries hardening prevention, immunity improvement, cancer resistance, blood fat and cholesterol reduction, blood pressure reduction, blood sugar reduction, bowel loosening for relieving constipation, intestinal microecology improvement, beneficial bacteria propagation and bacterium resistance and suppression. The invention aims to solve a technical problem that the nutrients were not fully used by Chinese people in the past 2,000 due to high salinity (such as that of lobster sauce, soybean paste, preserved bean curd and soy sauce) and disagreeable flavor (such as that of natto and tempe). The invention provides a novel drink and a novel sauce which contain nutrients and bioactivators of fermenting soybeans, are edible and contribute to absorption. Till now, no records of the uses of the soybean food have been found in Chinese and foreign documents. The drink and the sauce fill the gap of health care products in China, are expected to contribute to the promotion of the health care cause in China.

The invention discloses a method for processing dye wastewater, comprising the following steps of: injecting dye wastewater which undergoes a pretreatment into a nanofiltration water inflow tank for nanofiltration to form a nanofiltration concentrated solution with a smaller volume and a nanofiltration dialysate with a larger volume; diluting the nanofiltration concentrated solution to decrease the salt content and then carrying out an anaerobic-aerobic treatment; and carrying out an activated carbon adsorption treatment on the nanofiltration dialysate. In allusion to the features of high salt content and high COD concentration in the dye wastewater, the pretreatment is performed at the front end to reduce part of COD loads, and the nanofiltration technology is adopted at the back end to separate the salt in sewage from organic matters; the concentrated solution with high concentration of organic matters is diluted to reduce COD, simultaneously decrease the salt content and carry out the anaerobic-aerobic biochemical process so as to complete the processing of the sewage. As it is tested that the COD of the dialysate is low, the dialysate undergoes the activated carbon adsorption to directly discharge salts; absorbed organic matters undergo activated carbon desorption and regeneration process as well as biodegradation. The part of wastewater has been desalinized, thus not influencing the biochemical process.

The present invention discloses compounds of formula (I) or (II), or pharmaceutically acceptable salts, esters, or prodrugs thereof:

which inhibit, preventing or treating abnormal cellular proliferation and/or a viral infection, particularly by HIV, HCV or HBV. Consequently, the compounds of the present invention interfere with the replication cycle of a virus and are also useful as antiviral agents, or interfere with host cellular biochemical process and are also useful as antiproliferative agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from viral infection and/or cell proliferation. The invention also relates to methods of treating a viral infection and/or cell proliferation in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The present invention relates to novel antiviral/anti-proliferative compounds represented herein above, pharmaceutical compositions comprising such compounds, and methods for the treatment or prophylaxis of viral infection in a subject in need of such therapy with said compounds.

The invention relates to a method for comprehensively utilizing low-concentration heavy metal-containing soil improvement and repairing damaged soil by plants after detoxification of a contaminated field. The method comprises the following steps of: conveying of low-concentration soil after heavy metal-containing soil is detoxified, sludge and pulverized fuel ash; principal fermentation, mixing of various ingredients; primary fermentation; static state of post-fermentation (secondary fermentation); uniform turning (aerobic and anaerobic) fermentation; conveying of improved soil; and vegetation repairing (woody and herbaceous plants) planting for the contaminated soil. In the method, a modifier is added for modification, so that the content of heavy metals in the soil is reduced, the structure and pores of the damaged soil are repaired, and the permeation and air permeability of the soil are improved; and organic matters and other noxious matters in sludge and soil are decomposed and degraded in a certain condition by utilizing microbes in the sludge to reduce volume weight and compactness, so that the improved soil forms a substance similar to humus soil to serve as a biochemical process of the improved soil and fertilizer. According to the method, the planted vegetation growing environment of the land which uses the improved soil as a soil base material is ensured, so that the waste is used to treat waste, and the comprehensive utilization is improved.

