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35 results about "Nerve tract" patented technology
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A nerve tract is a bundle of nerve fibers (axons) connecting nuclei of the central nervous system. In the peripheral nervous system this is known as a nerve, and has associated connective tissue. The main nerve tracts in the central nervous system are of three types: association fibers, commissural fibers, and projection fibers. A tract may also be referred to as a commissure, fasciculus or decussation. A commissure connects the two cerebral hemispheres at the same levels. Examples are the posterior commissure and the corpus callosum. A decussation is a connection made by fibres that cross at different levels (obliquely), such as the sensory decussation. Examples of a fascicle are the subthalamic fasciculus and the lenticular fasciculus.
Compositions and methods for enhancing structural and functional nervous system reorganization and recovery
InactiveUS20060104969A1Improve the degradation problemSimple structurePeptide/protein ingredientsInorganic phosphorous active ingredientsNervous systemDelivery vehicle
The present invention provides methods and compositions for enhancing recovery in a subject suffering from damage to the nervous system. In particular, the invention includes a method for promoting recovery and / or reorganization in the nervous system of a subject in need of enhancement of recovery and / or reorganization of the nervous system as a result of ischemic, hemorrhagic, neoplastic, degenerative, or traumatic damage by focally administering a composition comprising a proteolysis-enhancing agent such as tissue plasminogen activator (tPA), plasmin, or a PAI inhibitor to the nervous system of the subject. In some embodiments an additional active agent is also administered. The composition can be delivered using a variety of techniques including injection, via infusion pump, from an implantable microchip, or using a polymeric delivery vehicle. The composition can be administered, for example, to one or more subdivisions or areas of the brain, the spinal cord, or to one or more nerves or nerve tracts innervating diverse regions of the body. The invention also includes a drug delivery device for implantation into the nervous system to promote nervous system reorganization and / or recovery following ischemic, hemorrhagic, neoplastic, traumatic or degenerative damage, the drug delivery device comprising a biocompatible polymer and a proteolysis-enhancing agent such as tissue plasminogen activator (tPA), plasmin, or a PAI inhibitor, wherein the proteolysis-enhancing agent is released from the polymer in an amount effective to promote structural reorganization of the nervous system. In some embodiments the biocompatible polymer is a hydrogel.
Owner:THE BRIGHAM & WOMEN S HOSPITAL INC +1
Flexible nerve tract electrode and preparation method thereof
ActiveCN102764479APromote growthPrecise dockingInternal electrodesExternal electrodesNerve tractEngineering
The invention relates to a flexible nerve tract electrode, which comprises a flexible substrate, an electrode unit, an electrode lead, a lead welding spot and an insulating layer, wherein the electrode lead is electrically connected with the electrode unit and the lead welding spot; the electrode unit, the electrode lead and the lead welding spot form an electrode assembly together; the electrode assembly is arranged on the flexible substrate; the insulating layer is arranged on the flexible substrate and covers the electrode lead; and the electrode unit is electrically connected with a nerve tract. The invention also relates to a preparation method for the flexible nerve tract electrode. The flexible nerve tract electrode can be used for distinguishing moving nerve tracts and sensory nerve tracts in a nerve trunk, and can realize functions of a nerve cannula and provide space protection for growth of broken and injured nerves; functional electrical stimulation can be applied to the broken and injured nerves, so that the growth of the broken and injured nerves is accelerated; and the repair state of the broken and injured nerves can be monitored in real time by acquiring electrical physiological information at two ends of the broken and injured nerves. Moreover, the flexible nerve tract electrode can also be used for acquiring nerve information of normal nerve tracts to realize intelligent control of external instruments.
Owner:SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
Microelectronic system aided nerve channel function recovering method and apparatus
ActiveCN1810203AAchieve autonomous controlSpinal electrodesDiagnostic recording/measuringNerve fiber bundleElectricity
The present invention discloses method and apparatus of detecting, exciting and regenerating sensation, motor and internal organ signals of vertebrate including human, and is especially one kind microelectronic system aided nerve channel function recovering method and apparatus. The nerve channel function recovering apparatus includes two parts, one part for the function reconstruction of the ascending nerve channel and the other part for the function reconstruction of the descending nerve channel. The weak electric signal of the damaged nerve tract or nerve fiber is detected with detecting electrodes, amplified, recognized and extracted to generate controlled electric exciting signal for exciting the damaged nerve tract or nerve fiber to regenerate corresponding nerve signal and restore the function of the damaged nerve tract or nerve fiber micro electronically.
