16 results about "Control subjects" patented technology

The invention discloses a safety control method and system for an emerging control main body, and belongs to the technical field of power system active control, and the method comprises the steps: carrying out the bidirectional data interaction through a master station AGC and a field station AGC, and carrying out the bidirectional data interaction based on a bidirectional data interaction result and a cooperative anti-error parameter; whether the emerging control main body is in a controllable state or not is judged in real time through collaborative security locking logic; if the control main body is in the controllable state, active measurement data of the emerging control main body are obtained, and jump detection and multi-source checking are carried out on the active measurement data; after verification is passed, a pre-control instruction is generated based on the control strategy, and reasonability verification and control effect simulation verification are carried out; and after the control effect simulation verification is passed, the pre-control instruction is taken as a final control instruction to be issued to the emerging control main body for execution. The method can greatly improve the safety control capability of AGC on an emerging control main body, guarantees the frequency operation safety of a power grid, and improves the safe and reliable power supply capability of the power grid.

Disclosed herein are methods of treating ALS in a subject by administering to the subject a therapeutically effective amount of a composition comprising, for example, EV derived from nerve cells, such as neural progenitor cells. The EVs may be administered distally or peripherally to the CNS such that these EVs cross the blood-brain barrier and exert their therapeutic function in the CNS. The methods may reduce inflammation (e.g., NLRP3 inflammatory pathway signaling), reduce disease activity or progression, and / or improve motor or neurological performance, signs or symptoms associated with ALS, or survival in an ALS subject as compared to a control ALS subject. Also provided are methods of inhibiting necroptosis in a cell by contacting the cell with a therapeutically effective amount of a composition comprising EV.

The invention provides a game interaction control method and device, equipment, a storage medium and a program product, and the method comprises the steps: responding to a first operation, controlling to separate a second object from a first object, and controlling the second object to move in a game scene; and in response to the condition that the second object and the third object meet the preset position, controlling to provide the target resource for the first object, in response to the condition that the target resource meets the preset condition, the use permission of a target skill is configured for the first object, and the target skill comprises a first skill which consumes the target resource during use so as to enable the first object to move towards the second object and / or a second skill which consumes the target resource during use so as to enable the second object to move towards the first object. Spatial linkage is established between the first object and the second object based on a bidirectional displacement skill of target resource unlocking, complex tactical maneuver can be realized without frequently switching a control main body, and the tactical dimension and the strategy depth of a game are expanded.

Provided herein is a method of training a machine-learning model to detect cardiomyopathy in a subject, the method including providing a training dataset, the training dataset including cardiac diagnostic data from a group of subjects; identifying, in the training dataset, cardiac diagnostic data from positive subjects with cardiomyopathy and cardiac diagnostic data from control subject without cardiomyopathy; and training the machine-learning model with the training dataset to discriminate between the cardiac diagnostic data from positive subjects and the cardiac diagnostic data from control subjects. Also provided herein are a method of detecting cardiomyopathy in a subject using the machine-learning model trained according to the methods disclosed herein, an apparatus for implementing the method of detection cardiomyopathy, and a computer readable storage medium storing computer-executable instructions for performing the method.

A system for detecting alcoholism using EEG signal processing, comprising: an EEG signal acquisition module configured to acquire digitized EEG signals from a plurality of electrodes placed on the scalp of a subject according to a 10-20 electrode placement system; a signal preprocessing module operationally connected to the EEG signal acquisition module and configured to preprocess the acquired digitized EEG signals, the preprocessed EEG signals being stored in a database containing signals from both alcohol-dependent and control subjects;a computing unit comprising at least one processor with dedicated memory, wherein the processor is configured to receive the preprocessed digitized EEG signals and perform a multi-resolution signal decomposition based on the discrete cosine harmonic wavelet packet transform (DCHWPT) to generate transformed signal representations corresponding to different frequency subbands; a feature extraction module connected to the computing unit and configured to extract a variety of features from the transformed signal representations; a feature selection module configured to perform a statistical test to reduce the dimensionality of the extracted features and retain only relevant features;a classification module configured to categorize EEG signals into an alcoholic or control category based on the retained relevant features; and an output module connected to the classification module, the output module comprising a user interface configured to display the classified results to the user.

