Flexible peripheral neurological deficit repairing duct and preparation method thereof

Abstract

The invention discloses a flexible peripheral neurological deficit repairing duct. The flexible peripheral neurological deficit repairing duct is a flexible threaded pipe prepared from high molecularmaterials and extracellular matrices through electrospinning. The invention also discloses a preparation method of the flexible peripheral neurological deficit repairing duct. The preparation method comprises the following steps of adding the high molecular materials and the extracellular matrices into an organic solvent under room-temperature condition, so as to obtain an electrospinning stock solution of 4%-16%(w / v, mg / ml); preparing soluble or non-soluble materials into a thread model containing thread-shaped side walls; uniformly spraying the electrospinning stock solution onto the threadmodel, and forming the threaded pipe from electrospinning on the thread model; and removing the threaded model so as to obtain the threaded pipe shaped flexible peripheral neurological deficit repairing duct.

Description

technical field [0001] The invention relates to the technical field of bionic preparation of peripheral nerve defect repair materials, in particular to a flexible peripheral nerve defect repair catheter and a preparation method thereof. Background technique [0002] Nerves are composed of nerve fibers gathered into bundles, and the nerve fibers themselves are formed by covering the axons of neurons with myelin sheath formed by Schwann cells. Many of these nerve fibers gather into bundles, which are then filled with connective tissue to form peripheral nerves. Large sections of nerve defects must be treated by nerve transplantation or artificial repair materials. The repair and reconstruction of peripheral nerve defects is a major problem in the field of current treatment of peripheral nerve injuries. Human nerve defects exceeding 3 cm need to be implanted with repair materials to assist repair. For example, a Chinese invention patent of CN105288730A discloses a nerve defect...

AI Technical Summary

Problems solved by technology

[0004] According to the analysis of the feedback data of the nerve guide approved by the US FDA for clinical application, the failure of the nerve defect repair can be attributed to: 1) With the movement of the limbs, due to insufficient flexibility, the tension at the suture is too large, and the nerve guide anastomoses Avulsion of end sutures, such as Figure 2A 2) Due to excessive stress concentration caused by joint bending, the nerve conduit collapses, such as Figure 2B 3) Tissue edema due to biomaterial degradation hinders nerve regeneration

Images