Solution for promoting growth of tissue cells at wound sites and production process therefor

Inactive Publication Date: 2002-10-31
SONOMA PHARMA INC
View PDF19 Cites 86 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

On the other hand, when the active oxygen is 500 ppm or more, it is not suitable as a solution for promoting the growth of cells since the toxicity of the active oxygen gives undesired effects on the biobody cells.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Solution for promoting growth of tissue cells at wound sites and production process therefor
  • Solution for promoting growth of tissue cells at wound sites and production process therefor
  • Solution for promoting growth of tissue cells at wound sites and production process therefor

Examples

Experimental program
Comparison scheme
Effect test

experiment 1

[0071] Experiment 1

[0072] Anode-electrolyzed water with 1 to 500 ppm concentration of active oxygen, such as hydroxy radicals HO. and hypochlorous ions ClO.sup.- as the precursor therefor and at 10 to 10,000 ppm concentration of halogen ions such as chlorine ions Cl.sup.- is thus formed.

[0073] In the experiment, an anode-electrolyzed water with 80 to 130 ppm concentration of active oxygen, and with 1,000 to 4,000 ppm concentration of halogen ions such as chloride ions Cl.sup.- is used, to which sodium chloride is added to make the concentration of chlorine ions to 5,500 ppm isotonic with that of physiological saline. Further, a solution L.sub.1 for promoting the growth of tissue cells is formed by adding an aqueous solution of sodium hydroxide to adjust pH to 7.4 and a solution L.sub.2 for promoting the growth of tissue cells at pH 2.4 as it is with no pH adjustment are formed. For comparison, physiological saline C.sub.1 containing dissolved hypochlorous acid and cathode-electrolyz...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
pHaaaaaaaaaa
flow rateaaaaaaaaaa
flow rateaaaaaaaaaa
Login to view more

Abstract

A tissue cell growth-promoting solution produced by this invention comprising water containing at least 1 to 500 ppm of active oxygen, when applied to a wound, supplies active oxygen originating from outside the biobody to supplement the active oxygen produced by the biobody's own protective system cells such as neutrophils and macrophages which gather at the wound site, thus increasing the concentration of active oxygen at the site of the wound, mimicking a state in which a large quantity of such bio-signals is secreted by the biobody itself, to promote the reconstruction of tissues, the action corresponding to the last of the four main steps involved in wound healing biochemical processes of "blood vessel reaction", "blood vessel coagulation", "inflammation", "reconstruction of tissues" and which would otherwise have to rely on the natural healing power of the biobody itself.

Description

[0001] This is a Continuation-In-Part of and claims priority to US non-provisional application Ser. No. 09 / 714,826 filed Nov. 17, 2000 and claims priority to Japanese Patent Application No. 326,993 / 1999 filed Nov. 17, 1999. The contents of each of these applications are hereby incorporated by reference herein in their entireties.[0002] 1. Field of the Invention[0003] This invention concerns the making of a solution for promoting the growth of tissue cells at the site of a wound, a process that promotes regeneration of tissue and wound healing.[0004] 2. Related Art Statement[0005] Wound means a pathological state in which tissue either inside or on the outer surface of a biobody is fragmented or damaged, with accompanying less or restriction of the functions of the affected tissues.[0006] It has long been known that when a wound is inflicted, the affected region heals through four steps: "blood vessel reaction", "blood clotting", "inflammation", and "reconstruction of tissue".[0007] ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(United States)
IPC IPC(8): A61K33/00A61K33/14A61K33/40A61K9/08A61P17/02A61P43/00C02F1/461C25B1/10C25C1/02
CPCA61K33/20A61K33/40C02F1/4672C02F2103/026C02F2201/46115C25B1/10Y02E60/366A61K2300/00A61P17/02A61P43/00Y02E60/36C25B1/04C25B9/73A61K33/00
Inventor YAHAGI, NAOKISUMITA, OSAO
Owner SONOMA PHARMA INC
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products