This invention discloses a new method for innocuity of mud including the following steps: 1, putting dehydrated mud into a mixing basin to adjust the pH value to 8-9 and mixing them and inputting them to an anaerobic tower, 2, the mud mixture is fermented and separated automatically in the tower, 3, marsh gas is used in burning and generation, 4, the solution is used in fertilizing farms and the part can't be used passes through a SBR biochemical process device and enters into a slant pipe to be deposited and separated in solid and liquid, mud flows back and the water is discharged if meets the standard, 5, the slags are mixed with the mud discharged by the SBR process device and enter into a ferment basin for the second fermentation, 6, material of the fermentation basin is input into a fertilizing process to be dried, cooled, crushed, screened, packaged and get agricultural high efficient organic fertilizer.

The invention discloses a method for treating high-content ammonia and nitrogen for shortcut nitrification to discharge effluent by coupling simultaneous denitrification of sludge fermentation with autotrophic nitrogen removal, belonging to the technical field of biochemical process sewage treatment. The high-efficiency removal of total nitrogen in wastewater and the reduction of sludge are realized in the same space by combined action of hydrolysis acidifying bacteria, denitrifying bacteria and anaerobic ammonium oxidation bacteria. The method is characterized in that part of NO2--N in effluent is reduced by short-chain fatty acid generated by hydrolytic acidification of residual sludge under the action of the denitrifying bacteria; and the other part of NO2--N and ammonia nitrogen released in the hydrolytic acidification process are removed by an anaerobic ammonia oxidation reaction, thereby greatly reducing the concentration of total nitrogen in the effluent and finishing the reduction of the residual sludge simultaneously. The technology is suitable for advanced treatment of high-content ammonia and nitrogen for shortcut nitrification to discharge the effluent.

The invention provides a pretreatment method for removing antibiotics in ferment antibiotic pharmaceutical wastewater. The method removes antibiotics in the ferment antibiotic pharmaceutical wastewater mainly through adjustment of the pH value of the wastewater and high-temperature catalytic hydrolysis, and the treated pharmaceutical wastewater without antibiotics can enter a subsequent biochemical treatment process for treatment. The method provided by the invention can basically remove antibiotics in the pharmaceutical wastewater, reduce inhibition effect of high-concentration antibiotics on microbes, lower down difficulty in treatment of the wastewater by using the subsequent biochemical process and decrease generation of drug-resistant bacteria and drug-resistant genes in subsequent biochemical treatment.

A method for implementing a temperature cycling operation for a biochemical sample to be reacted includes applying an infrared (IR) heating source to the sample at a first infrared wavelength selected so as to generate a first desired temperature for a first duration and produce a first desired reaction within the sample. Following the first desired reaction, applying the infrared (IR) heating source to the sample at a second infrared wavelength selected so as to generate a second desired temperature for a second duration and produce a second desired reaction within the sample.

The invention discloses a method for deep denitrification of metaphase landfill leachate through single-stage SBR (Styrene Butadiene Rubber) post denitrification treatment, which belongs to the technical field of sewage treatment by using biochemical process. Aiming at the characteristics that the landfill leachate is high in organism concentration, high in ammonia concentration, high in C/P ratio (grater than 200), the invention discloses a real-time control method with the combination of 'anaerobic/aerobiotic/anoxic' operation modes, and SBR post denitrification is achieved. Under long-term domestication, glycan bacteria (GAO) can be enriched, volatile organic acids (VFA (Volatile Fatty Acid)) in water are converted into poly-beta-hydroxy-alkanoic acid ester (PHA) through glycogen glycolysis at an anaerobic stage by using GAO, in an aerobiotic stage (the dissolved oxygen is less than 0.8mg/L), when partial nitrification is carried out, most part of PHA is converted into glycogen, and in the anoxic stage, the residual PHA and the glycogen are utilized to perform carbon source denitrification, so that the effluent meets the latest national emission standard. The method has the advantages of simple devices, rapid starting, freedom of external carbon source, good denitrification effect, simplicity in operation, low cost and the like.

