6 results about "Nerve guide" patented technology

The present invention provides a medical molded article including a bioabsorbable polyester and having excellent followability to a living body, and the present invention is a medical molded article including a bioabsorbable polyester, the medical molded article having an amount-of-work-holding rate of 55% or more, the amount-of-work-holding rate defined as a rate of an amount of work generated finally by an operation that is repeated 10 times to an amount of work generated first by the operation, the operation in which a tensile stress is applied to the medical molded article in a direction of a maximum length of the medical molded article to generate a tensile strain of 100% with respect to an initial length.

The invention provides a nerve guidance type speech enhancement method based on personalized brain electrode distribution, and the training method of a speech enhancement model in the speech enhancement method comprises the steps: obtaining a training set which comprises a plurality of training sample combinations corresponding to at least one training user, the training sample combination comprises real biological auxiliary information, mixed distribution auxiliary information, Gaussian distribution auxiliary information, mixed training voice information and an enhanced voice tag of the training user, and the auxiliary information represents the attention degree of the training user to a certain recognition user in the mixed training voice information; performing adversarial training on the plurality of initial enhancement models by using the real biological auxiliary information, the mixed distribution auxiliary information, the Gaussian distribution auxiliary information and the mixed training voice information to obtain a plurality of pieces of enhanced voice information; generating an initial loss value according to the enhanced voice information and the enhanced voice tag; and iteratively adjusting network parameters of the initial enhancement model according to the initial loss value to obtain a speech enhancement model.

Provided is a medical device formed entirely from or formed partially from a polymer, e.g., a polysaccharide such as chitosan. In some embodiments, the medical device may be formed as a sheet of a chitosan material. This chitosan sheet may be used to wrap around tissue, such as a nerve or tendon to help with the regeneration or healing process of the nerve or tendon, as applicable. In addition or in the alternative, the sheet may be wrapped to form a tube or other shape that can wrap around the nerve.

This invention belongs to the field of tissue engineering and regenerative medicine technology, specifically a multi-layered biomimetic skin structure and its synchronous bio-3D printing preparation method and system, comprising a sequentially combined epidermal layer and dermal layer. This invention highly mimics natural skin through a multi-layered structure. A micropillar array in the dermal layer provides a strong mechanical anchor between the epidermis and dermis, while embedded PLGA microspheres can sustainably release VEGF and EGF for 3-4 weeks, continuously promoting repair. Integrated vascular network channels and nerve guidance structures address the challenges of nutrient delivery and the lack of neural perception function, respectively, filling the functional gaps in traditional biomimetic skin. The synchronous bio-3D printing process enables integrated fabrication of the multi-layered structure. Combined with a four-channel printhead and a multi-physics coupling module, along with a visual positioning and pressure feedback system, printing accuracy and stability are ensured, preventing filament breakage or ink overflow. An intelligent cultivation system simulates the physiological environment, further enhancing skin maturity. This invention is applicable to the repair of skin defects such as burns and chronic ulcers.

The present disclosure relates to a system and method for the production of a medical device for use as a nerve guide. The system and method provide for coating a polymer layer with particles, wherein the particles can comprise active agents for the repair or regeneration of nerve defects. The present invention further provides an implantable device for repairing or regenerating a nerve defect prepared by the system and method set forth above, and methods of treatment using said device.

The present invention relates to a porous nerve guidance conduit produced using a combination of additive manufacturing and rotary jet spinning techniques from any bioabsorbable polymer, wherein the conduit can be incorporated or not with anti-inflammatory drugs. The nerve guidance conduit of the present invention can be used in the field of tissue engineering, in applications and preparations for medical purposes and, more specifically, to repair peripheral nerve injuries.