Owner:SOUTHEAST UNIV +1
Nerve grafting object containing orientation nanofiber nerve tract and preparing method of nerve grafting object
The invention relates to the biomedical field of high molecular materials, in particular to a nerve grafting object containing an orientation nanofiber nerve tract and a preparing method of the nerve grafting object. A core (A) composed of the nanofiber tract is placed in the middle of the nerve grafting object, a sheath (B) composed of an irregular fiber layer (B2) and an orientation layer (B1) is arranged on the outer face of the nerve grafting object, the diameter of the core (A) composed of the nanofiber tract is 2-5mm, the length of the core (A) composed of the nanofiber tract is 3-15mm, the fiber diameter of the nanofiber tract is 40-300nm, the length of the sheath (B) is 9-25mm, the orientation layer (B1) comprises parallel-arrayed fibers of 100-500nm, and the irregular fiber layer (B2) comprises disorder-arrayed fibers of 100-500nm. The technology is stable, grafting object size is adjustable, the clinic requirement is met, production efficiency is improved, industrialization is convenient, guiding performance is high, using is convenient, and practicability is improved.
Owner:NANTONG TEXTILE VOCATIONAL TECH COLLEGE
Wireless energy supply and wireless acquisition system of nerve tract implanted electrode based on vlsivery large scale integrated circuit
InactiveCN101651369AEasy wiringFirmly connectedElectromagnetic wave systemCircuit arrangementsEngineeringPeripheral neuron
The invention relates to a wireless energy supply and wireless acquisition system of a nerve tract implanted electrode based on a vlsivery large scale integrated circuit (VLSI), comprising an internalimplanted circuit device and an external circuit device, wherein the internal implanted circuit device comprises a nerve tract complex potential acquisition circuit, an encode circuit and a 2ASK modulation circuit of a 2ASK modulation device, a rectifying circuit and a voltage stabilizing circuit of a wireless energy transmission receiving circuit, and an internal coupling coil, and the wirelessenergy transmission receiving circuit is manufactured by a VLSI technology; and the external circuit device comprises a 2ASK demodulation circuit, a radio-frequency oscillator and a class-E amplifierof a wireless energy transmission emitting circuit, a circuit board assembled by separate elements and an external coupling coil. The wireless energy supply and wireless acquisition system not only realizes the wireless energy supply of the internal implanted circuit device, but also realizes the wireless transmission of the nerve tract implanted electrode recorded on nerve tract complex potential, and can be used for detecting a peripheral nerve system when an animal does somatic movement in a waking state; and in addition, the power consumption of the wireless energy supply and wireless acquisition system is reduced by manufacturing a wireless energy supply chip and a wireless acquisition system by the VLSI technology.
Owner:CHONGQING UNIV
Implanted spiral electrode and manufacturing method thereof
ActiveCN104353181AImprove connection strengthReduce viscosityInternal electrodesExternal electrodesNerve tractSilanes
The invention discloses an implanted spiral electrode and a manufacturing method of the implanted spiral electrode, and belongs to the range of medical instruments. The implanted spiral electrode is of a flexible structure formed by first spiral bodies and a second spiral body, and a nerve tract is sleeved with the flexible structure. One ends of metal spiral wires in two insulation sleeve pipes are connected with stimulation contacts on the two first spiral bodies respectively, a traction line penetrates through one first spiral body and penetrates out of the other first spiral body, and a stimulation screw is formed by the traction line, the metal spiral wires and the simulation contacts. The stimulation contacts of a hollow flat annular structure is adopted, a silane coupling agent layer on the surface of the traction line and a lubricating coating on the surface of a connecting guide pipe are added, the connecting strength of all the parts of the simulation screw and a locating screw is enhanced, the glutinousness of the connecting guide pipe and human tissue is reduced, and the mechanical injury and physiological injury of the whole electrode to nerves can be reduced.
