35 results about "Nerve tract" patented technology

The present invention discloses method and apparatus of detecting, exciting and regenerating sensation, motor and internal organ signals of vertebrate including human, and is especially one kind microelectronic system aided nerve channel function recovering method and apparatus. The nerve channel function recovering apparatus includes two parts, one part for the function reconstruction of the ascending nerve channel and the other part for the function reconstruction of the descending nerve channel. The weak electric signal of the damaged nerve tract or nerve fiber is detected with detecting electrodes, amplified, recognized and extracted to generate controlled electric exciting signal for exciting the damaged nerve tract or nerve fiber to regenerate corresponding nerve signal and restore the function of the damaged nerve tract or nerve fiber micro electronically.

The invention relates to the biomedical field of high molecular materials, in particular to a nerve grafting object containing an orientation nanofiber nerve tract and a preparing method of the nerve grafting object. A core (A) composed of the nanofiber tract is placed in the middle of the nerve grafting object, a sheath (B) composed of an irregular fiber layer (B2) and an orientation layer (B1) is arranged on the outer face of the nerve grafting object, the diameter of the core (A) composed of the nanofiber tract is 2-5mm, the length of the core (A) composed of the nanofiber tract is 3-15mm, the fiber diameter of the nanofiber tract is 40-300nm, the length of the sheath (B) is 9-25mm, the orientation layer (B1) comprises parallel-arrayed fibers of 100-500nm, and the irregular fiber layer (B2) comprises disorder-arrayed fibers of 100-500nm. The technology is stable, grafting object size is adjustable, the clinic requirement is met, production efficiency is improved, industrialization is convenient, guiding performance is high, using is convenient, and practicability is improved.

The invention relates to a wireless energy supply and wireless acquisition system of a nerve tract implanted electrode based on a vlsivery large scale integrated circuit (VLSI), comprising an internalimplanted circuit device and an external circuit device, wherein the internal implanted circuit device comprises a nerve tract complex potential acquisition circuit, an encode circuit and a 2ASK modulation circuit of a 2ASK modulation device, a rectifying circuit and a voltage stabilizing circuit of a wireless energy transmission receiving circuit, and an internal coupling coil, and the wirelessenergy transmission receiving circuit is manufactured by a VLSI technology; and the external circuit device comprises a 2ASK demodulation circuit, a radio-frequency oscillator and a class-E amplifierof a wireless energy transmission emitting circuit, a circuit board assembled by separate elements and an external coupling coil. The wireless energy supply and wireless acquisition system not only realizes the wireless energy supply of the internal implanted circuit device, but also realizes the wireless transmission of the nerve tract implanted electrode recorded on nerve tract complex potential, and can be used for detecting a peripheral nerve system when an animal does somatic movement in a waking state; and in addition, the power consumption of the wireless energy supply and wireless acquisition system is reduced by manufacturing a wireless energy supply chip and a wireless acquisition system by the VLSI technology.

The invention discloses a method for controlling bone implantation artificial limb by means of biological electrical signal in human body, which comprises the steps of, plugging the upper end of the implantation member with holes into the remnant bones of the amputee's stump, connecting the lower projecting member with the artificial limb, implanting the electrodes into the nerve-tract or muscle hank in the soft tissue, leading the contact conductor to the external signal conditioning device through the through-hole on the implantation member, carrying out magnification and filtration to the signal collected by the electrodes, mapping the signal into the control message for artificial limb motion, the control signal feeding to the motor to drive the artificial limb.

The disclosure relates to a method of manufacturing a flexible spiral electrode and a nerve tract detection and treatment device. The method comprises: a substrate is heated to be at a transformationtemperature and the substrate winds around a first forming rod spirally to form a to-be-formed substrate; the temperature of the to-be-formed substrate is kept to be larger than or equal to a first plastic deformation within first time and thus a spiral substrate is formed; the spiral substrate is heated to be at a transformation temperature and the substrate is flattened to obtain a flattened substrate; a metal electrode is transferred to the flattened substrate; a lead is connected to a lead connection end of the metal electrode, so that an electrical stimulation signal is sent to the metalelectrode through the lead and/or an electrical signal of a nerve tract in contact with the metal electrode is obtained; heating is carried out to reach a transformation temperature and thus the shapeof the flattened substrate is transformed into a spiral shape, so that a flexible spiral electrode is obtained. The manufactured flexible spiral electrode has high extensibility and the contact degree and the matching degree with the nerve tract are high; and the operation is carried out conveniently. Moreover, the service life is long; the stability is high; and the side effects are low.