The present invention relates to a method of diagnosing cancer in a subject comprising detecting in the DNA of said subject at least one hypermethylated CpG island associated with said cancer, wherein an elevation in the level of methylation in said CpG island of said subject, relative to the level of methylation in said CpG island of a control subject, is indicative of said CpG island being hypermethylated.

Disclosed is an application of sBCMA as a biomarker in cerebrospinal fluid in diagnosis and monitoring of antibody-mediated central nervous system autoimmune diseases. Taking NMOSD as an example, the level of sBCMA in cerebrospinal fluid of NMOSD patients is significantly higher than that of control subjects matched for age and gender, and there is a positive correlation between the level of sBCMA in cerebrospinal fluid and a nerve injury-related index NFL, a blood-cerebrospinal fluid barrier breakdown-related index QAlb, or a neuroinflammation-related index sTREM2 in cerebrospinal fluid of NMOSD patients. This indicates that the level of sBCMA in cerebrospinal fluid can be used as a biomarker for the diagnosis of antibody-mediated central nervous system autoimmune diseases such as NMOSD and the evaluation of the severity of nerve injuries, the degree of damage to blood-cerebrospinal fluid barrier, and the level of neuroinflammation in patients.

The invention relates to the technical field of industrial control systems, and discloses a carrier attitude adaptive compensation system in a complex motion environment, which comprises a distributed adaptive control module, a multi-dimensional state synchronization module and an axial control module, and is characterized in that the axial control module obtains a transmission time delay state, and when the transmission time delay exceeds a threshold interval, the multi-dimensional state synchronization module carries out adaptive compensation on a carrier attitude; a speed residual error sequence is extracted, the zero-crossing frequency of the speed residual error sequence is counted, an attenuation factor is determined according to the zero-crossing frequency so as to reduce the cross-axis compensation amount amplitude, an axial control module converts deviation energy generated by link congestion into a virtual uncertainty boundary parameter and injects the virtual uncertainty boundary parameter into a stability constraint criterion, and dynamic adjustment of the updating step length is completed. According to the method, the uncertainty of a communication link is quantified into robust gain reserve of a control system, the excitation phenomenon caused by high-frequency disturbance is effectively suppressed, and negative definite convergence of a controlled subject attitude control law is guaranteed.

Schizophrenia (SCZ) is the most debilitating of the Serious Mental Illnesses, a group of disorders affecting 4.8% of Arizona adults. The lack of a biologically based test makes diagnosing SCZ difficult, particularly for the 40% of Arizonans in areas with inadequate mental health care. Even under ideal circumstances, it can take months to years to accurately diagnose SCZ and identify an effective medication regimen. There is a critical need to identify biological markers to rapidly diagnose SCZ, which will lead to faster symptom resolution and improved patient outcomes. Methods described herein capitalize on the long-recognized association between SCZ risk and immune system dysfunction by stimulating peripheral blood immune cells with immunogenic agents to gain insight into disrupted pathways of gene expression in the brain. The immune stimulation of peripheral blood cells produces a unique pattern of gene expression, which will differ between SCZ and healthy control subjects.

The application discloses application of sBCMA in cerebrospinal fluid as a biomarker in diagnosis and disease monitoring of antibody-mediated central nervous system autoimmune diseases. Taking NMOSD as an example, the level of sBCMA in cerebrospinal fluid of NMOSD patients is significantly higher than that of age and gender matched control subjects, and the level of sBCMA in cerebrospinal fluid is positively correlated with NFL, QAlb and sTREM2, which are related indexes of nerve injury, blood-cerebrospinal fluid barrier damage and nerve inflammation in cerebrospinal fluid of NMOSD patients, which shows that the level of sBCMA in cerebrospinal fluid can be used as a biomarker for diagnosis of NMOSD and other antibody-mediated central nervous system autoimmune diseases, and can also be used for evaluation of the severity of nerve injury, the degree of blood-cerebrospinal fluid barrier damage and the level of nerve inflammation of patients with central nervous system autoimmune diseases.

