Solution for promoting growth of tissue cells at wound sites and production process therefor

Abstract

A tissue cell growth-promoting solution produced by this invention comprising water containing at least 1 to 500 ppm of active oxygen, when applied to a wound, supplies active oxygen originating from outside the biobody to supplement the active oxygen produced by the biobody's own protective system cells such as neutrophils and macrophages which gather at the wound site, thus increasing the concentration of active oxygen at the site of the wound, mimicking a state in which a large quantity of such bio-signals is secreted by the biobody itself, to promote the reconstruction of tissues, the action corresponding to the last of the four main steps involved in wound healing biochemical processes of "blood vessel reaction", "blood vessel coagulation", "inflammation", "reconstruction of tissues" and which would otherwise have to rely on the natural healing power of the biobody itself.

Description

[0001] This is a Continuation-In-Part of and claims priority to US non-provisional application Ser. No. 09 / 714,826 filed Nov. 17, 2000 and claims priority to Japanese Patent Application No. 326,993 / 1999 filed Nov. 17, 1999. The contents of each of these applications are hereby incorporated by reference herein in their entireties.[0002] 1. Field of the Invention[0003] This invention concerns the making of a solution for promoting the growth of tissue cells at the site of a wound, a process that promotes regeneration of tissue and wound healing.[0004] 2. Related Art Statement[0005] Wound means a pathological state in which tissue either inside or on the outer surface of a biobody is fragmented or damaged, with accompanying less or restriction of the functions of the affected tissues.[0006] It has long been known that when a wound is inflicted, the affected region heals through four steps: "blood vessel reaction", "blood clotting", "inflammation", and "reconstruction of tissue".[0007] ...

AI Technical Summary

Benefits of technology

[0029] As a result, growth of the biobody cells is further promoted and the tissues at the wound site are reconstructed (regenerated) in a short period of time, so that this can provide an effect that the healing for the wounds can also be promoted.

[0037] Further, it is preferred in this invention that sodium chloride (NaCl) is added to the solution until the solution is isotonic with body fluids (i.e., of a similar osmotic pressure). Thus the solution has ingredients in common with the body fluids, as well as a similar pH and osmotic pressure, and it is considered that, as a consequence, the active oxygen contained therein functions more effectively as a bio-signal. Furthermore, it has been experimentally confirmed that the solution according to this invention at a pH similar to that of the body fluids is effective for internal wounds, as well as for wounds at the body's external surface.

[0038] This invention also provides a process for producing a solution for promoting the growth of tissue cells, which can produce the solution simply at a reduced cost such as even in hospitals.

Problems solved by technology

On the other hand, when the active oxygen is 500 ppm or more, it is not suitable as a solution for promoting the growth of cells since the toxicity of the active oxygen gives undesired effects on the biobody cells.

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