Owner:BEIJING PINS MEDICAL +1
Method for controlling bone implantation type artificial limb using internal bioelectricity signal
The invention discloses a method for controlling bone implantation artificial limb by means of biological electrical signal in human body, which comprises the steps of, plugging the upper end of the implantation member with holes into the remnant bones of the amputee's stump, connecting the lower projecting member with the artificial limb, implanting the electrodes into the nerve-tract or muscle hank in the soft tissue, leading the contact conductor to the external signal conditioning device through the through-hole on the implantation member, carrying out magnification and filtration to the signal collected by the electrodes, mapping the signal into the control message for artificial limb motion, the control signal feeding to the motor to drive the artificial limb.
Owner:TSINGHUA UNIV
Method for manufacturing flexible spiral electrode and nerve tract detection and treatment device
The disclosure relates to a method of manufacturing a flexible spiral electrode and a nerve tract detection and treatment device. The method comprises: a substrate is heated to be at a transformationtemperature and the substrate winds around a first forming rod spirally to form a to-be-formed substrate; the temperature of the to-be-formed substrate is kept to be larger than or equal to a first plastic deformation within first time and thus a spiral substrate is formed; the spiral substrate is heated to be at a transformation temperature and the substrate is flattened to obtain a flattened substrate; a metal electrode is transferred to the flattened substrate; a lead is connected to a lead connection end of the metal electrode, so that an electrical stimulation signal is sent to the metalelectrode through the lead and / or an electrical signal of a nerve tract in contact with the metal electrode is obtained; heating is carried out to reach a transformation temperature and thus the shapeof the flattened substrate is transformed into a spiral shape, so that a flexible spiral electrode is obtained. The manufactured flexible spiral electrode has high extensibility and the contact degree and the matching degree with the nerve tract are high; and the operation is carried out conveniently. Moreover, the service life is long; the stability is high; and the side effects are low.
Owner:TSINGHUA UNIV
Method for separating and purifying schwann cells
The invention belongs to the field of cell biology and relates to a method for separating and purifying schwann cells. The method sequentially comprises the following steps of: firstly, taking a nerve segment under the aseptic condition and removing an epineurium; secondly, digesting a nerve tract by using a NB4 composite collagenase and dispase mixed digestive enzyme solution and discarding the solution; thirdly, placing the mixture in a trypsin and an ethylene diamine tetraacetic acid (EDTA) for 5 to 10 minutes to obtain a nerve fiber from which a perineurium is removed; fourthly, placing the obtained nerve fiber in the mixed enzyme solution, and oscillating the mixture to obtain a cell suspension; and finally, performing centrifugation and heavy suspension. By using the method, a greatquantity of high-purity schwann cells are obtained in a low-cost and high-efficiency mode so that the abundant and high-quality schwann cells are supplied for repairing the damaged nerve.
Owner:SHANGHAI FIRST PEOPLES HOSPITAL
Multi-channel artificial nerve catheter and preparation method thereof
InactiveCN110115645AOptimize the matching relationshipReduce interweavingTissue regenerationProsthesisAnatomical structuresNerve tract
The invention relates to a multi-channel artificial nerve catheter and a preparation method thereof. The multi-channel artificial nerve catheter can be used for customized bridging repair of far and near ends of a nerve defect site. The multi-channel artificial nerve catheter capable of performing customized imitation on a natural anatomical structure of nerves mainly comprises a multi-channel stent (neural catheter tube body) imitating the natural anatomical structure of the nerves and a biofilm structure (neural catheter tube wall) wrapping the outer layer of the multi-channel stent. The tube multi-channel structure can form a better customized matching relation with nerve tract tissue of different sizes in different areas of the to-be-repaired nerves, and by guiding specific nerve tracttissue at the near ends of the nerve defect site in reaching the far ends in different customized channel structures, the decrease of the diverged growth and mutual interweave phenomenon of the nervetracts during growth is achieved, and the decrease of the mismatch rate of near-end new nerve tract tissue with a far-end target region is facilitated.