The invention belongs to the field of cell biology and relates to a method for separating and purifying schwann cells. The method sequentially comprises the following steps of: firstly, taking a nerve segment under the aseptic condition and removing an epineurium; secondly, digesting a nerve tract by using a NB4 composite collagenase and dispase mixed digestive enzyme solution and discarding the solution; thirdly, placing the mixture in a trypsin and an ethylene diamine tetraacetic acid (EDTA) for 5 to 10 minutes to obtain a nerve fiber from which a perineurium is removed; fourthly, placing the obtained nerve fiber in the mixed enzyme solution, and oscillating the mixture to obtain a cell suspension; and finally, performing centrifugation and heavy suspension. By using the method, a greatquantity of high-purity schwann cells are obtained in a low-cost and high-efficiency mode so that the abundant and high-quality schwann cells are supplied for repairing the damaged nerve.

The invention relates to a multi-channel artificial nerve catheter and a preparation method thereof. The multi-channel artificial nerve catheter can be used for customized bridging repair of far and near ends of a nerve defect site. The multi-channel artificial nerve catheter capable of performing customized imitation on a natural anatomical structure of nerves mainly comprises a multi-channel stent (neural catheter tube body) imitating the natural anatomical structure of the nerves and a biofilm structure (neural catheter tube wall) wrapping the outer layer of the multi-channel stent. The tube multi-channel structure can form a better customized matching relation with nerve tract tissue of different sizes in different areas of the to-be-repaired nerves, and by guiding specific nerve tracttissue at the near ends of the nerve defect site in reaching the far ends in different customized channel structures, the decrease of the diverged growth and mutual interweave phenomenon of the nervetracts during growth is achieved, and the decrease of the mismatch rate of near-end new nerve tract tissue with a far-end target region is facilitated.

The invention relates to a method of discriminating the nature of the nerve-tract through the near infrared spectrometer and analytical method, which comprises the following steps: a) getting several nerve sport-tract and feeling-tract, sampling them by the near infrared spectrometer and getting the spectrogram; b) cluster analyzing the collecting data and establishing the model parameter used for processing of the near infrared spectrometer; c) setting the identification model of the nerve sport-tract and feeling-tract, d) scanning with different neurotransmitters in the nerve-tract in the same condition and making principal factor analysis with the wave spectrum and sport-tract wave spectrum, finding the discriminating main factor, and acquiring the nature of the nerve-tract.

The invention relates to the technical field of medical instruments, and discloses a cervical dilatation balloon catheter. According to the cervical dilatation balloon catheter, tablets are placed in a medicine storage cavity by rotating a head end, the head end is tightened, lubricating physiological liquid medicine is injected into a sealing injection ring, the lubricating physiological liquid medicine dissolves the tablets into particles and flows out of the medicine outlet holes, so that the inner wall of the vagina of a puerpera is lubricated, meanwhile, the aims of stopping bleeding and suppressing pain are achieved, and comfort is improved; According to the cervical dilatation balloon catheter, a first balloon and a second balloon are filled with normal saline and placed on the inner opening of the cervix uteri, mild mechanical expansion force is generated on the lower uterine segment and the cervix uteri, disappearance of the lower uterine segment and dilatation of the uterine opening are promoted, meanwhile, secretion of endogenous prostaglandin is stimulated through separation and stripping of a fetal membrane, so that the cervix uteri of the puerpera is gradually expanded unconsciously, and accordingly nerves reflect, so that nerve tracts of posterior pituitary release oxytocin, the oxytocin level in maternal blood circulation is increased, uterus contraction is promoted to be continuously enhanced, then labor induction is successful, and the operation efficiency is improved.

The invention discloses an application of an acetylcholinesterase piezoelectric biosensor in detecting nerve bundle property. A choline esterase antibody fixed on a quartz crystal reacts to acetylcholinesterase contained in a nerve sample to be measured, the oscillation frequency of the quartz crystal changes in the reaction process, then the content of the acetylcholinesterase is measured and mirrored through a computer monitor system, the nerve bundle to be measured with high content is of a motion tract, and the nerve bundle to be measured with low content is of a sensory tract. The invention starts with the difference of the content of the acetylcholinesterase in the peripheral nerve motion tract and the sensory tract, can fast detect an acetylcholinesterase piezoelectric biosensor system, fast discriminate the peripheral nerve motion tract and the sensory tract, and realize the correct sewing of the motion tract to the motion tract, and the sensory tract to the sensory tract. The invention can be widely popularized in the further clinical application.

The invention provides a sandwich-type composite membrane support, comprising a dense outer layer, a sandwich layer and an inner layer from top to bottom, the dense outer layer is a polylactic acid film, and the sandwich layer is a mesoporous organism loaded with biologically active factors Active glass spheres, the inner layer is a chitosan membrane loaded with seed cells. In order to solve the problem that the single nerve bundle that has been damaged (but not dead) cannot be repaired and treated by the existing technology; the existing drug-loaded system cannot achieve the directional release of the drug and cannot guarantee the high concentration of the damaged local factor; most loading The drug system is easy to degrade, the drug loading is low, and the drug release cannot run through the repair process of spinal cord injury. The drug loading system is too large, which may compress the spinal cord, and is not conducive to suturing the dura mater, resulting in the formation of cerebrospinal fluid leakage.

