17 results about "Neurological deficit" patented technology

The present invention relates to a system and method configured for analysing acoustic parameters of speech to detect, diagnose, predict and / or monitor progression of a condition, disorder, or disease, and more particularly, any of paediatric and adult neurological and central nervous system conditions including but not limited to low back pain, multiple sclerosis, stroke, seizures, Alzheimer's disease, Parkinson's disease, dementia, motor neuron disease, muscular atrophy, acquired brain injury, cancers involving neurological deficits, paediatric developmental conditions and rare genetic disorders such as spinal muscular atrophy. The system and method extracts a first formant data set from words spoken by an individual and uses these to classify the vowels in the words on a first computing device, such as a mobile smart phone equipped with a microphone into which an individual speaks. The system stores at least some of these frequencies for the vowel formants in a second formant data set as a recorded file and provides the second formant data set as input to acoustic metrics to generate score data from which an assessment is made to determine the articulation level of the vowels in the words spoken by the individual, allowing allow for detection, diagnosis, prediction and / or monitoring progression of the condition, disorder, or disease.

The application provides a traditional Chinese medicine preparation for treating or improving cerebral hemorrhage and a preparation method thereof, and relates to the technical field of traditional Chinese medicine pharmacy. The traditional Chinese medicine preparation is composed of nacre, antelope horn powder, dragon's blood, Herba Schizonepetae, Prunella vulgaris, Stink-bug, Smilax riparia, bamboo juice, dried tangerine or orange peel, clubmoss, radix puerariae, Zizania aquatica and leaf of Chinese pear. The preparation has a significant therapeutic effect on cerebral hemorrhage, can obviously improve the neurological deficit of cerebral hemorrhage rats, reduce the water content of brain tissue to alleviate brain edema, simultaneously alleviate the inflammatory response in the body, thereby playing a neuroprotective effect on cerebral hemorrhage rats. In addition, the preparation can obviously improve the consciousness state of cerebral hemorrhage patients, alleviate the degree of neurological deficit, relieve the related TCM syndromes of the patients, simultaneously effectively improve the daily life ability of the patients, significantly improve the total effective rate of clinical treatment, and no obvious adverse reactions are observed in the treatment process, and the safety is good, thereby providing a safe and effective treatment scheme for the conservative treatment of cerebral hemorrhage.

The invention provides a traditional Chinese medicine preparation for treating or improving cerebral hemorrhage and a preparation method thereof, and relates to the technical field of traditional Chinese medicine pharmacy, the traditional Chinese medicine preparation is composed of nacre mother of pearl, antelope horn powder, dragon's blood, motherwort fruit, selfheal, aspongopus, radix actinidiae chinensis, bamboo juice, pericarpium citri reticulatae, selaginella tamariscina, radix puerariae, zizania aquatica and folium eriobotryae. The traditional Chinese medicine composition can obviously improve neurological impairment of cerebral hemorrhage rats, reduce the water content of brain tissues to relieve encephaledema and reduce inflammatory response in vivo, thereby playing a role in protecting the nerves of the cerebral hemorrhage rats. Besides, the preparation can obviously improve the consciousness state of a cerebral hemorrhage patient, relieve the degree of neurological impairment, relieve related traditional Chinese medicine syndromes of the patient, effectively improve the daily living ability of the patient and obviously improve the total effective rate of clinical treatment, no obvious adverse reaction is observed in the treatment process, and the preparation is good in safety and free of toxic and side effects. And a safe and effective treatment scheme is provided for the conservative treatment of cerebral hemorrhage.

The invention belongs to the technical field of biological medicine, and particularly relates to a nano-micelle preparation loaded with minocycline and application of the nano-micelle preparation to treatment of cerebral hemorrhage, the nano-micelle preparation is prepared by taking a polyethylene glycol-polycaprolactone nano material PEG3000-PCL2000 as a carrier, and jointly loading minocycline MINO and a CD147 monoclonal antibody Anti-CD147, so that the nano-micelle preparation is prepared. And the bionic nano-drug MINO (at) PNM (at) CD147 with an active targeting function is constructed. The nano-micelle preparation has a brain targeting property and can be enriched in cerebral hemorrhage tissues, so that the local drug concentration and the treatment efficiency are remarkably improved; the traditional Chinese medicine composition can improve neurological impairment caused by cerebral hemorrhage and significantly reduce the volume of cerebral hematoma, and has an obvious treatment effect on cerebral hemorrhage; the number of inflammatory cells in the peripheral area of hematoma and expression of inflammatory mediators can be remarkably reduced, and therefore the inflammatory response in cerebral hemorrhage tissue is relieved.

Aspects are directed to providing or administering novel therapeutic combinations for the treatment of tauopathies such as AD and other neurological deficiencies or dementias. Certain aspects include methods of using two or more drugs selected from an immunomodulator (IMD), antiviral (AVT), and magnesium (Mg) for the treatment of AD and / or other tauopathies; or compositions containing two or more drugs selected from an immunomodulator (IMD), antiviral (AVT), and magnesium (Mg).