Owner:THE FIRST TEACHING HOSPITAL OF XINJIANG MEDICAL UNIVERCITY
Method for quick-speed in-situ authentication of peripheral nerve tracts
InactiveCN1664564AAchieving non-destructive access analysisAchieving Correct StitchingColor/spectral properties measurementsBiological testingModel parametersData treatment
The invention relates to a method of discriminating the nature of the nerve-tract through the near infrared spectrometer and analytical method, which comprises the following steps: a) getting several nerve sport-tract and feeling-tract, sampling them by the near infrared spectrometer and getting the spectrogram; b) cluster analyzing the collecting data and establishing the model parameter used for processing of the near infrared spectrometer; c) setting the identification model of the nerve sport-tract and feeling-tract, d) scanning with different neurotransmitters in the nerve-tract in the same condition and making principal factor analysis with the wave spectrum and sport-tract wave spectrum, finding the discriminating main factor, and acquiring the nature of the nerve-tract.
Owner:JIANGSU PROVINCE HOSPITAL
Cervical dilatation balloon catheter
ActiveCN113398440ATo stop bleedingFor pain reliefBalloon catheterMedical devicesFoetal membranesOxytocin
The invention relates to the technical field of medical instruments, and discloses a cervical dilatation balloon catheter. According to the cervical dilatation balloon catheter, tablets are placed in a medicine storage cavity by rotating a head end, the head end is tightened, lubricating physiological liquid medicine is injected into a sealing injection ring, the lubricating physiological liquid medicine dissolves the tablets into particles and flows out of the medicine outlet holes, so that the inner wall of the vagina of a puerpera is lubricated, meanwhile, the aims of stopping bleeding and suppressing pain are achieved, and comfort is improved; According to the cervical dilatation balloon catheter, a first balloon and a second balloon are filled with normal saline and placed on the inner opening of the cervix uteri, mild mechanical expansion force is generated on the lower uterine segment and the cervix uteri, disappearance of the lower uterine segment and dilatation of the uterine opening are promoted, meanwhile, secretion of endogenous prostaglandin is stimulated through separation and stripping of a fetal membrane, so that the cervix uteri of the puerpera is gradually expanded unconsciously, and accordingly nerves reflect, so that nerve tracts of posterior pituitary release oxytocin, the oxytocin level in maternal blood circulation is increased, uterus contraction is promoted to be continuously enhanced, then labor induction is successful, and the operation efficiency is improved.
Owner:深圳麦普奇医疗科技有限公司
Application of acetylcholine esterase piezoelectricity biosensor in the detection of nerve tract property
InactiveCN101231286AQuality improvementChange the oscillation frequencyMicrobiological testing/measurementBiological testingPeripheral neuronPeripheral nerve
The invention discloses an application of an acetylcholinesterase piezoelectric biosensor in detecting nerve bundle property. A choline esterase antibody fixed on a quartz crystal reacts to acetylcholinesterase contained in a nerve sample to be measured, the oscillation frequency of the quartz crystal changes in the reaction process, then the content of the acetylcholinesterase is measured and mirrored through a computer monitor system, the nerve bundle to be measured with high content is of a motion tract, and the nerve bundle to be measured with low content is of a sensory tract. The invention starts with the difference of the content of the acetylcholinesterase in the peripheral nerve motion tract and the sensory tract, can fast detect an acetylcholinesterase piezoelectric biosensor system, fast discriminate the peripheral nerve motion tract and the sensory tract, and realize the correct sewing of the motion tract to the motion tract, and the sensory tract to the sensory tract. The invention can be widely popularized in the further clinical application.