The invention provides a whole-brain nerve tract projection path automatic tracking method and system, and the method comprises the following steps: data preprocessing; signal extraction; data space partitioning; signal density calculation; projection path calculation; path integration and visualization. The method and system can achieve the automatic tracking of a nerve tract projection path fora whole-brain data set, and a calculation result can highly accord with a signal, and the accuracy is high. A calculated vectorized nerve tract path can quantitatively describe the connection relationof a brain region.

The invention provides a preparation method of a sandwich-type composite film stent. A polylactic acid/bioactive glass/chitosan sandwich-type composite film carrier loaded with bioactive factors is created. The preparation method includes 1), preparing a polylactic acid film, mesoporous bioactive glass loaded with the bioactive factors and a chitosan film loaded with seed cells as an outer sealinglayer, a sandwich layer and an inner controlled release and stem cell stent layer respectively; 2), coating the polylactic acid film with the sandwich layer of the bioactive glass loaded with the bioactive factors, and loading the bioactive glass layer with the chitosan film loaded with the seed cells to create the sandwich-type composite film carrier. The preparation method has the advantages that the problem of incapability of repairing and treating single nerve tracts impaired (but not died yet) in the prior art can be solved; the problems that oriented release of drugs cannot be realizedand high concentration of impaired local factors cannot be guaranteed by existing drug delivery systems are also solved.

The invention relates to a nerve graft capable of guiding nerve tracts to be regenerated accurately. The nerve graft comprises a plurality of nerve guide wires and an outer sleeve, and is prepared from a material with good nerve biocompatibility. The guide wires are inserted into the nerve tracts corresponding to two broken ends of a nerve trunk, so that a function of accurately guiding the nerve tracts to grow in an orientated manner is fulfilled, meanwhile, the two broken ends of the nerve trunk are fixedly connected through the outer sleeve, and the circumstance that the guide wires slip due to pulling of the nerve trunk in a moving process of limbs is prevented. The whole nerve graft is simple in structure, and is convenient and speedy in an implanting process, and meanwhile, the effect of nerve regeneration and repair can be improved.

The invention discloses a nerve block puncture and catheterization kit, which comprises a packaging component, a puncture component and a fixing component. The packaging component comprises an airtight bag, a seal strip, a lock and a handle, the top of the airtight bag is provided with the seal strip which is fixedly connected with the airtight bag, the handle is arranged at the top of the seal strip and fixedly connected with the seal strip, and the lock is positioned on the upper front surface of the airtight bag and fixedly connected with the airtight bag. The puncture component comprises apuncture needle, a rotating connector, a silicon rubber handle, a puncture needle clamp, a guide tube and a nerve block indwelling tube, and the puncture needle is positioned in the airtight bag. Byvarious apparatuses in the nerve block puncture and catheterization kit, convenience in single-time nerve blocking including nerve blocking at parts difficult for common puncture needles to reach is achieved, continuous blocking of target nerve or nerve tract catheterization can be realized, and accordingly ideal anesthesia or treatment effects can be achieved.

The invention provides a method for preparing a double-layer membrane for spinal cord treatment. A polylactic acid/bioactive glass/chitosan sandwich type composite membrane carrier supported with bioactive factors is established. The method comprises the following steps: 1) respectively preparing a polylactic acid membrane, mesoporous bioactive glass supported with bioactive factors and a chitosan membrane loaded with stem cells so as to serve as an outside sealing layer, a sandwich layer and an inside sustained-release and stem cell scaffold layer; and 2) covering the bioactive glass sandwich layer supported with bioactive factors on the polylactic acid membrane, covering the chitosan membrane loaded with stem cells on the bioactive glass layer so as to establish the sandwich composite membrane carrier. Therefore, the problems that in the prior art that a single damaged (but not dead) nerve tract cannot be repaired and treated and that targeted release of the medicine cannot be realized by the conventional drug delivery system and high concentrations of damaged local factors cannot be guaranteed are solved.

The invention provides near-infrared LED physiotherapy equipment for increasing CD4+T lymphocytes and reducing disease rod of HIV patient, and application thereof, wherein the equipment belongs to thefield of medicine technology. The equipment is composed of a controller, an LED matrix with a wavelength range of 650nm-780nm, and fixing bands. The bottom end output of the controller is connected with an LED matrix with a wavelength range of 650nm-780nm through an output line. The fixing bands are fixedly mounted at two sides of the LED matrix. The near-infrared LED physiotherapy equipment hasadvantages of higher clinic safety, simpler and more convenient use, and low cost. Through simulating a central nerve tract and peripheral blood, immunocyte division of an immunizing system is promoted and dormant T cell is activated. The total number of the T cells in increased. Furthermore simulation can excite signal expression up-regulation of CD4+T and TM cells, and then self detection is performed. furthermore an apoptosis instruction is transmitted to the cell with varied DNA caused by HIV.