39 results about "Nerve guide" patented technology

Devices formed of or including biocompatible polyhydroxyalkanoates are provided with controlled degradation rates, preferably less than one year under physiological conditions. Preferred devices include sutures, suture fasteners, meniscus repair devices, rivets, tacks, staples, screws (including interference screws), bone plates and bone plating systems, surgical mesh, repair patches, slings, cardiovascular patches, orthopedic pins (including bone filling augmentation material), adhesion barriers, stents, guided tissue repair/regeneration devices, articular cartilage repair devices, nerve guides, tendon repair devices, atrial septal defect repair devices, pericardial patches, bulking and filling agents, vein valves, bone marrow scaffolds, meniscus regeneration devices, ligament and tendon grafts, ocular cell implants, spinal fusion cages, skin substitutes, dural substitutes, bone graft substitutes, bone dowels, wound dressings, and hemostats. The polyhydroxyalkanoates can contain additives, be formed of mixtures of monomers or include pendant groups or modifications in their backbones, or can be chemically modified, all to alter the degradation rates. The polyhydroxyalkanoate compositions also provide favorable mechanical properties, biocompatibility, and degradation times within desirable time frames under physiological conditions.

The instant invention provides electrospun fiber compositions comprising one or more polymers and one or more biologically active agents. In specific embodiments, the biologically active agents are nerve growth factors. In certain embodiments, the electrospun fiber compositions comprising one or more biologically active agents are on the surface of a film, or a tube. The tubes comprising the electrospun fiber compositions of the invention can be used, for example, as nerve guide conduits.

Disclosed is a bio-electrospinning technique for preparing a cell-containing, oriented, continuous tubular scaffold, made of biodegradable polymer, designed for use as a nerve guide conduit (NGC) in nerve regeneration. With a coaxial spinneret, the PC-12 cell medium solution was co-electrospun into a core of tubular fibers, with PLA on the outer shell. The resulted fibers' morphology was characterized via SEM and optical microscopy, and following structural characteristics were found: 1. the larger, hollow fibers had diameters in tenth of microns and wall thicknesses around few microns, 2. an orientation in a preferred direction with the aid of a high-rotating collection device. The fluorescent PC12 cells embedded within the scaffold were cultured and nerve growth factor was added. We observed cells could not only survive the process, but also sustain their viability by undergoing differentiation process, extending neurite along the micro tubular scaffold in the desired direction. All these results demonstrate its potential application for advanced NGC.

The present invention is directed to the compositions and methods of preparing hydrogel-grafted nerve guides for peripheral nerve regeneration. Particularly, the present invention describes the nerve guides and methods for preparation of hydrogel-grafted nerve guides with encapsulated neurotrophic factors and a nanofiber mesh lining the inner surface of the guide. The present invention also provides methods for peripheral nerve repair using these hydrogel-grafted nerve guides.

A biological nerve guide for implantation into a human body is made by providing a natural animal tissue membrane, crosslinking and fixing the membrane, minimizing the antigens from the membrane, tanning the membrane, coupling an active layer to an inner surface of the membrane, cutting the membrane into a desired shape and size, positioning the cut membrane onto a rod-shaped mold so that the cut membrane assumes a cylindrical configuration, and attaching a spiral support to the outer surface of the cut membrane.

The present invention relates to specific DL-lactide-ε-caprolactone copolymers and the application of these polymers in the production of biodegradable medical applications. According to the present invention a polymeric material comprising poly(DL-lactide-co-ε-caprolactone) is provided, which is obtained by the copolymerization of DL-lactide and ε-caprolactone, having a lactide content of 51-75 mol %, most preferably of 62-69 mol %.

The materials of the present invention have excellent mechanical properties and may be used to provide articles for medical application, in particular nerve guides.

The invention relates to a nerve graft capable of guiding nerve tracts to be regenerated accurately. The nerve graft comprises a plurality of nerve guide wires and an outer sleeve, and is prepared from a material with good nerve biocompatibility. The guide wires are inserted into the nerve tracts corresponding to two broken ends of a nerve trunk, so that a function of accurately guiding the nerve tracts to grow in an orientated manner is fulfilled, meanwhile, the two broken ends of the nerve trunk are fixedly connected through the outer sleeve, and the circumstance that the guide wires slip due to pulling of the nerve trunk in a moving process of limbs is prevented. The whole nerve graft is simple in structure, and is convenient and speedy in an implanting process, and meanwhile, the effect of nerve regeneration and repair can be improved.

The present invention discloses a medicine compound preparation for treating osteoarthritis. The compound preparation is preferably a compound injection and comprises a nerve guiding factor Sema and asodium hyaluronate injection. A concentration of the nerve guiding factor Sema in the sodium hyaluronate injection is 4-9 [mu]g/mL. In a preferred embodiment, the nerve guiding factor Sema is selected from Sema 3a protein. Results of clinical trials show that the injection prepared by combination of the nerve guiding factor Sema 3a protein and the sodium hyaluronate injection has a superior therapeutic effect for patients with early stage degenerative osteoarthritis than that of a sodium hyaluronate injection treatment alone.