Owner:JIANGSU PROVINCE HOSPITAL
Sandwich type composite membrane stent
InactiveCN107252499AImprove acceleration performanceCreativeTissue regenerationProsthesisHigh concentrationSpinal dura mater
The invention provides a sandwich-type composite membrane support, comprising a dense outer layer, a sandwich layer and an inner layer from top to bottom, the dense outer layer is a polylactic acid film, and the sandwich layer is a mesoporous organism loaded with biologically active factors Active glass spheres, the inner layer is a chitosan membrane loaded with seed cells. In order to solve the problem that the single nerve bundle that has been damaged (but not dead) cannot be repaired and treated by the existing technology; the existing drug-loaded system cannot achieve the directional release of the drug and cannot guarantee the high concentration of the damaged local factor; most loading The drug system is easy to degrade, the drug loading is low, and the drug release cannot run through the repair process of spinal cord injury. The drug loading system is too large, which may compress the spinal cord, and is not conducive to suturing the dura mater, resulting in the formation of cerebrospinal fluid leakage.
Owner:无锡市锡山人民医院
Double-layer membrane for spinal cord treatment
InactiveCN107213139AOvercoming the problem of not being able to pass the blood-brain barrierAvoid lostNervous disorderPeptide/protein ingredientsHigh concentrationDrug release
The invention provides a double-layer membrane for spinal cord treatment. The double-layer membrane comprises a dense outer layer and an inner layer from top to bottom, wherein the dense outer layer is a polylactic acid membrane; the inner layer is a chitosan membrane supported with seed cells and mesoporous bioactive glass spheres; and bioactive factors are supported in the mesoporous bioactive glass spheres. The double-layer membrane is square or circular. The bioactive factors refer to nerve growth stimulating factors. The double-layer membrane aims to solve the problems in the prior art that a single damaged (but not dead) nerve tract cannot be repaired and treated; the problem that targeted release of the medicine cannot be realized by the conventional drug delivery system, and high concentrations of damaged local factors cannot be guaranteed, the problems that most of drug delivery systems are easy to degrade and low in drug-loading rate and drug release cannot always penetrate through the spinal cord injury repair process, and the problems that the drug delivery system is extremely large in volume, possibly compresses the spinal cord and is unfavorable for suture of duramater spinalis so as to cause leakage of a cerebrospinal fluid.
Owner:无锡市锡山人民医院
Sandwich type composite membrane support
InactiveCN108744046AGood tissue compatibilityRepair damageTissue regenerationProsthesisHigh concentrationSandwich like
The invention provides a sandwich type composite membrane support which comprises a compact outer layer, a sandwich layer and an inner layer, wherein the compact outer layer, the sandwich layer and the inner layer are arranged from top to bottom; the compact outer layer is a polylactic acid membrane, the sandwich layer is prepared from biological active factor loaded mesoporous biological active glass balls, and the inner layer is a seed cell loaded chitosan membrane. Therefore, the problem that a single nerve tract which is damaged (but not died) cannot be repaired and treated by the prior art is solved; the problems that an existing drug carrier system cannot achieve directional medicine release and cannot ensure high concentrations of damaged partial factors are solved; the problems that most drug carrier systems are easy to degrade, the drug carrier amount is low, and medicine release cannot run through a spinal cord injury repairing process all the time are solved; the problems that the drug carrier systems is overlarge in volume, may compress spinal cord and meanwhile are not favorable for sewing endorhachis to cause leakage of cerebrospinal fluid are solved.
Owner:无锡市锡山人民医院
Whole-brain nerve tract projection path automatic tracking method and system
The invention provides a whole-brain nerve tract projection path automatic tracking method and system, and the method comprises the following steps: data preprocessing; signal extraction; data space partitioning; signal density calculation; projection path calculation; path integration and visualization. The method and system can achieve the automatic tracking of a nerve tract projection path fora whole-brain data set, and a calculation result can highly accord with a signal, and the accuracy is high. A calculated vectorized nerve tract path can quantitatively describe the connection relationof a brain region.