The present application relates to the technical field of medicine, especially relates to application of a small molecule compound LZ-09 in preparation of a medicine for treating and / or preventing multiple sclerosis. The present application adopts H2O2 damage OLN-93 cells as a nerve cell oxidative stress model, and the result shows that LZ-09 treatment significantly weakens the cell viability decrease caused by H2O2. The classic EAE model is made by using MOG35-55 to induce C57BL / 6 mice, and it is found that after LZ-09 intervention, the mouse neurological deficit symptom score is significantly reduced, and the disease progression is delayed, and spinal cord tissue HE and LFB staining find that the inflammation infiltration and demyelination are reduced. Therefore, the compound can effectively alleviate the symptoms of multiple sclerosis, can be used as a medicine for treating multiple sclerosis, and has wide development and application prospect.

Provided in the present invention is use of bremelanotide in the preparation of a drug for preventing and / or treating ischemic stroke. Bremelanotide can ameliorate neurological deficits, reduce the cerebral infarction area, and improve the cerebral blood flow in ischemic stroke.

This invention provides a composite composition containing nervonic acid and its use in brain nerve repair, belonging to the field of biotechnology. The invention uses nervonic acid and phosphatidylserine, combined with plant extracts fermented by a microbial concoction of *Lactobacillus acidophilus*: *Lactobacillus rhamnosus*: *Bacillus belyssae* = (2-3):1:1, to form a composite composition. This scientific formulation achieves synergistic effects from multiple components, improving neurological deficits, reducing cerebral infarction volume, decreasing the release of neurotrophic markers, and upregulating neurotrophic factor expression through multi-target synergistic effects. Furthermore, this synergistic effect depends on specific component ratios, providing crucial experimental support for the development of subsequent brain-protective functional compositions. This composition can be widely applied to the preparation of brain nerve repair drugs, functional foods, and dietary supplements, possessing promising industrialization prospects and clinical value.

This invention discloses a traditional Chinese medicine composition for treating cerebrovascular diseases, belonging to the technical field of cerebrovascular disease drugs. The composition comprises the following components in parts by weight: 10-30 parts of Polygonatum sibiricum, 6-15 parts of Rosa laevigata, 6-12 parts of Euonymus alatus, 6-15 parts of Polygonum cuspidatum, 3-9 parts of Acorus tatarinowii, 3-10 parts of Alpinia oxyphylla, 3-6 parts of Aralia elata septum, 3-10 parts of Rhodiola rosea, 3-10 parts of Bletilla striata, and 1-6 parts of Cinnamomum cassia. This invention addresses the pathological characteristics of cerebrovascular diseases, including long disease courses, multiple risk factors, and involvement of multiple target organs. Through the systematic combination of ten herbs, it can simultaneously achieve cerebrovascular protection, nerve function repair, and protection against multi-organ damage. Animal experiments and clinical observations have confirmed that this composition can significantly improve patients' neurological deficit scores, reduce the incidence of complications, and has clear preventive and therapeutic effects on secondary complications such as stress ulcers and renal impairment, while also possessing antithrombotic and hemostatic properties and high safety.

The present invention provides an application of α-asarone in the preparation of a medicine for preventing or treating hemorrhagic strokes. α-asarone has the structure shown in formula I, and may significantly improve short-term neurological deficits and long-term learning and memory functions of model rats, reduce cerebral edema, improve the permeability of the blood-brain barrier, and prevent or mitigate the atrophy of brain tissue during a recovery period. α-asarone has a precise therapeutic effect on animal models of hemorrhagic stroke without obvious toxic side effects, and is expected to have great application prospects as a medicine for preventing / treating hemorrhagic strokes.

FIELD: neurosurgery and neurology.SUBSTANCE: after surgical access, a vessel located on the surface of the tumor tissue and extending into adjacent areas of the cortex is visualized. On both sides of the vessel, a bipolar electrode is used to coagulate the areas of the cortex affected by the tumor. Then, using microscissors, the arachnoid membrane is opened in the area of coagulation zones. An encephalotomy is performed. Next, subpial resection of the tumor in these areas is performed using an ultrasonic destroyer-aspirator, preserving the arachnoid membrane in which the preserved vessel passes. When visualizing a vessel located deep in the groove, dissection of the groove is performed while preserving the arachnoid membrane in which the vessel passes. The tumor around the vessel is resected using an ultrasonic destroyer-aspirator. In this case, first the part of the tumor on one side of the vessel is resected, then the part on the other side. These resection areas are connected to each other under the vessel. Then the residual tumor fragments on the vessel are removed. When visualizing a vessel passing through a tumor to healthy areas of the brain, this vessel is preserved, and the tumor tissue is separated from it along the periphery using an ultrasonic destroyer-aspirator. During the isolation of cortical and subcortical vessels, they are irrigated with saline solution. Then, through the resulting “intervascular windows,” deeply located tumor fragments are removed.EFFECT: method allows for the preservation of blood flow in cortical vessels during the removal of glial brain tumors, reducing the risk of developing ischemic complications in functionally significant areas of the cortex adjacent to the tumor resection zone, as well as in the subcortical structures of the brain, which, as a consequence, is associated with lower risks of developing postoperative neurological deficit.1 cl, 3 ex

