2 results about "Nerve guide" patented technology

The present invention provides a medical molded article including a bioabsorbable polyester and having excellent followability to a living body, and the present invention is a medical molded article including a bioabsorbable polyester, the medical molded article having an amount-of-work-holding rate of 55% or more, the amount-of-work-holding rate defined as a rate of an amount of work generated finally by an operation that is repeated 10 times to an amount of work generated first by the operation, the operation in which a tensile stress is applied to the medical molded article in a direction of a maximum length of the medical molded article to generate a tensile strain of 100% with respect to an initial length.

This invention belongs to the field of tissue engineering and regenerative medicine technology, specifically a multi-layered biomimetic skin structure and its synchronous bio-3D printing preparation method and system, comprising a sequentially combined epidermal layer and dermal layer. This invention highly mimics natural skin through a multi-layered structure. A micropillar array in the dermal layer provides a strong mechanical anchor between the epidermis and dermis, while embedded PLGA microspheres can sustainably release VEGF and EGF for 3-4 weeks, continuously promoting repair. Integrated vascular network channels and nerve guidance structures address the challenges of nutrient delivery and the lack of neural perception function, respectively, filling the functional gaps in traditional biomimetic skin. The synchronous bio-3D printing process enables integrated fabrication of the multi-layered structure. Combined with a four-channel printhead and a multi-physics coupling module, along with a visual positioning and pressure feedback system, printing accuracy and stability are ensured, preventing filament breakage or ink overflow. An intelligent cultivation system simulates the physiological environment, further enhancing skin maturity. This invention is applicable to the repair of skin defects such as burns and chronic ulcers.