The invention relates to the technical field of industrial wastewater processing, and specifically relates to a method for processing viscose fiber production wastewater. A large amount of acidic and alkaline wastewater is generated during production of viscose fiber, and severe water pollution and loss and waste of a large amount of fiber source are caused by direct discharge of the wastewater. The method for processing viscose fiber production wastewater is a technology formed by adding a processing technology combining shallow-layer air floatation and iron chip filtering on the basis of a processing technology combining a physicochemical process and a biochemical process. The beneficial effects generated by execution of the technical scheme comprise that source is utilized, cellulose in production wastewater of viscose fiber is recovered, fixed investment is reduced, production cost is reduced, and the quality of processed water can steadily reach national first-level discharge standard.

In principle, protein-based biotherapeutics offers a way to control biochemical processes in living cells under non-steady state conditions and with fewer off-target effects than conventional small molecule therapeutics. However, systemic protein delivery in vivo has been proven difficult due to poor tissue penetration and rapid clearance. Protein transduction exploits the ability of some cell-penetrating peptide (CPP) sequences to enhance the uptake of proteins and other macromolecules by mammalian cells. Previously developed hydrophobic CPPs—named membrane translocating sequence (MTS), membrane translocating motif (MTM) and macromolecule transduction domain (MTD)—are able to deliver biologically active proteins into a variety of cells and tissues. Various cargo proteins fused to these CPPs have been used to test the functional and/or therapeutic efficacy of protein transduction. Previously, recombinant proteins consisting of suppressor of cytokine signaling 3 (SOSC3) fused to the fibroblast growth factor (FGF) 4-derived MTM were developed to inhibit inflammation and apoptosis. However, this SOCS3 fusion proteins expressed in bacteria cells were hard to be purified in soluble form. To address these critical limitations, CPP sequences called advanced MTDs (aMTDs) have been developed in this art. The development of this art has been accomplished by (i) analyzing previous developed hydrophobic CPP sequences to identify specific critical factors (CFs) that affect intracellular delivery potential and (ii) constructing artificial aMTD sequences that satisfy each critical factor. Furthermore, solubilization domains (SDs) have been incorporated into the aMTD-fused SOCS3 recombinant proteins to enhance solubility with corresponding increases in protein yield and cell-/tissue-permeability. These recombinant SOCS3 proteins fused to aMTD/SD having much higher solubility/yield and cell-/tissue-permeability have been named as improved cell-permeable SOCS3 (iCP-SOCS3) proteins. Previously developed SOCS3 recombinant proteins fused to MTM were only tested or used as anti-inflammatory agents to treat acute liver injury. In the present art, iCP-SOCS3 proteins have been tested for use as anti-angiogenic agents. Since SOCS3 is known to be an endogenous inhibitor of pathological angiogenesis, we reasoned that iCP-SOCS3 could be used as a protein-based intracellular replacement therapy for inhibiting angiogenesis in tumor cells. The results demonstrated in this art support this following reasoning: Cancer treatment with iCP-SOCS3 results in reduced endothelial cell viability, loss of cell migration potential and suppressed vascular sprouting potentials. In the present invention with iCP-SOCS3, where SOCS3 is fused to an empirically determined combination of newly developed aMTD and customized SD, macromolecule intracellular transduction technology (MITT) enabled by the advanced MTDs may provide novel protein therapy against cancer cell-mediated angiogenesis.

The invention relates to the field of water treatment, and discloses a method and an apparatus for swirling flow strengthened biodegradation treatment of sewage. The method comprises: a, under an anoxic treatment condition, carrying out anoxic treatment on sewage and an active-sludge-containing material in an anoxic pool; b, carrying out aerobic treatment on the mixture obtained through the anoxictreatment in an aerobic pool to obtain a mixture A; and c, carrying out swirling flow breaking treatment on the part of the mixture A, returning the treated material to the anoxic pool, carrying outsolid-liquid separation on the remaining mixture A to separate the active sludge, sequentially carrying out swirling flow breaking treatment and hydrolysis acidification treatment on the at least partially separated active sewage, and returning the supernatant obtained through the hydrolysis acidification treatment to the anoxic pool. According to the present invention, with the method, the totalnitrogen removal effect in the biochemical process can be effectively improved, and the resource utilization of the sludge can be improved.