The application discloses application of CADM3 in preparation of products for treating autoimmune diseases, belongs to the technical field of biological medicine, and the amino acid sequence of the CADM3 is shown as SEQ ID NO.2.The application discloses that CADM3 is up-regulated on the surface of activated APC, in vitro cell intervention experiments are carried out by using prepared hCADM3-Ig fusion protein, it is confirmed that the fusion protein can effectively block the activation and proliferation of T cells, and further regulate the overactive autoimmune response.Through animal experiment verification, compared with the control group, the hCADM3-Ig fusion protein treatment group can significantly improve the neurological deficit symptoms of EAE model mice, obviously reduce the intestinal dysfunction of IBD model mice, effectively reduce the degree of inflammatory reaction in the two models, and significantly inhibit the activation and proliferation of pathological T cells.

The invention relates to the field of medical information processing, in particular to a stroke home rehabilitation guidance method and system based on multi-dimensional classification. The method comprises the following steps: acquiring basic conditions of a stroke patient, and classifying disease characteristics, neurological function defect parts, severity and complications to form a classification result; executing patient group mapping based on a classification result, and establishing corresponding key monitoring related indexes; change collection and change analysis are carried out according to key monitoring related indexes, and stage rehabilitation scheme suggestions are generated; and carrying out abnormal judgment and online guidance according to the stage rehabilitation scheme suggestions, forming adjustment suggestions, and writing back the adjustment suggestions. According to the invention, the classification result is used as an organization basis throughout the whole process, so that a consistent closed-loop processing link is formed by monitoring, analysis, guidance and write-back, and the continuity, traceability and collaborative stability of the scheme generation and adjustment process in the stroke home rehabilitation guidance process are improved.

This invention discloses a material-empowered stem cell-derived exosome, its preparation method, and its application, belonging to the field of biomedical technology. The method involves the following steps: mesenchymal stem cells are seeded onto a substrate fused with N / VE-cadherin-Fc fusion protein and cultured to assemble into aggregates; the aggregates are dynamically cultured under staged shear stress; the culture medium is collected, and the exosomes are separated and purified. The preparation method of this invention overcomes the shortcomings of existing mesenchymal stem cell exosome preparation technologies, such as low yield and insufficient neurovascular repair function. It significantly activates exosome biogenesis-related molecular pathways, increases exosome yield by approximately four times, and is rich in miRNAs related to neurovascular repair. It can significantly improve neurological deficits in stroke mice and hindlimb motor function in rats with spinal cord injury, providing a highly efficient and stable cell-free therapeutic strategy for the treatment of central nervous system injuries.

This invention belongs to the field of biomedicine, specifically disclosing the use of a combination of Panax notoginseng total saponins and chemical drugs as effective components in the preparation of drugs for the prevention and treatment of stroke. Experiments have shown that the combination of Panax notoginseng total saponins and chemical drugs can effectively improve neurological deficits, significantly reduce the incidence of combined cardiovascular and cerebrovascular events within one year, and further significantly reduce the incidence of combined cardiovascular and cerebrovascular events in long-term follow-ups of 2 and 3 years. Therefore, the combination of Panax notoginseng total saponins and chemical drugs can be used for the prevention of combined cardiovascular and cerebrovascular events in stroke patients, with good efficacy and safety.

Methods and apparatuses for sensory electrical stimulation of the peripheral nervous system to improve human motor function and performance are described. Methods and devices may be used to enhance physical performance of athletes, professionals, and gamers or improve motor function (hand, finger and limb movement) in patients rehabilitating from neurological deficits and impairments caused by stroke, traumatic brain injury and other neurologic or non-neurologic conditions. These apparatuses and methods may be used for physical training and mental training (to improve memory and functional performance including motor coordination, limb-eye coordination, occupational and recreational skills) through periodic or sustained sensory electrical stimulation. Treatment plans may be based on biomarkers and may be used alone or in combination with other apparatuses. Learning and feedback techniques individualize treatment parameters depending on the subject's neurologic and motor function in diseased patients and healthy users.

This invention relates to the field of pharmaceutical technology, specifically to a perioperative neuroprotective anesthetic composition and its application for ischemic stroke. The composition comprises the active ingredient remimazolam or a pharmaceutically acceptable salt thereof, MCC950, TRO19622, levamisole or a pharmaceutically acceptable salt thereof, lipoic acid, and a pharmaceutically acceptable carrier, with each active ingredient formulated in a specific molar ratio. This composition combines stable and controllable anesthetic effects with multi-target synergistic neuroprotective effects, adapting to the entire perioperative anesthesia needs for ischemic stroke. Through upstream and downstream synergistic inhibition of mitochondrial damage and the NLRP3 pyroptosis pathway, dual regulation of perioperative sympathetic tone to stabilize cerebral perfusion, synergistic reduction of glutamate excitotoxicity, and enhancement of endogenous antioxidant defense, it comprehensively blocks the core links of perioperative ischemia-reperfusion brain injury, significantly reducing the risk of postoperative neurological deficits and cognitive impairment. It exhibits excellent circulatory and respiratory safety, rapid awakening without affecting early postoperative neurological function assessment.