Owner:HUST SUZHOU INST FOR BRAINMATICS
Preparation method of sandwich-type composite film stent
InactiveCN108714248AGood tissue compatibilityRepair damageTissue regenerationProsthesisHigh concentrationComposite film
The invention provides a preparation method of a sandwich-type composite film stent. A polylactic acid / bioactive glass / chitosan sandwich-type composite film carrier loaded with bioactive factors is created. The preparation method includes 1), preparing a polylactic acid film, mesoporous bioactive glass loaded with the bioactive factors and a chitosan film loaded with seed cells as an outer sealinglayer, a sandwich layer and an inner controlled release and stem cell stent layer respectively; 2), coating the polylactic acid film with the sandwich layer of the bioactive glass loaded with the bioactive factors, and loading the bioactive glass layer with the chitosan film loaded with the seed cells to create the sandwich-type composite film carrier. The preparation method has the advantages that the problem of incapability of repairing and treating single nerve tracts impaired (but not died yet) in the prior art can be solved; the problems that oriented release of drugs cannot be realizedand high concentration of impaired local factors cannot be guaranteed by existing drug delivery systems are also solved.
Owner:无锡市锡山人民医院
Nerve graft capable of guiding nerve tracts to be regenerated accurately
The invention relates to a nerve graft capable of guiding nerve tracts to be regenerated accurately. The nerve graft comprises a plurality of nerve guide wires and an outer sleeve, and is prepared from a material with good nerve biocompatibility. The guide wires are inserted into the nerve tracts corresponding to two broken ends of a nerve trunk, so that a function of accurately guiding the nerve tracts to grow in an orientated manner is fulfilled, meanwhile, the two broken ends of the nerve trunk are fixedly connected through the outer sleeve, and the circumstance that the guide wires slip due to pulling of the nerve trunk in a moving process of limbs is prevented. The whole nerve graft is simple in structure, and is convenient and speedy in an implanting process, and meanwhile, the effect of nerve regeneration and repair can be improved.
Owner:邹玉华
Nerve block puncture and catheterization kit
InactiveCN108210223AConvenient Single Nerve BlockSatisfactory anesthesiaAnaesthesiaMedical devicesNerve tractTherapeutic effect
The invention discloses a nerve block puncture and catheterization kit, which comprises a packaging component, a puncture component and a fixing component. The packaging component comprises an airtight bag, a seal strip, a lock and a handle, the top of the airtight bag is provided with the seal strip which is fixedly connected with the airtight bag, the handle is arranged at the top of the seal strip and fixedly connected with the seal strip, and the lock is positioned on the upper front surface of the airtight bag and fixedly connected with the airtight bag. The puncture component comprises apuncture needle, a rotating connector, a silicon rubber handle, a puncture needle clamp, a guide tube and a nerve block indwelling tube, and the puncture needle is positioned in the airtight bag. Byvarious apparatuses in the nerve block puncture and catheterization kit, convenience in single-time nerve blocking including nerve blocking at parts difficult for common puncture needles to reach is achieved, continuous blocking of target nerve or nerve tract catheterization can be realized, and accordingly ideal anesthesia or treatment effects can be achieved.
Owner:THE FIRST PEOPLES HOSPITAL OF NANTONG
Method for quick-speed in-situ authentication of peripheral nerve tracts
InactiveCN100425976CAchieving non-destructive access analysisAchieving Correct StitchingColor/spectral properties measurementsBiological testingModel parametersData treatment
The invention relates to a method of discriminating the nature of the nerve-tract through the near infrared spectrometer and analytical method, which comprises the following steps: a) getting several nerve sport-tract and feeling-tract, sampling them by the near infrared spectrometer and getting the spectrogram; b) cluster analyzing the collecting data and establishing the model parameter used for processing of the near infrared spectrometer; c) setting the identification model of the nerve sport-tract and feeling-tract, d) scanning with different neurotransmitters in the nerve-tract in the same condition and making principal factor analysis with the wave spectrum and sport-tract wave spectrum, finding the discriminating main factor, and acquiring the nature of the nerve-tract.
