39 results about "Nerve guide" patented technology

Devices formed of or including biocompatible polyhydroxyalkanoates are provided with controlled degradation rates, preferably less than one year under physiological conditions. Preferred devices include sutures, suture fasteners, meniscus repair devices, rivets, tacks, staples, screws (including interference screws), bone plates and bone plating systems, surgical mesh, repair patches, slings, cardiovascular patches, orthopedic pins (including bone filling augmentation material), adhesion barriers, stents, guided tissue repair / regeneration devices, articular cartilage repair devices, nerve guides, tendon repair devices, atrial septal defect repair devices, pericardial patches, bulking and filling agents, vein valves, bone marrow scaffolds, meniscus regeneration devices, ligament and tendon grafts, ocular cell implants, spinal fusion cages, skin substitutes, dural substitutes, bone graft substitutes, bone dowels, wound dressings, and hemostats. The polyhydroxyalkanoates can contain additives, be formed of mixtures of monomers or include pendant groups or modifications in their backbones, or can be chemically modified, all to alter the degradation rates. The polyhydroxyalkanoate compositions also provide favorable mechanical properties, biocompatibility, and degradation times within desirable time frames under physiological conditions.

An RGD polypeptide grafted poly (glycolic acid-L-lysine-L-lactic acid) / β-tricalcium phosphate composite material is composed of β-tricalcium phosphate particles and RGD polypeptide grafted poly (glycolic acid-L-lysine-L-lactic acid) with mass ratio of 1:10-1:100, in which the β-tricalcium phosphate particles are uniformly dispersed in the RGD polypeptide grafted poly (glycolic acid-L-lysine-L-lactic acid) matrix. The preparation method includes that poly (glycolic acid-L-lysine-L-lactic acid) is polymerized with GRGDY short peptide (glycin-arginine-glycin-aspartic acid-tyrosine sequence) to obtain RGD polypeptide grafted poly (glycolic acid-L-lysine-L-lactic acid), and then RGD polypeptide grafted poly (glycolic acid-L-lysine-L-lactic acid) is compounded with β-tricalcium phosphate particles. The composite material exhibits favorable biocompatibility, cellular affinity, biodegradability and mechanical behavior, and can avoid aseptic necrosis of tissues, which may be used as nerve guide or porous bone scaffold for repairing nerve tissue and bone tissue.

The present invention is directed to the compositions and methods of preparing hydrogel-grafted nerve guides for peripheral nerve regeneration. Particularly, the present invention describes the nerve guides and methods for preparation of hydrogel-grafted nerve guides with encapsulated neurotrophic factors and a nanofiber mesh lining the inner surface of the guide. The present invention also provides methods for peripheral nerve repair using these hydrogel-grafted nerve guides.

Nerve guides which are formed from three dimensional (3D) arrays of highly aligned electrospun fibers are provided. The electrospun fibers are oriented parallel to the long axis of the guide, and gaps and elongated spaces between the stacked fiber arrays provide channels for directed axonal growth. In some embodiments, the nerve guides also comprise high precision gradients of beneficial substances such as growth factors, which aid in nerve regeneration and growth along the guide.

The present invention is directed to the compositions and methods of preparing hydrogel-grafted nerve guides for peripheral nerve regeneration. Particularly, the present invention describes the nerve guides and methods for preparation of hydrogel-grafted nerve guides with encapsulated neurotrophic factors and a nanofiber mesh lining the inner surface of the guide. The present invention also provides methods for peripheral nerve repair using these hydrogel-grafted nerve guides.

A biological nerve guide for implantation into a human body is made by providing a natural animal tissue membrane, crosslinking and fixing the membrane, minimizing the antigens from the membrane, tanning the membrane, coupling an active layer to an inner surface of the membrane, cutting the membrane into a desired shape and size, positioning the cut membrane onto a rod-shaped mold so that the cut membrane assumes a cylindrical configuration, and attaching a spiral support to the outer surface of the cut membrane.

The aim of the invention is to provide a nerve guide that allows the axons to develop fairly freely during regeneration. For this purpose, the nerve guide is produced based on a shaped body from a cross-linked, resorbable, gelatin-based material. The shaped body is a tubular hollow body having a wall with an exterior surface and an interior surface, which wall defines a lumen. The nerve guide comprises a semipermeable layer surrounding the lumen.

The invention provides for methods for delivering a nucleic acid into a peripheral neuron by identifying a target neuron in a dorsal root ganglion and intrathecally delivering a vector comprising the nucleic acid to the dorsal root ganglion neuron. The nucleic acid may encode a neurotrophic factor that may be used to treat a peripheral neuropathy or, in conjunction with a nerve guide conduit, to treat a transected peripheral nerve.

