The invention discloses a wood sandwich panel, comprising a board layer one (1), a sandwich layer (2) and a board layer two (3) which are inter-layer stuck and laminated into a whole; the sandwich layer (2) comprises a wood structure framework (5) and filling agents filled in the wood structure framework (5); the wood structure framework (5) is crisscross and uniformly distributed in the sandwich layer; the board layer one (1) and the board layer two (3) can adopt reconstituted decorative veneer or other boards. By introducing the wood elements to the production of the sandwich panels, the invention increases the decorative effect, expands the use ranges of the sandwich panel to meet the requirements of high-grade decoration; in addition, the panel is high in strength, stable, solid, good in sound insulation effect, light as well as massive and has good thermal insulation performance, so the panel can be widely applied for partition, floors, doors, interior wall decoration and repairs of ceilings and roofs and is suitable for high-grade places such as hotels, airports, exhibition centers, villas, and the like.