Owner:JIANGSU PROVINCE HOSPITAL
Method for increasing definition of Micro CT of peripheral nerve image
ActiveCN105997114ASolve the accuracy problemSolve the image is not clearRadiation diagnostic clinical applicationsComputerised tomographsPeripheral neuronPeripheral nerve
The invention relates to the technical field of medical science and discloses a method for increasing definition of Micro CT of a peripheral nerve image. The method comprises the steps that soft tissues such as peripheral nerves are dyed by a solution containing calcium ions; and the Micro CT is then used for scanning of the dyed soft tissues. By the method disclosed by the invention, the definition of the scanned image reaches a requirement for nerve tract reconstruction; and the problems of insufficient accuracy and the low image definition during the peripheral nerve three-dimensional reconstruction can be solved. The method disclosed by the invention is characterized in that calcium agent dyeing is carried out to peripheral nerve samples; an original structure of the human body soft tissues is fully maintained and the structure becomes applicable to the CT; and the problem that the CT cannot be applied during the soft tissue reconstruction is solved.
Owner:THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
Wireless energy supply and wireless acquisition system of nerve tract implanted electrode
InactiveCN101651369BWiring is inconvenientFirmly connectedElectromagnetic wave systemCircuit arrangementsPeripheral neuronPeripheral nerve
The invention relates to a wireless energy supply and wireless acquisition system of a nerve tract implanted electrode based on a vlsivery large scale integrated circuit (VLSI), comprising an internal implanted circuit device and an external circuit device, wherein the internal implanted circuit device comprises a nerve tract complex potential acquisition circuit, an encode circuit and a 2ASK modulation circuit of a 2ASK modulation device, a rectifying circuit and a voltage stabilizing circuit of a wireless energy transmission receiving circuit, and an internal coupling coil, and the wirelessenergy transmission receiving circuit is manufactured by a VLSI technology; and the external circuit device comprises a 2ASK demodulation circuit, a radio-frequency oscillator and a class-E amplifierof a wireless energy transmission emitting circuit, a circuit board assembled by separate elements and an external coupling coil. The wireless energy supply and wireless acquisition system not only realizes the wireless energy supply of the internal implanted circuit device, but also realizes the wireless transmission of the nerve tract implanted electrode recorded on nerve tract complex potential, and can be used for detecting a peripheral nerve system when an animal does somatic movement in a waking state; and in addition, the power consumption of the wireless energy supply and wireless acquisition system is reduced by manufacturing a wireless energy supply chip and a wireless acquisition system by the VLSI technology.
Owner:CHONGQING UNIV
Degradable flexible nerve tract repair device
ActiveCN110464983ALittle side effectsSpeed up the healing processSpinal electrodesExternal electrodesBiological bodySide effect
The invention relates to a degradable flexible nerve repair device. The device includes a flexible base for carrying a nerve repair electrode, an energy receiving coil and a connecting wire; the connecting wire can connect the energy receiving coil and the nerve repair electrode together; the energy receiving coil is used for generating induced current when an electromagnetic wave corresponding tothe self resonance frequency is received; the flexible base includes a nerve tract fixing part corresponding to the nerve repair electrode, and the nerve tract fixing part and the nerve repair electrode are wound on a nerve tract to be repaired together, and the nerve repair electrode makes contact with the nerve tract to be repaired; the nerve tract fixing part is used for fixing the nerve tractto be repaired; the nerve repair electrode is used for transferring the received current to the nerve tract to be repaired. The device provided by the embodiment of the invention is degradable in anorganism, has little side effect on the organism, accelerates the treatment and repair process of the nerve tract, has good flexibility and ductility, and cannot bring inconvenience to the life and work of the organism.
Owner:TSINGHUA UNIV
Method for preparing double-layer membrane for spinal cord treatment
InactiveCN107213140AOvercoming the problem of not being able to pass the blood-brain barrierAvoid lostNervous disorderPeptide/protein ingredientsHigh concentrationSpinal cord
The invention provides a method for preparing a double-layer membrane for spinal cord treatment. A polylactic acid / bioactive glass / chitosan sandwich type composite membrane carrier supported with bioactive factors is established. The method comprises the following steps: 1) respectively preparing a polylactic acid membrane, mesoporous bioactive glass supported with bioactive factors and a chitosan membrane loaded with stem cells so as to serve as an outside sealing layer, a sandwich layer and an inside sustained-release and stem cell scaffold layer; and 2) covering the bioactive glass sandwich layer supported with bioactive factors on the polylactic acid membrane, covering the chitosan membrane loaded with stem cells on the bioactive glass layer so as to establish the sandwich composite membrane carrier. Therefore, the problems that in the prior art that a single damaged (but not dead) nerve tract cannot be repaired and treated and that targeted release of the medicine cannot be realized by the conventional drug delivery system and high concentrations of damaged local factors cannot be guaranteed are solved.