The invention discloses a water supply network leakage cooperative control method and system, and the method comprises the steps: carrying out the unified organization of the multi-source operation information of the operation state of an execution mechanism based on the topological structure of a water supply network, and constructing an action condition leakage confidence field which can be recursively updated along with the control action and monitoring response; under the constraint conditions of the water supply service level and the operation safety, the action condition leakage confidence field is used as a control state to represent a self-adaptive determined control mode, and the control action intensity of the active identification stage is constrained through excitation budget parameters; dividing a pipe network into a plurality of cooperative control units and setting control subjects, wherein each control subject generates candidate control actions based on local observed quantity and confidence summary information exchanged by adjacent units; and projecting the candidate control action to a safe and feasible action set through an action mapping operator, and executing consistency coordination correction at a partition boundary or a shared execution mechanism to obtain a final control action, and issuing and executing the final control action.

An electrolysis apparatus operation system includes an electrolysis apparatus, a control unit, a target state-of-health value input unit, and a control parameter calculating unit. The electrolysis apparatus has a plurality of electrolytic stacks in which a plurality of electrolytic cells that produce hydrogen by electrolyzing water are stacked. The control unit controls a controlled subject based on a control parameter that affects state-of-health of the controlled subject. The target state-of-health value input unit allows a system user to input a target state-of-health value that is a target value for state-of-health. The control parameter calculating unit calculates a control parameter of the controlled subject based on the target state-of-health value. The controlled subject is the electrolysis apparatus.

The invention discloses a computer fan grading regulation control system based on multi-sensor feedback, which relates to the technical field of fan grading regulation, takes a fan grading regulation control platform as a core, and cooperatively controls an execution decision unit, a regulation execution influence evaluation unit and a fault-tolerant analysis substitution unit. An internal hardware performance evaluation unit and an operation control unit are combined to form a closed-loop control link of perception-decision-execution-feedback; the aging coefficient dynamic evaluation mechanism is used for acquiring the operation deviation and data precision difference of the control main body and the monitoring main body in a continuous / single adjustment scene in real time, constructing an aging coefficient curve after de-dimensionalization processing, and accurately quantifying the hardware performance attenuation trend; the environment self-adaptive adjusting strategy is based on the matching relation between environment parameters such as air pressure and the graded adjusting wind speed range; and fault-tolerant analysis and anomaly suppression capability are realized, and the reliability of an adjustment instruction is ensured through monitoring data anomaly detection and accidental data discrimination.

Various embodiments are directed to analyzing host gene expression levels and microbial diversity in a biological sample, to determine a likelihood of lower-respiratory tract infection (LRTI) in subjects. Embodiments can include determining a probability value of a subject having LRTI based on differential gene expression of the subject and reference levels of control subjects. Embodiments can also include determining the likelihood of LRTI in subjects based on amicrobial diversity index or abundance levels of microbes that are considered as potential pathogens. Embodiments can also include applying an integrated classifier to gene expression levels, virus abundance levels, and microbial diversity to determine the likelihood of LRTI in subjects.

Central Serous chorioretinopathy (CSCR) is primarily an ocular disease, affecting the choroid and the retinal pigment epithelium. To date, no systemic biomarker of CSCR have been discovered that could link both forms and help the diagnosis in challenging cases. In the present invention, the inventors measure in European cohorts of CSCR patients (n=168) with (n=90) or without epitheliopathy (n=78) and a cohort of 153 control subjects without any ocular disease history, the serum levels of NGAL and the NGAL / MMP9 complex. Serum NGAL (ng / ml) was significantly higher in the control group (108.8±46.8) than in the CSCR cohort (80.4±46.4, p<0.0001). Serum NGAL (ng / ml) was significantly lower in the acute / recurrent cohort (n=78, 71.3±32.1) than in the control and, than in the chronic cohort (n=90, 88.3±55, p=0.03). Similarly, Serum NGAL / MMP9 (ng / ml) levels was lower in the whole CSCR cohort (44.5±39.6) as compared to the controls (77.6±47.8, p<0.0001). Serum NGAL / MMP9 (ng / ml) were significantly lower in the acute / recurrent cohort (37.6±37.9) than in the control and, than in the chronic cohort (50.5±40.3, p=0.002). Thus, in both forms of CSCR serum NGAL and NGAL / MMP9 are lower than in the control population, providing a biological link between the two forms and a potential susceptibility to oxidative stress and innate immune dysregulation. Systemic LCN2 being elevated in other retinal diseases, it represents a specific biomarker for CSCR.