Belonging to the technical field of medical biomaterials, the invention in particular relates to a polylactic acid-chitosan composite nerve conduit. The composite nerve conduit is composed of oriented polylactic acid electrospun fiber and a chitosan layer wrapping the fiber. The invention also provides a preparation method of the polylactic acid / chitosan composite nerve conduit, and application of the nerve conduit in preparation of peripheral nerve defect repair materials. The polylactic acid-chitosan composite nerve conduit prepared by the invention has excellent biomechanical properties and superior hydrophilcity, also has good biological tissue compatibility, can significantly promote the attachment, migration and proliferation of Schwann cells, is easy to cut and preserve, and is simple to operate during clinical use, thus having good clinical application prospects in the peripheral nerve damage repair field.

The invention discloses a nerve guide and a preparation method thereof. The nerve conduit comprises an inner layer, an outer layer and at least one micro-cavity for storing bioactive factor solution, the inner layer is a hydrophilic cell support layer, and the outer layer is a hydrophobic nerve guide support layer. The nerve guide may also comprise a transition layer between the inner and outer layers. The preparation method of the nerve guide is to firstly prepare the inner layer by electrospinning, then add the material for preparing the cavity, and then prepare the outer layer, and after taking out or dissolving the material for preparing the cavity, the nerve guide can be obtained. The nerve guide has a micro-cavity, which can be loaded with biologically active factors according to the need before the operation, such as injection, soaking, etc., which not only makes the production quality of the product easy to control, but also greatly improves the survival rate of the biologically active factors, and more efficiently promotes Nerve regeneration and enhanced nerve repair effect.

The invention relates to a method for preparing a multi-channel antibacterial nerve conduit by a variable-spindle weaving method, comprising the following steps: braiding a plurality of inner conduit braiding yarns on the outside of an inner core material to form a conduit, and the conduit includes an inner core material and an inner core material. The tube body is sleeved on the outside; the color difference between the braided yarn of the inner conduit and the inner core material is obvious, and the inner core material is in the shape of a solid cylinder with a smooth surface. The number of braided yarns in the inner conduit can be estimated by the following formula ; Among them, m represents the number of braided yarns in the inner conduit, and d y Represents the diameter of the braided yarn of the inner catheter, R represents the inner diameter of the outer catheter, n represents the number of inner catheters in the multi-channel antibacterial nerve guide, r represents the inner radius of the inner catheter; 0<k≤1, 0<λ≤1; The catheter is divided into n tubes, and the n tubes are arranged side by side as the core material, and the outer catheter braided yarn is woven on the outside of the core material to form an outer catheter outside the core material, and then the inner core material is removed to obtain a multi-channel antibacterial nerve guide.

The invention relates to the field of biomedical engineering, and discloses an axial gradient protein-loaded silk nerve guide and its preparation and application. In the present invention, by grafting o-nitrobenzyl photosensitive molecules on silk fibroin, silk fibroin modified by o-nitrobenzyl photosensitive molecules is obtained, and then prepared into a photoactive silk nerve guide, and finally The silk nerve guide is soaked in the nerve growth factor solution, the front end, the middle part and the end are irradiated with blue light along the axial direction, after washing and freeze-drying, an axial gradient protein-loaded silk nerve guide is obtained. The invention gradually reduces the light irradiation time in the front, middle and end regions of the silk nerve guide, and realizes the precise and controllable gradient loading of the silk nerve guide. The biological activity of the silk nerve guide of the invention is greatly improved, can effectively promote the proliferation and migration of nerve cells, can induce the rapid growth of new nerve tissue, and achieve good nerve repair effect in clinical practice.

The invention discloses a conductive nerve conduit based on butterfly lepidopteran and a preparation method thereof. The method comprises modifying reduced graphene oxide on the surface of butterfly lepidopteran and coating a layer of methacrylated gelatin solution containing neurotrophic factor BDNF, UV light cures it and then crimps it into a nerve guide. The micro-nano structures arranged in parallel on the inner surface of the prepared nerve conduit can guide the nerve cells to extend in the direction of the lepidopteran ridge, and the BDNF in the hydrogel can be slowly released, which can effectively promote nerve regeneration. This butterfly lepidopteran-based nerve conduit uses butterfly lepidoptery as a raw material, which is easy to obtain, low in cost, safe and non-toxic, and combines various factors that promote nerve regeneration, such as nano-bionics, directional induction, and sustained release of nutritional factors.

The application discloses a nerve injury repairing material, its preparation method and application. The preparation method of the material comprises: solidifying and drying the following mixed solution: the solute of the mixed solution includes collagen and chitosan, and the solvent is an acid solution; the collagen in the mixed solution The concentration is 60-90mg / mL; the concentration of the chitosan in the mixed solution is 20-40mg / mL. The product of the present invention retains the advantages of the original collagen nerve repair product, has been significantly improved in suture performance and degradation performance, and can also increase the conductive function, which is more in line with the requirements of an ideal nerve guide. Repair, without adding new solvents, and without new chemical reagent residue problems.