Owner:无锡市锡山人民医院
Surgical fat separator
The present invention discloses a surgical fat separator. The surgical fat separator uses high-speed water jet to cut and separate fat and at the same time adjusts pressure to control a water jet flowrate, so that the water jet can just break fat cells, but has no damage to vital organs of blood vessel walls, nerve tracts, etc. The fat separator can be disassembled into a high pressure water pumpsystem, a high pressure water outlet pipe, a water gun and a spraying nozzle. Special features are as follows pressure of the high pressure water pump system can be adjusted, an internal pipeline canbe disinfected, a water inlet is connected with a rinsing bag, and a water outlet is connected to a high pressure outlet pipe. The high pressure outlet pipe can be sterilized. The water gun has a slender tubular stainless steel structure, can be disassembled and disinfected and is provided with a hand push switch in middle, a tail end is connected with the high pressure water outlet pipe and a head end is internally threadedly connected with the spraying nozzle. A head part of the spraying nozzle is in a small hole shape and made of a stainless steel metal structure, and has a waterproof rubber ring, and a tail end is provided with an external thread connected with an internal thread of a head end of the water gun.
Owner:邵长帅 +1
A method to enhance the clarity of micro CT scanning peripheral nerve images
ActiveCN105997114BSolve the accuracy problemSolve the image is not clearRadiation diagnostic clinical applicationsComputerised tomographsHuman bodyComputed tomography
The invention relates to the technical field of medical science and discloses a method for increasing definition of Micro CT of a peripheral nerve image. The method comprises the steps that soft tissues such as peripheral nerves are dyed by a solution containing calcium ions; and the Micro CT is then used for scanning of the dyed soft tissues. By the method disclosed by the invention, the definition of the scanned image reaches a requirement for nerve tract reconstruction; and the problems of insufficient accuracy and the low image definition during the peripheral nerve three-dimensional reconstruction can be solved. The method disclosed by the invention is characterized in that calcium agent dyeing is carried out to peripheral nerve samples; an original structure of the human body soft tissues is fully maintained and the structure becomes applicable to the CT; and the problem that the CT cannot be applied during the soft tissue reconstruction is solved.
Owner:THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
Near-infrared LED physiotherapy equipment for increasing CD4+T lymphocytes and reducing disease rod of HIV patient, and application thereof
The invention provides near-infrared LED physiotherapy equipment for increasing CD4+T lymphocytes and reducing disease rod of HIV patient, and application thereof, wherein the equipment belongs to thefield of medicine technology. The equipment is composed of a controller, an LED matrix with a wavelength range of 650nm-780nm, and fixing bands. The bottom end output of the controller is connected with an LED matrix with a wavelength range of 650nm-780nm through an output line. The fixing bands are fixedly mounted at two sides of the LED matrix. The near-infrared LED physiotherapy equipment hasadvantages of higher clinic safety, simpler and more convenient use, and low cost. Through simulating a central nerve tract and peripheral blood, immunocyte division of an immunizing system is promoted and dormant T cell is activated. The total number of the T cells in increased. Furthermore simulation can excite signal expression up-regulation of CD4+T and TM cells, and then self detection is performed. furthermore an apoptosis instruction is transmitted to the cell with varied DNA caused by HIV.
Owner:江西汉江科技发展有限公司
Flexible nerve tract electrode and preparation method thereof
ActiveCN102764479BPromote growthPrecise dockingInternal electrodesExternal electrodesNerve tractEngineering
Owner:SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
A method for constructing a live animal model for studying neuronal autophagy
Owner:SHANGHAI INST OF ORGANIC CHEM CHINESE ACAD OF SCI
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