Multi-channel artificial nerve catheter and preparation method thereof

A technology of nerve conduits and artificial nerves, applied in the field of nerve conduits, can solve the problems of not being able to truly restore the distribution and shape rules, and not being able to simulate the arrangement and distribution of nerve bundles well, so as to increase the number, reduce interweaving, and reduce error. The effect of ratio

Inactive Publication Date: 2019-08-13
THE FIRST TEACHING HOSPITAL OF XINJIANG MEDICAL UNIVERCITY
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  • Abstract
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  • Application Information

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Problems solved by technology

[0004] Therefore, the current nerve conduit structure is limited to single-channel or regular-matrix multi-channel nerve conduits, which cannot well simulate the arrangement and distribution of nerve bundles in the nerve, and cann

Method used

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  • Multi-channel artificial nerve catheter and preparation method thereof
  • Multi-channel artificial nerve catheter and preparation method thereof
  • Multi-channel artificial nerve catheter and preparation method thereof

Examples

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Embodiment 1

[0028] in accordance with figure 1 The pseudo-bionic New Zealand white rabbit sciatic nerve histological section is shown, and a multi-channel artificial nerve guide is customized. The multi-channel artificial nerve guide includes a nerve guide tube body, and there are 4 channels in the nerve guide tube body. The artificial nerve guide is a 4-channel nerve guide (4-CANC), and the cross-section of the guide tube is designed using computer-aided design software. figure 2 shown in the figure on the right.

[0029] The nerve guide body is an oval structure, the length of the nerve guide body is 10 mm, the major axis of the nerve guide body is 4 mm, and the short axis of the nerve guide body is 2.5 mm.

[0030] There are 4 channels in the nerve conduit body, which are respectively defined as the 1# lumen channel, the 2# lumen channel, the 3# lumen channel, and the 4# lumen channel mentioned in the figure.

[0031] The diameter of the 1# lumen channel is 1.2mm, the diameter of th...

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Abstract

The invention relates to a multi-channel artificial nerve catheter and a preparation method thereof. The multi-channel artificial nerve catheter can be used for customized bridging repair of far and near ends of a nerve defect site. The multi-channel artificial nerve catheter capable of performing customized imitation on a natural anatomical structure of nerves mainly comprises a multi-channel stent (neural catheter tube body) imitating the natural anatomical structure of the nerves and a biofilm structure (neural catheter tube wall) wrapping the outer layer of the multi-channel stent. The tube multi-channel structure can form a better customized matching relation with nerve tract tissue of different sizes in different areas of the to-be-repaired nerves, and by guiding specific nerve tracttissue at the near ends of the nerve defect site in reaching the far ends in different customized channel structures, the decrease of the diverged growth and mutual interweave phenomenon of the nervetracts during growth is achieved, and the decrease of the mismatch rate of near-end new nerve tract tissue with a far-end target region is facilitated.

Description

technical field [0001] The invention relates to the field of nerve conduits, and relates to the design and preparation method of a customized bionic multi-channel artificial nerve conduit that imitates the natural anatomical structure of nerves. Background technique [0002] Peripheral nerve injury is a common clinical problem that often results from severe injury, resulting in neurological deficits. For defects larger than 4 mm, a simple direct suture approach cannot be adopted, but a graft bridge needs to be provided between the proximal and distal ends of the defect. Autologous nerve transplantation is currently the "gold standard" for repairing nerve defects, but it often results in damage to the donor site and incomplete functional recovery. [0003] Nerve conduits have been developed as an alternative to autografts to repair nerve defects, and their structures are currently limited to simple single-channel or multi-channel structures with regular matrices. However, t...

Claims

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Application Information

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IPC IPC(8): A61F2/02A61L27/40A61L27/18A61L27/22A61L27/50A61L27/56
CPCA61F2/02A61F2240/001A61L27/18A61L27/222A61L27/50A61L27/56A61L2430/32C08L67/04
Inventor 艾合买提江·玉素甫亚穆罕默德·阿力克阿里木江·阿不来提任鹏马创阿不来提·阿不拉夏依买尔旦·买买提买买艾力·玉山程二林
Owner THE FIRST TEACHING HOSPITAL OF XINJIANG MEDICAL UNIVERCITY
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